Solutions: types and properties of solutions. Units of concentration, ideal and real
solutions. Henry’s law, distribution of solids between two immiscible liquids, distribution
law. Partition coefficient and solvent extraction.
The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts.
The suspension dosage form has long been used for poorly soluble active ingredients for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts.
Additive, constitutive and colligative properties with examples; Concept of tonicity in pharmacy, methods to adjust isotonicity; Dipole moment, Dielectric constant and significance to pharmacy
Refractive index and molar refraction, Principle and working of Abbe’s refractometer and Application of molar refraction to determine structures
Optical rotation, Specific rotation, measurement of optical rotation and its applications
content-
Chemistry & Chemical Engineering
History of Catalysis
Catalysis
Recent trends in Catalysis
Future trends in Catalysis
Summary
role-
24% of GDP from Products made using catalysts (Food, Fuels, Clothes, Polymers, Drug, Agro-chemicals)
> 90 % of petro refining & petrochemicals processes use catalysts
90 % of processes & 60 % of products in the chemical industry
> 95% of pollution control technologies
Catalysis in the production/use of alternate fuels (NG,DME, H2, Fuel Cells, biofuels…)
What is solubility in physical pharmacy?
Solubility is the concentration of a solute when the solvent has dissolved all the solute that it can at a given temperature. A useful definition of solubility is the concentration of solute in a saturated solution at equilibrium.Solubility is one of the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response [12]. Poorly water soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration.
Complexation and Protein Binding [Part-1](Introduction and Classification an...Ms. Pooja Bhandare
Complexation: Classification of complexation:
Metal ion or co-ordination complexes :
Inorganic type Organic molecular complexes :
Quinhydrone type
Picric acid type
Caffeine and other drug complexes
Polymer type
Inclusion or occlusion compound
Channel lattice type
Layer type
Monomolecular type
Macromolecular type
Chelates
Olefin type
Aromatic type
Pi (п) complexes
Sigma (б) complexes
Sandwich complexes
Additive, constitutive and colligative properties with examples; Concept of tonicity in pharmacy, methods to adjust isotonicity; Dipole moment, Dielectric constant and significance to pharmacy
Refractive index and molar refraction, Principle and working of Abbe’s refractometer and Application of molar refraction to determine structures
Optical rotation, Specific rotation, measurement of optical rotation and its applications
content-
Chemistry & Chemical Engineering
History of Catalysis
Catalysis
Recent trends in Catalysis
Future trends in Catalysis
Summary
role-
24% of GDP from Products made using catalysts (Food, Fuels, Clothes, Polymers, Drug, Agro-chemicals)
> 90 % of petro refining & petrochemicals processes use catalysts
90 % of processes & 60 % of products in the chemical industry
> 95% of pollution control technologies
Catalysis in the production/use of alternate fuels (NG,DME, H2, Fuel Cells, biofuels…)
What is solubility in physical pharmacy?
Solubility is the concentration of a solute when the solvent has dissolved all the solute that it can at a given temperature. A useful definition of solubility is the concentration of solute in a saturated solution at equilibrium.Solubility is one of the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response [12]. Poorly water soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration.
Complexation and Protein Binding [Part-1](Introduction and Classification an...Ms. Pooja Bhandare
Complexation: Classification of complexation:
Metal ion or co-ordination complexes :
Inorganic type Organic molecular complexes :
Quinhydrone type
Picric acid type
Caffeine and other drug complexes
Polymer type
Inclusion or occlusion compound
Channel lattice type
Layer type
Monomolecular type
Macromolecular type
Chelates
Olefin type
Aromatic type
Pi (п) complexes
Sigma (б) complexes
Sandwich complexes
Drug administration and pharmacy council of Bangladesh, their scope and functions.
Regulations and laws governing the practices of pharmacy (The pharmacy ordinance 1976). Control of drug advertisements, prices, patented and trade market medicine, proprietary medicine, schedules of drugs and poisons, regulation of cosmetics and poison control
Colligative properties of dilute solutions: lowering of vapour pressure, elevation of
boiling point, depression of freezing point and osmotic pressure including necessary
thermodynamic derivations.
Surface Tension is defined as the tension of the surface film of a liquid caused by the attraction of the particles in the surface layer by the bulk of the liquid, which tends to minimize surface area.
