Folic acid is a water-soluble B vitamin that is essential for cell growth and division. It is involved in amino acid metabolism and the formation of DNA and RNA. A deficiency can lead to megaloblastic anemia due to impaired DNA synthesis. Folic acid is found naturally in green leafy vegetables and citrus fruits. Dietary deficiencies are common and can be caused by inadequate intake, malabsorption, or drug interactions. Supplementation is important during pregnancy to prevent neural tube defects in newborns.
VITAMIN B3
GUL MUNEER
Niacin
Niacinamide 0R Nicotinamide
Vitamin P OR PP (pellagra preventive)
Pellagra preventive factor
Anti black tongue factor
Nicotinic acid
Vitamin G (after Goldberger’s death, vitamin B3 was some times called in his honor)
Structure of Vitamin B3
Function of Vitamin B3
DISCOVERY of Vitamin B3
PROPERTIES of Vitamin B3
Nicotinic Acid (Plant form)
CHEMISTRY of Vitamin B3
Sources of Vitamin B3
RECOMMENDED DAILY ALLOWANCE (RDA) of Vitamin B3
BIOCHEMICAL FUNCTIONS of Vitamin B3
Digestion and Absorption of Dietary Niacin
Metabolism of B-3
Deficiency of B3
VITAMIN B3
GUL MUNEER
Niacin
Niacinamide 0R Nicotinamide
Vitamin P OR PP (pellagra preventive)
Pellagra preventive factor
Anti black tongue factor
Nicotinic acid
Vitamin G (after Goldberger’s death, vitamin B3 was some times called in his honor)
Structure of Vitamin B3
Function of Vitamin B3
DISCOVERY of Vitamin B3
PROPERTIES of Vitamin B3
Nicotinic Acid (Plant form)
CHEMISTRY of Vitamin B3
Sources of Vitamin B3
RECOMMENDED DAILY ALLOWANCE (RDA) of Vitamin B3
BIOCHEMICAL FUNCTIONS of Vitamin B3
Digestion and Absorption of Dietary Niacin
Metabolism of B-3
Deficiency of B3
Folic acid- Chemistry, One carbon metabolism and megaloblastic anemiaNamrata Chhabra
Folic acid- Structure, forms, absorption, transportation, storage, excretion, role in one-carbon metabolism, role in methionine synthesis, role in nucleotide biosynthesis, folate trap, folate antagonists, megaloblastic anemia
Water soluble vitamins include Vitamin C and the vitamin B complex: thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), Vitamin B6, biotin (B7), folic acid (B9), Vitamin B12. Vitamin A in its Beta-Carotene form is also water-soluble.
Vitamin B12- Chemistry, functions and clinical significanceNamrata Chhabra
Vitamin B12- Chemical structure, Forms of B12, Sources, absorption, storage, transportation, metabolic role, deficiency, megaloblastic anemia and neurological changes, laboratory diagnosis and treatment
a ppt about vitamins especially about vitamin b9 or folate or folic acid
this is definitely helpful for medical students
prepared based on their characteristics
B12 metabolism..................................... and role of various proteins in b12 metabolism..... necessity of supplementation..........................................
Chemistry of Vitamin E, Biochemical role of Vitamin E, Recommended dietary Allowances, Dietary sources of Vitamin E, Deficiency symptoms of vitamin E, Hypervitaminosis of vitamin E, Toxicity of Vitamin E,
Folic acid- Chemistry, One carbon metabolism and megaloblastic anemiaNamrata Chhabra
Folic acid- Structure, forms, absorption, transportation, storage, excretion, role in one-carbon metabolism, role in methionine synthesis, role in nucleotide biosynthesis, folate trap, folate antagonists, megaloblastic anemia
Water soluble vitamins include Vitamin C and the vitamin B complex: thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), Vitamin B6, biotin (B7), folic acid (B9), Vitamin B12. Vitamin A in its Beta-Carotene form is also water-soluble.
Vitamin B12- Chemistry, functions and clinical significanceNamrata Chhabra
Vitamin B12- Chemical structure, Forms of B12, Sources, absorption, storage, transportation, metabolic role, deficiency, megaloblastic anemia and neurological changes, laboratory diagnosis and treatment
a ppt about vitamins especially about vitamin b9 or folate or folic acid
this is definitely helpful for medical students
prepared based on their characteristics
B12 metabolism..................................... and role of various proteins in b12 metabolism..... necessity of supplementation..........................................
