This document discusses bio activity related to preterm labour. It begins by explaining how uterine quiescence is maintained during pregnancy similarly to term labour, but preterm birth carries risks of neonatal morbidity and mortality. Over 50% of preterm births are idiopathic, while 25% involve preterm premature rupture of membranes (PPROM). The structure and composition of fetal membranes is described in detail. Increased matrix metalloproteinase activity and decreased tissue inhibitor of metalloproteinases lead to inappropriate degradation of the extracellular matrix of fetal membranes, which can cause membrane rupture and preterm birth.
Successful implantation of the embryos in the uterus after IVF cycle is about 20%. It represents the bottleneck in the procedure of in vitro fertilization and embryo transfer. In this presentation we look at factors affecting implantation and how to improve it.
Endometrial cycle and infertility DR.RAHUL,PHYSIOLOGY,SMS MC JAIPUR email drr...Dr.Rahul ,Jaipur
-Histology and functional component of the endometrium- why we to learn histology inPhysiology?
-SONOGRAPHIC FINDINGS in different phases of the normal endometrium cycle.
-In-vitro fertilization
-Role of ENDOMETRIUM related Infertility and how to come up with this limitation.
-Importance of endometrium in treatment of DUB
-A CASE STUDY : A novel approach to treat endometrial related infertility in near future.
-RELATED REFERENCES
Successful implantation of the embryos in the uterus after IVF cycle is about 20%. It represents the bottleneck in the procedure of in vitro fertilization and embryo transfer. In this presentation we look at factors affecting implantation and how to improve it.
Endometrial cycle and infertility DR.RAHUL,PHYSIOLOGY,SMS MC JAIPUR email drr...Dr.Rahul ,Jaipur
-Histology and functional component of the endometrium- why we to learn histology inPhysiology?
-SONOGRAPHIC FINDINGS in different phases of the normal endometrium cycle.
-In-vitro fertilization
-Role of ENDOMETRIUM related Infertility and how to come up with this limitation.
-Importance of endometrium in treatment of DUB
-A CASE STUDY : A novel approach to treat endometrial related infertility in near future.
-RELATED REFERENCES
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Successful implantation requires
a receptive endometrium,
a normal embryo at the blastocyst developmental stage and
a synchronized dialogue between maternal and embryonic tissues
USMLE GENERAL EMBRYOLOGY 008 First week of development A embryo .pdfAHMED ASHOUR
The initial week of embryonic development is a vital period commencing with fertilization, leading to the creation of the zygote and early cell divisions. It's noteworthy that, throughout this week, the developing embryo remains in the pre-implantation stage, journeying from the fallopian tube toward the uterus. Key events such as fertilization, cleavage, and the formation of the blastocyst are crucial for the embryo's early development.
These events lay the foundation for subsequent processes in the following weeks. The successful implantation of the blastocyst into the uterus marks the transition from the first week to the second week of embryonic development.
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ASA GUIDELINE
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2 Case Reports of Gastric Ultrasound
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
1. Bio activity of Preterm Labour
Prof. M.C. Bansal.
MBBS. MS. MJCOG. FICOG.
Founder Principal& Controller;
Jhalawar Medical College And Hospital
Jhalawar.
Ex. Principal & Controller;
Mahatma Gandhi Medical College And
Hospital, Sitapura , Jaipur.
2. INTRODUCTION
• Before onset of preterm labour, Uterine quiescence is
maintained as in other Pregnancies ---after initiation and
establishment of preterm labour—all the events involved
in all 4 phases of parturition occur in similar manner as in
term Labour.
• Preterm Birth carry major adverse risks of human
consequences.
• After congenital anomalies it is the major cause of neonatal
morbidity and mortality.
• Spontaneous preterm labour without Pre PROM occurs in >
50% cases while rest 25 % have pre PROM before the onset
of Preterm Uterine activity.
• Many factors increase likelihood of preterm delivery---
Genetics, infection , malnutrition, behavior and
environmental etc.
7. Genetic Influence on Preterm Labour
• Analogous to another disease processes ,
multiple co-existing genetic alterations and
favorable environment for expression of genetic
factor may lead to preterm labour.