It is due to the phenomena of surface tension that the drops of water tend to assume a spherical shape to attain minimum surface area. the presentation gives a brief description of the methods to measue this important property of the interface of two fluid.
ANURAG TYAGI CLASSES (ATC) is an organisation destined to orient students into correct path to achieve
success in IIT-JEE, AIEEE, PMT, CBSE & ICSE board classes. The organisation is run by a competitive staff comprising of Ex-IITians. Our goal at ATC is to create an environment that inspires students to recognise and explore their own potentials and build up confidence in themselves.ATC was founded by Mr. ANURAG TYAGI on 19 march, 2001.
VISIT US AT;
www.anuragtyagiclasses.com
or call us @ 09818777622
Solutions: types and properties of solutions. Units of concentration, ideal and real
solutions. Henry’s law, distribution of solids between two immiscible liquids, distribution
law. Partition coefficient and solvent extraction.
Sl. No. Date Name of the experiment Page No.
01 Conversion of different water insoluble or sparingly soluble substances into water soluble form. 01 – 07
02 Name of the Experiment: Manufacture of Aluminium Hydroxide Gel from the supplied material. 08 – 10
03-A Qualitative analysis (identification) of anions from inorganic salt solutions. 11 – 15
03-B Qualitative analysis (identification) of group I & group II cations. 16 – 20
03-C Qualitative analysis (identification) of group III cation. 21 – 27
03-D Qualitative analysis (identification) of group IV & group V cations. 28 – 31
Appendix 32
Safety Rules for chemistry laboratory 33
Qualitative analysis of inorganic salts, Identification of anions and cations,Conversion of different water insoluble or sparingly soluble substances into water soluble form.
Name of the Experiment: Manufacture of Aluminium Hydroxide Gel from the supplied material.
Qualitative analysis (identification) of anions from inorganic salt solutions.
Qualitative analysis (identification) of group I & group II cations.
Qualitative analysis (identification) of group III cation.
Qualitative analysis (identification) of group IV & group V cations.
How to test the Ammonium with Litmus paper?
How to Clean a Platinum Wire?
What is Qualitative Analysis?
Pharmaceutical SOLTUIONS by Hemas Mehmood .pdfHEMAS MEHMOOD
THE SOLUTIONS ARE THE HIOMOGENOUS MIXTURES OF TWO OR MORE THAN TWO COMPONENTS
THE PHARMACETICAL SOLUTIONS ARE THE SOLUTIONS THATARE TO USED IN THE MANUFACTURING OF THE MEDICINAL PRODCUTS
SUCH MEDICAL RELATED SOLUTIONS ARE CATEGORIZED IN MANY DIFFERENT CLASSES GIVEN ALONG WITH THE DETAILS IN THE SLIDES
Solubility is defined as the maximum amount of a substance that will dissolve in a given amount of solvent at a specified temperature. Solubility is a characteristic property of a specific solute–solvent combination, and different substances have greatly differing solubilities.
Standardization of Acids and bases.
2. Determination of pKa and pKb values
3. Preparation of solutions of different pH & buffer capacities.
4. Determination of phase diagram of binary systems.
Determination of distribution coefficients.
6. Determination of molecular weight by Victor Meyer’s Method.
7. Determination of heats of solutions by measuring solubility as a function of temperature
(Van’t Hoff equation.)
A. Qualitative analysis of metal ions and acid radicals:
Na+, K+, Ca+2, Ag+, Mn+4, Fe+2, Fe+3, Co+2, Mg+2, Al+3, Cu+2 and acid radicals CO3,
halides, Citrate
SO4-2, NO3-, SO3-2, etc.
B. Identification of inorganic drugs in their formulation:
1. Ca+2, from supplied preparations
2. Fe+2 from supplied preparations
3. Al+3 from supplied preparations
4. Mg+2 from supplied preparations
5. K+ from supplied reparations
6. Na+ from supplied preparations
C. Conversion of different water insoluble or sparingly soluble drugs into water soluble
forms:
1. Na/ K – salicylate from salicylic acid
2. Na/ K – benzoate from benzoic acid
3. Na/ K – citrate from citric acid
Plants in complimentary and traditional systems of medicine MANIKanikImran Nur Manik
Plants in complimentary and traditional systems of medicine: Introduction-different types of
alternative systems of treatments (e.g. Ayurvedic, Unani and Homeopathic medicine). Contribution
of traditional drugs to modern medicines. Details of some common indigenous traditional drugs:
Punarnava, Vashaka, Anantamul, Arjuna, Chirata, Picrorhiga, Kalomegh, Amla, Asoka, Bahera,
Haritaki, Tulsi, Neem, Betel nut, Joan, Karela, Shajna, Carrot, Bael, Garlic, Jam and Madar.
