Smallpox is a contagious, disfiguring, and often deadly disease caused by the variola virus. There are two main forms of smallpox - variola major, which has a 30% fatality rate, and variola minor, which has a fatality rate below 1%. After incubation, smallpox progresses through several stages including prodrome, early rash, pustular rash, and scabs. It is most contagious during the early rash stage. Through global vaccination efforts beginning in the 1960s, the WHO declared smallpox eradicated worldwide in 1980. However, concerns remain about bioterrorism using the smallpox virus, which is classified as a