Ideal Solubility Parameters, Regular Solutions Theory, Unit Solubility Parameters, Application of Solubility Parameters, Methods of Determining Ideal Solubility Parameters

1. SOLUBILITY - 2
Presented By:
Mr. S.M. Ambore
Asst. Professor,
DK Patil Institute of Pharmacy, Loha. Nanded

2. LEARNING OUTCOMES….
Ideal Solubility Parameters
Regular Solutions Theory
Unit Solubility Parameters
Application of Solubility
Parameters
Methods of Determining Ideal
Solubility Parameters
2

3. 3
1. To estimate solubility some Ideal Solubility Parameters
are required.
2. These are explained with REGULAR SOLUTION
THEORY.
3. Regular Solution Theory mainly deals with non-polar
molecules like polymers.
4. It suggest a numerical estimation about extent of
solubility.
IDEAL SOLUBILITY PARAMETERS

4. REGULAR SOLUTION THEORY
4
Where,
d1 = solubility parameter
dU = Molar energy
V = Molar volume of solvent
dU / V = Cohesive energy of solvent
dH = Heat of vaporization of solvent
R = Gas constant
T = Temperature
V = Molar volume of solvent

5. 5
d1 – d2 = Gives numerical value for solubility

6. 6
Unit of Solubility
Parameters
Conventional SI

7. REFLECTION SPOT
Can you guess what will be the applications of solubility
parameters?
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8. 8
Selection of Solvent
Preparation of Polarity Scale
Co solvency Power
determination
Chemical Kinetic
determination
Determination of mechanism in
drug action
Structural activity
relationship (SAR)
Drug transport through model
membrane
APPLICATION OF SOLUBILITY PARAMETERS

9. 9
Regular Solution
Theory
Advantage:
To predict excess
free energy of
solution
Disadvantage:
Unable to predict
Heat of solution,
Volume after mixing

10. 10
METHODS OF DETERMINING IDEAL
SOLUBILITY PARAMETERS
Small’s Method
Hoy’s Method
Van Krevelen’s Method
Konstam & Feairheller
Method
Rheineck Method
Feder’s Method
Wolf’s Method

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