The document discusses the structure and function of the kidneys. It describes the key roles of the kidneys in excretion, homeostasis, osmoregulation, and regulating salts and pH in the body. The gross and microscopic structures of the kidneys are outlined. Key components include the cortex, medulla, nephrons, glomeruli, and tubules. Ultrafiltration and selective reabsorption processes are explained in relation to kidney function. The production and transport of urea from deamination of proteins is also summarized.
- Introduction
- Normal anatomy of kidney
- Nephron
- Juxtaglomerular apparatus
- Clearance
- tubular function
- Regulation of water and ion reabsorption
- Types of water reabsorption
- Mechanism of urine concentration and dilution
- Countercurrent mechanism
Human kidney,structure and functions of kidneyAnand P P
human kidney structural and functions.different types of structural components present in kidney and each structure having definite functions.structural and functional aspects of kidney.
- Introduction
- Normal anatomy of kidney
- Nephron
- Juxtaglomerular apparatus
- Clearance
- tubular function
- Regulation of water and ion reabsorption
- Types of water reabsorption
- Mechanism of urine concentration and dilution
- Countercurrent mechanism
Human kidney,structure and functions of kidneyAnand P P
human kidney structural and functions.different types of structural components present in kidney and each structure having definite functions.structural and functional aspects of kidney.
Each kidney contains over 1 million tiny structures called nephrons. Each nephron has a glomerulus, the site of blood filtration. The glomerulus is a network of capillaries surrounded by a cuplike structure, the glomerular capsule (or Bowman’s capsule). As blood flows through the glomerulus, blood pressure pushes water and solutes from the capillaries into the capsule through a filtration membrane. This glomerular filtration begins the urine formation process.Inside the glomerulus, blood pressure pushes fluid from capillaries into the glomerular capsule through a specialized layer of cells. This layer, the filtration membrane, allows water and small solutes to pass but blocks blood cells and large proteins. Those components remain in the bloodstream. The filtrate (the fluid that has passed through the membrane) flows from the glomerular capsule further into the nephron.The glomerulus filters water and small solutes out of the bloodstream. The resulting filtrate contains waste, but also other substances the body needs: essential ions, glucose, amino acids, and smaller proteins. When the filtrate exits the glomerulus, it flows into a duct in the nephron called the renal tubule. As it moves, the needed substances and some water are reabsorbed through the tube wall into adjacent capillaries. This reabsorption of vital nutrients from the filtrate is the second step in urine creation.The filtrate absorbed in the glomerulus flows through the renal tubule, where nutrients and water are reabsorbed into capillaries. At the same time, waste ions and hydrogen ions pass from the capillaries into the renal tubule. This process is called secretion. The secreted ions combine with the remaining filtrate and become urine. The urine flows out of the nephron tubule into a collecting duct. It passes out of the kidney through the renal pelvis, into the ureter, and down to the bladder.The nephrons of the kidneys process blood and create urine through a process of filtration, reabsorption, and secretion. Urine is about 95% water and 5% waste products. Nitrogenous wastes excreted in urine include urea, creatinine, ammonia, and uric acid. Ions such as sodium, potassium, hydrogen, and calcium are also excreted
The nephron is the microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and an encompassing Bowman's capsule. The renal tubule extends from the capsule.
