The document provides an overview of the excretory system. It discusses the anatomy and functions of the kidneys, including their role in regulating blood composition, volume, and pressure. The kidneys filter blood to form urine, which passes through the ureters into the bladder and then exits the body through the urethra. The functional unit of the kidneys is the nephron, which filters blood in the glomerulus and reabsorbs or secretes substances along the renal tubule. The kidneys play an important role in homeostasis.
Kidney (STRUCTURE AND FUNCTIONS) (: The Guyton and Hall physiology)Maryam Fida
STRUCTURE AND FUNCTIONS OF KIDNEY
There are two kidneys in body , Rt & Lt, lying on post abdominal wall, outside peritoneal cavity.
There weight is aprx. 150 Gm and size is clenched fist.
On medial side, there is a region called hilum through which pass blood & lymphatic vessels, nerve fibers and ureterKidney is surrounded by a protective fibrous capsule.
Each kidney has two major zones, outer thick known as cortex and part known as medulla.
Medulla is divided into multiple cone shaped tissue masses called renal pyramid.
The base of pyramid begins at junction of cortex & medulla and terminates in papilla which projects into space of renal pelvis.
Renal pelvis is funnel shaped continuation of upper end of ureter.
1- Excretion of metabolic waste products such as urea, creatinine, uric acid, Bilirubin, hormones & drugs.
2-. ELIMINATE HARMFUL FOREIGN COMPOUNDS.
Such as toxins, drugs, heavy metals, pesticides.
3- Regulation of water & electrolyte balance to maintain normal homeostasis of body by re-absorption and adjustment of rate of excretion of various substances.
4- Regulation of Arterial Pressure.
*Long term regulation by excreting variable amounts of water and sodium
and
*short term by secreting vaso-active substance (renin).
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
- Introduction
- Normal anatomy of kidney
- Nephron
- Juxtaglomerular apparatus
- Clearance
- tubular function
- Regulation of water and ion reabsorption
- Types of water reabsorption
- Mechanism of urine concentration and dilution
- Countercurrent mechanism
Renal blood flow (The Guyton and Hall physiology)Maryam Fida
In an average 70-kilogram man, the combined blood flow through both kidneys is about 1100 ml/min, or about 22 per cent of the cardiac output. Two kidneys makes about 0.4 % of total body weight but receive very high blood flow as compared with other body organ. The purpose of additional blood flow is to supply sufficient plasma for high rates of GF which is essential for regulating body fluid volumes & solute concentrations.
Characteristics of the renal blood flow:
1, High blood flow. 1100 ml/min, or 22 percent of the cardiac output. 94% to the cortex.
2, Two capillary beds
High hydrostatic pressure in glomerular capillary (about 60 mmHg) and low hydrostatic pressure in peritubular capillaries (about 13 mmHg)
Blood flow to renal medulla is supplied by vasa recta.
Blood flow in vasa recta of medulla is very low as compared to blood flow in cortex.
Blood flow in renal medulla is 1-2 % of total renal blood flow.
Vasa recta are important to form concentrated urine.
Kidney (STRUCTURE AND FUNCTIONS) (: The Guyton and Hall physiology)Maryam Fida
STRUCTURE AND FUNCTIONS OF KIDNEY
There are two kidneys in body , Rt & Lt, lying on post abdominal wall, outside peritoneal cavity.
There weight is aprx. 150 Gm and size is clenched fist.
On medial side, there is a region called hilum through which pass blood & lymphatic vessels, nerve fibers and ureterKidney is surrounded by a protective fibrous capsule.
Each kidney has two major zones, outer thick known as cortex and part known as medulla.
Medulla is divided into multiple cone shaped tissue masses called renal pyramid.
The base of pyramid begins at junction of cortex & medulla and terminates in papilla which projects into space of renal pelvis.
Renal pelvis is funnel shaped continuation of upper end of ureter.
1- Excretion of metabolic waste products such as urea, creatinine, uric acid, Bilirubin, hormones & drugs.
2-. ELIMINATE HARMFUL FOREIGN COMPOUNDS.
Such as toxins, drugs, heavy metals, pesticides.
