This document discusses suppurative lung diseases including bronchiectasis, lung abscesses, and empyema with broncho-pleural fistula. It defines the conditions, describes causes, clinical features, investigations, and treatment approaches. Key points include that bronchiectasis is irreversible dilatation of airways leading to infection and damage, lung abscesses begin as areas of pneumonia that progress to cavitation, and empyema is pus in the pleural space that can form a fistula with the bronchial tree through various causes like pneumonia or lung abscess rupture. Treatment involves controlling infections, clearing secretions, and surgery in chronic or complicated cases.
Bronchiectasis
A condition characterized by chronic permanent dilation & destruction of bronchi due to destructive changes in the elastic and muscular layers of bronchial walls.
The common thread in the pathogenesis of bronchiectasis consists of difficulty clearing secretions & recurrent infections with a “vicious circle” of infection and inflammation resulting in airway injury and remodelling.
PLEASE REFER TO REFERENCE TEXTBOOKS FOR CLARITY.
Bronchiectasis
A condition characterized by chronic permanent dilation & destruction of bronchi due to destructive changes in the elastic and muscular layers of bronchial walls.
The common thread in the pathogenesis of bronchiectasis consists of difficulty clearing secretions & recurrent infections with a “vicious circle” of infection and inflammation resulting in airway injury and remodelling.
PLEASE REFER TO REFERENCE TEXTBOOKS FOR CLARITY.
Interstitial lung disease is a general category that includes many different lung conditions. All interstitial lung diseases affect the interstitium, a part of the lungs' anatomic structure.
Some of the types of interstitial lung disease include:
Interstitial pneumonia: Bacteria, viruses, or fungi may infect the interstitium of the lung. A bacterium called Mycoplasma pneumonia is the most common cause.
Idiopathic pulmonary fibrosis : A chronic, progressive form of fibrosis (scarring) of the interstitium. Its cause is unknown.
Nonspecific interstitial pneumonitis: Interstitial lung disease that's often present with autoimmune conditions (such as rheumatoid arthritis or scleroderma).
SLD includes bronchiectasis, lung abscess, and empyema thoracis
under each disease epidemiology, etiology, clinical manifestations, diagnostic approaches, and management options discussed
there is the introduction part of the torso trauma,
check out my next ppts for further more about torso trauma.
contents are in following order...
introduction
mechanism of injury
junctional zones of torso
tension pneumothorax
cardiac temponade
massive hemothorax
etc.
check out all slides
Apparently a lengthy presentation actually very good for junior physicians as it covers all aspects of assessment, diagnosis and treatment of pleural effusion
Interstitial lung disease is a general category that includes many different lung conditions. All interstitial lung diseases affect the interstitium, a part of the lungs' anatomic structure.
Some of the types of interstitial lung disease include:
Interstitial pneumonia: Bacteria, viruses, or fungi may infect the interstitium of the lung. A bacterium called Mycoplasma pneumonia is the most common cause.
Idiopathic pulmonary fibrosis : A chronic, progressive form of fibrosis (scarring) of the interstitium. Its cause is unknown.
Nonspecific interstitial pneumonitis: Interstitial lung disease that's often present with autoimmune conditions (such as rheumatoid arthritis or scleroderma).
SLD includes bronchiectasis, lung abscess, and empyema thoracis
under each disease epidemiology, etiology, clinical manifestations, diagnostic approaches, and management options discussed
there is the introduction part of the torso trauma,
check out my next ppts for further more about torso trauma.
contents are in following order...
introduction
mechanism of injury
junctional zones of torso
tension pneumothorax
cardiac temponade
massive hemothorax
etc.
check out all slides
Apparently a lengthy presentation actually very good for junior physicians as it covers all aspects of assessment, diagnosis and treatment of pleural effusion
Lecture slides about bronchiectasis with contents including definition, causes, pathogenesis and pathology, and how to make diagnosis. Treatment for bronchiectasis is presented separately.
