SlideShare a Scribd company logo
Scientificity and Feasibility Study of Non-Invasive
Central Arterial Pressure Measurement in
Hypertensive Patients in Different Activity States
Beijing Anzhen Hospital, Capital Medical University,
Beijing, China
Background(1/2)
Central Arterial Pressure
• An independent predictor of cardiovascular and cerebrovascular
diseases[1,2]
• A better predictor of cardiovascular events than brachial arterial
blood pressure[1,3]
• Significantly associated with coronary artery diseases (CAD) [3,4]
Measurement: Office single time VS ambulatory or continuous
monitoring
• To obtain more comprehensive and accurate data
• At different time points and under different conditions
• White coat hypertension, masked hypertension (MH) and isolated
nocturnal hypertension
Brachial artery
blood pressure
Central arterial
pressure
[1] Dong Y, Jiang L, Wang X, et al. Central rather than brachial
pressures are stronger predictors of cardiovascular outcomes:
a longitudinal prospective study in a Chinese population[J]. The
Journal of Clinical Hypertension, 2020, 22(4): 623-630.
[2] Sánchez R, Pessana F, Lev G, et al. Central blood pressure
waves assessment: a validation study of non-invasive aortic
pressure measurement in human beings[J]. High Blood
Pressure & Cardiovascular Prevention, 2020, 27: 165-174.
[3] 孙玉,郭守玉,龙明智.中心动脉压与靶器官损害的研究进展[J].
心血管病学进展, 2023, 44(5):457-459.
[4] 匡泽民,唐欣颖,奉淑君,等.无创中心动脉压与靶器官损害研究
进展[J].中华高血压杂志 2019(9):4.
Background(2/2)
Ambulatory blood pressure monitoring[1,2]
• Brachial à Central Arterial ?
Requires further verification: the scientific validity and clinical feasibility[3,4]
• To measure in different states: uneven breathing and light physical activities
• The scientificity and feasibility for using SphygmoCor®
to measure central arterial
pressure under different conditions need to be verified.
[1] European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension position paper on ambulatory blood
pressure monitoring. J Hypertens 2013; 31(9):1731-1768.
[2] European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension practice guidelines for ambulatory
blood pressure monitoring. J Hypertens 2014; 32(7):1359-1386.
[3] Is isolated nocturnal hypertension a novel clinical entity ? Findings from a Chinese population study. Hypertension 2007; 50:333-339.
[4] Prognostic value of isolated nocturnal hypertension in 8711 subjects from 10 populations. J Hypertens 2010; 28(10):2036-2045.
Aims and Objectives
• Use SphygmoCor®
to measure the central arterial pressure of the patients, and compare the difference between
single-point measurement and multi-point measurement of central arterial pressure for patients in resting state.
• Simulate central arterial pressure monitoring under different activity states by asking the patients to perform uneven
breathing and light physical activities. Evaluate the scientificity and feasibility of clinical operation of SphygmoCor® in
measuring central arterial pressure under different activity states of patients.
• Compare and analyze he blood pressure data of the patients under different activity states.
• Constructing a database of non-invasive arterial vascular function changes in hypertensive patients.
• Establishing a standardized procedure for measuring central arterial pressure in different activity states.
• Establishing a personalized disease risk prediction model based on central arterial pressure.
Aims
Objectives
Methods (1/4)
Technology and Equipment
• SphygmoCor® (AtCor Medical, Australia) : A non-invasive cardiac
monitoring device based on a hemodynamic mechanism that can accurately
measure central arterial pressure.
• The device estimates central arterial pressure by analyzing peripheral pulse
waveform and calculating PWV, combined with individual physiological
parameters (such as age, sex, height and weight).
• The measurement results of the device are highly consistent with those of
the traditional invasive floating catheter, with a precision of 99% and an
error of less than 1mmHg.
Methods (2/4)
Study Design / Data Collection:
1. Age, gender, height, weight, medical history, medication use and other basic information of
the patients were recorded. According to age, the patients were divided into the elderly
group and the young and middle-aged group.
2. Perform multiple measurements of central arterial pressure using a SphygmoCor® as the
following:
a. Ask the patients to rest for 5-10 minutes before their first measurement, and
measure their central arterial pressure while they remain in resting state, take 3
measurements in total at an interval of 2 minutes between each measurement.
b. Ask the patients to take 6 deep breaths (within about 1 minute) [1,2] , then measure
their central arterial pressure, followed by a resting period of 2 minutes. Repeat the
process for 2 more times to collect a total of 3 measurements under uneven
breathing state.
c. Ask the patients to take 6 Minute Walk Test (6MWT) [3] , followed by a resting period
of 2 minutes, then measure their central arterial pressure. Repeat the process for 2
more times to collect a total of 3 measurements under the state of light physical
activities.
d. Ask the patients to rest for 5-10 minutes before their final measurement, and
