Ethical issues in assisted reproductionSoibi Harry
The document discusses several ethical issues related to assisted reproduction including autonomy, non-maleficence, beneficence, justice, and the status of embryos. It outlines debates around the use of donor eggs/sperm, embryo cryopreservation, surrogacy, preimplantation genetic testing, and access issues due to cost. Regulations vary internationally and in Nigeria assisted reproduction is not yet regulated by law, though medical guidelines have been proposed. Overall the document maps the complex ethical landscape of assisted reproductive technologies.
MEDICO LEGAL ISSUES In Infertility & IVF DR. SHARDA JAIN Dr. Jyoti Agarwal ...Lifecare Centre
MEDICO LEGAL ISSUES In Infertility & IVF DR. SHARDA JAIN Dr. Jyoti Agarwal Dr. Jyoti Bhaskar
HISTORY of IVF
THE WORLD FIRST IVF BABY..LOUISE BROWN 25/7/1978
WORLD 2nd but INDIA,s first undocumented IVF BABY..KANUPRIYA [DURGA]…was born
67 days later on 3/10/1978 through effort of
DR SUBHAS MUKHERJEE****Mainly went unnoticed
BABY HARSHA 6/8/1986 …
BOMBAY KEM HOSPITAL + ICMR Effort.
Assisted Reproductive Technologies (ART)
First Successful IVF: Birth of Louise Brown in 1978
Rapid developments in the field of ART
Moral panic
Ethics
Ethical issues
Ethical concerns
Moral issues
Social issues
Religion
Case study
The HFEA is the independent regulator for IVF treatment and human embryo research and came into effect on 1 August 1991. The 1990 Act ensured the regulation, through licensing, of:
the creation of human embryos outside the body and their use in treatment and research
the use of donated gametes and embryos
the storage of gametes and embryos.
Media is used in IVF to keep cells wet, feed them, and control the environment. There are different types of media for gametes, fertilization, cleavage, and blastocyst stages. While studies have compared various media formulations, no clear treatment effect has been found on clinical outcomes like live birth or ongoing pregnancy rates. Optimal media aims to mimic the natural embryo environment with constant temperature, pH, and avoidance of contaminants.
PPT-Embryo grading and ART Summary.pptxKajal530634
Embryo grading is important in IVF to select good quality embryos for transfer based on developmental rate and morphology. The most followed grading systems are Gardner and Istanbul consensus, which assess embryos daily from fertilization to blastocyst stage based on criteria like cell number, size, and fragmentation. Good quality embryos with early cleavage and cell number on day 2 often develop into good blastocysts. Donor oocyte and sperm criteria and screening are also outlined to follow regulations. Oocyte donors can donate up to 7 oocytes only once in their lifetime from age 23-35.
Surrogacy Regulation Act 2021 has been notified in the Gazette on 25th December 2021 and there are important implications for all who practice surrogacy in India both for patients and clinics and ART Banks.
The document discusses recommendations for setting up an IUI lab. It recommends that the lab have both a non-sterile and sterile area with adequate space to avoid compromising quality. Key considerations include basic infrastructure like air quality, lighting, temperature control and water supply. The document also recommends proper staffing with an embryologist, andrologist, nurses and counselor. Equipment, disposables, and high quality culture media are also essential to set up the IUI lab. Quality control, assurance and improvement should be prioritized. The lab design should have considerable input from embryologists and specialists to ensure success.
Ethical issues in assisted reproductionSoibi Harry
The document discusses several ethical issues related to assisted reproduction including autonomy, non-maleficence, beneficence, justice, and the status of embryos. It outlines debates around the use of donor eggs/sperm, embryo cryopreservation, surrogacy, preimplantation genetic testing, and access issues due to cost. Regulations vary internationally and in Nigeria assisted reproduction is not yet regulated by law, though medical guidelines have been proposed. Overall the document maps the complex ethical landscape of assisted reproductive technologies.
MEDICO LEGAL ISSUES In Infertility & IVF DR. SHARDA JAIN Dr. Jyoti Agarwal ...Lifecare Centre
MEDICO LEGAL ISSUES In Infertility & IVF DR. SHARDA JAIN Dr. Jyoti Agarwal Dr. Jyoti Bhaskar
HISTORY of IVF
THE WORLD FIRST IVF BABY..LOUISE BROWN 25/7/1978
WORLD 2nd but INDIA,s first undocumented IVF BABY..KANUPRIYA [DURGA]…was born
67 days later on 3/10/1978 through effort of
DR SUBHAS MUKHERJEE****Mainly went unnoticed
BABY HARSHA 6/8/1986 …
BOMBAY KEM HOSPITAL + ICMR Effort.
Assisted Reproductive Technologies (ART)
First Successful IVF: Birth of Louise Brown in 1978
Rapid developments in the field of ART
Moral panic
Ethics
Ethical issues
Ethical concerns
Moral issues
Social issues
Religion
Case study
The HFEA is the independent regulator for IVF treatment and human embryo research and came into effect on 1 August 1991. The 1990 Act ensured the regulation, through licensing, of:
the creation of human embryos outside the body and their use in treatment and research
the use of donated gametes and embryos
the storage of gametes and embryos.