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Dr Bashir Ahmed Dar associate professor medicine chinkipora sopore kashmir presently working in malaysia speaks about bronchiectasis.Bronchiectasis which is defined as the irreversible dilatation of the cartilage-containing airways bronchi or bronchioles.
What are the pulmonary function tests used?
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Bronchiectasis is a long-term condition where the airways of the lungs become abnormally widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection.
In bronchiectasis , one or more of bronchi are abnormally widened . Damage caused to the lungs by bronchiectasis is permanent.
Bronchiectasis – first described- rené Laennec (inventor – stethoscope).
History, Pharmacokinetics and Drug Deposition, Types, Techniques, Differences between different inhalers, Pitfalls and Errors of use, and Drugs used by inhalation
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
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AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
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2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
15. • CXR:
Suspicious but not diagnostic radiographic findings include:
focal pneumonitis, scattered irregular opacities that may represent
mucopurulent plugs, linear or plate-like atelectasis , dilated and thickened
airways that appear as ring-like shadows (of airways that are seen on end)
or tram lines (airways that are perpendicular to the x-ray beam)
• HRCT:
Major features on HRCT include AW dilatation & bronchial wall thickening
• Bronchoscopy:
For diagnosis of tumor, foreign body, localize site of hemoptysis.
• PFTs
• Blood (including serology) & Sputum
16.
17. Sputum Organisms
Typical offending organisms:
• Klebsiella species,
• Staphylococcus aureus,
• Mycobacterium tuberculosis,
• Mycoplasma pneumoniae,
• Non-tuberculous mycobacteria,
Once a patient develops bronchiectasis:
- Many of these same organisms colonize the damaged bronchi and may
result in ongoing damage and episodic infectious exacerbations.
- The organisms found most typically include Haemophilus species and
Pseudomonas species (Staph Aureus in CF)
•Measles virus,
•Pertussis virus,
•Influenza virus,
•Herpes simplex virus, and
•Certain types of adenovirus.
•Aspergillus fumigatus
19. Chest radiography showing a) cystic bronchiectasis with multiple cystic airspaces and
b) cylindrical bronchiectasis and tram track opacities in a cystic fibrosis patient.
(a) (b)
26. Categories of bronchiectasis. Normal bronchus (arrow) (A), cylindrical bronchiectasis with lack of bronchial tapering
(arrow) (B), varicose bronchiectasis with string-of-pearls appearance (arrow) (C), and cystic bronchiectasis (arrow) (D).
BA C
D
Abnormal bronchial contour.
27. *
High-resolution computed tomography image demonstrating bronchiectasis with bronchial
wall thickening (asterisk) and mucous plugging (arrow) in the right lower lobe.
Bronchial wall thickening
28. Inspiratory high-resolution computed tomography image showing bronchiectasis
and widespread areas of low attenuation, representing air-trapping.
Air-trapping Sign.
29. High-resolution computed tomography showing a) proximal bronchiectasis affecting
segmental airways and b) high attenuation mucous plugs in patients with allergic
bronchopulmonary aspergillosis. No intravenous contrast medium was used in (b).
a)
b)
Mucous plugs Impaction.
30. Cystic Bronchiectasis. CT: Markedly dilated bronchi are seen, some
with air-fluid levels (yellow arrows), mostly in the right lung.
Cystic changes with air-fluid levels.
32. Mounier-Kuhn syndrome, also known as tracheobronchomegaly, is a rare
congenital abnormality of the trachea and main bronchi characterized by
cystic dilatation of the tracheobronchial tree and recurrent respiratory infections.