• There is polymorphism in genes associated with
inflammation and infection and in those with
collagen turnover.
• Inherit ant mutation in genes regulating collagen
assembly may produce cervical insufficiency-or
Pre PROM.
8. Pre PROM(PPROM)
This defines premature rupture of membranes before 37
weeks and before onset of true labour.
STRUCTURE OF THE FETAL MEMBRANES
• The human amnion is composed of five distinct layers.
• It contains no blood vessels or nerves; the nutrients it
requires are supplied by the amniotic fluid.
• The innermost layer, nearest the fetus, is the amniotic
epithelium. Amniotic epithelial cells secrete collagen types
III and IV and noncollagenous glycoproteins (laminin,
nidogen, and fibronectin) that form the basement
membrane, the next layer of the amnion.
• The compact layer of connective tissue adjacent to the
basement membrane forms the main fibrous skeleton of
the amnion.
9. Structure of Fetal membrane----
• The collagens of the compact layer are secreted by
mesenchymal cells in the fibroblast layer.
• Interstitial collagens (types I and III) predominate and form
parallel bundles that maintain the mechanical integrity of the
amnion Collagen types V and VI form filamentous connections
between the interstitial collagens and the epithelial basement
membrane .
• The fibroblast layer is the thickest of the amniotic layers,
consisting of mesenchymal cells and macrophages within an
extracellular matrix.
• The collagens in this layer form a loose network with islands
of noncollagenous glycoproteins.
• The intermediate layer (spongy layer, or zona spongiosa) lies
between the amnion and the chorion. Its abundant content of
hydrated proteoglycans and glycoproteins gives this layer its
“spongy” appearance in histologic preparations, and it
contains a non fibrilar meshwork of mostly type III collagen
10. : structure of the fetal membranes
Layer Extracellular-Matrix Composition MMP or TIMP Produced
Amnion
Epthelium MMP-1, MMP-2,
MMP-9
Basement membrane Collagen types III, IV, V: laminin,
fibronectin, nidogen
Compact layer Collagen types I, III, V, VI; fibronectin
Fibroblast layer Collagen types I, III, VI; nidogen laminin,
fibronectin
Intermediate (spongy) layer Collagen type I, III, IV; proteglycans
Chorion
Reticular layer Collagen types, I, III, IV, V, VI;
proteoglycans
Basement membrane Collagen types IV; fibronectin laminin
Trophoblasts MMP-9
11. Machanism of rupture of Membranes
• Intrapartum rupture of the fetal membranes has been attributed to
generalized weakening due to uterine contractions and repeated
stretching. The tensile strength of the membranes is reduced in
specimens obtained after labour as compared with those obtained
during caesarean delivery without labour
• Generalized weakness of the membranes has been more difficult to
establish when prematurely ruptured membranes have been
compared with membranes that were artificially ruptured during
labour
• Membranes that rupture prematurely, however, appear to be
focally defective rather than generally weakened. The area near the
rupture site has been described as a “restricted zone of extreme
altered morphology” that is characterized by marked swelling and
disruption of the fibrilar collagen network within the compact,
fibroblast, and spongy layers ; Because this zone does not include
the entire rupture site, it may appear before membrane rupture
and represent the initial breakpoint.
12. CHANGES IN COLLAGEN CONTENT,
STRUCTURE, AND CATABOLISM
• The maintenance of the tensile strength of
fetal membranes appears to involve an
equilibrium between the synthesis and the
degradation of the components of the
extracellular matrix. It has been proposed that
changes in the membranes, including
decreased collagen content, altered collagen
structure, and increased collagenolytic
activity, are associated with premature
rupture of the membranes.
13. Connective-Tissue Disorders and Nutritional Deficiencies
as Risk Factors
• Although there are conflicting data regarding changes in the composition
of fetal-membrane collagen in association with the length of gestation and
membrane rupture, a decline in membrane collagen content or a change
in collagen structure probably precedes rupture of the membranes.
• Connective-tissue disorders are associated with weakened fetal
membranes and an increased incidence of preterm premature rupture of
the membranes.