Each kidney contains over 1 million tiny structures called nephrons. Each nephron has a glomerulus, the site of blood filtration. The glomerulus is a network of capillaries surrounded by a cuplike structure, the glomerular capsule (or Bowman’s capsule). As blood flows through the glomerulus, blood pressure pushes water and solutes from the capillaries into the capsule through a filtration membrane. This glomerular filtration begins the urine formation process.Inside the glomerulus, blood pressure pushes fluid from capillaries into the glomerular capsule through a specialized layer of cells. This layer, the filtration membrane, allows water and small solutes to pass but blocks blood cells and large proteins. Those components remain in the bloodstream. The filtrate (the fluid that has passed through the membrane) flows from the glomerular capsule further into the nephron.The glomerulus filters water and small solutes out of the bloodstream. The resulting filtrate contains waste, but also other substances the body needs: essential ions, glucose, amino acids, and smaller proteins. When the filtrate exits the glomerulus, it flows into a duct in the nephron called the renal tubule. As it moves, the needed substances and some water are reabsorbed through the tube wall into adjacent capillaries. This reabsorption of vital nutrients from the filtrate is the second step in urine creation.The filtrate absorbed in the glomerulus flows through the renal tubule, where nutrients and water are reabsorbed into capillaries. At the same time, waste ions and hydrogen ions pass from the capillaries into the renal tubule. This process is called secretion. The secreted ions combine with the remaining filtrate and become urine. The urine flows out of the nephron tubule into a collecting duct. It passes out of the kidney through the renal pelvis, into the ureter, and down to the bladder.The nephrons of the kidneys process blood and create urine through a process of filtration, reabsorption, and secretion. Urine is about 95% water and 5% waste products. Nitrogenous wastes excreted in urine include urea, creatinine, ammonia, and uric acid. Ions such as sodium, potassium, hydrogen, and calcium are also excreted
The nephron is the microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and an encompassing Bowman's capsule. The renal tubule extends from the capsule.
This was done as a Student presentation on the kidney.
Here following topics are covered.
Macroscopic structure of the urinary system
Microscopic anatomy of the urinary system
Functions of the nephron
Renal blood supply
Kidneys and blood pressure regulation
Structure of ureters and urinary bladder to perform its function
Renal failure
1 GNM Anatomy - Unit - 8 Excretory system.pptxthiru murugan
By:M. Thiru murugan
Unit – 8:
Structure and functions of the kidney, ureters, urinary bladder and urethra
Formation and composition of urine.
Fluid and electrolyte balance
Structure and functions of the skin.
Regulation of the body temperature.
Excretory system:
The excretory system is performs the function of excretion
It is the process of removing the wastes
There are several parts of the body that are involved in this process such as sweat glands, the liver, the lungs and the kidney system
Kidney:
The kidneys are a bean-shaped organs - found abdominal cavity, just below the rib cage.
The right kidney is slightly lower than the left because of the position of the liver.
Every human has two kidneys.
Diagram of Renal System
Structure of kidney:
Kidney consist of 3 basic parts
Renal cortex (outer layer )
Renal medulla (inner layer )
Renal pelvis.
Renal cortex:
The renal cortex is the outer layer of the kidney, it is covered with capsule
Erythropoietin a hormone is produced in the renal cortex (Erythropoiesis)
Renal medulla:
Renal medulla is the inner layer of the kidney. The medulla consists of multiple pyramidal tissue masses, called the renal pyramids, which are triangle structures that contain a network of nephrons
Renal pelvis:
The renal pelvis contains the hilum.
The hilum is the concave part of the bean-shape where blood vessels and nerves enter and exit the kidney
It is also the point of exit for the ureters carry urine away from the kidney
Both of the ureters supply the urine into urinary bladder,
From there, urine is expelled through the urethra and out of the body.
The blood arrives at the kidney via the renal artery, renal veins collect deoxygenated blood
Nephron:
The nephron is the structural and functional unit of the kidney.
It is composed of renal corpuscle and a renal tubule.
Parts of Nephron:
Renal corpuscle (glomerulus within bowman's capsule)
Proximal convoluted tubule
Intermediate tubule (loop of Henle)
Distal convoluted tubule
Collecting ducts
1. The Glomerulus:
The glomerulus is receives blood supply from an afferent arteriole of the renal circulation.
Here, fluid and solutes are filtered out of the blood and into the space made by Bowman’s capsule.
A group of specialized cells known as juxtaglomerular apparatus (JGA) are located around the afferent arteriole where it enters the renal corpuscle. The JGA secretes an enzyme called renin, it is involved in the process of blood volume homeostasis (Bp).
2. Proximal Convoluted Tubule:
The proximal tubule is the first site of water reabsorption into the bloodstream, and the site where the majority of water and salt reabsorption takes place.
