This document provides information about various lipids (fats and oils) obtained from plants and animals. It discusses the basic chemistry of lipids, describing them as esters of fatty acids and alcohols. Specific lipids are then outlined, including their source, composition, properties, and some uses. Key lipids discussed include olive oil, coconut oil, castor oil, linseed oil, peanut oil, chaulmoogra oil, and beeswax.
Pharmacognosy of carbohydrates containing drugs Jegan Nadar
This PPT covers Pharmacognosy of carbohydrates containing drugs. It includes Pharmacognosy of Agar, Acacia, Guar Gum, Honey ,Starch, Isapgol,Tragacanth,Sterculia Gum,Chitin and Pectin.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
: In this video the viewers will come to know about Castor oil that is one of the Lipid containing crude drugs obtained from the plant sources Castor oil is the fixed oil obtained by cold expression of the seeds of Ricinus communis Linn., belonging to family Euphorbiaceae. This drug becomes important since it is obtained from seed source. Here the synonyms, biological sources (scientific names & Family), geographical sources (what are the countries where it can be collected), chemical constituents, identification tests and uses has been discussed in brief.
Portion explained:
1. Synonyms of Castor oil
2. Biological Sources of Castor oil
3. Geographical Sources of Castor oil
4. Preparation of Castor oil
5. Description of Castor oil
6. Chemical Constituents of Castor oil
7. Chemical Test of Castor oil
8. Uses of Castor oil
Pharmacognosy of carbohydrates containing drugs Jegan Nadar
This PPT covers Pharmacognosy of carbohydrates containing drugs. It includes Pharmacognosy of Agar, Acacia, Guar Gum, Honey ,Starch, Isapgol,Tragacanth,Sterculia Gum,Chitin and Pectin.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
: In this video the viewers will come to know about Castor oil that is one of the Lipid containing crude drugs obtained from the plant sources Castor oil is the fixed oil obtained by cold expression of the seeds of Ricinus communis Linn., belonging to family Euphorbiaceae. This drug becomes important since it is obtained from seed source. Here the synonyms, biological sources (scientific names & Family), geographical sources (what are the countries where it can be collected), chemical constituents, identification tests and uses has been discussed in brief.
Portion explained:
1. Synonyms of Castor oil
2. Biological Sources of Castor oil
3. Geographical Sources of Castor oil
4. Preparation of Castor oil
5. Description of Castor oil
6. Chemical Constituents of Castor oil
7. Chemical Test of Castor oil
8. Uses of Castor oil
This slide includes the plants containing Volatile oil, their chemical components, Structures and uses. As well as how the volatile oil is being obtained from different methods and techniques with the pictorial representation.
1) BASED ON THE CHEMICAL NATURE OF NON SUGAR MOIETY
2) BASED ON TE NATURE OF SUGAR MOITY
3) BASED ON LINKAGE BETWEEN GLYCON AND AGLYCON PORTION
4) BASED ON THERAPEUTIC NATURE OF GLYCOSIDE
Cultivation,Collection, Processing and Storage of crude drugsJegan Nadar
Thus PPT covers Cultivation,Collection, Processing and Storage of crude drugs. This ppt includes different methods of propagation, pest and pest control management, growth regulators, polyploidy, hybridization, collection of crude drugs and storage of crude drugs.
Crude drugs are plant, animal or their parts which after collection are subjected only to drying or making them into transverse/ longitudinal slices pieces or peeling them in some cases. They exist in natural form.
Crude drugs may be derived from various natural sources like Plants, Animals, Minerals, Marine and Micro-organisms etc
Cultivation of medicinal plants requires intensive care and management.
The conditions and duration of cultivation required vary depending on the quality of medicinal plant materials required.
Carbohydrate and related compounds: Sugars and sugar containing drugs. Sucrose,
dextrose, glucose, fructose etc. Polysaccharides and polysaccharide containing drugs,
Starches, dextrins etc. Gums and mucilages, tragacanth, acacia, sterculia, sodium
alginate, agar and cellulose.
Chemistry and pharmaceutical uses of Lipids and Oils .pptxssuser35e86c1
Lipids are esters of long-chain fatty acids and alcohols, typically glycerol. Ex- fixed oils, fats, waxes etc.