• Nutritional deficiencies that predispose women to abnormal collagen
structure have also been associated with an increased risk of preterm
premature rupture of the membranes. Collagen cross-links, which are
formed in a series of reactions initiated by lysyl oxidase, increase the
tensile strength of fibrilar collagens.
• Lysyl oxidase is produced by amniotic mesenchymal cells, which lay down
the collagenous compact layer of the amnion. .
• Lysyl oxidase is a copper-dependent enzyme, and women with premature
rupture of the membranes have lower copper concentrations in maternal
and umbilical-cord serum than women whose fetal membranes are
artificially ruptured during labour.
14. Increased Collagen Degradation
The degradation of collagen is mediated primarily by matrix metalloproteinases,
which are inhibited by specific tissue inhibitors and other protease inhibitors.
The matrix metalloproteinases are a family of enzymes produced by various types
of cells that hydrolyze at least one component of the extracellular matrix. Because of
the various substrate specificities of matrix metalloproteinases, effective catabolism of
the many component molecules in the extracellular matrix requires the concerted
actions of several enzymes.
The interstitial collagenases matrix metalloproteinase-1 (MMP-1) and MMP-8
cleave the triple helix of the fibrilar collagens (types I and III), which are then further
degraded by the gelatinases MMP-2 and MMP-9.
These gelatinases also cleave type IV collagen, fibronectin, and proteoglycans. In
human fetal membranes, MMP-1 and MMP-9 messenger
RNA and protein have been localized to amniotic epithelial cells and chorionic
trophoblasts.
15. • Thus, the compact (collagenous) layer of the fetal membranes is
sandwiched between two layers of cells that produce matrix
metalloproteinases.
• Tissue inhibitors of metalloproteinases form 1:1 stoichiometric
complexes with matrix metalloproteinases and inhibit their
proteolytic activity. Tissue inhibitor of metalloproteinase-1 (TIMP-1)
binds to activated MMP-1, MMP-8, and MMP-9, and TIMP- 2 binds
to latent and active forms of MMP-2.
• The more recently described TIMP-3 and TIMP-4 appear to inhibit
matrix metalloproteinases as efficiently as TIMP-1.Coordinated
activities of matrix metalloproteinases and tissue inhibitors of
matrix metalloproteinases are essential to the process of
extracellular matrix remodelling.
• Near the time of delivery, however, the balance between activated
matrix metalloproteinase's and their tissue inhibitors shifts toward
proteolysis degradation of the extracellular matrix of the fetal
membranes.
16. • In human amnion and chorion, MMP-9 activity increases and TIMP-1
concentrations decrease dramatically with labour ;
• These changes may reflect a coordinated progression of events preceding
and during parturition, resulting in the controlled degradation of collagen
within the fetal membranes.
• Premature rupture of the membranes may also be caused by an
imbalance between the activities of matrix metalloproteinases and their
tissue inhibitors, leading to inappropriate degradation of the membranes’
extracellular matrixes.
• Collagenase activity is increased in prematurely ruptured membranes at
term.
• Overall, protease activity is increased in membranes of women with
preterm premature rupture of the membranes, the predominant activity
being that of MMP-9.
• Furthermore, gelatinolytic activity corresponding to latent and active
forms of MMP-9 is increased and the concentration of TIMP-1 is low in
amniotic fluid obtained from women whose pregnancies were
complicated by preterm premature rupture of the membranes
18. Spontaneous Preterm labour
• Pregnancies with intact membranes and spontaneous labor
must be distinguished from those complicated by PPROM.
• Even so the Spontaneous preterm labour do not constitutes
the homogenous group characterized singularly by
initiation of parturition.
• Among the most common associated findings are multiple
pregnancy , Intra uterine infection, IUFD, IUGR, bleeding ,
placental infarction , premature cervical dilatation, cervical
incompetence , uterine and fetal anomalies.
• Many forms of spontaneous preterm labour result from
preterm initiation of 2nd phase of parturition although this
is also questioned.
• Identification of common and uncommon factors has
begun to explain the physiological process of human
labour at term and preterm ----A, Uterine distension B.
maternal—fetal risk ,C Infection.
19. A. Uterine over distension & Preterm labour
• There is no doubt that multiple pregnancy and poly
hydroaminos – associated with over distension of uterus lead
to preterm labour.
