This document summarizes systemic lupus erythematosus (SLE), an autoimmune disorder that can affect multiple systems of the body. It discusses the epidemiology, etiology, pathology, clinical features, and laboratory diagnosis of SLE. SLE predominantly affects females and commonly presents in the second to third decade of life. Genetic and environmental factors contribute to its development by causing a failure of self-tolerance and production of autoantibodies that can damage tissues. SLE is characterized by the formation of various antibodies and can involve organs like the skin, kidneys, blood vessels, heart, and central nervous system. Diagnosis involves testing for autoantibodies and supportive evidence from tests like urinalysis, MRI, ech
Multiple sclerosis pathophysiology, diagnosis, and treatment FatenAlsadek
simple presentation about multiple sclerosis disease and its pathophysiology, diagnosis, causes, symptoms and treatment
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
Systemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues.
The extreme heterogeneity of the disease has led some investigators to propose that SLE represents a syndrome rather than a single disease.
Lupus was first recognised as a systemic disease with visceral manifestations by Moriz Kaposi (1837–1902).
Lupus erythematosus (LE) is an autoimmune connective tissue disorder that can affect one or several organs. Circulating autoantibodies and immune complexes are due to loss of normal immune tolerance and are pathogenic. Clinical features of LE are highly variable. LE nearly always affects the skin to some degree.
Multiple sclerosis pathophysiology, diagnosis, and treatment FatenAlsadek
simple presentation about multiple sclerosis disease and its pathophysiology, diagnosis, causes, symptoms and treatment
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
Systemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues.
The extreme heterogeneity of the disease has led some investigators to propose that SLE represents a syndrome rather than a single disease.
Lupus was first recognised as a systemic disease with visceral manifestations by Moriz Kaposi (1837–1902).
Lupus erythematosus (LE) is an autoimmune connective tissue disorder that can affect one or several organs. Circulating autoantibodies and immune complexes are due to loss of normal immune tolerance and are pathogenic. Clinical features of LE are highly variable. LE nearly always affects the skin to some degree.
Systemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the immune system of the body mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs
This presentation is a comprehensive & updated presentation that delves deeply into Multiple Sclerosis. It is intended for healthcare professionals and features the Anatomy and Physiology, Common Etiology, a focused review of the disease Pathophysiology, Prevalence & Morbidity, Clinical Manifestations, Diagnostics, Classification & Prognosis, Treatment (Both current and experimental), Nutrition, and Psychosocial issues and resources available to patients. It is very rich in details, diagrams (on every slide), and interactive content when in slide presentation mode. The presentation has also hyperlinks to videos (3 D Patho) and controversial treatments. Finally, it concludes with a Case Study to highlight the clinical application.
Please note that you're welcome to use any slides as long as you reference my post when you do so to maintain the integrity of authorship
If interested in detailed answers, please email: aamirdash@yahoo.com
Thanks, Ahmad
Genetic Insights Into Multiple Sclerosis PathogenesisAaron Sparshott
A segment of a group presentation reflecting upon some of the genetic components that may contribute to Multiple Sclerosis pathogenesis.
IL2Rα and IL7Rα were the two genes of focus.
(This presentation was originally done for Semester 2 , 2008)
neurological disorders of demyelination, for generalized idea as a seminar work for university, department of pathophysiolog.
for more information feel free to contact me
The term ‘lupus’ (Latin for ‘wolf’) was first used during the Middle Ages to describe erosive skin lesions evocative of a ‘wolf’s bite’.
Lupus is an autoimmune disease, which means that the body's natural defense system (immune system) attacks its own tissues instead of attacking foreign substances like bacteria and viruses. This causes inflammation which can causes swelling, pain, and tissue damage throughout the body.
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease. The immune system attacks the body’s cell and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidney and nervous system.
Over 40 different genes predispose to SLE.
Characterized by remission and exacerbation.
Systemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the immune system of the body mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs
This presentation is a comprehensive & updated presentation that delves deeply into Multiple Sclerosis. It is intended for healthcare professionals and features the Anatomy and Physiology, Common Etiology, a focused review of the disease Pathophysiology, Prevalence & Morbidity, Clinical Manifestations, Diagnostics, Classification & Prognosis, Treatment (Both current and experimental), Nutrition, and Psychosocial issues and resources available to patients. It is very rich in details, diagrams (on every slide), and interactive content when in slide presentation mode. The presentation has also hyperlinks to videos (3 D Patho) and controversial treatments. Finally, it concludes with a Case Study to highlight the clinical application.
Please note that you're welcome to use any slides as long as you reference my post when you do so to maintain the integrity of authorship
If interested in detailed answers, please email: aamirdash@yahoo.com
Thanks, Ahmad
Genetic Insights Into Multiple Sclerosis PathogenesisAaron Sparshott
A segment of a group presentation reflecting upon some of the genetic components that may contribute to Multiple Sclerosis pathogenesis.
IL2Rα and IL7Rα were the two genes of focus.
(This presentation was originally done for Semester 2 , 2008)
neurological disorders of demyelination, for generalized idea as a seminar work for university, department of pathophysiolog.
for more information feel free to contact me
The term ‘lupus’ (Latin for ‘wolf’) was first used during the Middle Ages to describe erosive skin lesions evocative of a ‘wolf’s bite’.