In general, lipids are soluble in the usual fat solvents such as- ether, chloroform and are insoluble in water. They are hydrophobic in nature.
The chief difference among fixed oils, fats and waxes is the type of alcohol present in it-
In fixed oils and fats, glycerol combines with the fatty acids.
In waxes, monohydric alcohol combines with fatty acids which has a higher molecular weight, e.g., cetyl alcohol [CH3(CH2)15OH].
They have a high-energy value (25% of body needs) and they provide more energy per gram than carbohydrates and proteins.
Supply the essential fatty acids that cannot be synthesized by the body.
Supply the body with fat-soluble vitamins (A, D, E and K).
Tissue fat (phospholipid in nature) is an essential constituent of cell membrane and nervous system.
Stored lipids as “depot fat” is stored in all human cells acts as:
A store of energy.
Protect internal organs from outside shocks.
Act as subcutaneous thermal insulator against loss of body heat.
This slide includes the plants containing Volatile oil, their chemical components, Structures and uses. As well as how the volatile oil is being obtained from different methods and techniques with the pictorial representation.
1) BASED ON THE CHEMICAL NATURE OF NON SUGAR MOIETY
2) BASED ON TE NATURE OF SUGAR MOITY
3) BASED ON LINKAGE BETWEEN GLYCON AND AGLYCON PORTION
4) BASED ON THERAPEUTIC NATURE OF GLYCOSIDE
Cultivation,Collection, Processing and Storage of crude drugsJegan Nadar
Thus PPT covers Cultivation,Collection, Processing and Storage of crude drugs. This ppt includes different methods of propagation, pest and pest control management, growth regulators, polyploidy, hybridization, collection of crude drugs and storage of crude drugs.
Crude drugs are plant, animal or their parts which after collection are subjected only to drying or making them into transverse/ longitudinal slices pieces or peeling them in some cases. They exist in natural form.
Crude drugs may be derived from various natural sources like Plants, Animals, Minerals, Marine and Micro-organisms etc
Cultivation of medicinal plants requires intensive care and management.
The conditions and duration of cultivation required vary depending on the quality of medicinal plant materials required.
Carbohydrate and related compounds: Sugars and sugar containing drugs. Sucrose,
dextrose, glucose, fructose etc. Polysaccharides and polysaccharide containing drugs,
Starches, dextrins etc. Gums and mucilages, tragacanth, acacia, sterculia, sodium
alginate, agar and cellulose.
Chemistry and pharmaceutical uses of Lipids and Oils .pptxssuser35e86c1
Lipids are esters of long-chain fatty acids and alcohols, typically glycerol. Ex- fixed oils, fats, waxes etc.
In general, lipids are soluble in the usual fat solvents such as- ether, chloroform and are insoluble in water. They are hydrophobic in nature.
The chief difference among fixed oils, fats and waxes is the type of alcohol present in it-
In fixed oils and fats, glycerol combines with the fatty acids.
In waxes, monohydric alcohol combines with fatty acids which has a higher molecular weight, e.g., cetyl alcohol [CH3(CH2)15OH].
They have a high-energy value (25% of body needs) and they provide more energy per gram than carbohydrates and proteins.
Supply the essential fatty acids that cannot be synthesized by the body.
Supply the body with fat-soluble vitamins (A, D, E and K).
Tissue fat (phospholipid in nature) is an essential constituent of cell membrane and nervous system.
Stored lipids as “depot fat” is stored in all human cells acts as:
A store of energy.
Protect internal organs from outside shocks.
Act as subcutaneous thermal insulator against loss of body heat.
This is for Bachelor of Pharmacy 3rd semester students that cover the chapter fats and oils. This is useful and also help them to prepare for examination.
Lipids are organic compounds formed mainly from alcohol and fatty acids combined together by ester
Lipids are insoluble in water, but soluble in fat or organic solvents (ether, chloroform, benzene, acetone).
Lipids include fats, oils, waxes and related compounds.
They are widely distributed in nature both in plants and in animals.
Standardization of Acids and bases.
2. Determination of pKa and pKb values
3. Preparation of solutions of different pH & buffer capacities.
4. Determination of phase diagram of binary systems.
Determination of distribution coefficients.