measure their central arterial pressure while they remain in resting state, take 3
measurements in total at an interval of 2 minutes between each measurement.
[1] Yau K K Y, Loke A Y. Effects of diaphragmatic deep breathing exercises
on prehypertensive or hypertensive adults: A literature review[J].
Complementary therapies in clinical practice, 2021, 43: 101315.
[2] Gholamrezaei A, Van Diest I, Aziz Q, et al. Psychophysiological
responses to various slow, deep breathing techniques[J]. Psychophysiology,
2021, 58(2): e13712.
[3] Agarwala P, Salzman S H. Six-minute walk test: clinical role, technique,
coding, and reimbursement[J]. Chest, 2020, 157(3): 603-611.
Methods (3/4)
Data Analysis: (1/2)
1. Data preprocessing: Cleaning data to exclude outlier measurements;
2. Statistical analysis:
① Analyzing the consistency of central arterial pressure measurements under the same activity state. For each of
the following activity states, compare the value of the first measurement, the average value of the next two
measurements, and the average value of all three measurements; in addition, calculate the maximum value,
minimum value, mean value, and mean square deviation under each activity state.
a) Resting state prior to any physical activity experiments;
b) Uneven breathing state after 6 deep breaths;
c) Light physical activity state after taking the 6 Minute Walk Test (6MWT);
d) Resting state at the end of all physical activity experiments.
② Analyzing resting state central arterial pressure measurements at the beginning and the end of the experiment,
by comparing the following indicators:
a) Value of the first measurements;
b) Average value of the last two measurements;
c) Average value of all three measurements;
Methods (4/4)
Data Analysis: (2/2)
③ Analyzing the central arterial pressure between the resting state at the beginning of the experiment with uneven
breathing state, by comparing the same set of indicators as above in ②.
④ Analyzing the central arterial pressure between the resting state at the beginning of the experiment with light
physical activity state, by comparing the same set of indicators as in ②.
⑤ Analyzing central arterial pressure variability of individual patients under different activity states:
a) Plot a curve to reflect the change in central arterial pressure for each subject undertaking the experiment;
b) Calculate the difference between the maximum value and the minimum value, the mean value and the
mean square deviation;
c) Define the coefficient of variation (CV) of central arterial pressure: Using step-by-step method to calculate
the difference between every two adjacent values, then calculate the coefficient of variation by averaging
the sum of the absolute values of these differences;
d) Compare the resting state central arterial pressure at the beginning of the experiment to that of all other
activity states.
⑥ Other secondary analysis measures: conduct user experience questionnaire with HCPs and patients
undertaking the experiment to evaluate the acceptance and satisfaction of using the SphygmoCor® for
ambulatory central arterial pressure monitoring.
Methods
•Research Roadmap
Stage 1: Preparation
Applying for equipment and
ethical approval
3 month
Patients recruitment
and data acquisition
# of patients: 80-100
6 month
Data analysis and
preparation for the
deliverables
3 month
Stage 2: Collecting Data Stage 3: Analysis and Summary
Requested Funding: $80,000
Deliverables:
• To construct a database of non-invasive arterial vascular function changes in hypertensive patients
• To construct a cardiovascular disease risk prediction model based on central arterial pressure
• To publish 1-2 articles and apply for 1-2 patents
Relative Groundwork
Fundings:
• Received funding from the Dean's Fund of Anzhen Hospital from 2015 to 2017 for a new management strategy
and effectiveness evaluation of "four-dimensional monitoring" for hypertension in the elderly population.
Publication:
• 匡泽民,唐欣颖,奉淑君,等.无创中心动脉压与靶器官损害研究进展[J].中华高血压杂志 2019(9):4.
• Li Y, Chen X, Zhang Y, et al. Noninvasive continuous blood pressure estimation with peripheral pulse transit
time[C]//2016 IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE, 2016: 66-69.
• Li Y, Li S, Deng N. Noninvasive and continuous blood pressure monitoring with better accuracy by combining
pulse arrival time and peak delay[J]. International Journal of Distributed Sensor Networks, 2018, 14(12.
• Li Y, Li S, Song H, et al. Noninvasive blood pressure estimation with peak delay of different pulse waves[J].
International Journal of Distributed Sensor Networks, 2019, 15(3.
Significance & Contribution
• Increase the frequency of device measurement and promote the clinical value of the device
• Develop new clinical potential service for the hospital by leveraging the superior performance of the device
• Provide more clinical options for the HCP in various patient population
• The role and contribution of equipment in this project
• Accurate acquisition of multiple central arterial pressure
• To provide important basis for evaluating vascular status and clinical diagnosis of related diseases
Future study
• Ambulatory and continuous monitoring of central arterial pressure
• Expansion of clinical scenarios and indications

