Ribozymes are RNA molecules with catalytic activity, such as self-splicing introns that catalyze their own excision from pre-mRNA or RNase P that is involved in tRNA processing. Examples of ribozymes discussed include self-splicing introns, snRNAs that catalyze splicing, RNase P, and therapeutic ribozymes like angiozyme and herzyme. The ribosome is also identified as a ribozyme due to its peptidyl transferase activity.

1. RIBOZYMES

2. RIBOZYMES
•Ribozymes are RNAs with catalytic activity

3. EXAMPLES
1) 23S / 28S rRNA – Peptidyl transferase activity
2) Self-splicing introns (Group I and II)
3) snRNAs – catalyse splicing
4) RNAse P – involved in tRNA processing
5) Hairpin ribozyme
6) Hammerhead ribozyme

4. The Ribosome is a Ribozyme

5. Self-Splicing introns

6. SnRNA

7. RNase P

8. THERAPEUTIC RIBOZYMES
• ANGIOZYME
• HERZYME

9. ABZYMES
SYNZYMES
Extra - Edge

10. All of the following are ribozymes, EXCEPT
a) Ribosome
b) SnRNA
c) RNAse H
d) RNAse P