3. The Loop of Henle:
The loop of Henle is a U-shaped tube that consists of a descending limb and ascending limb. It transfers fluid from the proximal to the distal tubule
4. Distal Convoluted Tubule:
The distal convoluted tubule is the final site of reabsorption in the nephron.
5. Collecting Duct:
The collecting duct
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Defect reporting
SAP heatmap example with demo
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2. Learning Outcomes
• 5.4.6 (a), (b) and (d).
• List main components of 3 body fluids
• Describe how to test for glucose, protein and
urea
• Describe how to find concentration of urea in a
solution
• Determine the urea concentration of a fluid
• Outline the roles of the kidney in excretion and
osmoregulation
4. Roles of the kidney
Excretion
homeostasis
osmoregulation
regulation of salts in the body
• regulation of pH
• production of a hormone (EPO)
5. Kidney dissection
Learning outcomes
• Describe the external features of the kidney
• Describe the position of the kidneys in the body
and relationships with blood supply and rest of
urinary system
• Draw and label LS kidney
• Recognise different parts of the kidney
• Make a drawing to scale
15. Excretion and the kidneys
Learning outcomes
• State main excretory substances
• Describe production and transport of urea
• Explain why urea is produced
• Explain why [salts] are regulated
17. Sources
Where do these come from?
• Water
• Protein
• Glucose
• Urea
• Uric acid
• Creatinine
• Ammonia
18. Sources
• Water ingested drink and food / metabolic water
• Protein ingested food / tissue breakdown
• Glucose ingested food / glycogen / other compounds
• Urea deamination / urea cycle
• Uric acid metabolism of nucleotide bases
• Creatinine metabolism of creatine (creatine phosphate)
• Ammonia deamination
19. Urea formation
• Excess protein / excess amino acids
• Where from?
• Deamination
• Where?
• Urea formation
• Where?
• Transport and excretion
20. Deamination
• Oxidative deamination
• Aerobic!
• Liver (and other tissues)
• Amino acid (glutamic acid) + oxygen
• Keto acid + ammonia
• Coupled with reduction of NAD (co-enzyme)
• Ammonia!! Beware.
• Ammonia enters the urea cycle
• What happens to the keto acid?
21. Deamination
Deamination is part of protein metabolism
Catabolic reaction
Details are at:
http://www.elmhurst.edu/~chm/vchembook/632oxdeam.html
22. Urea/ornithine cycle
• Ammonia comes from
– deamination
– and from aspartic acid produced from
transamination
• Carbon dioxide comes from link reaction
and Krebs cycle
• Urea is excreted
• Requires ATP
23. Urea/ornithine cycle
• Linked to:
– deamination
– transamination
– Krebs cycle
– phosphorylation of ADP (because ATP is
required)
• Details are at:
http://www.elmhurst.edu/~chm/vchembook/633ureacycle.html
24. Protein metabolism
• Deamination and urea cycle are part of the
metabolism of proteins and amino acids in
the body.
More details of biochemistry (useful for
MPB) at:
http://www.elmhurst.edu/~chm/vchembook/index.html
The link is on my web site for you.
25. Functions of the nephron
Learning outcomes
• Explain how ultrafiltration occurs relating
structure to function
• Explain how selective reabsorption occurs
relating structure to function
• Explain how structure of medulla is related to
water potential gradients
• Explain how water is reabsorbed throughout the
nephron
26. Processes in the kidneys
Ultrafiltration
Selective reabsorption
• Secretion
• Osmoregulation
28. Selective reabsorption
• Proximal convoluted tubule
• Returning substances to the blood
• Active uptake
• Requires energy
• Co-transport
• Passive uptake
• Endocytosis
29. Movement across membranes
• Driven by ATP
• Driven by sodium pumps that create low
intracellular concentration of sodium ions
• Require specialised membrane proteins
• Occurs across two cell membranes – that have
different permeability/pumping properties
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/D/Diffusion.html#indirect