More Related Content

Similar to Scientificity and feasibility study of non-invasive central arterial pressure measurement in hypertensive patients in different activity states

A study of autonomic function tests in hypertensives 723 new
A study of autonomic function tests in hypertensives 723 newA study of autonomic function tests in hypertensives 723 new
A study of autonomic function tests in hypertensives 723 new
Chiranjeevi JIPMER Puducherry
 
International Journal of Clinical Endocrinology
International Journal of Clinical EndocrinologyInternational Journal of Clinical Endocrinology
International Journal of Clinical Endocrinology
SciRes Literature LLC. | Open Access Journals
 
Journal club edgt 2016 (1)
Journal club edgt 2016 (1)Journal club edgt 2016 (1)
Journal club edgt 2016 (1)
sath_gasclub
 
Journal club 20 10-2016
Journal club 20 10-2016Journal club 20 10-2016
Journal club 20 10-2016
Amit Verma
 
Standing response fossaanec2014
Standing response fossaanec2014Standing response fossaanec2014
Standing response fossaanec2014
Sasha Latypova
 
Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx
     Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx     Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx
Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx
robert345678
 
Exercícios controle motor e lombalgia
Exercícios controle motor e lombalgiaExercícios controle motor e lombalgia
Exercícios controle motor e lombalgia
Podoposturologia Palmilhas Posturais
 
HEALTH SCREENING SERVICES
HEALTH SCREENING SERVICESHEALTH SCREENING SERVICES
HEALTH SCREENING SERVICES
Ramesh Ganpisetti
 
Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.
Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.
Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.
Liza Volv
 
Cranial electrotherapy stimulation
Cranial electrotherapy stimulationCranial electrotherapy stimulation
Cranial electrotherapy stimulation
Liz Volv
 
International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)
inventionjournals
 
Functional scales in cardio pulmonary condition
Functional scales in cardio pulmonary condition Functional scales in cardio pulmonary condition
Research Poster
Research PosterResearch Poster
Research Poster
Yan Teng
 
Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...
Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...
Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...
Games for Health Europe
 
EXERCISE TOLERENCE TEST
EXERCISE TOLERENCE TEST EXERCISE TOLERENCE TEST
EXERCISE TOLERENCE TEST
AneriPatwari
 
Ojchd.000525
Ojchd.000525Ojchd.000525
Design of a High Directive Gain Reconfigurable Circular Patch Antenna
Design of a High Directive Gain Reconfigurable Circular Patch AntennaDesign of a High Directive Gain Reconfigurable Circular Patch Antenna
Design of a High Directive Gain Reconfigurable Circular Patch Antenna
Associate Professor in VSB Coimbatore
 
A comparitive study of autonomic function sensitivity testing in type 2 diabetes
A comparitive study of autonomic function sensitivity testing in type 2 diabetesA comparitive study of autonomic function sensitivity testing in type 2 diabetes
A comparitive study of autonomic function sensitivity testing in type 2 diabetes
Chiranjeevi JIPMER Puducherry
 
Articulo cardio
Articulo cardioArticulo cardio
Articulo cardio
MelissaDelgado32
 
htaalmllsklklskdlñksldklskflskdlñkslñdklmññ
htaalmllsklklskdlñksldklskflskdlñkslñdklmññhtaalmllsklklskdlñksldklskflskdlñkslñdklmññ
htaalmllsklklskdlñksldklskflskdlñkslñdklmññ
cristianleon66
 

Similar to Scientificity and feasibility study of non-invasive central arterial pressure measurement in hypertensive patients in different activity states (20)

A study of autonomic function tests in hypertensives 723 new
A study of autonomic function tests in hypertensives 723 newA study of autonomic function tests in hypertensives 723 new
A study of autonomic function tests in hypertensives 723 new
 
International Journal of Clinical Endocrinology
International Journal of Clinical EndocrinologyInternational Journal of Clinical Endocrinology
International Journal of Clinical Endocrinology
 
Journal club edgt 2016 (1)
Journal club edgt 2016 (1)Journal club edgt 2016 (1)
Journal club edgt 2016 (1)
 
Journal club 20 10-2016
Journal club 20 10-2016Journal club 20 10-2016
Journal club 20 10-2016
 
Standing response fossaanec2014
Standing response fossaanec2014Standing response fossaanec2014
Standing response fossaanec2014
 
Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx
     Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx     Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx
Effectiveness of Aerobic Exercise on Ambulatory Blood P.docx
 
Exercícios controle motor e lombalgia
Exercícios controle motor e lombalgiaExercícios controle motor e lombalgia
Exercícios controle motor e lombalgia
 
HEALTH SCREENING SERVICES
HEALTH SCREENING SERVICESHEALTH SCREENING SERVICES
HEALTH SCREENING SERVICES
 
Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.
Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.
Cranial electrotherapy stimulation by Ray B. Smith, Ph.D.
 