3- Regulation of water & electrolyte balance to maintain normal homeostasis of body by re-absorption and adjustment of rate of excretion of various substances.
4- Regulation of Arterial Pressure.
*Long term regulation by excreting variable amounts of water and sodium
and
*short term by secreting vaso-active substance (renin).
I am a medical student. I have one friend who is persuing his MBBS degree in Taishan Medical UNiversity. I got these notes from him.
These notes are by Dr. Bikesh, He is a famous lecturer of TMU.
These notes have helped me a lot and i also watch his lecture videos , which are great; highly simple and huge content.
I am uploading with Renal physiology. If you want some other topics i would upload for you.
"Let the Knowledge be spread" Dr. Bikesh
- Introduction
- Normal anatomy of kidney
- Nephron
- Juxtaglomerular apparatus
- Clearance
- tubular function
- Regulation of water and ion reabsorption
- Types of water reabsorption
- Mechanism of urine concentration and dilution
- Countercurrent mechanism
Renal blood flow (The Guyton and Hall physiology)Maryam Fida
In an average 70-kilogram man, the combined blood flow through both kidneys is about 1100 ml/min, or about 22 per cent of the cardiac output. Two kidneys makes about 0.4 % of total body weight but receive very high blood flow as compared with other body organ. The purpose of additional blood flow is to supply sufficient plasma for high rates of GF which is essential for regulating body fluid volumes & solute concentrations.
Characteristics of the renal blood flow:
1, High blood flow. 1100 ml/min, or 22 percent of the cardiac output. 94% to the cortex.
2, Two capillary beds
High hydrostatic pressure in glomerular capillary (about 60 mmHg) and low hydrostatic pressure in peritubular capillaries (about 13 mmHg)
Blood flow to renal medulla is supplied by vasa recta.
Blood flow in vasa recta of medulla is very low as compared to blood flow in cortex.
Blood flow in renal medulla is 1-2 % of total renal blood flow.
Vasa recta are important to form concentrated urine.
Each kidney contains over 1 million tiny structures called nephrons. Each nephron has a glomerulus, the site of blood filtration. The glomerulus is a network of capillaries surrounded by a cuplike structure, the glomerular capsule (or Bowman’s capsule). As blood flows through the glomerulus, blood pressure pushes water and solutes from the capillaries into the capsule through a filtration membrane. This glomerular filtration begins the urine formation process.Inside the glomerulus, blood pressure pushes fluid from capillaries into the glomerular capsule through a specialized layer of cells. This layer, the filtration membrane, allows water and small solutes to pass but blocks blood cells and large proteins. Those components remain in the bloodstream. The filtrate (the fluid that has passed through the membrane) flows from the glomerular capsule further into the nephron.The glomerulus filters water and small solutes out of the bloodstream. The resulting filtrate contains waste, but also other substances the body needs: essential ions, glucose, amino acids, and smaller proteins. When the filtrate exits the glomerulus, it flows into a duct in the nephron called the renal tubule. As it moves, the needed substances and some water are reabsorbed through the tube wall into adjacent capillaries. This reabsorption of vital nutrients from the filtrate is the second step in urine creation.The filtrate absorbed in the glomerulus flows through the renal tubule, where nutrients and water are reabsorbed into capillaries. At the same time, waste ions and hydrogen ions pass from the capillaries into the renal tubule. This process is called secretion. The secreted ions combine with the remaining filtrate and become urine. The urine flows out of the nephron tubule into a collecting duct. It passes out of the kidney through the renal pelvis, into the ureter, and down to the bladder.The nephrons of the kidneys process blood and create urine through a process of filtration, reabsorption, and secretion. Urine is about 95% water and 5% waste products. Nitrogenous wastes excreted in urine include urea, creatinine, ammonia, and uric acid. Ions such as sodium, potassium, hydrogen, and calcium are also excreted
The nephron is the microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and an encompassing Bowman's capsule. The renal tubule extends from the capsule.
Human kidney,structure and functions of kidneyAnand P P
human kidney structural and functions.different types of structural components present in kidney and each structure having definite functions.structural and functional aspects of kidney.
Nephron (The Guyton and Hall physiology)Maryam Fida
Structural and Functional unit of kidney is called nephron.