Media is used in IVF to keep cells wet, feed them, and control the environment. There are different types of media for gametes, fertilization, cleavage, and blastocyst stages. While studies have compared various media formulations, no clear treatment effect has been found on clinical outcomes like live birth or ongoing pregnancy rates. Optimal media aims to mimic the natural embryo environment with constant temperature, pH, and avoidance of contaminants.
PPT-Embryo grading and ART Summary.pptxKajal530634
Embryo grading is important in IVF to select good quality embryos for transfer based on developmental rate and morphology. The most followed grading systems are Gardner and Istanbul consensus, which assess embryos daily from fertilization to blastocyst stage based on criteria like cell number, size, and fragmentation. Good quality embryos with early cleavage and cell number on day 2 often develop into good blastocysts. Donor oocyte and sperm criteria and screening are also outlined to follow regulations. Oocyte donors can donate up to 7 oocytes only once in their lifetime from age 23-35.
Surrogacy Regulation Act 2021 has been notified in the Gazette on 25th December 2021 and there are important implications for all who practice surrogacy in India both for patients and clinics and ART Banks.
The document discusses recommendations for setting up an IUI lab. It recommends that the lab have both a non-sterile and sterile area with adequate space to avoid compromising quality. Key considerations include basic infrastructure like air quality, lighting, temperature control and water supply. The document also recommends proper staffing with an embryologist, andrologist, nurses and counselor. Equipment, disposables, and high quality culture media are also essential to set up the IUI lab. Quality control, assurance and improvement should be prioritized. The lab design should have considerable input from embryologists and specialists to ensure success.
PRESENTED AT MASTER CLASS MUMBAI...........THNX TO MANY WHO HAVE CONTRIBUTED TO THIS PRESENTATION.....FEEL FREE TO USE THIS , BUT PLEASE ACKNOWLEDGE THE EFFORTS OF ALL ...........jaideep-narendra
This document discusses the principles of management of vesico-vaginal fistula (VVF). It begins with definitions and classifications of different types of fistulas. The main causes of VVF are discussed as obstructed labor and other obstetric complications. Clinical features include continuous urinary leakage. Surgical repair is the main treatment and involves excising scar tissue and closing the fistula in layers without tension. Factors like adequate drainage, preventing infection, and good surgical technique impact repair success.
Implementation of air quality control in the IVF laboratory and other critica...Sandro Esteves
This document summarizes Sandro C. Esteves' presentation on the implementation of air quality control in IVF laboratories and critical areas. It discusses the importance of air quality based on evidence from animal, human, and observational studies showing improved IVF outcomes with reduced particle and VOC levels. Regulatory agencies like the FDA, EU, and Brazil require particle and microbial filtration and some recommend VOC filtration. The presentation describes how ANDROFERT implemented air quality control through their facility design and ventilation system to meet ISO 5 cleanroom standards, including HEPA and activated carbon filtration. Monitoring equipment is used to ensure standards are maintained.
Legal , Ethical & Medical Issue of Commercial SURROGACY PROGRAMME in India, ...Lifecare Centre
Commercial surrogacy in India is legal and has grown into a large industry, but regulations are still lacking. The document discusses both positive and negative aspects of India's commercial surrogacy programs. It notes the financial benefits for surrogate mothers but also ways women may be exploited. It calls for standardized contracts, health protections, insurance requirements and citizenship guidelines for children to balance medical tourism growth with women's rights and welfare. Overall the need for improved laws and oversight is emphasized to manage the rapidly expanding industry.
This document discusses various assisted reproductive technologies (ART) such as in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and zygote intrafallopian transfer (ZIFT). It provides a brief history of ART and describes techniques like ovarian stimulation protocols, oocyte retrieval, fertilization, embryo culture, and preimplantation genetic diagnosis. Potential indications for ART include tubal factor infertility, endometriosis, and male factor infertility. Success rates are influenced by factors like maternal age and ovarian reserve.
THE ASSISTED REPRODUCTION TECHNOLOGY REGULATION RULES, 2010
Members of drafting committee11 members
1- Sr Advocate Supreme Court of India
2 – Public Interest Legal Support and Research
3 – Dept of Family Welfare, M of Fam Wel and Research
5 – experts from the field of Reproductive Medicine
This document discusses multiple pregnancies, specifically twins. It defines twins as the simultaneous development of more than one fetus in the uterus. The types of twins are discussed, including dizygotic/fraternal twins which develop from two separate eggs and monozygotic/identical twins which develop from one egg. The risks and complications associated with multiple pregnancies are summarized for both the mother and fetuses. The document concludes with describing the recommended management and care during antenatal, delivery, and postnatal periods for multiple pregnancies.