Lupus is an autoimmune disease, which means that the body's natural defense system (immune system) attacks its own tissues instead of attacking foreign substances like bacteria and viruses. This causes inflammation which can causes swelling, pain, and tissue damage throughout the body.
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease. The immune system attacks the body’s cell and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidney and nervous system.
Over 40 different genes predispose to SLE.
Characterized by remission and exacerbation.
This presentation encompasses SLE as well Lupus nephritis,Antiphospholipid Syndrome and other special situation related to SLE such as SLE and Pregnancy.
Systemic Lupus erythematous , is world wide health problem
Here we talk about criteria for diagnosis investigation , Management and complication
With some scenarios to about disease and complication
Systemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the immune system of the body mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs.
It contains following subheadings:
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-TMJ(Temporo mandibular joint)
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By:
Dr. Syed Irfan Qadeer
Prof. and HOD Department of Anatomy
SPIDMS,Lucknow
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
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Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
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Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
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DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
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Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
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Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
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I have heard many times that architecture is not important for the front-end. Also, many times I have seen how developers implement features on the front-end just following the standard rules for a framework and think that this is enough to successfully launch the project, and then the project fails. How to prevent this and what approach to choose? I have launched dozens of complex projects and during the talk we will analyze which approaches have worked for me and which have not.
"Impact of front-end architecture on development cost", Viktor Turskyi
Systemic Lupas Eruthmatosus
1. Diseases of the autoimmune
system
Dr. Fardan Qadeer
Dept. Of Pathology
CIMS and H, Lucknow
2. SLE
Systemic Lupus Erythematosus
It is an autoimmune disorder which involves
multiple systems of the body
Incidence: it is a fairly common disease and the
prevalence is as high as 1 in 2500
Gender: It has a strong female predisposition,
female is to male ratio is as high as 9:1
Age: it can occur at any age group but usually
common in 2nd to 3rd decade of life
3. Etiology: The exact etiology of the disease is
unknown but various factors are attributed to
the development of autoimmunity
• Genetic factors:
▫ A high rate of concordance in monozygotic twins
(25%)
▫ Positive association of disease with class 2 HLA
gene particularly HLA-DQ
4. • Environmental factors:
▫ Ultraviolet radiation (sun exposure) exacerbates
the lesion
▫ Drugs: certain drugs like procainamide and
hydralazine may lead to development of SLE like
features
▫ Role of estrogens can be attributed to the higher
incidance of disease in females
5.
6. The fundamental defect in SLE is failure to
maintain self-tolerance
• As a result of this a large number of auto
antibodies are produced which cause tissue
destruction by two mechanism
▫ Type 2 hypersensitivity: characterised by
formation of antibodies against blood components
and resulting in haematological derangement
▫ Type 3 hypersensitivity: immune complex get
deposited in different tissues resulting in systemic
resposes
7. Pathology: The disease is characterised by formation of
various antibodies
• Antinuclear antibodies(ANA): these are antibodies
against common nuclear antigen that include both DNA
and RNA
• Antibodies to Double stranded DNA (anti-dsDNA) and
single stranded DNA (anti-ssDNA) are most specific
• Antibodies to smith antigen(anti-SmAg) are also formed
which is a part of ribonuleoprotein
• Anti ribonuleoproteins(anti-RNP) antibodies
• Anti histone antibodies
• Anti nucleolor antibodies
• Anti phospholipid antibodies
8. • Renal lesions: kidney involvement is one of the
most important feature of SLE
▫ It commonly involves the glomeruli however
tubules and interstitium may be affected
▫ It is due to depostion of immune complexes in the
kidney and subsequent destruction
10. • Small Blood vessels: Small arteries and
arterioles are involved. It is characterised by
necrosis and immune complex deposition
11. • Skin: There is liquifactive
degeneration of the basal layer of
the epidermis and deposition of
immune complexes at the dermo
epidermal junction
• Cardiac lesions (Libman Sacks
endocarditis) characterised by
presence of vegitations on the
mitral and tricuspid valves. It can
also cause pericarditis.
12. • CNS: involvement due to formation of thrombus
in the vessel walls caused by ANA deposits. It
leads to microinfarcts and subsiquent
neurological deficit.
13. Clinical Features
• Malar rash:
Characterised by erythematous and maculopapular
eruptions over the malar eminance and bridge of the nose
• Discoid rash
• Photosensitivity
• Pain less oral or oropharyngeal ulcers
• Arthritis
• Serositis: Pluritis and Pericarditis
• Renal disorders: Renal failure in advanced disease is
the most important cause of death
Persistant proteinuria >0.5 gm/dl
Presence of cellular cast
16. Laboratory Diagnosis
• LE cells: It was the first
diagnostic test for SLE. It is
based on the principal that the
ANAs cannot penetrate the
intact cells hence the cell
nucleus is exposed to bind the
ANA resulting in formation of a
homogenous mass called as LE
body
• This mass is further engulfed
by phagocytic leucocytes
(polymorphs and monocytes)
to form a LE cell
• This is positive in 70% cases of
SLE only
17. • Antibody titre: It is more reliable than LE cells
immunofluorescence test is positive in almost
100% cases
▫ Anti DNA antibodies
▫ Anti Smith antibodies
▫ Ant nucleolar antibodies
• Supportive evidances
▫ Proteinuria
▫ MRI brain showing microinfarct
▫ Evidance of Pleural effusion on X Ray
▫ Evidance of valvular lesions on 2D Echo