• It is likely that over distension of uterus acts to initiate early
expression of contraction associated proteins ( CAP )in
myometrium.
• The CAP genes influenced by stretch include those coding for
gap junction proteins such as connexin43 for oxytocin
receptors and PGs synthase.-- decrease uterine quiescence.
• Excessive myometrial stretch also initiate premature
activation of placental—fetal endocrinal cascade ---early rise
in CRH, increased Estriole and premature with drawl of
progesterone.
• Early uterine stretch also play a role in premature onset of
cervical remodeling --- cervical softening, ripening and
dilatation.
21. Maternal - fetal biological Stress
Response
• There are plenty of evidences that maternal physical
and psychological stress ( PIH, APH, Infection ,
Nutritional deficiency , anemia etc.)and fetal distress (
IUGR, IUFD, Placental infection/ infestation, multiparty,
hydraminos etc,) initiates stimulate placental –adrenal
endocrine axis provides a potential mechanism for
initiation of preterm labour .
• Serial estimation of Rising levels of placental CRH and
estriole in maternal circulation have been noted as an
important precursor of predicting on set of preterm
labour
Phenomenon --- explained in next flow chart
22. Maternal -fetal stress Increased Placental
- CRH
Increased ACTH
Adult
adrenal
fetal
Adrenal
Production of steroids
Increased - fetal
cortisol
Decreased uterine
quiescence- PTL
Decreased Uterine
Quiescence
Abstract to
increase production
of Maternal Estriol
DHEA-S biosynthesis
Fetal Adrenal
cortisol
23. Intra uterine infection And Preterm
Labour
• A great interested has generated in the role of intra uterine
infection ---though intra amniotic culture studies have hardly
demonstrated 10-40 % positivity for microbes.
• Microbes associate with preterm labour are– Gardenella Vaginalis ,
Fusobacterium , Micoplasm Hominis and Uroplasma urealyticum
• But subclinical intrauterine infection is not uncommon, has been
promoted as the most common accompaniment and cause of
preterm labour,
• Microbes entered in maternal tissue produce endo toxins -reach
the amniotic cavity --- produce inflammatory response---
cytokinins in amnion –chorion.
• these cytokynins– initiate PGs synthesis --- cascade Of placental
CRH – adrenal axis
26. Inflammatory response to bacterial
invasion --- Preterm labour
• Bacteria invasion -Endotoxins production Toll like receptor present or develop
in de novo on invading Mononuclear phagocytes, Decidual , amniotic , trophoblast
cells ---Legends –polysaccharides Increased release of chemokines , cytokines
and PGs ---resulting switched on Cascade initiate myometrial contraction.
• Thus microbes may not invade the cells and amniotic cavity but there is Increased
invasion of Inflammatory cells in decidua, myometrium , amnion and cervix.
• Myometrial cells produce –cytokines –IL-1-6-8 and TNF alpha.
• Cervical stroma and glands ---IL-1-8 and TNF alpha .IL cytokines play a critical role
in cervical remodeling and dilatation.
• Leukocytes infiltration in fetal membranes --- synthesis of chemokines ---
Monocyte Chemotactic protein( MCP-1). MCP-1 is more in fore water than hind
water bag.
• Mcp-1 infiltration amniotic cells PGs synthesis .
• Infiltration of inflammatory cells in placenta --- Increased production of CRH
Placental – adrenal endocrine axis stimulation.
27. Summary of Preterm Labour--
Machanism
• Preterm Labour is a pathological condition with multifactoral
etiologies – now Termed As “Preterm Parturition Syndrome “.
• Role of intra uterine infection ( clinical / subclinical ) is an important
and major mediator of Preterm birth .
• In recent years our understanding of other influences in parturition
process, such as nutrition before and during pregnancy ,Genetic
and dynamics regulating the process of remodeling the extra
cellular matrix, have led to new awareness in this complicated and
multifactoral process.
• Current and future application of genomic and bio
informatics as well as microcellular biological studies will shed a
new light on the pathways involved in term and preterm parturition
• These will help to identify ongoing process in all phases of cervical
remodeling and myometrial activity.