Cranial electrotherapy stimulation
Cranial electrotherapy stimulationCranial electrotherapy stimulation
Cranial electrotherapy stimulation
 
International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)
 
Functional scales in cardio pulmonary condition
Functional scales in cardio pulmonary condition Functional scales in cardio pulmonary condition
Functional scales in cardio pulmonary condition
 
Research Poster
Research PosterResearch Poster
Research Poster
 
Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...
Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...
Exergames for Patients in Acute Care Settings: Systematic Review of the Repor...
 
EXERCISE TOLERENCE TEST
EXERCISE TOLERENCE TEST EXERCISE TOLERENCE TEST
EXERCISE TOLERENCE TEST
 
Ojchd.000525
Ojchd.000525Ojchd.000525
Ojchd.000525
 
Design of a High Directive Gain Reconfigurable Circular Patch Antenna
Design of a High Directive Gain Reconfigurable Circular Patch AntennaDesign of a High Directive Gain Reconfigurable Circular Patch Antenna
Design of a High Directive Gain Reconfigurable Circular Patch Antenna
 
A comparitive study of autonomic function sensitivity testing in type 2 diabetes
A comparitive study of autonomic function sensitivity testing in type 2 diabetesA comparitive study of autonomic function sensitivity testing in type 2 diabetes
A comparitive study of autonomic function sensitivity testing in type 2 diabetes
 
Articulo cardio
Articulo cardioArticulo cardio
Articulo cardio
 
htaalmllsklklskdlñksldklskflskdlñkslñdklmññ
htaalmllsklklskdlñksldklskflskdlñkslñdklmññhtaalmllsklklskdlñksldklskflskdlñkslñdklmññ
htaalmllsklklskdlñksldklskflskdlñkslñdklmññ
 

More from Catherine Liao

The hemodynamic and autonomic determinants of elevated blood pressure in obes...
The hemodynamic and autonomic determinants of elevated blood pressure in obes...The hemodynamic and autonomic determinants of elevated blood pressure in obes...
The hemodynamic and autonomic determinants of elevated blood pressure in obes...
Catherine Liao
 
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
Catherine Liao
 
Non-Invasive assessment of arterial stiffness in advanced heart failure patie...
Non-Invasive assessment of arterial stiffness in advanced heart failure patie...Non-Invasive assessment of arterial stiffness in advanced heart failure patie...
Non-Invasive assessment of arterial stiffness in advanced heart failure patie...
Catherine Liao
 
Arterial health throughout cancer treatment and exercise rehabilitation in wo...
Arterial health throughout cancer treatment and exercise rehabilitation in wo...Arterial health throughout cancer treatment and exercise rehabilitation in wo...
Arterial health throughout cancer treatment and exercise rehabilitation in wo...
Catherine Liao
 
"Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t...
"Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t..."Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t...
"Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t...
Catherine Liao
 
Young at heart: Cardiovascular health stations to empower healthy lifestyle b...
Young at heart: Cardiovascular health stations to empower healthy lifestyle b...Young at heart: Cardiovascular health stations to empower healthy lifestyle b...
Young at heart: Cardiovascular health stations to empower healthy lifestyle b...
Catherine Liao
 
Impact of cancers therapies on the loss in cardiac function, myocardial fffic...
Impact of cancers therapies on the loss in cardiac function, myocardial fffic...Impact of cancers therapies on the loss in cardiac function, myocardial fffic...
Impact of cancers therapies on the loss in cardiac function, myocardial fffic...
Catherine Liao
 
Is preeclampsia and spontaneous preterm delivery associate with vascular and ...
Is preeclampsia and spontaneous preterm delivery associate with vascular and ...Is preeclampsia and spontaneous preterm delivery associate with vascular and ...
Is preeclampsia and spontaneous preterm delivery associate with vascular and ...
Catherine Liao
 
Effects of vaping e-cigarettes on arterial health
Effects of vaping e-cigarettes on arterial healthEffects of vaping e-cigarettes on arterial health
Effects of vaping e-cigarettes on arterial health
Catherine Liao
 
Relationship between vascular system disfunction, neurofluid flow and Alzheim...
Relationship between vascular system disfunction, neurofluid flow and Alzheim...Relationship between vascular system disfunction, neurofluid flow and Alzheim...
Relationship between vascular system disfunction, neurofluid flow and Alzheim...
Catherine Liao
 
Compare home pulse pressure components collected directly from home
Compare home pulse pressure components collected directly from homeCompare home pulse pressure components collected directly from home
Compare home pulse pressure components collected directly from home
Catherine Liao
 

More from Catherine Liao (11)

The hemodynamic and autonomic determinants of elevated blood pressure in obes...
The hemodynamic and autonomic determinants of elevated blood pressure in obes...The hemodynamic and autonomic determinants of elevated blood pressure in obes...
The hemodynamic and autonomic determinants of elevated blood pressure in obes...
 