There are about 1.3 million nephron in each kidney.
New nephrons can not be regenerated by kidneys.
Functioning nephrons decrease about 10 % every 10 years at the age of 40.
At the age of 80, there are 40 % of functioning nephrons as compared to 40 yrs.
It is formed by two parts.
1. GLOMERULUS
2. BOWMAN’S CAPSULE
1- Glomerulus:
It consists of tuft of glomerular capillaries.
There is anastomosing & branching network of glomerular capillaries.
Glomerular capillaries have high hydrostatic pressure (nearly 60 mm Hg) as compared with other capillaries.
Glomerulus is surrounded by a membranous cover called Bowman’s capsule.
Each glomerulus is about 0.2 mm in diameter.
Glomerulus and Bowman’s capsule together constitute renal corpuscle.
Each renal tubule is divided into various part as they have different functions.
i- Proximal convulated tubule.
It is continuation of Bowman’s capsule.
ii- Loop of Henle. It is continuation of prox. conv. tubule.
* Loop of Henle has three parts.
a- descending limb,
b- u turn or bend in medulla and
c- ascending limb.
Ascending limb has initial thin segment followed by thick segment.
At the end of thick ascending limb, there is short segment called macula densa, which plays important role in controlling functions of nephron.
Each kidney contains over 1 million tiny structures called nephrons. Each nephron has a glomerulus, the site of blood filtration. The glomerulus is a network of capillaries surrounded by a cuplike structure, the glomerular capsule (or Bowman’s capsule). As blood flows through the glomerulus, blood pressure pushes water and solutes from the capillaries into the capsule through a filtration membrane. This glomerular filtration begins the urine formation process.Inside the glomerulus, blood pressure pushes fluid from capillaries into the glomerular capsule through a specialized layer of cells. This layer, the filtration membrane, allows water and small solutes to pass but blocks blood cells and large proteins. Those components remain in the bloodstream. The filtrate (the fluid that has passed through the membrane) flows from the glomerular capsule further into the nephron.The glomerulus filters water and small solutes out of the bloodstream. The resulting filtrate contains waste, but also other substances the body needs: essential ions, glucose, amino acids, and smaller proteins. When the filtrate exits the glomerulus, it flows into a duct in the nephron called the renal tubule. As it moves, the needed substances and some water are reabsorbed through the tube wall into adjacent capillaries. This reabsorption of vital nutrients from the filtrate is the second step in urine creation.The filtrate absorbed in the glomerulus flows through the renal tubule, where nutrients and water are reabsorbed into capillaries. At the same time, waste ions and hydrogen ions pass from the capillaries into the renal tubule. This process is called secretion. The secreted ions combine with the remaining filtrate and become urine. The urine flows out of the nephron tubule into a collecting duct. It passes out of the kidney through the renal pelvis, into the ureter, and down to the bladder.The nephrons of the kidneys process blood and create urine through a process of filtration, reabsorption, and secretion. Urine is about 95% water and 5% waste products. Nitrogenous wastes excreted in urine include urea, creatinine, ammonia, and uric acid. Ions such as sodium, potassium, hydrogen, and calcium are also excreted
The nephron is the microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and an encompassing Bowman's capsule. The renal tubule extends from the capsule.
Human kidney,structure and functions of kidneyAnand P P
human kidney structural and functions.different types of structural components present in kidney and each structure having definite functions.structural and functional aspects of kidney.
Nephron (The Guyton and Hall physiology)Maryam Fida
Structural and Functional unit of kidney is called nephron.
There are about 1.3 million nephron in each kidney.
New nephrons can not be regenerated by kidneys.
Functioning nephrons decrease about 10 % every 10 years at the age of 40.
At the age of 80, there are 40 % of functioning nephrons as compared to 40 yrs.
It is formed by two parts.
1. GLOMERULUS
2. BOWMAN’S CAPSULE
1- Glomerulus:
It consists of tuft of glomerular capillaries.
There is anastomosing & branching network of glomerular capillaries.
Glomerular capillaries have high hydrostatic pressure (nearly 60 mm Hg) as compared with other capillaries.
Glomerulus is surrounded by a membranous cover called Bowman’s capsule.
