Biotin is a water-soluble B vitamin that acts as a coenzyme for carboxylase enzymes involved in steps like converting pyruvate to oxaloacetate. It is required for fatty acid synthesis and leucine catabolism by acetyl-CoA carboxylase and methylcrotonyl-CoA carboxylase respectively. Biotin deficiency is rare in humans due to its presence in many foods and intestinal bacterial synthesis, but can cause dermatitis or hair loss. Avidin in raw egg whites tightly binds biotin and prevents its absorption.
Biotin (vitamin b7) biological functions, clinical indications and its techn...rohini sane
An illustrative presentation on Biotin (Vitamin B7), clinical indications and technological applications for Medical, Dental, Pharmacology & Biotechnology students to facilitate easy- learning.
Biotin (vitamin b7) biological functions, clinical indications and its techn...rohini sane
An illustrative presentation on Biotin (Vitamin B7), clinical indications and technological applications for Medical, Dental, Pharmacology & Biotechnology students to facilitate easy- learning.
this presentation is about Vitamin B6 which include structure , biochemical function , biochemical reaction, effect of deficiency of vitamin B6, Toxicity and function of Vitamin B6.
Water soluble vitamin pyridoxine (vitamin B6) introduction, Chemistry of vitamin B6, Biochemical role of vitamin B6, active form of vitamin B 6 (pyridoxal phosphate) synthesis and their role, Recommended dietary allowance of vitamin B6, Dietary sources of vitamin B 6, Deficiency symptoms of Vitamin B6.
Vitamin B12- definition, functions, absorption, storage, transportation, deficiency, pernicious anemia, relationship between vitamin B12 and folate deficiency, sign & symptoms, deficiency in case of maternal & child health care, RDA, sources, prevention and treatment.
Introduction about Vitamin B2, Chemistry of Riboflavin, Biochemical Functions of Riboflavin, Recommended Dietary Allowance of Vitamin B2, Dietary Sources of Riboflavin, Deficiency Symptoms of Vitamin B2, Synthesis of FMN, FAD from Riboflavin pathway, Coenzymes of Riboflavin.
this presentation is about Vitamin B6 which include structure , biochemical function , biochemical reaction, effect of deficiency of vitamin B6, Toxicity and function of Vitamin B6.
Water soluble vitamin pyridoxine (vitamin B6) introduction, Chemistry of vitamin B6, Biochemical role of vitamin B6, active form of vitamin B 6 (pyridoxal phosphate) synthesis and their role, Recommended dietary allowance of vitamin B6, Dietary sources of vitamin B 6, Deficiency symptoms of Vitamin B6.
Vitamin B12- definition, functions, absorption, storage, transportation, deficiency, pernicious anemia, relationship between vitamin B12 and folate deficiency, sign & symptoms, deficiency in case of maternal & child health care, RDA, sources, prevention and treatment.
Introduction about Vitamin B2, Chemistry of Riboflavin, Biochemical Functions of Riboflavin, Recommended Dietary Allowance of Vitamin B2, Dietary Sources of Riboflavin, Deficiency Symptoms of Vitamin B2, Synthesis of FMN, FAD from Riboflavin pathway, Coenzymes of Riboflavin.
this is presentation on vitamin a production by the microorganism various microorganism produced vitamin a commercially by which we can obtain it easily and produced industrial application. what are the vitamin a classification and production
University Institute of Pharmaceutical Sciences is a flag bearer of excellence in Pharmaceutical education and research in the country. Here is another initiative to make study material available to everyone worldwide. Based on the new PCI guidelines and syllabus here we have a presentation dealing with the vitamins and there deficiencies.
Thank you for reading.
Hope it was of help to you.
UIPS,PU team
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
1. BIOTIN (B7]
Gandham. Rajeev
Department of Biochemistry,
Akash Institute of Medical Sciences
& Research Centre,
Devanahalli, Bangalore,
Karnataka, India.
E-Mail: gandhamrajeev33@gmail.com
2.