Crude drugs: A general view of their origin, distributions, cultivation, collection, drying and
storage, commerce and quality control.
a) Classification of drugs.
b) Preparation of drugs for commercial market
c) Evaluation of crude drugs.
d) Drug adulteration.
Carbohydrate and related compounds: Sugars and sugar containing drugs. Sucrose,
dextrose, glucose, fructose etc. Polysaccharides and polysaccharide containing drugs,
Starches, dextrins etc. Gums and mucilages, tragacanth, acacia, sterculia, sodium
alginate, agar and cellulose.
Volatile oils and related terpenoids-Methods of obtaining volatile oils,
chemistry, their medicinal and commercial uses, biosynthesis of some important
volatile oils used as drugs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Solution (Chemistry) MANIK
1. PHARM
Md. Imran Nur Manik
Lecturer
Department of Pharmacy
Northern University Bangladesh
2. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 1
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Definitions
A solution may be defined as a homogeneous mixture of two or
more components that form a single phase.
The component that determines the phase of the solution is termed the solvent and usually constitutes
the largest proportion of the system. The other components dispersed as molecules or ions throughout
the solvent are termed solutes.
The transfer of molecules or ions from a solid state into solution is known as dissolution. The extent to
which the dissolution proceeds under a given set of experimental conditions is referred to as the
solubility of the solute in the solvent.
Solute molecules
Solvent molecules
Fig. Molecular model of a solution
In the pharmaceutical terms,
solutions are “liquid preparations
that contain one or more chemical
substances dissolved in a suitable
solvent or mixture of mutually
miscible solvents”
Solvent
Solute
SolutionMd.
Imran
Nur
Manik
3. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 2
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Physical Properties of Solutions
1. Colligative properties
- The properties which depend on the number of particles in the solution (i.e. relative
proportions of the molecules of the solute and solvent) and not on the size or chemical nature of the
particles are called Colligative properties
Boiling Point elevation, Freezing Point depression, Vapor Pressure lowering, Osmotic Pressure
- The values are same for equal concentrations of different nonelectrolytes in solution.
- Related to each other.
2. Additive properties
- The properties of substance which depends upon the total contribution of the atoms or
functional groups within the molecules are called additive properties. e.g Mass, Molecular weight (sum
of masses of each atom in the molecule).
3. Constitutive properties
- The properties which mainly depend on the structural arrangement, number and kinds of
atoms in molecules are called constitutive properties.
- e.g. Optical rotation – depends on the chirality of the molecule which is determined by the
atomic bonding order; surface tension, viscosity etc.
Types of Solution
i.) Based on the amount of solute -
a) Saturated Solution
Saturated solution is a solution to which no more solute can be added at a particular temperature.
As temperature affects the solubility of a substance, a saturated solution at lower temperature may become a
dilute solution at higher temperature.
b) Unsaturated Solution
It is a solution to which more solute can be added to dissolve. They are also otherwise called dilute
solutions. An unsaturated solution contains less solute than the solvent has the capacity to dissolve at a
specific temperature.
c) Supersaturated solution
A solution that contains a higher than saturation concentration of solute; slight disturbance or seeding
causes crystallization of excess solute.
The solubility of the salt will increase with increase in temperature. Hence we can add more solute to
the saturated solution at an elevated temperature (nearly at its boiling point). A solution where the solute
cannot be added further even at elevated temperature is called a super saturated solution. It is highly
unstable and the solute will crystallize when the temperature is reduced. A supersaturated contains more
solute than is present in a saturated solution at a specific temperature.
Md.
