This paper presents optimized ESD protection solutions for high-speed SERDES interfaces (28Gbps to 112Gbps) in advanced technologies like SOI, BiCMOS, and FinFET. It emphasizes the need to reduce parasitic capacitance in ESD protection circuits to facilitate faster data transfer while addressing the limitations of traditional diode-based approaches. Case studies demonstrate the effectiveness of local clamp concepts that achieve low capacitance and maintain protection across various high-speed communication applications.