SlideShare a Scribd company logo
What if you learned that today’s Alzheimer’s
research, treatments and approved drugs were
grounded in a medical fallacy?
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
Problem with current approaches
The Neuroscientific community’s understanding of
the brain's neurofluids dynamics was built upon
the only feasible way to measure flow of Cerebrospinal Fluid (CSF) -
using MRI or PET scan imaging with the subject at rest.
Scientists therefore presumed
CSF dynamics at rest equate to those in a moving body, which is a
Medical fallacy of simple extrapolation
Cardiac and Respiratory functions are correlated to
bodily movement...
so is CSF flow
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
Moto Glymphatic Medical Hypothesis
We hypothesized CSF dynamics and production during active, awake state was
controlled by motion of spinal column and respiration
We collaborated with University of Oulu to measure CSF dynamics in the human
body during movement, leveraging novel functional near-infrared brain imaging
(fNIR) which has been validated across 1800+ human CSF measurements and
published in 10 separate papers
The findings showed that the cerebrospinal fluid dynamics is dramatically different
and subjective to human spinal movement
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
Validation - CSF dynamics differences in active and passive body
99.9% of Neuroscientists and
Doctors will tell you Cerebrospinal
fluid dynamics is well described.
We proved (MEASURED) them wrong.
https://youtu.be/8-72TaDSGYY
Device
Activation
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
We connected Dots across hundreds of Clinical Papers Linking Brain
Waste Clearance to Cognitive Status
Comprehensive papers available upon request
There is untapped potential for new therapies that can augment or enhance the body's
natural defense mechanisms and help the body to prevent, stop, and potentially restore
itself from underlying diseases
This includes Alzheimer's Disease
Such therapies should be based on scientific evidence and should aim to modulate,
stimulate, or support the body's natural defense mechanisms in a safe and effective
way
What is the significance of our findings
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
WE DESIGN THERAPIES BACKED BY SCIENTIFIC EVIDENCE, TO
AUGMENT THOSE NATURAL MECHANISMS TO
PREVENT, STOP, AND RESTORE ITSELF OF UNDERLYING DISEASE
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
Where Ciatrix Goes Next
Alzheimer's Clinical Trials Commencing
• International Center for Neurodegenerative Disorders Research Center (INDRC), led by Dr. Sherdova – Head of Memory
Care
• Key Data Collection
•Dynamics of median prefrontal cortex CSF pulsations during each therapy session
•Collect and analyze Alzheimer's blood plasma biomarkers related to neuro inflammation, oxidative stress, neurogenesis, and amyloid
clearance.
•Biomarkers include: Aβ 40/42, pTau 181, pTau 217, pTau 231, GFAP, NfL and S100B
•Assessment of cognitive function using standardized neuropsychological tests in two different domains. Alzheimer's Disease
Assessment Scale-Cognitive subscale (ADAS-Cog) and Assessment of Different Profiles of Spatial Navigation Deficits In Alzheimer’s
Disease
•Evaluate the quality of life of our patients using validated instruments, such as the Alzheimer's Disease Cooperative Study-Activities of
Daily Living (ADCS-ADL) and the Quality of Life in Alzheimer's Disease (QoL-AD) scales
•PET Amyloid Imaging pre and post 12 week treatment
•Collect wide range of supporting data on each study participant – continuous HRV, body temperature, sleep patterns and activity via
medical grade wearables
•Collect pre and post session (3x week) central blood pressure, arterial stiffness, vascular age, and heart stress of our patients using
SphygmoCor® devices at baseline and compare them with normative values and healthy controls
Executive Team
Zdenko Grajcar
CEO/CSO
Nash Rittmann
COO
Luke Dohmen, JD
Legal counsel
Nathan Piland, M. Eng, MBA
Head of Strategy, Growth
and Ventures
Michael Young, MD, JD
Neurologist
Intellectual Property
Dr. Katka Sherdova
Neurologist, Scientific
Advisor, Head of Memory
Center by International
Neurodegenerative Disorders
Research Center (INDRC)
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
Let’s Collaborate
Email:
nathan.piland@ciatrix.com
www.ciatrix.com
Ciatrix Inc, a Latify Inc company, Confidential – do not distribute

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Relationship between vascular system disfunction, neurofluid flow and Alzheimer's progression

  • 1. What if you learned that today’s Alzheimer’s research, treatments and approved drugs were grounded in a medical fallacy?
