The presentation focuses on the theoretical concept of the size reduction. It also includes the the principle, construction, working, uses, advantages & disadvantages of various instruments like hammer mill, ball mill, fluid energy mill, edge runner mill, end runner mill etc. used for size reduction.

1. Size Reduction
Mr. A. T. Sharma
Assist. Professor
Nanded Pharmacy College, Nanded

2. Size Reduction/ Comminution/ Diminution/
Pulverisation
Definition: Process of reducing large solid unit masses into small
unit masses, coarse particles or fine particles.
• Polydisperse powders and mono-size particles
Advantages:
• Content uniformity
• Uniform flow
• Effective extraction of drugs
• Effective drying
• Improved physical stability
• Improved dissolution rate
• Improved rate of absorption

3. Disadvantages:
• Drug degradation
• Poor mixing
• Contamination
Modes of Stress Applied in Size Reduction
• Cutting e.g. Cutter mill
• Compression e.g. Roller mill
• Impact e.g. Hammer mill, Fluid energy mill
• Attrition e.g. Fluid energy mill

4. Mechanism of Size Reduction
Impact: Particle - Flaws – Stress ( Impact/ Shear/
Compression) – Cracks – Cleavage – Small particles
Attrition: Particle – Particle surfaces chip – Small
particles

5. Equipments
Hammer Mill

7. Ball Mill

8. Fluid Energy Mill

9. Edge Runner Mill

10. End Runner Mill

11. BEVELED COG FITTING

12. Thank You…!!!
(Disclaimer: The images and diagrams in this
presentation have been downloaded from the google
source. I am grateful to all the publishers & the google.)