33. Treatment• Goals:
1. Controlling infections and bronchial secretions
2. Relieving airway obstructions
3. Removal of affected portions of lung by surgical removal or artery
embolization
4. Preventing complications.
• Treatment of bronchiectasis include:
1. The prolonged usage of Antibiotics to prevent detrimental infections
2. Eliminating accumulated fluid with Bronchial Hygiene therapy +
Humidification & Mucolytics (dornase, HS, ACC) +/- Anti-oxidants
3. Inhaled Bronchodilators (in obst.) & Steroids (in exac., ABPA)
4. Surgery is used to treat localized bronchiectasis, removing obstructions,
recurrent hemoptysis & exacerbations Transplantation
5. Vaccination (S. pn, H. Inf., M., P.), IgG (25mg/kg /wk), O2, Smoke Cess
6. Pulmonary Rehabilitation (add ADEK, Panc enz to CF)
34. Antibiotic Use
During Exacerbation:
• Mild to Moderate Exacerbation (7-10 ds): Amoxacillin,
Tetracycline, Trimethoprim-Sulfamethoxazole, New Macrolides,
Cephalosporin, Quinolones
• Moderate to Severe Exacerbation (10-14 ds):
Antipseudomonal IV (dual therapy) or MAC treatment if proved
(clarithromycin, ethambutol, rifampicin, sterptomycin 18-14 Ms)
Regular Treatment for Colonization:
• Intermittent courses are used for 7 days and Ab- free periods of 7
days each month can be used (oral previous drugs) or
• Long term antibiotics for 3 to 6 Ms (macrolides)
• Inhaled Antibiotics: Tobramycin, Colistin, Gentamycin, Astreonam
35.
36. • Postural drainage
• Percussion
• Directed cough: as Forced expiratory technique (huffing:
small long (LL) or big short huff (UL) in cycle; 10 mins twice /d)
• Active cycle of breathing (breathing control (hands on abd.),
deep breathing exercises e’ breath hold (ribs) & huffing +/-
manual technique)
• Autogenic drainage (self drainage: unstick, collect, evacuate)
• Positive expiratory pressure (behind mucus to push)
• Incentive Spirometry
Bronchial Hygiene Techniques
Can be associated with others
41. Definition:Definition:
• A lung abscess is a localized area of destruction of lungA lung abscess is a localized area of destruction of lung
parenchyma in which infection by a Pyogenic organism resultsparenchyma in which infection by a Pyogenic organism results
in tissue necrosis and suppuration and cavity formation.in tissue necrosis and suppuration and cavity formation.
42. Classification
Lung abscesses can be classified based on:
- Duration:
• Acute abscesses are less than 4-6 wks old
• Chronic abscesses are of longer duration
- Etiology:
• Primary Abscess is infectious in origin: caused by aspiration or
pneumonia in the healthy host.
• Secondary Abscess
- Pre-existing lung condition (obstruction, bronchiectasis, cyctic lung,
c).
- Hematogenous: Spread from an extra-pulmonary site (septic emboli)
- Immuno-compromised state.
- Inhalation of infected material
- Necrotizing pneumonia (klebsiella, staph., pseudomonus, anearobic,
- Number: single or multiple
43. Pathogenesis:Pathogenesis:
• Lung abscess begin as an area of pneumonia Lung abscess begin as an area of pneumonia
necrosis or microabscess necrosis or microabscess coalesce to form a coalesce to form a
single or sometimes multiple areas of suppuration single or sometimes multiple areas of suppuration
reach a size > 1cm in diameter reach a size > 1cm in diameter lung abscess. lung abscess.
• Inflammation erodes adjacent bronchi Inflammation erodes adjacent bronchi
suppuration is expectorated suppuration is expectorated air finds its way to air finds its way to
the abscess cavity the abscess cavity fluid air interface. fluid air interface.
44. Clinical features:Clinical features:
• Presence of the predisposing factorsPresence of the predisposing factors
• Symptoms of acute lung abscess:Symptoms of acute lung abscess:
• TheThe onsetonset may be abruptmay be abrupt or gradual.or gradual.
• FeverFever withwith rigorsrigors,, sweatingsweating,, coughcough (dry cough at first(dry cough at first
which is followed by sudden onset ofwhich is followed by sudden onset of expectorationexpectoration ofof
large amounts of sputum after which fever drop).large amounts of sputum after which fever drop).
