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Liver Disease

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Miami Dade
Miami Dade

The document discusses liver regeneration and function. It states that individual liver cells can regenerate destroyed liver tissue, while larger destroyed sections will cause surrounding tissue to expand. Complete liver function relies on unimpeded blood flow, as cirrhosis can only generate poorly perfused nodules. The document also outlines the liver's role in bile production, blood filtration, nutrient breakdown, and more. It describes various tests of liver function including bilirubin levels, clotting factors, and enzymes that indicate tissue damage.

Health & Medicine
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[object Object],Diseases of the Liver & Biliary System
Liver regeneration ,[object Object],[object Object],[object Object],[object Object]
 
 
NORMAL CT SCAN
Liver blood supply ,[object Object],[object Object]
Functional anatomy ,[object Object],[object Object],[object Object]
Functional anatomy ,[object Object],[object Object],[object Object]
 
Hepatic Ducts ,[object Object],[object Object],[object Object],[object Object]
Gallbladder ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
What Does the Liver Do? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Role of Liver (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Role of the liver (cont) ,[object Object],[object Object],[object Object],[object Object]
Role of the liver (cont) ,[object Object],[object Object]
Liver Physiology ,[object Object],[object Object],[object Object]
Hepatic Physiology (cont.) ,[object Object],[object Object]
 
 
 
 
Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
History ,[object Object],[object Object]
Physical exam ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Tests of liver function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tests of Liver Function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
PT (prothrombin time) & INR (international normalized ratio) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
LFT’s/Transaminases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
AST/ALT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
AST/ALT ,[object Object],[object Object],[object Object]
Serum Alkaline Phosphatase- (Alk Phos) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alk Phos
Alk Phos
Alk Phos
 
 
 
LFT’s/ Diagnostic Tests ,[object Object],[object Object],[object Object],[object Object]
Tests for biliary obstruction/cholestasis &/or hepatocellular damage ,[object Object],[object Object],[object Object],[object Object]
Approach to Jaundice ,[object Object],[object Object],[object Object],[object Object],[object Object]
Bilirubin Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bilirubin conjugation ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Bilirubin Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Unconjugated (Indirect) hyperbilirubinemia ,[object Object],[object Object],[object Object]
Unconjugated (Indirect) hyperbilirubinemia ,[object Object]
Unconjugated (Indirect) hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conjugated (Direct) hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conjugated (Direct) hyperbilirubinemia ,[object Object],[object Object],[object Object],[object Object]
Causes of Conjugated (Direct) hyperbilirubinemia ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Diagnosis of conjugated hyperbilirubinemia
Disorders of the Biliary System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Special diagnostic procedures in cholestatic jaundice ,[object Object],[object Object],[object Object]
Hyperbilirubin Mneumonic ,[object Object]
 
 
 
 
 
 
 
 
Hepatitis ,[object Object],[object Object]
Hepatitis Causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],**Hepatitis E & A are fecal-oral (f E c A l –oral) **While Hep B,C,D are blood borne (parenteral) “ C oming in the B ack D oor”
 
 
Acute Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Acute Hepatitis ,[object Object],[object Object],[object Object],[object Object]
Acute Hepatitis ,[object Object],[object Object],[object Object]
Symptoms of Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical findings of Hepatitis ,[object Object],[object Object],[object Object],[object Object]
Laboratory Tests (LFT’s) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications of Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Don’t complain about the seating arrangements
Mononucleosis Epstein-Barr Virus (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis Epstein-Barr virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mononucleosis (EBV) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cytomegalic Virus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis A ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis A (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis A (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B (Lab continued) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Serologic Markers: ,[object Object],[object Object],[object Object],[object Object]
Serologic Markers: ,[object Object],[object Object]
Serologic Markers: (cont) ,[object Object]
Serologic Markers: (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Serologic Markers: (cont) ,[object Object],[object Object],[object Object],[object Object]
Serologic Markers: (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunization for HBV (with HBsAg) - - - + - Low-level HBsAg carrier or remote past infection +/- - IgG - - Recovery from HBV infection +/- - IgG + - Acute HBV infection (anti-HBc window) +/- +/- IgM - - Heterotypic anti-HBs with HBsAg; usually indicates chronic HBV carrier state +/- +/- + + + Late-acute or chronic HBV infection, low infectivity + - IgG - + Chronic HBV, high infectivity - + IgG - + Acute HBV, high infectivity - + IgM - + Interpretation Anti-HBe HBeAg Anti-HBc Anti-HBs HbsAg
Screening ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis B ,[object Object],[object Object],[object Object],[object Object]
 
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis C treatment (cont) ,[object Object],[object Object],[object Object]
Hepatitis C ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Hepatitis D ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatitis E ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
Alcoholic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Physical Findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Damage to liver causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Damage to the Portal System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Alcoholic Hepatitis Diagnostic Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alcoholic Hepatitis Diagnostic Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Acute Hepatitis Course ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute hepatitis course (cont.) ,[object Object],[object Object],[object Object],[object Object]
Acute hepatitis Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Acute Hepatitis Therapy (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute Hepatitis Nutritional Complications: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Related Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Related Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object]
Chronic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Chronic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Chronic Hepatitis Autoimmune Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chronic Hepatitis Autoimmune Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other causes of Chronic Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Wilson’s Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Wilson’s disease (cont) ,[object Object],[object Object],[object Object]
 
 
 
Haemochromatosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alpha 1-Antitrypsin Deficiency ,[object Object],[object Object],[object Object],[object Object]
Reye’s Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object]
REYE'S SYNDROME ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Hepatic (Liver) Failure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Hepatic Failure (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver failure (chronic): signs found on the arms Mneumonic ,[object Object]
 
Hepatic Failure (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hepatic encephalopathy: precipitating factors Mneumonic ,[object Object]
 
Hepatic failure (cont) Hepatic Encephalopathy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cirrhosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Causes of hepatic cirrhosis Mneumonic ,[object Object]
Cirrhosis: differential: common and rarer · Mneumonic ,[object Object],[object Object]
Cirrhosis
 
 
Cirrhosis (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cirrhosis (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cirrhosis (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
Ascites (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ascites
Ascites (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ascites treatment (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Portal Hypertension ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Portal Hypertension (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
Liver Review ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Review ,[object Object],[object Object],[object Object],[object Object]
Liver review ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Liver Jeopardy Facts ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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  • 129. Immunization for HBV (with HBsAg) - - - + - Low-level HBsAg carrier or remote past infection +/- - IgG - - Recovery from HBV infection +/- - IgG + - Acute HBV infection (anti-HBc window) +/- +/- IgM - - Heterotypic anti-HBs with HBsAg; usually indicates chronic HBV carrier state +/- +/- + + + Late-acute or chronic HBV infection, low infectivity + - IgG - + Chronic HBV, high infectivity - + IgG - + Acute HBV, high infectivity - + IgM - + Interpretation Anti-HBe HBeAg Anti-HBc Anti-HBs HbsAg
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