3. Biotin is formerly known as anti-egg white injury
factor or vitamin H
It is water soluble sulfur containing B-complex
vitamin
Biotin mainly participates in the carboxylation
reactions
4. Biotin (B7) is a heterocyclic sulfur containing
monocarboxylic acid
Biotin is imidazole derivative
It is formed by fusion of imidazole & thiophene
rings with a valeric acid side chain
Biotin covalently bound to ε – amino group of
lysine to form biocytin
5. Biocytin is the coenzyme form of Biotin
Biotin is a prosthetic group of carboxylase
6. Biotin is required for carboxylation reactions (CO2
fixation reaction)
Biotin is required for the enzymes
Pyruvate carboxylase
Acetyl CoA carboxylase
Propionyl carboxylase
β - Methyl crotonyl CoA carboxylase
7. Pyruvate carboxylase
Pyruvate carboxylase catalyzes the conversion of
pyruvate to oxaloacetate
Pyruvate
Oxaloacetate
CO2, ATP Pyruvate
carboxylase
BiotinADP+Pi
Mg++/Mn
8. Acetyl CoA carboxylase
Acetyl CoA carboxylase catalyzes the formation of
malonyl CoA from acetyl CoA
The reaction provides acetate molecule for fatty
acid synthesis
AcetylCoA
Malonyl CoA
CO2, ATP Acetyl CoA
carboxylase
BiotinADP+Pi
Mg++/Mn
9. Propionyl CoA Carboxylase
Propionyl CoA carboxylase catalyzes the formation
of D – Methyl malonyl CoA from propionyl CoA
It required for entry of Propionyl CoA to TCA cycle
via succinyl CoA
Propionyl CoA
D – Methyl malonyl CoA
CO2, ATP Propionyl CoA
carboxylase
BiotinADP+PiMg++/Mn
10. β - Methyl crotonyl CoA carboxylase
β - Methyl crotonyl CoA carboxylase catalyzes the
formation of β – Methylglutaconyl CoA from β -
Methyl crotonyl CoA
It essential for leucine catabolism
β - Methyl crotonyl CoA
β – Methylglutaconyl CoA
CO2, ATP β - Methyl crotonylCoA
carboxylase
BiotinADP+PiMg++/Mn
11. All the carboxylation reactions in the biological
system are not dependent on Biotin
Few carboxylation reactions which do not require
biotin
Formation of carbamoyl phosphate in urea cycle
Incorporation of CO2 in purine synthesis
13. Biotin deficiency is generally not seen in man
because of
Its wide distribution in foods
Synthesis of vitamin by the bacterial flora in the
gut
Clinical features
Severe dermatitis, weakness, & nausea
In animals muscle weakness, dermatitis & loss of
hair around the eye
14. Avidin (Raw egg white injury factor )
Raw egg white injury factor is a heat labile protein
known as avidin & is present in raw egg white
Avidin binds to biotin & makes its unavailable for
absorption
Avidin is inactivated by boiling the eggs & biotin is
readily absorbed when boiled eggs are used in the
diet
15. One molecule of avidin can combine with four
molecules of biotin
Egg white contains Avidin & egg yolk contains
biotin
The affinity of Avidin to biotin is greater than most
of the usual antigen-antibody reactions
Avidin-biotin system is commonly utilized for
detection of pathogenesis in ELISA test
DNA is generally labelled by radioactive
nucleotides
16. Recently, biotin labelling of DNA is becoming more
popular
Biotin is added to nucleotides, which will be
incorporated into the newly synthesized DNA
The fixed biotin can be identified by reaction with
Avidin
Intake of 20 raw eggs/day will produce Biotin
deficiency in humans
Prolonged use of antibacterial drugs such as
sulfonamides
17. References
Harper’s Biochemistry 25th Edition.
Fundamentals of Clinical Chemistry by Tietz.
Text Book of Medical Biochemistry-A R Aroor.
Text Book of Biochemistry-DM Vasudevan
Text Book of Biochemistry-MN Chatterjea
Text Book of Biochemistry-Dr.U.Satyanarana