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
 
Non-Invasive assessment of arterial stiffness in advanced heart failure patie...
Non-Invasive assessment of arterial stiffness in advanced heart failure patie...Non-Invasive assessment of arterial stiffness in advanced heart failure patie...
Non-Invasive assessment of arterial stiffness in advanced heart failure patie...
 
Arterial health throughout cancer treatment and exercise rehabilitation in wo...
Arterial health throughout cancer treatment and exercise rehabilitation in wo...Arterial health throughout cancer treatment and exercise rehabilitation in wo...
Arterial health throughout cancer treatment and exercise rehabilitation in wo...
 
"Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t...
"Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t..."Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t...
"Central Hypertension"‚ in China: Towards the nation-wide use of SphygmoCor t...
 
Young at heart: Cardiovascular health stations to empower healthy lifestyle b...
Young at heart: Cardiovascular health stations to empower healthy lifestyle b...Young at heart: Cardiovascular health stations to empower healthy lifestyle b...
Young at heart: Cardiovascular health stations to empower healthy lifestyle b...
 
Impact of cancers therapies on the loss in cardiac function, myocardial fffic...
Impact of cancers therapies on the loss in cardiac function, myocardial fffic...Impact of cancers therapies on the loss in cardiac function, myocardial fffic...
Impact of cancers therapies on the loss in cardiac function, myocardial fffic...
 
Is preeclampsia and spontaneous preterm delivery associate with vascular and ...
Is preeclampsia and spontaneous preterm delivery associate with vascular and ...Is preeclampsia and spontaneous preterm delivery associate with vascular and ...
Is preeclampsia and spontaneous preterm delivery associate with vascular and ...
 
Effects of vaping e-cigarettes on arterial health
Effects of vaping e-cigarettes on arterial healthEffects of vaping e-cigarettes on arterial health
Effects of vaping e-cigarettes on arterial health
 
Relationship between vascular system disfunction, neurofluid flow and Alzheim...
Relationship between vascular system disfunction, neurofluid flow and Alzheim...Relationship between vascular system disfunction, neurofluid flow and Alzheim...
Relationship between vascular system disfunction, neurofluid flow and Alzheim...
 
Compare home pulse pressure components collected directly from home
Compare home pulse pressure components collected directly from homeCompare home pulse pressure components collected directly from home
Compare home pulse pressure components collected directly from home
 

Recently uploaded

Call Girl Pune 7339748667 Vip Call Girls Pune
Call Girl Pune 7339748667 Vip Call Girls PuneCall Girl Pune 7339748667 Vip Call Girls Pune
Call Girl Pune 7339748667 Vip Call Girls Pune
Mobile Problem
 
Public Health Lecture 4 Social Sciences and Public Health
Public Health Lecture 4 Social Sciences and Public HealthPublic Health Lecture 4 Social Sciences and Public Health
Public Health Lecture 4 Social Sciences and Public Health
phuakl
 
District Residency Programme (DRP) for PGs in India.pptx
District Residency Programme (DRP) for PGs in India.pptxDistrict Residency Programme (DRP) for PGs in India.pptx
District Residency Programme (DRP) for PGs in India.pptx
CommunityMedicine46
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
NephroTube - Dr.Gawad
 
biomechanics of running. Dr.dhwani.pptx
biomechanics of running.   Dr.dhwani.pptxbiomechanics of running.   Dr.dhwani.pptx
biomechanics of running. Dr.dhwani.pptx
Dr. Dhwani kawedia
 
Hemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.Gawad
Hemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.GawadHemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.Gawad
Hemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.Gawad
NephroTube - Dr.Gawad
 
Ageing, the Elderly, Gerontology and Public Health
Ageing, the Elderly, Gerontology and Public HealthAgeing, the Elderly, Gerontology and Public Health
Ageing, the Elderly, Gerontology and Public Health
phuakl
 
Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024
Torstein Dalen-Lorentsen
 
PARASITIC INFECTIONS IN CHILDREN peads.pptx
PARASITIC INFECTIONS IN CHILDREN peads.pptxPARASITIC INFECTIONS IN CHILDREN peads.pptx
PARASITIC INFECTIONS IN CHILDREN peads.pptx
MwambaChikonde1
 
Cervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptxCervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptx
LEFLOT Jean-Louis
 
PGx Analysis in VarSeq: A User’s Perspective
PGx Analysis in VarSeq: A User’s PerspectivePGx Analysis in VarSeq: A User’s Perspective
PGx Analysis in VarSeq: A User’s Perspective
Golden Helix
 
Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes
Pharmacology of Prostaglandins, Thromboxanes and LeukotrienesPharmacology of Prostaglandins, Thromboxanes and Leukotrienes
Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes
Dr. Nikhilkumar Sakle
 
Giloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and SynonymsGiloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and Synonyms
Planet Ayurveda
 
pharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdfpharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdf
KerlynIgnacio
 
KENT'S REPERTORY by dr niranjan mohanty.pptx
KENT'S REPERTORY by dr niranjan mohanty.pptxKENT'S REPERTORY by dr niranjan mohanty.pptx
KENT'S REPERTORY by dr niranjan mohanty.pptx
SravsPandu1
 
pharmacy exam preparation for undergradute students.pptx
pharmacy exam preparation for undergradute students.pptxpharmacy exam preparation for undergradute students.pptx
pharmacy exam preparation for undergradute students.pptx
AdugnaWari
 
Microbiology & Parasitology Exercises Parts of the Microscope
Microbiology & Parasitology Exercises Parts of the MicroscopeMicrobiology & Parasitology Exercises Parts of the Microscope
Microbiology & Parasitology Exercises Parts of the Microscope
ThaShee2
 
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
shruti jagirdar
 
Call Girls Lucknow 9024918724 Vip Call Girls Lucknow
Call Girls Lucknow 9024918724 Vip Call Girls LucknowCall Girls Lucknow 9024918724 Vip Call Girls Lucknow
Call Girls Lucknow 9024918724 Vip Call Girls Lucknow
nandinirastogi03
 
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
Université de Montréal
 

Recently uploaded (20)

Call Girl Pune 7339748667 Vip Call Girls Pune
Call Girl Pune 7339748667 Vip Call Girls PuneCall Girl Pune 7339748667 Vip Call Girls Pune
Call Girl Pune 7339748667 Vip Call Girls Pune
 
Public Health Lecture 4 Social Sciences and Public Health
Public Health Lecture 4 Social Sciences and Public HealthPublic Health Lecture 4 Social Sciences and Public Health
Public Health Lecture 4 Social Sciences and Public Health
 
District Residency Programme (DRP) for PGs in India.pptx
District Residency Programme (DRP) for PGs in India.pptxDistrict Residency Programme (DRP) for PGs in India.pptx
District Residency Programme (DRP) for PGs in India.pptx
 
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.GawadHemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
 
biomechanics of running. Dr.dhwani.pptx
biomechanics of running.   Dr.dhwani.pptxbiomechanics of running.   Dr.dhwani.pptx
biomechanics of running. Dr.dhwani.pptx
 
Hemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.Gawad
Hemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.GawadHemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.Gawad
Hemodialysis: Chapter 6, Hemodialysis Adequacy and Dose - Dr.Gawad
 
Ageing, the Elderly, Gerontology and Public Health
Ageing, the Elderly, Gerontology and Public HealthAgeing, the Elderly, Gerontology and Public Health
Ageing, the Elderly, Gerontology and Public Health
 
Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024Physical demands in sports - WCSPT Oslo 2024
Physical demands in sports - WCSPT Oslo 2024
 
PARASITIC INFECTIONS IN CHILDREN peads.pptx
PARASITIC INFECTIONS IN CHILDREN peads.pptxPARASITIC INFECTIONS IN CHILDREN peads.pptx
PARASITIC INFECTIONS IN CHILDREN peads.pptx
 
Cervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptxCervical Disc Arthroplasty ORSI 2024.pptx
Cervical Disc Arthroplasty ORSI 2024.pptx
 
PGx Analysis in VarSeq: A User’s Perspective
PGx Analysis in VarSeq: A User’s PerspectivePGx Analysis in VarSeq: A User’s Perspective
PGx Analysis in VarSeq: A User’s Perspective
 
Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes
Pharmacology of Prostaglandins, Thromboxanes and LeukotrienesPharmacology of Prostaglandins, Thromboxanes and Leukotrienes
Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes
 
Giloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and SynonymsGiloy in Ayurveda - Classical Categorization and Synonyms
Giloy in Ayurveda - Classical Categorization and Synonyms
 
pharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdfpharmacology for dummies free pdf download.pdf
pharmacology for dummies free pdf download.pdf
 
KENT'S REPERTORY by dr niranjan mohanty.pptx
KENT'S REPERTORY by dr niranjan mohanty.pptxKENT'S REPERTORY by dr niranjan mohanty.pptx
KENT'S REPERTORY by dr niranjan mohanty.pptx
 
pharmacy exam preparation for undergradute students.pptx
pharmacy exam preparation for undergradute students.pptxpharmacy exam preparation for undergradute students.pptx
pharmacy exam preparation for undergradute students.pptx
 
Microbiology & Parasitology Exercises Parts of the Microscope
Microbiology & Parasitology Exercises Parts of the MicroscopeMicrobiology & Parasitology Exercises Parts of the Microscope
Microbiology & Parasitology Exercises Parts of the Microscope
 
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
 
Call Girls Lucknow 9024918724 Vip Call Girls Lucknow
Call Girls Lucknow 9024918724 Vip Call Girls LucknowCall Girls Lucknow 9024918724 Vip Call Girls Lucknow
Call Girls Lucknow 9024918724 Vip Call Girls Lucknow
 
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...
 