Imran
Nur
Manik
4. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 3
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
ii) Based on the physical state of the solutes and solvents
Sl. Solute Solvent Example
01. Gas Gas Air
02. Liquid Gas Water in oxygen
03. Solid Gas Iodine vapour in air
04. Gas Liquid Carbonated water
05. Liquid Liquid Alcohol in water
06. Solid Liquid Aqueous NaCl solution
07. Gas Solid Hydrogen in palladium
08. Liquid Solid Hg in Ag, Mineral oil in paraffin
09. Solid Solid Gold-silver mixture
Ideal and real solutions
Ideal solution is defined as a solution in which there is no change in the properties of the
components other than dilution when they are mixed to form the solution
Molecules exhibit complete freedom of motion and randomness of distribution in the solution.
Ideality in solutions means complete uniformity of attractive forces
Md.
Imran
Nur
Manik
5. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 4
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Concentration of a Solution
The concentration of a solution is defined as: the amount of solute present in a given amount of
solution.
Concentration is a general measurement unit stating the amount of solute (solu.) present in a known
amount of solution (soln.)
A solution containing a relatively low concentration of solute is called Dilute solution. A solution of high
concentration is called Concentrated solution.
Concentration Expression
Expression Symbol Definitions
Molarity M Number of moles (gm molecular weight) of solute in 1 L of
solution.
Normality N Gram equivalent weights of solute in 1 L of solution
Molality m Moles of solute in 1000 g solvent
Mole Fraction X Ratio of moles of one constituent of a solution to the total
moles of all constituents (solute & solvent)
Mole percent -- Moles of one constituent in 100 moles of the solution. It is
obtained by multiplying X by 100
Percent by weight %w/w Gram of solute in 100 gm solution
Percent by volume %v/v ml of solute in 100 ml of solution
Percent by weight-in-volume %w/v Gram of solute in 100 ml solution
Milligram percent --- mg of solute in 100 ml of solution
Molarity (M)
Molarity is the number of moles of solute dissolved per liter of solution.
Problems
What is the molarity of a solution prepared by dissolving 75.5 g of pure KOH in 540 ml of solution?
Calculate the amount of HCl present in 150 ml of a 0.5 M solution?
Normality (N)
Number of gram equivalent (eq.) weights of solute in 1L of solution.
Md.
Imran
Nur
Manik
6. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 5
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Relationship between molarity and normality for the same solute in the same solution:
So
Thus: n ≥ ≥1 therefore N ≥ M
Equivalent mass (Eq. M.): equivalent mass of a substance can be calculated by dividing its molar mass
per the number of active units in one molecule of this substance (n) thus:
The active unit in the acid-base reactions is the number of hydrogen ions liberated by a single molecule
of an acid or reacted with a single molecule of a base.
Md.
Imran
Nur
Manik
7. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 6
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Acid: one definition of acid is any substance that ionizes in water to form H+, includes monoprotic and
polyprotic. Monoprotic acid like hydrochloric acid (HCl) which includes only one proton (hydrogen ion),
and polyprotic acid like sulfuric acid (H2SO4) that contains two protons (hydrogen ion).
The active unit in the oxidation-reduction (redox) reactions is the number of electrons (e) transferred
from one reactant to another during the reaction.
A 3M H2SO4 solution is the same as a 6N H2SO4 solution.
For a basic solution, n is the number of OH- ions provided by a formula unit of base.
A 1M Ca(OH)2 solution is the same as a 2N Ca(OH)2 solution
Problems for using Molarity and Normality
1. Volume of solution change with temperature. So it should not be used when one wishes to study the
properties of solutions at various temperatures.
2. Difficult to study the properties of solutions such as vapor pressure and osmotic pressure which are
related to the concentration of the solvent.
Problem
Calculate the amount required to produce 250ml, 1N HCl solution. The purity of HCl 37.0 % & the
density of the reagent is 1.19 g/mL.?
Find the Normality of 0.67 g. KOH in 120 mL of water?
Molality (m)
Number of moles of solute in 1000 g solvent. It does not change with temperature.
A solution obtained by dissolving one mole of the solute in 1000 g of solvent is called one molal or 1m
solution.
Problem
What is the molality of a solution prepared by dissolving 50.0 g of HCl in 225 g of water?
Mole Fraction(X)
Mole fraction is the ratio of the number of moles of one constituent (solute) in solution to the total
number of moles of solute and solvent.
Where XA and XB represent mole fractions of each substance
Md.
Imran
Nur
Manik
8. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 7
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Mole Percent
Moles of one constituent in 100 moles of the solution. It is obtained by multiplying ‘X’ by 100.
