FISH is a technique that uses fluorescent probes that bind to only those regions of DNA or RNA that have nucleotide sequences complementary to the probe's sequence. It allows researchers to visualize chromosomes and specific genetic loci. There are several types of FISH probes including whole chromosome painting probes, repetitive sequence probes, and locus-specific probes. FISH has many diagnostic applications such as detecting chromosomal abnormalities, genetic translocations, and deletions associated with conditions like Prader-Willi syndrome.