6. Determination of molecular weight by Victor Meyer’s Method.
7. Determination of heats of solutions by measuring solubility as a function of temperature
(Van’t Hoff equation.)
A. Qualitative analysis of metal ions and acid radicals:
Na+, K+, Ca+2, Ag+, Mn+4, Fe+2, Fe+3, Co+2, Mg+2, Al+3, Cu+2 and acid radicals CO3,
halides, Citrate
SO4-2, NO3-, SO3-2, etc.
B. Identification of inorganic drugs in their formulation:
1. Ca+2, from supplied preparations
2. Fe+2 from supplied preparations
3. Al+3 from supplied preparations
4. Mg+2 from supplied preparations
5. K+ from supplied reparations
6. Na+ from supplied preparations
C. Conversion of different water insoluble or sparingly soluble drugs into water soluble
forms:
1. Na/ K – salicylate from salicylic acid
2. Na/ K – benzoate from benzoic acid
3. Na/ K – citrate from citric acid
Plants in complimentary and traditional systems of medicine MANIKanikImran Nur Manik
Plants in complimentary and traditional systems of medicine: Introduction-different types of
alternative systems of treatments (e.g. Ayurvedic, Unani and Homeopathic medicine). Contribution
of traditional drugs to modern medicines. Details of some common indigenous traditional drugs:
Punarnava, Vashaka, Anantamul, Arjuna, Chirata, Picrorhiga, Kalomegh, Amla, Asoka, Bahera,
Haritaki, Tulsi, Neem, Betel nut, Joan, Karela, Shajna, Carrot, Bael, Garlic, Jam and Madar.
Crude drugs: A general view of their origin, distributions, cultivation, collection, drying and
storage, commerce and quality control.
a) Classification of drugs.
b) Preparation of drugs for commercial market
c) Evaluation of crude drugs.
d) Drug adulteration.
Volatile oils and related terpenoids-Methods of obtaining volatile oils,
chemistry, their medicinal and commercial uses, biosynthesis of some important
volatile oils used as drugs.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
Lipids (Pharmacognosy) MANIK
1. Md. Imran Nur Manik
Lecturer
Department of Pharmacy, NUB
Lipids
1103: Pharmacognosy
2. Lipids (fixed oils, fats, and waxes) are esters of long-
chain fatty acids and alcohols, or of closely related
derivatives.
• The chief difference between these substances is the
type of alcohol.
• In fixed oils and fats, glycerol combines with
the fatty acids.
• In waxes, the alcohol has a higher molecular weight.
For example: Cetyl alcohol, [CH3(CH2)15OH].
Fats and fixed oils are obtained from
either plants (olive oil, peanut oil) or
animals (lard).
Their primary function is food (energy)
storage.
4. 1. Simple lipids
(a) Fats and oils which yield fatty acids and
glycerol upon hydrolysis.
(b) Waxes, which yield fatty acids and long-
chain alcohols upon hydrolysis.
2. Compound lipids
(a) Phospholipids, which yield fatty acids,
glycerol, amino alcohol sphingosine,
phosphoric acid and nitrogen-containing
alcohol upon hydrolysis.They may be
glycerophospholipids or sphingophospholipid
depending upon the alcohol group present
(glycerol or sphingosine).
(b) Glycolipids, which yield fatty acids,
sphingosine or glycerol, and a carbohydrate
upon hydrolysis.They may also be
glyceroglycolipids or sphingoglycolipid
depending upon the alcohol group present
5. Fats and oils are made from two kinds of molecules glycerol (a
type of alcohol with a hydroxyl group on each of its three
carbons) and three fatty acids joined by dehydration synthesis.
Since there are three fatty acids attached, these are known as
triglycerides.
Chemically, the fixed oils and fats are glycerides of fatty acids
Fixed oils and Fats differ only as to melting point.
Those that are liquid at normal temperatures are known as fatty or fixed oils,
Whereas those that are semisolid or solid at ordinary temperatures are known as fats.
Usually, the glycerides of unsaturated fatty
acids are liquid
Whereas the glycerides of saturated fatty acids
(no C=C bonds) of sufficient chain length are
solid.
When a drop of fats or oils is placed on a paper, they
form a permanent translucent stain on it. Due to this
property they are called as fixed oils.