Each glomerulus is about 0.2 mm in diameter.
Glomerulus and Bowman’s capsule together constitute renal corpuscle.
Each renal tubule is divided into various part as they have different functions.
i- Proximal convulated tubule.
It is continuation of Bowman’s capsule.
ii- Loop of Henle. It is continuation of prox. conv. tubule.
* Loop of Henle has three parts.
a- descending limb,
b- u turn or bend in medulla and
c- ascending limb.
Ascending limb has initial thin segment followed by thick segment.
At the end of thick ascending limb, there is short segment called macula densa, which plays important role in controlling functions of nephron.
Anatomy of the urinary system
Anatomy of the kidneys
Anatomy of the nephron
Anatomy of the ureters
Anatomy of the urinary bladder
Anatomy of the urethra; male and female urethra
BP201T. Human Anatomy And Physiology-II
Unit-III: - Urinary System.
Anatomy of urinary tract with special reference to anatomy of kidney and
nephrons, functions of kidney and urinary tract, physiology of urine formation,
micturition reflex and role of kidneys in acid base balance, role of RAS in kidney
and disorders of kidney.
Kidney is a vital organ. Each individual has a pair of kidneys .
kidney is bean shaped organ on either side of your spine, below your ribs and behind your belly. Each kidney is about 4 - 5 inches long, roughly the size of a large fist.
The kidney job is to filter the blood.
kidney is reddish brown in color.
kidneys are also called as retro-peritoneal organ.
There are three layers of tissues that surrounds kidney
1. renal capsule
2. adipose capsule
3. renal fascia.
KIDNEY IS A VITAL ORGAN IN HUMAN BEINGS. EVERY HUMAN HAS A PAIR OF KIDNEYS WHICH HELP TO EXCRETE OUT WASTE PRODUCTS FROM THE BODY IN THE FORM OF URINE...
URINE IS FORMED IN KIDNEY BY THREE STEPS WHICH ARE
(1) FILTRATION.
(2) ABSORPTION
(3) SECRETION
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
2. INTRODUCTION
• The urinary system consists of 2 kidneys, 2 ureters one urinary
bladder and one urethra.
• Once the kidneys filter the blood plasma, they return most of the
water and solutes to the blood stream. The remaining water and
solutes constitute URINE which passes through ureters and is
stored in bladder until it is excreted from body through urethra.
• NEPHROLOGY: scientific study of anatomy , physiology and
pathology of kidneys.
• UROLOGY: branch of medicine that deals with male and female
urinary
3. FUNCTIONS OF KIDNEYS
Regulation of blood ionic composition
Regulation of blood PH
Regulation of blood volume
Regulation of BP
Maintenance of blood osmolarity
Production of hormones
Regulation of blood glucose levels
Excretion of wastes and foreign substances
4. 1.BLOOD IONIC COMPOSITION
• Regulates the levels of several
ions , mostly Na+,ca+2,cl-,Hpo4-
3.REGULATION OF BLOOD VOLUME:
• Kidneys adjust blood volume by
conserving or eliminating water in
urine.
• Increase in blood volume increases
blood pressure and decrease in blood
volume decreases blood pressure.
FUNCTIONS OF KIDNEYS
2.REGULATION OF BLOOD PH:
• They excrete a variable amount of
H+into the urine and conserve Hco3-
which is an important buffer of H+
ion balance.
• Both these activities helps to regulate
PH
5. 4. REGULATION OF BP:
• They secrete renin a hormone which
activates Renin-Angiotensin-
Aldosterone pathway.
• Increased renin causes increased BP
6.PRODUCTION OF HORMONES:
1.CALCITRIOL: active form of vitamin
D that regulates calcium homeostasis.
2. ERYTHROPOIETIN: helps in
production of RBC’s.
FUNCTIONS OF KIDNEYS
5.MAINTAIN BLOOD OSMOLARITY
• By separately regulating loss of
water and loss of solutes in urine.
Kidneys maintain blood osmolarity
to 300 mosm/lit.
6. 7. REGULATION OF BLOOD GLUCOSE
LEVELS:
• Like liver , kidneys can use amino acid
glutamine in gluconeogenesis which
releases glucose into blood to maintain
normal blood glucose levels.