Scientificity and feasibility study of non-invasive central arterial pressure measurement in hypertensive patients in different activity states

  • 1. Scientificity and Feasibility Study of Non-Invasive Central Arterial Pressure Measurement in Hypertensive Patients in Different Activity States Beijing Anzhen Hospital, Capital Medical University, Beijing, China
  • 2. Background(1/2) Central Arterial Pressure • An independent predictor of cardiovascular and cerebrovascular diseases[1,2] • A better predictor of cardiovascular events than brachial arterial blood pressure[1,3] • Significantly associated with coronary artery diseases (CAD) [3,4] Measurement: Office single time VS ambulatory or continuous monitoring • To obtain more comprehensive and accurate data • At different time points and under different conditions • White coat hypertension, masked hypertension (MH) and isolated nocturnal hypertension Brachial artery blood pressure Central arterial pressure [1] Dong Y, Jiang L, Wang X, et al. Central rather than brachial pressures are stronger predictors of cardiovascular outcomes: a longitudinal prospective study in a Chinese population[J]. The Journal of Clinical Hypertension, 2020, 22(4): 623-630. [2] Sánchez R, Pessana F, Lev G, et al. Central blood pressure waves assessment: a validation study of non-invasive aortic pressure measurement in human beings[J]. High Blood Pressure & Cardiovascular Prevention, 2020, 27: 165-174. [3] 孙玉,郭守玉,龙明智.中心动脉压与靶器官损害的研究进展[J]. 心血管病学进展, 2023, 44(5):457-459. [4] 匡泽民,唐欣颖,奉淑君,等.无创中心动脉压与靶器官损害研究 进展[J].中华高血压杂志 2019(9):4.
  • 3. Background(2/2) Ambulatory blood pressure monitoring[1,2] • Brachial à Central Arterial ? Requires further verification: the scientific validity and clinical feasibility[3,4] • To measure in different states: uneven breathing and light physical activities • The scientificity and feasibility for using SphygmoCor® to measure central arterial pressure under different conditions need to be verified. [1] European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension position paper on ambulatory blood pressure monitoring. J Hypertens 2013; 31(9):1731-1768. [2] European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring. J Hypertens 2014; 32(7):1359-1386. [3] Is isolated nocturnal hypertension a novel clinical entity ? Findings from a Chinese population study. Hypertension 2007; 50:333-339. [4] Prognostic value of isolated nocturnal hypertension in 8711 subjects from 10 populations. J Hypertens 2010; 28(10):2036-2045.
  • 4. Aims and Objectives • Use SphygmoCor® to measure the central arterial pressure of the patients, and compare the difference between single-point measurement and multi-point measurement of central arterial pressure for patients in resting state. • Simulate central arterial pressure monitoring under different activity states by asking the patients to perform uneven breathing and light physical activities. Evaluate the scientificity and feasibility of clinical operation of SphygmoCor® in measuring central arterial pressure under different activity states of patients. • Compare and analyze he blood pressure data of the patients under different activity states. • Constructing a database of non-invasive arterial vascular function changes in hypertensive patients. • Establishing a standardized procedure for measuring central arterial pressure in different activity states. • Establishing a personalized disease risk prediction model based on central arterial pressure. Aims Objectives
  • 5. Methods (1/4) Technology and Equipment • SphygmoCor® (AtCor Medical, Australia) : A non-invasive cardiac monitoring device based on a hemodynamic mechanism that can accurately measure central arterial pressure. • The device estimates central arterial pressure by analyzing peripheral pulse waveform and calculating PWV, combined with individual physiological parameters (such as age, sex, height and weight). • The measurement results of the device are highly consistent with those of the traditional invasive floating catheter, with a precision of 99% and an error of less than 1mmHg.
  • 6. Methods (2/4) Study Design / Data Collection: 1. Age, gender, height, weight, medical history, medication use and other basic information of the patients were recorded. According to age, the patients were divided into the elderly group and the young and middle-aged group. 2. Perform multiple measurements of central arterial pressure using a SphygmoCor® as the following: a. Ask the patients to rest for 5-10 minutes before their first measurement, and measure their central arterial pressure while they remain in resting state, take 3 measurements in total at an interval of 2 minutes between each measurement. b. Ask the patients to take 6 deep breaths (within about 1 minute) [1,2] , then measure their central arterial pressure, followed by a resting period of 2 minutes. Repeat the process for 2 more times to collect a total of 3 measurements under uneven breathing state. c. Ask the patients to take 6 Minute Walk Test (6MWT) [3] , followed by a resting period of 2 minutes, then measure their central arterial pressure. Repeat the process for 2 more times to collect a total of 3 measurements under the state of light physical activities. d. Ask the patients to rest for 5-10 minutes before their final measurement, and measure their central arterial pressure while they remain in resting state, take 3 measurements in total at an interval of 2 minutes between each measurement. [1] Yau K K Y, Loke A Y. Effects of diaphragmatic deep breathing exercises on prehypertensive or hypertensive adults: A literature review[J]. Complementary therapies in clinical practice, 2021, 43: 101315. [2] Gholamrezaei A, Van Diest I, Aziz Q, et al. Psychophysiological responses to various slow, deep breathing techniques[J]. Psychophysiology, 2021, 58(2): e13712. [3] Agarwala P, Salzman S H. Six-minute walk test: clinical role, technique, coding, and reimbursement[J]. Chest, 2020, 157(3): 603-611.