Percent by weight in weight (%w/w)
It is the weight of the solute as a per cent of the total weight of the solution. That is,
For example, if a solution of HCl contains 36 per cent HCl by weight, it has 36 g of HCl for 100g of
solution.
Problem
What is the per cent by weight of NaCl if 2.75 g of NaCl is dissolved in 9.85 g of water?
Percent by volume in volume (%v/v)
ml of solute in 100 ml of solution
Problem
Make 1000ml of a 5% by volume solution of ethylene glycol in water.
Procedure
First, express the percent of solute as a decimal: 5% = 0.05
Multiply this decimal by the total volume: 0.05 x 1000ml = 50ml (ethylene glycol needed).
Subtract the volume of solute (ethylene glycol) from the total solution volume:
1000ml (total solution volume) - 50ml (ethylene glycol volume) = 950ml (water needed)
Dissolve 50ml ethylene glycol in a little less than 950ml of water. Now bring final volume of solution up
to 1000ml with the addition of more water. (This eliminates any error because the final volume of the
solution may not equal the calculated sum of the individual components).
So, 50ml ethylene glycol / 1000ml solution x100 = 5% (v/v) ethylene glycol solution.
Percent by weight-in-volume (%w/v)
Gram of solute in 100 ml solution
Md.
Imran
Nur
Manik
9. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 8
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
15mL of an aqueous solution of sucrose contains 750mg sucrose. What is the weight/volume
percentage concentration of this solution in g/100mL?
Dilution: addition of solvent to decrease the concentration of solute. The solution volume changes,
but the amount of solute is constant.
moles of solute (mol) = molarity (M) x volume (V)
M1V1 = M2V2
Initial values final values
Problem
Prepare 250 mL of 0.100 M NaCl solution from a 2.00 M NaCl solution.
M1 = molarity of starting solution (in this case 2.00M NaCl)
V1 = volume of starting solution required (always unknown)
M2 = molarity of final solution after dilution (in this case 0.100M NaCl)
V2 = volume of final solution, after dilution (in this case 250ml)
V1 = M2 V2 / M1
V1 = (0.100M) x (250 ml) / (2.00M) = 12.5ml
To make molar NaCl solutions of other concentrations dilute the mass of salt to 1000ml of solution as
follows:
0.1M NaCl solution requires 0.1 x 58.44 g of NaCl = 5.844g
0.5M NaCl solution requires 0.5 x 58.44 g of NaCl = 29.22g
2M NaCl solution requires 2.0 x 58.44 g of NaCl = 116.88g
Md.
Imran
Nur
Manik
10. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 9
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Solutions of Solids in Liquid
Will sugar dissolve in water? Will petroleum dissolve in water?
Like Dissolves Like
Polar molecules are soluble in polar solvents C2H5OH in H2O
Non-polar molecules are soluble in non-polar solvents e.g. CCl4 in C6H6
Polar compounds, like table sugar (C12H22O11), are soluble in polar solvents and insoluble in nonpolar
solvents.
Nonpolar compounds, like naphthalene (C10H8), are soluble in nonpolar solvents and insoluble in polar
solvents.
This it the like dissolves like rule.
Ionic compounds, like sodium chloride, are soluble in polar solvents and insoluble in nonpolar solvents.
An ionic solid dissolves in water because the number of water molecules around the surface is greater
than the number of other ions of the solid. The attraction between polar water molecules and a charged
ion enables the water molecules to pull ions away from the crystal, a process called dissolving.
The mechanism of solution of sodium crystal in water could be explained as follows. The polar water
molecules try to pull out the Na+ and Cl– ions from the crystal by hydration. This becomes possible
since the forces operating between the ion (Na+ or Cl–) and water molecules are strong enough to
overcome the force binding the ion in the crystal. The ions detached from the crystal are now
surrounded by cluster of water molecules. The layer of water molecules enveloping the ions effectively
shields them and prevents them from coming in contact with each other. Thus they hardly aggregate
into a crystal and remain in solution.
Md.
Imran
Nur
Manik
11. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 10
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Miscible & Immiscible
• Two liquids that completely dissolve in each other are miscible liquids.
• Two liquids that are not miscible in each other are immiscible liquids.
• Polar water and nonpolar oil are immiscible liquids and do not mix to
form a solution.