• Sputum:Sputum: foul-odor, purulent with relation to posture.foul-odor, purulent with relation to posture.
• Chest pain:Chest pain: it may be dull aching or severe pleuritic pain.it may be dull aching or severe pleuritic pain.
• HemoptysisHemoptysis may occur and may be massive.may occur and may be massive.
• Weight lossWeight loss,, anaemiaanaemia andand clubbingclubbing in chronic lungin chronic lung
abscess (8-12 weeks).abscess (8-12 weeks).
45. Complications:
• Local spread to the same or to the other lung.Local spread to the same or to the other lung.
• Prolonged fever and chronicity.Prolonged fever and chronicity.
• Massive hemoptysis.Massive hemoptysis.
• Residual bronchiectasis or fibrosisResidual bronchiectasis or fibrosis Trapped lungTrapped lung
• Extension to the pleura or skinExtension to the pleura or skin Empyema, BPFEmpyema, BPF or PCFor PCF
• Metastatic brain abscessMetastatic brain abscess..
• Perinephric abscess.Perinephric abscess.
• Amyloidosis.Amyloidosis.
46. Investigations:Investigations:
1.1. Chest x-ray PA and lateral viewChest x-ray PA and lateral view
In the acute abscess the wall is thin with surroundingIn the acute abscess the wall is thin with surrounding
consolidation, and the chronic abscess the wall is thick.consolidation, and the chronic abscess the wall is thick.
2. Laboratory:2. Laboratory:
-- Sputum examination:Sputum examination:
o Gram- stain film and culture (85% anaerobes)Gram- stain film and culture (85% anaerobes)
o Ziehl- Neelsen staining to exclude TBZiehl- Neelsen staining to exclude TB
o Sputum cytology for malignant cellsSputum cytology for malignant cells
o Sputum culture for fungi and parasitic ova (if suspected)Sputum culture for fungi and parasitic ova (if suspected)
-- Blood pictureBlood picture: leucocytosis (>30.000/mm3) and anemia.: leucocytosis (>30.000/mm3) and anemia.
47. Irregularly shaped cavity with an air-fluid level inside
posterior segments of the upper lobes or
the superior segments of the lower lobes
48. 3. Bronchoscopy:3. Bronchoscopy:
- Diagnostic:- Diagnostic: foreign body, tumors, or inspissatedforeign body, tumors, or inspissated
secretions.secretions.
- Therapeutic:- Therapeutic:
• Aspiration of secretions.Aspiration of secretions.
• Instillation of antibiotics.Instillation of antibiotics.
• Foreign body extraction.Foreign body extraction.
• Palliative treatment of bronchial carcinoma with laserPalliative treatment of bronchial carcinoma with laser
or cryotherapy.or cryotherapy.
4. C-T chest:4. C-T chest: for suspected bronchial carcinoma.for suspected bronchial carcinoma.
49. Treatment:Treatment:
1.1. Prophylactic:Prophylactic: proper attention to the etiologic factors.proper attention to the etiologic factors.
2.2. Acute lung abscess:Acute lung abscess:
• Medical treatment is usually sufficient:Medical treatment is usually sufficient:
a)a) Antibiotics:Antibiotics: 4 -6 wks4 -6 wks till resolution or small stabletill resolution or small stable
• It is usually given empirically in the form of combinedIt is usually given empirically in the form of combined
antibiotics to cover the spectrum of Gram positive,antibiotics to cover the spectrum of Gram positive,
Gram negative and anaerobic organisms (Clindamycin).Gram negative and anaerobic organisms (Clindamycin).
50. b)b) Postural drainagePostural drainage is an important item in theis an important item in the
management of lung abscess.management of lung abscess.
c)c) BronchoscopicBronchoscopic aspirationaspiration and instillation of antibiotics.and instillation of antibiotics.
d)d) Symptomatic treatmentSymptomatic treatment::
• Analgesics for pain.Analgesics for pain.