  • 7. Methods (3/4) Data Analysis: (1/2) 1. Data preprocessing: Cleaning data to exclude outlier measurements; 2. Statistical analysis: ① Analyzing the consistency of central arterial pressure measurements under the same activity state. For each of the following activity states, compare the value of the first measurement, the average value of the next two measurements, and the average value of all three measurements; in addition, calculate the maximum value, minimum value, mean value, and mean square deviation under each activity state. a) Resting state prior to any physical activity experiments; b) Uneven breathing state after 6 deep breaths; c) Light physical activity state after taking the 6 Minute Walk Test (6MWT); d) Resting state at the end of all physical activity experiments. ② Analyzing resting state central arterial pressure measurements at the beginning and the end of the experiment, by comparing the following indicators: a) Value of the first measurements; b) Average value of the last two measurements; c) Average value of all three measurements;
  • 8. Methods (4/4) Data Analysis: (2/2) ③ Analyzing the central arterial pressure between the resting state at the beginning of the experiment with uneven breathing state, by comparing the same set of indicators as above in ②. ④ Analyzing the central arterial pressure between the resting state at the beginning of the experiment with light physical activity state, by comparing the same set of indicators as in ②. ⑤ Analyzing central arterial pressure variability of individual patients under different activity states: a) Plot a curve to reflect the change in central arterial pressure for each subject undertaking the experiment; b) Calculate the difference between the maximum value and the minimum value, the mean value and the mean square deviation; c) Define the coefficient of variation (CV) of central arterial pressure: Using step-by-step method to calculate the difference between every two adjacent values, then calculate the coefficient of variation by averaging the sum of the absolute values of these differences; d) Compare the resting state central arterial pressure at the beginning of the experiment to that of all other activity states. ⑥ Other secondary analysis measures: conduct user experience questionnaire with HCPs and patients undertaking the experiment to evaluate the acceptance and satisfaction of using the SphygmoCor® for ambulatory central arterial pressure monitoring.
  • 9. Methods •Research Roadmap Stage 1: Preparation Applying for equipment and ethical approval 3 month Patients recruitment and data acquisition # of patients: 80-100 6 month Data analysis and preparation for the deliverables 3 month Stage 2: Collecting Data Stage 3: Analysis and Summary Requested Funding: $80,000 Deliverables: • To construct a database of non-invasive arterial vascular function changes in hypertensive patients • To construct a cardiovascular disease risk prediction model based on central arterial pressure • To publish 1-2 articles and apply for 1-2 patents
  • 10. Relative Groundwork Fundings: • Received funding from the Dean's Fund of Anzhen Hospital from 2015 to 2017 for a new management strategy and effectiveness evaluation of "four-dimensional monitoring" for hypertension in the elderly population. Publication: • 匡泽民,唐欣颖,奉淑君,等.无创中心动脉压与靶器官损害研究进展[J].中华高血压杂志 2019(9):4. • Li Y, Chen X, Zhang Y, et al. Noninvasive continuous blood pressure estimation with peripheral pulse transit time[C]//2016 IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE, 2016: 66-69. • Li Y, Li S, Deng N. Noninvasive and continuous blood pressure monitoring with better accuracy by combining pulse arrival time and peak delay[J]. International Journal of Distributed Sensor Networks, 2018, 14(12. • Li Y, Li S, Song H, et al. Noninvasive blood pressure estimation with peak delay of different pulse waves[J]. International Journal of Distributed Sensor Networks, 2019, 15(3.
  • 11. Significance & Contribution • Increase the frequency of device measurement and promote the clinical value of the device • Develop new clinical potential service for the hospital by leveraging the superior performance of the device • Provide more clinical options for the HCP in various patient population • The role and contribution of equipment in this project • Accurate acquisition of multiple central arterial pressure • To provide important basis for evaluating vascular status and clinical diagnosis of related diseases Future study • Ambulatory and continuous monitoring of central arterial pressure • Expansion of clinical scenarios and indications