Chemistry of Vitamin E, Biochemical role of Vitamin E, Recommended dietary Allowances, Dietary sources of Vitamin E, Deficiency symptoms of vitamin E, Hypervitaminosis of vitamin E, Toxicity of Vitamin E,
Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored as glycogen, and in fat cells (adipocytes) it is stored as triglycerides.
Thiamine (vitamin B1) and biochemical aspects of beriberirohini sane
A comprehensive presentation on Thiamine and biochemical aspects of Beriberi for MBBS, BDS, B Pham and Biotechnology students to facilitate easy leaning.
This presentation deals with Thiamine Pyrophosphate (TPP), Pyridoxal Phosphate (PLP) and Coenzyme- A .
A brief description about Vitamins and Co enzymes. Then synthesis and application of PLP, TTP and Co-enzyme A
Plants produce a vast and diverse organic compounds, which do not appear to participate directly in growth and development.These substances traditionally referred to as secondary metabolites which terpenes are one of them.
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. FOLIC ACID (B9]
Gandham. Rajeev
Department of Biochemistry,
Akash Institute of Medical Sciences &
Research Centre,
Devanahalli, Bangalore,
Karnataka, India.
E-Mail: gandhamrajeev33@gmail.com
2.
3.
4. The word folic acid is derived from latin word
Folium means leaf & it is also isolated from the
leafy vegetable spinach
Folic acid mainly consists of three components
Pteridine ring
PABA (p-amino benzoic acid)
Glutamic acid residue (1 to 7 residues)
Hence it is known as Pteroyl-glutamic acid
7. N
H
H
HN
I
H
H2N
N
N
H
I
N
- CH2 – NH-
O
II
- C
H
I
- N - CH –COO-
I
CH2
I
CH2
I
COO-
8
7
6
5
Folic Acid
Dihydrofolate
reductase
2NADPH + 2H+
2NADP
5,6,7,8 – Tetrahydrofolic acid (THF)
8. Absorption:
Formation of monoglutamate form:
Most of the dietary folic acid exists as
polyglutamate with 3-7 glutamate residues
It is not absorbed in the intestine
The glutamate side chains are cleaved by the
enzyme folate conjugase or
polylpolyglutamate hydrolase
9. Only monoglutamyl form of folic acid is absorbed
from the intestine
The enzyme folate conjugase is present in
duodenum & jejunum
Mucosal uptake & metabolism in mucosal cell
Folate monoglutamate is taken up by the
mucosal cell
In the mucosal cell, folate monoglutamate is
reduced to tetrahydrofolate & methylated to form
N5 methyl tetrahydrofolate (in circulation)
10. N5 methyl tetrahydrofolate enters the
circulation
Storage:
Inside the cells, tetrahydrofolates are found as
polyglumates (with 5-6 amino acid residues)
Which are biologically most potent
Polyglutamate is the storage form of folic acid
It is mainly stored in the liver (10-20 mg)
11. Folic acid is not biologically active
The active coenzyme forms of folic acid are
Tetrahydrofolic acid (FH4)
N5 methyl tetrahydrofolic acid (N5FH4)
N5,N10 methylene tetrahydrofolic acid
N10 formyl tetrahydrofolate(N10 formyl FH4)
N5 formimino tetrahydrofolate (N5 formimino
FH4)
13. The coenzymes of folic acid are actively
involved in the one carbon metabolism
THF acts as an acceptor or donor of one
carbon units (formyl, methyl etc.) in reactions
involving amino acid & nucleotide metabolism
The one carbon units bind with THF at
position N5 or N10 or on both N5 &N10 of
pteroyl structure
14. Amino acid metabolism is important for
transfer or exchange of one carbon units
The following one carbon fragments are
involved in biological reactions
Methyl (-CH3)
Hydroxymethyl (-CH2OH)
Methylene (=CH2)
Methenyl (-CH=)
Formyl (-CH=O)
Formimino (-CH=NH)
15. THF is a versatile coenzyme actively
participates in one carbon metabolism
Transfer of methyl groups from S-
adenosylmethionine
B12 is also involved
The one carbon units covalently binds with
THF at position N5 or N10 or on both N5
&N10 of pteroyl structure of folate
16. Many compounds particularly amino acids act as
donors of one carbon units
The formate is released from glycine & tryptophan
metabolism combines with THF to form N10 –
formyl THF