• Expectorants.Expectorants.
e)e) Rest, good nutritionRest, good nutrition withwith high protein diet.high protein diet.
51. 33.. Chronic lung abscessChronic lung abscess::
• ContinueContinue thethe medicalmedical treatment for another 6 wks.treatment for another 6 wks.
• Surgical treatmentSurgical treatment (lobectomy or pneumonectomy)(lobectomy or pneumonectomy)
is indicated in chronic situation with:is indicated in chronic situation with:
• Serious hemoptysis.Serious hemoptysis.
• Failed medical treatment.Failed medical treatment.
• Suspected neoplasmSuspected neoplasm
• Congenital lung malformationCongenital lung malformation
53. DefinitionDefinition
• Pus in the pleural space or infected pleuralPus in the pleural space or infected pleural
fluid with fistula (opening) between the pleuralfluid with fistula (opening) between the pleural
space and the bronchial tree.space and the bronchial tree.
54. Causes:Causes:
• Direct spreadDirect spread from adjacent bacterial pneumonia.from adjacent bacterial pneumonia.
• RuptureRupture of a lung abscess into the pleural space.of a lung abscess into the pleural space.
• InvasionInvasion from subphrenic collection either pyogenic orfrom subphrenic collection either pyogenic or
amoebic.amoebic.
• TraumaticTraumatic penetration orpenetration or IatrogenicIatrogenic
-- It may beIt may be acuteacute oror chronic (> 3 months).chronic (> 3 months).
- It may beIt may be loculatedloculated oror free.free.
- It may beIt may be post-operativepost-operative (2/3) or(2/3) or non-operativenon-operative (1/3)(1/3)
55. Clinical featuresClinical features
• Fever and chest pain.Fever and chest pain.
• Dyspnea.Dyspnea.
• Broncho-pleural fistula is characterized by posturalBroncho-pleural fistula is characterized by postural
cough and big amount of expectorated pus.cough and big amount of expectorated pus.
• Chronicity: pallor, malaise, weakness, easyChronicity: pallor, malaise, weakness, easy
fatigability, fever, anorexia and weight loss.fatigability, fever, anorexia and weight loss.
• Clubbing and pleural rub.Clubbing and pleural rub.
• Bubbling from chest tubeBubbling from chest tube
56.
57. InvestigationsInvestigations
• Chest x-rayChest x-ray (air-fluid level, tension pnx)(air-fluid level, tension pnx)
• CT of the chest:CT of the chest: the condition of the underlying lung, Pnxthe condition of the underlying lung, Pnx
• ThoracentesisThoracentesis::
o Foul - smelling aspirate (anaerobic infection).Foul - smelling aspirate (anaerobic infection).
o Gram stain and culture and sensitivity: identification of the causativeGram stain and culture and sensitivity: identification of the causative
organisms.organisms.
o Low PH (<7.2).Low PH (<7.2).
o Pleural fluid white cell count > 15.000/ mmPleural fluid white cell count > 15.000/ mm33
..
• Methylene blue test:Methylene blue test: injection of methylene blue 1% in theinjection of methylene blue 1% in the
pleural space, it will be expectorated in the sputum.pleural space, it will be expectorated in the sputum.
• Inhalation of radioactive isotopes:Inhalation of radioactive isotopes: detected in the pleuraldetected in the pleural
space.space.
• FOB: Methylene blue test and visualization of bubbles after bronchial
wash
58. TreatmentTreatment::
• Appropriate antibiotic therapy.Appropriate antibiotic therapy.
• Intercostal tube drainage under water seal &Intercostal tube drainage under water seal &
pleurodesispleurodesis
• DecorticationDecortication
• Muscle flap closure of fistulaMuscle flap closure of fistula
• Pleuropneumonectomy.Pleuropneumonectomy.