This document discusses protein receptors, including their identification and characterization. It begins by defining receptors as proteins that bind signaling molecules and initiate responses in cells. There are two main types of receptors - intracellular receptors found in the cytoplasm, and cell surface receptors embedded in the plasma membrane. Methods for identifying unknown protein receptors include biochemical approaches like isolating the receptor from a native source and identifying it through mass spectrometry. Molecular biology approaches involve screening cDNA libraries from tissues for genes that encode receptors that bind known ligands. Characterization of receptors involves studying their pharmacological responses to ligands, using radio ligand binding studies to analyze receptor dynamics and interactions, and examining biochemical pathways linked to receptor activation.