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Pre hepatic jaundice
1. NUR IZZATUL NAJWA BINTI SHARUPUDDIN
082015100036
JAUNDICED
INTRODUCTION, CLASSIFICATION AND
PRE – HEPATIC JAUNDICE
2. LEARNING OBJECTIVE
• ABLE TO DEFINE THE JAUNDICE
• ABLE TO UNDERSTAND THE ETIOLOGY OF
JAUNDICE
• ABLE TO LIST THE TYPES OF JAUNDICE AND
THEIR CLASSIFICATION
• ABLE TO KNOW THE SYMPTOM OF JAUNDICE
• ABLE TO EXPLAIN PRE – HEPATIC JAUNDICE
4. INTRODUCTION
• Refers to a yellowish discolouration of the
body tissues, including skin, sclera and
mucous membrane - ICTERUS
• Due to large quantities of bilirubin in the
exctracellular fluid
• Normal plasma concentration of :0.2-0.8
mg/dL
• Levels of bilirubin concentration
» > 1mg/dL (hyperbilirubinemia)
» > 2mg/dL (diffuse into tissue- JAUNDICE)
5. TYPES OF JAUNDICE
PRE – HEPATIC
(HAEMOLYTIC
JAUNDICE)
HEPATIC
(HEPATOCELLULAR
JAUNDICE)
POST – HEPATIC
(OBSTRUCTIVE
JAUNDICE)
6.
7. CLASSIFICATION OF JAUNDICE
TYPES OF
JAUNDICE
NATURE OF
HYPERBILIRUBINIMEA
FUNCTIONAL
DEFECT
PRE-HEPATIC
(HEMOLYTIC)
UNCONJUGATED RETENTION
HEPATIC
(HEPATOCELLULAR)
CONJUGATED AND
UNCONJUGATED
RETENTION AND
REGURGITATION
POST-HEPATIC
(OBSTRUCTIVE)
CONJUGATED REGURGITATION
9. PRE- HEPATIC JAUNDICE
• Also known as haemolytic jaundice
• Occurs before bile is made in liver
• Excess unconjugated bilirubin is produced
• Faster than the liver is able to conjugate it for
excretion
10.
11. Hemolytic jaundice
Blood, free bilirubin Increased
Blood, conj. bilirubin Normal
Blood, ALP Normal
Urine, bile salts Nil
Urine, conj. bilirubin Nil
Urine, bilinogen Increased
Fecal urobilinogen Increased
Hemolytic jaundice
Blood, free bilirubin Increased
Blood, conj. bilirubin Normal
Blood, ALP Normal
Urine, bile salts Nil
Urine, conj. bilirubin Nil
Urine, bilinogen Increased
Fecal urobilinogen Increased
13. TREATMENT
• Treatments for jaundice, depending on the
underlying cause
• Prevent the rapid breakdown of red blood
cells that's causing bilirubin levels to build up
in the blood.
• E.g.
- Blood transfusion
14. SUMMARY
• ABLE TO DEFINE THE JAUNDICE
• ABLE TO UNDERSTAND THE ETIOLOGY OF
JAUNDICE
• ABLE TO LIST THE TYPES OF JAUNDICE AND
THEIR CLASSIFICATION
• ABLE TO KNOW THE SYMPTOM OF JAUNDICE
• ABLE TO EXPLAIN PRE – HEPATIC JAUNDICE
15. REFERENCE
• Textbook of Medical Physiology, Prof GK Pal,
2nd edition
• Guyton and Hall, South Asian Edition
• http://www.nhs.uk/conditions/jaundice/Pages
/Treatment.aspx
