The document discusses various techniques for molecular genetic diagnostic testing to identify genetic defects, including karyotyping, PCR and DNA sequencing, single base primer extension, restriction fragment length polymorphism analysis, real-time PCR, and fluorescence in situ hybridization. Key considerations for diagnostic techniques include sensitivity, reproducibility, specificity, accuracy, and the ability to detect anomalies such as aneuploidy, deletions, duplications, and translocations. Prenatal and postnatal testing methods and common indications are also outlined.