Partition Coefficient
A partition-coefficient (P) is the ratio of concentrations of a compound in a
mixture of two immiscible phases at equilibrium.Partition coefficient is
generally defined as the fraction of drug in an oil phase to that of an adjacent aqueous
phase.
FORMULA
Cwater
Coil
wPo /
Accordingly compounds with relatively high partition coefficient are predominantly lipid soluble and
consequently have very low aqueous solubility.
Compounds with very low partition coefficients will have difficulty in penetrating membranes resulting
poor bioavailability.
Md.
Imran
Nur
Manik
12. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 11
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Factors Affecting Solubility of a Solute
1. Temperature
Generally in many cases solubility increases with the rise in temperature and decreases with the fall of
temperature but it is not necessary in all cases. However we must follow two behaviours:
In endothermic process solubility increases with the increase in temperature and vice versa.
For example: solubility of potassium nitrate increases with the increase in temperature.
In exothermic process solubility decrease with the increase in temperature.
For example: solubility of calcium oxide decreases with the increase in temperature.
2. Effect of pressure
The effect of pressure is observed only in the case of gases.
An increase in pressure increases of solubility of a gas in a liquid.
For example carbon di oxide is filled in cold drink bottles (such as coca cola, Pepsi 7up etc.) under
pressure.
3. Chemical natures of the solute and solvent
A polar solute will dissolve in a polar solvent but not in a nonpolar solvent. The adage "like dissolves
like" is very useful.
Example: Alcohol (polar substance) dissolves in water (polar substance). Water (polar substance) does
not dissolve in oil (nonpolar substance)
4. Stirring
With liquid and solid solute, stirring brings fresh portions of the solvent in contact with the solute,
thereby increasing the rate of dissolution.
5. Amount of solute already dissolved
When there is little solute already in solution, dissolving takes place relatively rapidly. As the solution
approaches the point where no solute can be dissolved, dissolving takes place more slowly.
6. Molecular size
The larger the molecules of the solute are, the larger is their molecular weight and their size. If the
pressure and temperature are the same than out of two solutes of the same polarity, the one with
smaller particles is usually more soluble.
Md.
Imran
Nur
Manik
13. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 12
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Nernst’s Distribution Law
Nernst gave a generalization governing the distribution of a solute between two non-miscible solvents.
This is called Nernst’s Distribution law or Nernst’s Partition law or simply Distribution law or Partition
law.
Statement of Nernst’s distribution law: If a solute X distributes itself between two immiscible solvents A
and B at constant temperature and X is in the same molecular condition in both solvents,
Thus, =KD
Or, 2
1
C
C
=KD
Where, C1 & C2 denotes the concentration of the solute in solvent A and B respectively.
Explanation: If we take two immiscible solvents A and B in a beaker, they form separate layers. When a
solute X which is soluble in both solvents is added, it gets distributed or partitioned between them.
Molecules of X pass from solvent A to B and from solvent B to A. Finally a dynamic equilibrium is set
up. At equilibrium, the rate, at which molecules of X pass from one solvent to the other is balanced.
Figure: Distribution of solute X between solvent A and B.
Now according to Nernst’s distribution law the distribution of solute x between solvent A and B
=a constant
Solubilities and distribution law
When a solute is shaken with two non-miscible solvents, at equilibrium both the solvents are saturated
with the solute. Since the solubility also represents concentration, we can write the distribution law as
2
1
C
C
= 2
1
S
S
=KD
Where S1 and S2 are the solubilities of the solute in the two solvents.
Md.
Imran
Nur
Manik
14. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 13
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Derivation of distribution law (Distribution law is an equilibrium law.)
Let us take two immiscible solvents A and B in a beaker. Now add a solute X which is soluble in both of
the solvents, thus it gets distributed or partitioned between them. Molecules of X pass from solvent A to
B and from solvent B to A. Finally a dynamic equilibrium is set up.
Fig. At equilibrium, the number of molecules of X passing from solvent A into B is proportional to its
concentration in A and vice versa. Also, the rate of migration of solute molecules from A to B and B to A is
equal (Illustration).
When the distribution of the solute X has reached dynamic equilibrium, the rate (R1) at which molecules
of X pass from solvent A to B is proportional to its concentration (C1) in A.
That is, R1 ∝ C1
or R1= k1C1 where k1 is a constant
The rate (R2) at which molecules of X pass from solvent B to A is proportional to its concentration (C2)
in B.