8. EXCRETION OF WASTES AND FOREIGN
SUBSTANCES:
• By forming urine kidneys help excrete wastes. Some
wastes are formed from metabolic reactions in body-
NH4 and urea( from deamination of aminoacids).
• BILIRUBIN: from catabolism of hemoglobin.
• CREATININE: breakdown of creatinine phosphate
in muscle fibers.
• URIC ACID: catabolism of nucleic acids.
• OTHER WASTES: metabolism of diet , drugs and
environmental toxins
FUNCTIONS OF KIDNEYS
7. • GROSS APPEARANCE: paired, reddish and bean shaped.
• LOCATION: located just above the waist between peritoneum
and posterior wall of abdomen.
• Because their position is posterior to peritoneum of abdominal
cavity – hence they are called RETROPERITONEAL ORGANS.
• Located between levels of last thoracic and 3rd lumbar
vertebrae protected by 11th and 12th pair of ribs.
• Right kidney is slightly lower than the left because of the
presence of liver
ANATOMY OF KIDNEYS
8. • LENGTH : 10-12cms
• WIDTH : 5-7cms
• THICKNESS: 3cms and size of bar soap
• WEIGHT: 135-150grams
• THE CONCAVE BOARDER: faces the vertebral column. Near
the center of the concave boarder there is an indentation
called HILUM/RENAL HILUS through which ureter emerges
along with blood vessels, lymphatic vessels and nerves.
ANATOMY OF KIDNEYS-EXTERNAL
9. • Inner layer.
• Smooth
transparent sheet
of dense irregular
connective tissue.
• Barrier against
trauma and helps
to maintain shape
of the kidney.
RENAL
CAPSULE
• Middle layer.
• Mass of fatty
tissue
surrounding the
renal capsule.
• Protects from
trauma and
holds kidney in
place within
abdominal cavity
ADIPOSE
CAPSULE
• Superficial layer
• Thin layer of
dense irregular
connective tissue
that anchors
kidney to
surrounding
structures
RENAL
FASCIA
ANATOMY OF KIDNEYS-EXTERNAL
10. • A frontal section through kidney reveals 2 distinct
regions:
RENAL CORTEX- superficial light red area
RENAL MEDULLA – darker reddish brown inner
region
• The renal medulla consists of several cone shaped
structures- RENAL PYRAMIDS.
BASE of renal pyramids – faces renal cortex
APEX – is called RENAL PAPILLA –points towards
renal hilum.
INTERNAL ANATOMY OF KIDNEYS
11. • RENAL CORTEX: smooth textured area extending
from renal capsule to bases of renal pyramids and
into the spaces between them.
• It is divided into 2 zones:
OUTER CORTICAL ZONE
INNER MEDULLARY ZONE
• Portions of renal cortex that extends between renal
pyramids is called RENAL COLUMNS.
INTERNAL ANATOMY OF KIDNEYS
12. • RENAL LOBE: Renal Pyramid+ overlying area of renal cortex+ half
of each adjacent renal column.
• Together ,the renal cortex and renal pyramids of renal medulla-
RENAL PARENCHYMA or the functional portion of kidney.
• Within the parenchyma , millions of functional units of kidneys
called NEPHRONS are present.
• Filtrate formed from nephrons drains into large papillary ducts and
then into large cup shaped structures called minor and major
calyces.
INTERNAL ANATOMY OF KIDNEYS
13. • Each kidney has 8-18 minor calyces and 2-3
major calyces.
• Minor calyx receives urine from papillary duct of
one real papilla and delivers it to a major calyx.
• Once the filtrate enters calyces it becomes urine
as further reabsorption doesnot occur
INTERNAL ANATOMY OF KIDNEYS
14. • Kidneys are abundantly supplied with blood vessels
• In adults renal blood flow is 1200ml/min
• Within the kidney the renal artery divides into several SEGMENTAL
ARTERIES.
• Each segmental artery gives off several branches that enter расенсута b/w
renal pyramids and pass through renal columns as INTERLOBAR
ARTERIES.