  • 2. Ciatrix Inc, a Latify Inc company, Confidential – do not distribute Problem with current approaches The Neuroscientific community’s understanding of the brain's neurofluids dynamics was built upon the only feasible way to measure flow of Cerebrospinal Fluid (CSF) - using MRI or PET scan imaging with the subject at rest. Scientists therefore presumed CSF dynamics at rest equate to those in a moving body, which is a Medical fallacy of simple extrapolation Cardiac and Respiratory functions are correlated to bodily movement... so is CSF flow
  • 3. Ciatrix Inc, a Latify Inc company, Confidential – do not distribute Moto Glymphatic Medical Hypothesis We hypothesized CSF dynamics and production during active, awake state was controlled by motion of spinal column and respiration We collaborated with University of Oulu to measure CSF dynamics in the human body during movement, leveraging novel functional near-infrared brain imaging (fNIR) which has been validated across 1800+ human CSF measurements and published in 10 separate papers The findings showed that the cerebrospinal fluid dynamics is dramatically different and subjective to human spinal movement
  • 4. Ciatrix Inc, a Latify Inc company, Confidential – do not distribute Validation - CSF dynamics differences in active and passive body 99.9% of Neuroscientists and Doctors will tell you Cerebrospinal fluid dynamics is well described. We proved (MEASURED) them wrong. https://youtu.be/8-72TaDSGYY Device Activation
  • 5. Ciatrix Inc, a Latify Inc company, Confidential – do not distribute We connected Dots across hundreds of Clinical Papers Linking Brain Waste Clearance to Cognitive Status Comprehensive papers available upon request
  • 6. There is untapped potential for new therapies that can augment or enhance the body's natural defense mechanisms and help the body to prevent, stop, and potentially restore itself from underlying diseases This includes Alzheimer's Disease Such therapies should be based on scientific evidence and should aim to modulate, stimulate, or support the body's natural defense mechanisms in a safe and effective way What is the significance of our findings Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
  • 7. WE DESIGN THERAPIES BACKED BY SCIENTIFIC EVIDENCE, TO AUGMENT THOSE NATURAL MECHANISMS TO PREVENT, STOP, AND RESTORE ITSELF OF UNDERLYING DISEASE
  • 8. Ciatrix Inc, a Latify Inc company, Confidential – do not distribute Where Ciatrix Goes Next Alzheimer's Clinical Trials Commencing • International Center for Neurodegenerative Disorders Research Center (INDRC), led by Dr. Sherdova – Head of Memory Care • Key Data Collection •Dynamics of median prefrontal cortex CSF pulsations during each therapy session •Collect and analyze Alzheimer's blood plasma biomarkers related to neuro inflammation, oxidative stress, neurogenesis, and amyloid clearance. •Biomarkers include: Aβ 40/42, pTau 181, pTau 217, pTau 231, GFAP, NfL and S100B •Assessment of cognitive function using standardized neuropsychological tests in two different domains. Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and Assessment of Different Profiles of Spatial Navigation Deficits In Alzheimer’s Disease •Evaluate the quality of life of our patients using validated instruments, such as the Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) and the Quality of Life in Alzheimer's Disease (QoL-AD) scales •PET Amyloid Imaging pre and post 12 week treatment •Collect wide range of supporting data on each study participant – continuous HRV, body temperature, sleep patterns and activity via medical grade wearables •Collect pre and post session (3x week) central blood pressure, arterial stiffness, vascular age, and heart stress of our patients using SphygmoCor® devices at baseline and compare them with normative values and healthy controls
  • 9. Executive Team Zdenko Grajcar CEO/CSO Nash Rittmann COO Luke Dohmen, JD Legal counsel Nathan Piland, M. Eng, MBA Head of Strategy, Growth and Ventures Michael Young, MD, JD Neurologist Intellectual Property Dr. Katka Sherdova Neurologist, Scientific Advisor, Head of Memory Center by International Neurodegenerative Disorders Research Center (INDRC) Ciatrix Inc, a Latify Inc company, Confidential – do not distribute
  • 10. Let’s Collaborate Email: nathan.piland@ciatrix.com www.ciatrix.com Ciatrix Inc, a Latify Inc company, Confidential – do not distribute