Histidine contributes formimino fragment to
produce N5 – formimino THF
Serine is converted to glycine, N5,N10 methylene
THF is formed
This is most common entry of 1C units into one
carbon pool
17. Choline contributes to the formation of N5
methyl THF
Different derivatives of THF carrying one
carbon units are interconvertible, & this is
metabolically significant for the continuity of
one carbon pool
Utilization of one carbon units
Utilized for synthesis of wide variety of
compounds
18. These includes
Purines
Formylmithionine tRNA (initiation of protein
synthesis)
Glycine
Pyrimidine nucleotide etc
Role of methionine & vitamin B12
Methyl group is an important one carbon unit
Methionine is active donor of methyl groups in
transmethylation reactions
19. After the release of methyl group, methionine
is converted to homocysteine
For regeneration of methionine, homocysteine
& N5-methyl THF are required & this reaction
is dependent on Vitamin B12
The one carbon pool, under the control of THF,
is linked with methionine metabolism through
Vitamin B12
23. Dietary deficiency is the most common cause
of folic acid
Dietary deficiencies are caused by
Inadequate intake seen in alcoholics
Overcooking of food resulting in loss of folic
acid activity
Impaired absorption due to small intestinal
diseases,
Drugs interfere with folic acid absorption-
sulfamethaxazole
24. Increased demand of folic acid seen in
pregnancy
Hemolytic anemia
Hence folic acid preparations are prescribed in
pregnancy &hemolytic anemia
Other causes
Loss of folic acid seen in patients undergoing
dialysis
Impaired synthesis of active form seen in
patients receiving folic acid antagonists such as
methotrexate
25. Megaloblastic anemia characterized by
hyperchromic macrocytic anemia (due to
maturation bloked)
Magaloblastic changes are seen in bone
marrow & mucosa
Patients look pale
Glossitis
26. Peripheral smear shows macrocytic
hyperchromic anemia
Hypersegmentation of neutrophils is common
28. FIGLU excretion test:-
Folic acid deficiency is associated with
increased excretion of formiminoglutamate
(FIGLU) in urine
Due to impaired conversion of FIGLU to
glutamate in a reaction requiring FH4
Histidine
FIGLU
Formimino FH4
Histidine
Glutamate
FH4
FIGLU
Formimino FH4
Glutamate
FH4
Urine
Folic acid
deficiency
29. Folic acid supplementation during pregnancy
helps to prevent neural tube defects
Mainly involved in brain & spinal cord
Science, folic acid involved in nucleic acid &
amino acid metabolism
Deficiency results in impaired & aberrant
neural development
30.
31. Homocysteine is a risk factor for CHD
Folic acid is required for conversion of
homocysteine to methionine
Deficiency is associated with increased
plasma levels of Homocysteine
Folic acid suplementation decreases plasma
homocysteine levels
Homocysteine levels are also increased in
Vitamin B12 & Pyridoxine deficiency
32.
33. Aminopterin & Amethopterin (methotrexate)
Aminopterin & Amethopterin (methotrexate)
competitevely inhibit the enzyme dihydrofolate
reductase in humans
It impaires the formation of active form of
tetrahydrofolate from dihydrofolate
Significance:-
During the conversion of deoxyuridylate to
deoxythymidylate, dihydrofalate is formed,
utilizes N5,10 methylene FH4
34. Deoxythymidylate is required for DNA
synthesis
Folic acid antagonists will block DNA synthesis
& inhibit cell division
Clinical uses:-
Aminopterin & Amethopterin (methotrexate)
inhibit DNA synthesis in cancer cells
Used in treatment of cancer
Particularly leukemia & choriocarcinoma
35. It is a folic acid antagonist & it inhibits the
bacterial dihydrofolate reductase
Thus impairs the deoxythymidylate synthesis
leading to decreased synthesis of DNA
It is mainly used in bacterial infections
36.
37. Harper’s Biochemistry 25th Edition.
Fundamentals of Clinical Chemistry by Tietz.
Text Book of Medical Biochemistry-A R Aroor.
Text Book of Biochemistry-DM Vasudevan
Text Book of Biochemistry-MN Chatterjea
Text Book of Biochemistry-Dr.U.Satyanarana