• At the base of renal pyramid. the interlobar arteries arch between renal
medulla & content= hence called as ARCUATE –ARTERIES
• Division of arcuate arteries produce a series of INTERLOBULAR
ARTERIES - They pass between lobules into Afferent arterioles.
BLOOD SUPPLY TO KIDNEYS
15. Each nephron receives one afferent arteriole which
divides into a tangled ,ball shaped capillary network
called GLOMERULUS.
The glomerular capillaries reunite to form efferent
arteriole that carries blood out of glomerulus.
The efferent .A divides to form Peritubular capillaries
BLOOD SUPPLY TO KIDNEYS
17. • Nephrons are the functional units of kidneys .
• Each nephron has 2 parts:
RENAL CAPSULE-where blood plasma is filtered
RENAL TUBULE- into which filtered fluid passes
1.RENAL CAPSULE: there are 2 components
GLOMERULUS- capillary network
GLOMERULAR CAPSULE- double walled epithelial cup that surrounds
capillaries
• Blood plasma is filtered in the glomerular capsule and the filtered fluid passes
into renal tubule
THE NEPHRON
18. 2.RENAL TUBULE: there are 2 main sections
Proximal convoluted tubule (PCT)
Loop of Henle (LOH)
Distal Convulued tubule (DCT)
• PCT denotes a part of tubule attached to
Glomerular capsule .
• Distal denotes the part that is farther away .
• Convoluted means tubule is tightly coiled
THE NEPHRON
19. • Renal corpuscle and both CT’s lie within the renal cortex, whereas LOH
extends into renal medulla , make a hairpin turn and returns to renal
cortex.
• The DCT of several nephrons empty into a single collecting duct.
• Collecting ducts unite and converge into several hundreds papillary ducts
that drain into minor calyces.
• In a nephron the LOH connects PCT and DCT. The first part of LOH dips
into the renal medulla, where it is called descending limb of LOH.
• It makes a hairpin turn and returns to renal cortex as the ascending limb of
LOH.
THE NEPHRON
20. CORTICAL NEPHRONS
• About 80-85%.
• Their renal corpuscles lie in outer
portion of renal cortex.
• They have short LOH that lie in
cortex and penetrate only into the
outer region of renal medulla.
JUXTRA-MEDULLARY NEPHRONS
• The other 15-20%.
• Their renal corpuscles lie deep in
the cortex, close to medulla.
• They have long LOH that extends
into the deepest region of
medulla.
• These nephrons have 2 additional
portions:
Thin ascending LOH
Thick ascending LOH
THE NEPHRON-TYPES
21. VISCERAL LAYER:
• modified SSE cells called
PODOCYTES.
• The many foot like projections of
these cells wrap around a single
layer of endothelial cells of
glomerular capillaries and form
inner wall of capsule.
PARIETAL LAYER:
• Consists of SSE and forms outer wall
of capsule.
• Fluid filtered from glomerular
capillaries enters capsular space (the
space between 2 layers of glomerular
capsule)
THE NEPHRON
A single layer of epithelial cells forms the entire wall of the glomerular capsule , renal tubule
and ducts.
However each part has distinctive histological features and reflect its articular functions:
1.GLOMERULAR CAPSULE: 2 layers
22. • IN PCT: Simple cuboidal cells with prominent brush boarder
of microvilli on their apical surface.
• These microvilli increase surface area of reabsorption and
secretion.
• Descending limb of LOH and 1st part of thin AL of LOH –
simple squamous epithelium.
• Thick ascending limb of LOH- simple cuboidal to low
columnar epithelium.
RENAL TUBULE AND COLLECTING DUCT
23. • In the renal corpuscle –the columnar tubule cells are crowded and are
called as MACULA DENSA.
• The site where the A/L touches the afferent arteriole – specialized cells
(cuboidal cells are crowded ) called macula densa. Only in macula densa
area the aff.arteriole has JG cells.
• Along side of macula densa the wall of afferent arteriole contains
modified smooth muscle fibers called JUXTRA GLOMERULAR CELLS.