6. Extraction by expression:
Fixed oils and fats of vegetable origin are obtained by expression in
hydraulic presses. If the expression is carried out in the cold, the oil is
known as a "virgin oil" or a "cold-pressed oil". In contrast, if the expression
is carried out in heat, the oil is known as a "hot-pressed oil."
Production of fixed oils and fats
Extraction by solvents:
Sometimes organic solvents are used for the
extraction of oils.
Animal fats are separated from other tissues
by rendering with steam, with or without
pressure.
The heat melts the fat, which rises to the top
and may be separated by decantation.
Animal fats are separated from other tissues
by rendering with steam, with or without
pressure. The heat melts the fat, which rises to
the top and may be separated by decantation.
7. Evaluation of fixed oils
According to United States Pharmacopeia, certain tests are
used to determine the identity, quality, and purity of fixed oils.
These tests are based on the chemical constitution of the fatty
acids.
1. The acid value or acid number: It is the number of
milligrams of potassium hydroxide (KOH) required to
neutralize the free fatty acids in one gram of the substance.
It indicates the amount of free fatty acids present in the oil.
2. The saponification value: It is the number of milligrams of
potassium hydroxide (KOH) required to neutralize the free
acids and saponify the esters contained in one gram of the
substance.
3. Iodine number: It is the number of grams of iodine
absorbed, under prescribed conditions, by 100 g of the
substance. It indicates the degree of unsaturation.
10. Castor oil is a fixed oil obtained by cold
expression from the ripen seeds (Castor bean or castor oil seed) of
Ricinus communis (Family: Euphorbiaceae).
Castor oil is a pale yellowish or almost colorless,
transparent, viscid liquid. It has a faint, mild odor and a bland,
characteristic taste.
Castor oil is composed of a mixture of triglycerides, about 75% of
which is tri-ricinolein. The fixed oil consists of the glycerides of
ricinoleic (87%), isorIcinoleic, stearic (1%), dihydroxystearic (traces),
linolelc (3%), oleic (7%), and palmitic (2%) acids.
1. Castor oil is a stimulant cathartic
2.Castor oil is used as a stiffening agent in some pharmaceutical
formulations
It is used as ointment base, for the preparation of flexible collodion
Castor Oil
11. Linseed Is the dried, ripe seed of Linum
usitatissimum Linn. Linseed oil is obtained by expression of linseeds.
Linseed oil is a yellowish liquid, with a peculiar odour
and bland taste.
On hydrolysis Linseed oil produces unsaturated acids like linolenic acid
(30-50%), linoleic acid (23-24%), oleic acid (10-18%) together with
saturated acids-myristic, stearic and palmitic (5-11%).
1. Linseed is used as demulcent and in form of poultices for gouty and
rheumatic swellings.
2. Internally it is used for gonorrhea and irritation of the genitourinary
system.
3. Linseed oil has emollient, expectorant, diuretic, demulcent and laxative
properties and is utilized externally in lotions and liniments.
Linseed Oil
Demulcent: An agent that forms a soothing, protective film when administered onto a mucous membrane surface. For example, mucilage and oils
12. Coconut oil is the fixed oil obtained by expression or
extraction from the seed of the coconut palm, Cocos
nucifera (Family: Palmae).
The oil consists of a mixture of glycerides in which 80 to
85% of the acids are saturated; it is a semisolid at 20C.
It consists of the triglycerides of mainly lauric and myristic
acids, together with smaller quantities of caproic. caprylic.
oleic, palmitic and stearic acids
1. Coconut oil and medium-chain triglycerides are used in
the balanced dietary supplements.
2. It is a useful nonaqueous medium for the oral
administration of some medicaments.
Coconut Oil
13. Olive oil is the fixed oil obtained from the ripe fruit of Olea europaea
(Family: Oleaceae). Olive oil is sometimes called sweet oil.
Olive oil Is a pale yellow or light greenish-yellow due to presence of
chlorophyll or carotenes, non-drying oily liquid with a pleasant delicate
flavor. Taste Is bland becoming faintly acrid.
Olive oil contains mixed glycerides of oleic acid (83.5%), palmitic acid
(9.4%), linoleic acid (7%), stearic acid (2.00/6), and arachidic acid
(0.9%).