R2 ∝ C2
or R2 = k2C2 where k2 is a constant
Also, at equilibrium, the rate of migration of solute from one solvent to the other is equal.
Thus we have, R1= R2
or, k1C1 = k2C2
or,
DK
k
k
C
C
1
2
2
1
or,
DK
C
C
2
1
If temperature is fixed the distribution coefficient KD is also constant, since k1 and k2 are constants at
the same temperature.
This is the Nernst’s Distribution law equation.
Md.
Imran
Nur
Manik
15. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 14
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Limitations of distribution law
The conditions to be satisfied for the application of the Nernst’s Distribution law are :
1. Constant temperature. The temperature is kept constant throughout the experiment.
2. Same molecular state. The molecular state of the solute has to be the same in the two solvents. The
law does not hold if there is association or dissociation of the solute in one of the solvents.
3. Equilibrium concentrations. The concentrations of the solute are noted after the equilibrium has
been established.
4. Dilute solutions. Suitable if solute concentration is low in two solvents. The law does not hold when
the concentrations are high.
5. Non-miscibility of solvents. The two solvents should be non-miscible or only slightly soluble in each
other. The extent of mutual solubility of the solvents remains unaltered by the addition of solute to
them.
Henry’s Law – A Form of Distribution Law
The relationship between pressure and solubility of a gas in a particular solvent was investigated by
William Henry (1803). He gave a generalisation which is known as Henry’s Law. It may be stated as
Henry’s law states: at a constant temperature the solubility of a gas in a liquid is proportional to the
pressure of the gas above it. Henry’s law may be mathematically expressed as
Mathematically, Henry’s Law may be expressed as
C ∝ P
Or C = k P
Where P = pressure of the gas;
C = concentration of the gas in solution; and
k = proportionality constant known as Henry’s
Law Constant.
The value of k depends on the nature of the gas
and solvent, and the units of P and C used.
(a) Equilibrium exists between the gas molecules
and those in solution; (b) When pressure is
applied, gas volume decreases and
concentration in gas phase increases;
(c) More gas molecules pass into solution to re-establish equilibrium whereby the pressure above the
gas is decreased.
Md.
Imran
Nur
Manik
16. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 15
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Derivation
Henry’s law is, is a form of Distribution law. If a vessel containing a liquid and a gas is shaken, at
equilibrium the gas can be regarded as distributed between the liquid (Phase A) and the space above
(Phase B).
Let C1 be the molar concentration of the gas in phase B
C be the concentration of the gas in phase A
Applying the Distribution law, 1C
C
=KD (a constant)
We know that molar concentration of gas is proportional to its pressure, P.
P
C
=K (a constant)
or C = KP
This is Henry’s Law equation.
Like distribution law, Henry’s law holds good for dilute solutions of gases which do not react with the
solvent.
Limitations of Henry’s Law
It applies closely to gases with nearly ideal behaviour.
(1) At moderate temperature and pressure.
(2) If the solubility of the gas in the solvent is low.
(3) The gas does not react with the solvent to form a new species. Thus ammonia (or HCl) which react
with water does not obey Henry’s Law
NH3 + H2O ⇌NH4
+ + OH–
(4) The gas does not associate or dissociate on dissolving in the solvent.
Md.
Imran
Nur
Manik
17. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 16
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Use
The influence of partial pressure on solubility is utilized in making carbonated beverages like beer,
champagne, and many soft drinks. So called ‘soda water’ is bottled under a carbon dioxide pressure of
about 4 atm. When the bottle is opened to the air, the partial pressure of CO2 above the solution is
decreased (about 0.001 atm), and CO2 bubbles out.
(a ) CO gas at 4 atm in equilibrium with dissolved CO resulting in high solubility of CO ; (b ) In opened bottle
pressure is released to 1 atm and hence equilibrium shifted upward, gas bubbles evolved causing brisk
effervescence; ( c) Partial pressure of CO in air being 0.001 atm, practically the whole of CO is removed from
solution, leaving the soft drink flat as the equilibrium is established.
Applications of Distribution Law
There are numerous applications of distribution law in the laboratory as well as in industry. Here we will
discuss some more important ones by way of recapitulation.
(1) Solvent Extraction
The removal of a substance(s) {solute} by a solvent of an organic substance from an aqueous solution is
called extraction.
