The document provides information about schizophrenia and other psychotic disorders: 1. Schizophrenia is characterized by disturbed thoughts, speech, behavior, social withdrawal, poor grooming, abnormal affect, and must include symptoms for 6 months including at least one period of actual psychosis. 2. Other psychotic disorders discussed include brief psychotic disorder, schizophreniform disorder, schizoaffective disorder, delusional disorder, and shared psychotic disorder. 3. Treatment involves antipsychotic medication, psychotherapy, and long-term support, with prognosis varying between disorders but generally chronic in nature.

1. INTRODUCTION TO MED (PSYCHIATRY) SCHIZOPHRENIA AND OTHER PSYCHOTIC DISORDERS

18. Classification Agent (Duration) Dose (mg/day) Clinical use Traditional Low - potency Thioridazine (Mellaril) 200 -600 Depression with intense anxiety or agitation Chlorpromazine(Thorazine) 100 – 800 To treat nausea and vomiting Hiccups Traditional High - potency Haloperidol (Haldol) 2 – 15 Psychosis secondary to organic syndrome; Tourette disorder Perphenazine (Trilafon) 8 – 40 To treat nausea and vomiting Pimozide (Orap) 1 –10 Tourette disorder, body dysmorphic disorder Trifluoperazine (Stelazine) 4 – 20 Non-psychotic anxiety (up to 12 weeks)

19. Classification Agent (Duration) Dose (mg/day) Clinical use Atypical Anti-psychotics Clozapine (Clozaril) 300 – 900 Effective for negative, chronic, and refractory symptoms Risperidone (Risperdal) 4 – 8 Useful for negative symptoms; has few side effects Olanzapine (Zyprexa) 10 – 20 Useful for negative symptoms; has few side effects