• Together with macula densa + JG cells= JG apparatus- very sensitive to
Na+and Cl- reabsorption
RENAL TUBULE AND COLLECTING DUCT
24. • There are two types of cells:
1. PRINCIPAL CELLS:
receptors for ADH and
aldosterone
2. INTERCALATED CELLS:
homeostasis of blood PH
DCT
25. • Each of 2 ureters transports urine from renal pelvis to the bladder.
• Peristalisis contractions of the muscular walls of the ureters push urine
towards the bladder, but the hydrostatic pressure and gravity also
contribute .
• Frequency of peristalitic waves – 5/min.
• LENGTH- 25-30cms
• DIAMETER- 1mm-10mm
• RETROPERITONEAL
URETERS
26. • There is no anatomical valve at the opening of each
ureter , into bladder , a physiological one is quiet
effective.
• As the bladder fills , pressure with in compresses the
oblique openings into ureters and prevents backflow of
urine.
• If the physiological valve is not functioning then the
microbes travel upto the ureter from bladder to infect
both kidneys.
URETERS
27. MUCOSA WITH
UNDERLYING
LAMINA PROPRIA
MUSCULARIS ADVENTITIA
• Deepest , lined with
transitional
epithelium and
goblet cells.
• Lamina propria is
the areolar
connective tissue
with collagen,
elastic fibers and
lymphatic tissue
• Middle layer
• INNER-
Longitudinal
• OUTER- circular
helps in peristalsis.
• Transitional
epithelium is able
to stretch- stretches
to accommodate
urine.
• Mucous secreted by
goblet cells
prevents cells of
mucosa to come in
contact with urine.
• Superficial layer-
areolar connective
tissue with blood
vessels, lymphatic
vessels and nerves
that serves
muscularis and
mucosa.
URETERS-LAYERS
28. • It is hollow , distensible muscular organ situated in pelvic cavity
posterior to the pubic symphysis.
• In males, it is anterior to rectum, in females it is anterior to
vagina and inferior to uterus .
• Folds of peritoneum holds bladder in position.
• SHAPE: spherical –when slightly distended due to accumulation
of urine.
• When it is empty , it collapses . As urine volume increases it
becomes pear shaped and rises into the abdominal cavity.
URINARY BLADDER
29. • Capacity-700-800ml
• It is smaller in females because the
uterus occupies the space just as
superior to urinary bladder.
URINARY BLADDER
30. • In the floor of bladder there is small
triangular area called the ‘TRIGONE’
• Posterior corners of trigone- has 2 ureteral
opening and 1 urethral opening called
internal urethral orifice.
• 3 coats makeup the wall of urinary
bladder.
URINARY BLADDER-ANATOMY&HISTOLOGY
31. 1.MUCOSA: deepest made of transitional epithelium +
underlying lamina propria similar to that of ureters.
• RUGAE- are also present to permit the expansion of bladder.
• Surrounding mucosa there is intermediate MUSCULARIS or
DETRUSOR MUSCLE- 3 layers of smooth muscles.
Inner longitudinal muscle
Middle circular muscles
Outer longitudinal muscles
URINARY BLADDER-ANATOMY&HISTOLOGY
32. • Around the opening to the urethra the circular
fibers form an IU sphincter inferior to it there is
external urethral sphincter composed of skeletal
muscle.
3.ADVENTITIA: most superficial layer
• Areolar connective tissue
• Over superior surface of urinary bladder is SEROSA layer of
visceral peritoneum.
URINARY BLADDER-ANATOMY&HISTOLOGY
33. • A tubular structure emerging from the neck of
the bladder and opens to the exterior.
• It is the outlet of the bladder and eliminates
urine to outside.
• Present in both males and females but there
are some differences between the two.
URETHRA
34. MALE URETHRA FEMALE URETHRA
Long Short
Length = 18-20cms Length =4cms
Function: urination
and ejaculation of
semen
Only urination
Course – curved
(double)
Nearly straight –foleys
catheterization is easy.
DIFFERENCES BETWEEN MALE AND FEMALE URETHRA
35. MALE URETHRA FEMALE URETHRA
Long Short
Length = 18-20cms Length =4cms
Function: urination
and ejaculation of
semen
Only urination
Course – curved
(double)
Nearly straight –foleys
catheterization is easy.
PARTS OF URETHRA