Classification
A. Simple extraction: when the process of extraction is carried out with the total amount of the
given solvent in a single operation, is referred to as simple extraction.
B. Multiple extraction or multi-step extraction: To recover the maximum amount of the substance
from aqueous solution, when the extraction is made in two or more successive operations using
small portions of the provided solvent, then it is called multiple extraction or multi-step
extraction.
Md.
Imran
Nur
Manik
18. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 17
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Simple extraction
The process of Simple extraction of organic substances from aqueous solutions is carried out by shaking
the aqueous solution with a immiscible organic solvent, say ether (ethoxyethane), in a separatory funnel.
The distribution ratio being in favour of ether, most of the organic substance passes into ether layer.
On standing, the aqueous and ether layers separate in the funnel. The lower aqueous layer is run out,
leaving the ether layer behind. This is then transferred to a distillation flask. Ether is distilled over while
the organic substance is left as residue in the flask.
Fig. Extraction in a separatory funnel
If desired, the process may be repeated with aqueous layer left after the first extraction with a fresh
quantity of the solvent.
The other common solvents used for extraction are hexane, benzene, chloroform, acetone, carbon
disulphide, etc.
The greater the distribution ratio is in favour of the organic solvent, the greater will be the amount
extracted in any one operation.
Multiple extractions
In Multiple extractions process the aqueous solution is first extracted with a portion of the solvent in a
separatory funnel. The aqueous layer from which some substance has been removed is then transferred
to another funnel. This is shaken with another ( second) portion of the solvent. Similarly, the aqueous
layer from the second extraction is treated with a third portion of solvent, and so on.
Md.
Imran
Nur
Manik
19. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 18
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Superiority of multiple extraction over simple extraction
(** For better extraction, multiple extraction is more efficient than single extraction.)
Generally it is more efficient to use a specified volume of solvent in small portions rather than in one
whole.
Suppose we have 100 ml of an aqueous solution containing A grams of an organic substance.
We can extract the substance with ether (ethoxyethane), its distribution ratio being twice in favour of
ether. Provided that 100 ml of ether which may be used in one lot or in two portions of 50 ml each.
1. Using all the ether in one lot.
Let x grams be the weight of the substance extracted in the solvent layer. Then the amount of
substance left in the water layer = (A – x) grams.
Therefore,
Concentration in ether layer = 100
x
Concentration in water layer = 100
)( xA
Md.
Imran
Nur
Manik
20. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 19
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
According to the Distribution law
K
C
C
water
ether
2
100
100
xA
x
Where K=2
Hence, x = A
3
2
Thus 66% of substance is extracted.
2. Using two 50 ml portions of ether.
Let x1 grams of substance be extracted in the first operation with 50 ml ether.
Thus,
Concentration in ether layer= 50
1x
Concentration in water layer =
100
1xA
According to the Distribution law
K
C
C
water
ether
Thus, 2
100
50
1
1
xA
x
Where K=2
Hence 2
1
A
x
50% of substance is extracted.
The substance left in water layer is 2
A
Let x2 grams be the substance removed from the water layer when it is extracted with another 50 ml
portion of ether.
Hence,
Concentration in ether layer = 50
2x
Md.
Imran
Nur
Manik
21. Solution
Prepared By: Md. Imran Nur Manik; B.Pharm; M.Pharm Page 20
manikrupharmacy@gmail.com; Lecturer; Department of Pharmacy; Northern University Bangladesh.
Concentration in water layer = 100
2
2x
A
= 200
2 2xA
According to the Distribution law
K
C
C
water
ether
Thus,
2
200
2
50
2
2
xA
x
Where K=2
Hence, 4
2
A
x
Thus 25% of substance is extracted.
Now the total percent of substance is extracted by using two 50 ml portions of the solvent is
= (50+25) %
=75%
It is greater than 66 percent obtained by using 100 ml solvent in one lot.
Hence multiple extraction is more efficient than simple extraction-proved.
(2) Partition Chromatography
This is a modern technique of separating a mixture of small amounts of organic materials.
(3) Desilverization of Lead (Parke’s Process)
(4) Confirmatory Test for Bromide and Iodide
(5) Determination of Association
(6) Determination of Dissociation
(7) Determination of Solubility
(8) Deducing the Formula of a Complex Ion (I3 )
(9) Distribution Indicators
Md.
Imran
Nur
Manik