1. It is used as a setting retardant for dental cements.
2. In the preparation of soaps, plasters, and liniments.
3. It is also a demulcent, an emollient, and a laxative.
4. Olive oil is a nutrient and is widely used as a salad oil
Olive Oil
Liniment is a liquid that you rub into the skin
in order to reduce pain or relieve stiffness.
Liniments can be rubbed into the skin to relieve
aches from arthritis and stiffness in muscles.
14. Peanut oil is the refined fixed oil obtained from the seed kernels of
one or more of the cultivated varieties of Arachis hypogaea
(Family: Leguminosae). Peanut oil is sometimes referred to as
arachis oil.
It is a colorless or a yellowish liquid with a slightly nutlike odor and a
bland taste. Peanut oil consists of a mixture of glycerides with
component acids of the following approximate composition: oleic
(50 to 65%); linoleic (18 to 30%); palmitic (8 to10%); stearic,
arachidic, behenic, and lignoceric acids (together, 10 to 12%).
1. Peanut oil is a solvent for intramuscular injections.
2. It is used for the manufacture of margarine, soap, paints,
liniments, plasters and ointments.
3. Groundnut oil is used as an edible oil, as a substitute for Olive
oil
Peanut oil
15. Chaulmoogra oil is the fixed oil obtained by cold expression from
ripe seeds of Taraktogenos kurzii King, (syn. Hydnocarpus kurzii
(king) Warb.), Hydnocarpus wightiana Blume and other speices of
Hydnocarpus.
The oil is yellow or brownish yellow. Below 25°C it is a soft solid. It
has peculiar odour and sharp taste. Chaulmoogra oil contains
glycerides of cyclopentenyl fatty acids like hydnocarpic acid (48%),
chaulmoogric acid (27%), gorlic acid with small amounts of
glycerides of hydrocarpic acid, palmitic acid (6%) and oleic acid
(12%
1. The oil has been widely used in Indian and Chinese traditional
medicine for the treatment of leprosy many skin diseases.
2. At present organic sulphones and antibiotics have replaced
Chaulmoogra oil in therapeutic use
Chaulmoogra oil
16. Waxes are the esters of higher straight-chain
fatty acids with long-chain or high molecular
weight monohydric alcohols, some containing
more than 30 carbons in the chain.
Plant origin: Carnauba wax , Bayberry wax
Animal origin: Beeswax, Wool-fat, Spermaceti,
etc.
In plants, waxes protect the loss of water
It also protects the penetration of water to the
inner part.
Waxes are employed in pharmaceuticals to
'harden" ointments and cosmetic creams.
17. Yellow beeswax or White beeswax is the purified wax from the
honeycomb of the bee, Apis mellifera or Apis mellifica Lime (Fam.
Apidae).
The beeswax is yellowish to brownish-yellow, or white, pieces or plates,
translucent when thin, soft to brittle, honey-like odour, slight balsamic
taste. Beeswax consists mainly of myricyl palmitate (myricin) (∼80%)
myricyl stearate, free cerotic acid (15%) , aromatic substance cerolein,
hydrocarbons, (∼12%), lactones, moisture, cholesteryl ester, pollen
pigments, and propolis (bee glue).
A beeswax and vegetable oil mixture is used as a vehicle for the
administration of respiratory forms of certain medicaments such. as
penicillin and curare.
It is used in the formulation of medicinal preparations for treating skin
cracks.
A combination containing of tallow, olive oil, camphor, beeswax and
common salt is used for ulcer and external tumour treatment.
Beeswax
Collodion is a flammable, syrupy solution of nitrocellulose in ether and alcohol. There are two basic types: flexible and non-flexible. The flexible type is often used as a surgical dressing or to hold dressings in place.
Moisturizer, or emollient, is a cosmetic preparation used for protecting, moisturizing, and lubricating the skin. An emollient is one of the ingredients in a moisturizer. Demulcent: An agent that forms a soothing, protective film when administered onto a mucous membrane surface. For example, mucilage and oilsLiniment is a liquid that you rub into the skin in order to reduce pain or relieve stiffness. Liniments can be rubbed into the skin to relieve aches from arthritis and stiffness in muscles.