Dr Sujoy Dasgupta moderated a panel in “Milan”, the conference of all of the Obstetric and Gynaecological Societies of West Bengal, held in Kolkata in February, 2022
This document discusses various assisted reproductive techniques (ART) used to treat infertility. It begins by defining ART and infertility. It then describes techniques like artificial insemination (IUI, ICI), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), and surrogacy. For each technique, it provides details on the procedure, indications for use, and success rates. It concludes by discussing some risks associated with IVF and ICSI, like prematurity, low birth weight, and possible genetic or epigenetic abnormalities in offspring.
EMERGENCY OBSTETRIC CARE - AN INTERVENTION OF MATERNAL MORTALITYImAn NoOr
This document discusses emergency obstetric care (EmOC) as an intervention for reducing maternal mortality. It notes that over 275,000 women die during childbirth each year globally. In Bangladesh, the maternal mortality ratio is 320 deaths per 100,000 births, with most deliveries occurring at home without skilled care. The document then outlines the direct and indirect causes of maternal mortality, as well as underlying social, economic, and medical factors. It describes the "three delays model" and introduces EmOC, which provides lifesaving obstetric functions. Key EmOC process indicators are presented, such as the number of EmOC facilities per population and the met need for EmOC services. The document recommends increasing EmOC availability,
ETHICAL ISSUES IN REPRODUCTIVE TECHNOLOGY AND ORGAN TRANSPLANTATIONaswathy krishna
This document discusses various ethical issues related to assisted reproductive technologies (ARTs) and organ transplantation. It provides an overview of ARTs including in vitro fertilization (IVF), surrogacy, and cloning. For IVF, it describes the basic process and notes both advantages like helping infertility as well as risks like multiple pregnancies. It discusses the first IVF babies and the growth of the IVF industry. For surrogacy, it defines traditional and gestational types and notes debates around commercial surrogacy and parental rights. For cloning, it explains the different types and highlights both potential medical benefits and risks/concerns about human cloning. The document also covers organ transplantation, including what can be donated, types of
In vitro fertilization and embryo transfer "IVF"; Overview on the Story FRO...Ahmed Mowafy
The document discusses the history and development of in vitro fertilization (IVF). It mentions:
- Aldous Huxley predicted IVF techniques in his 1931 novel "Brave New World".
- The first reported pregnancies from IVF occurred in the late 1950s and early 1960s involving animals.
- The first reported human pregnancy from IVF was in 1973, though it resulted in miscarriage.
- The first successful human birth from IVF, Louise Brown, occurred in 1978 in the UK from the work of Steptoe and Edwards.
This document summarizes surrogacy, including its history, types, and the Surrogacy Regulation Bill of 2020 in India. It defines surrogacy as when one woman bears a child for a couple with the intention of handing the child over after birth. The history of surrogacy began in the 1970s in the US and 1980s in India. There are two types - traditional surrogacy uses the surrogate's egg, while gestational uses IVF. The 2020 Bill legalizes only altruistic surrogacy and sets rules for intended parents, surrogate mothers, and clinics. It aims to prevent commercialization and ensure rights of the surrogate child.
The document discusses future developments in IVF labs in three main areas: 1) Embryo culture techniques aim to better mimic the reproductive tract using microfluidics and dynamic culture systems. 2) Automation seeks to robotically assist processes like ICSI. 3) Non-invasive embryo selection techniques study the chemical fingerprints embryos leave in culture media using spectroscopy and proteomics to predict viability without biopsy. The goal is improving IVF success rates through more physiological culture conditions, precision of techniques, and selecting the highest quality embryos.
This document summarizes key aspects of human oogenesis and oocyte quality assessment. It describes the process of oogenesis, including formation of follicles in the ovaries and maturation of oocytes. It also discusses morphological features used to assess oocyte quality, such as the cumulus-oocyte complex, nuclear maturity, size and shape, the zona pellucida, polar body morphology, and perivitelline space. While some studies found correlations between certain morphological features and development outcomes, others found no significant correlations. Overall assessment of oocyte quality relies on evaluating multiple morphological characteristics.
Ms. Doel Bose Pande discusses various semen preparation methods and principles. Common techniques include simple wash, swim-up, and density gradient centrifugation. The choice of method depends on factors like semen quality, intended use, and practical considerations. Density gradient is best for separating motile sperm from debris but is more time-consuming than direct swim-up. The goal is to recover high-quality sperm with minimal processing time and damage. Practical issues like sample volume and number of patients may also influence the choice of preparation technique.
This document discusses Assisted Reproductive Technologies (ART) such as in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT). It outlines the steps of an IVF cycle including down regulation, ovarian stimulation, oocyte retrieval, fertilization, embryo transfer, and luteal phase support. Key indications for IVF include tubal disease, endometriosis, male factor infertility, and others. Ideal patient selection criteria include age under 35, normal ovarian reserve, and screened partners. GIFT is a more invasive procedure that involves transferring eggs and sperm directly into the fallopian tubes for fertilization to occur in vivo.
This document provides an overview of Assisted Reproductive Technology (ART) including a brief history and description of some key ART techniques. It notes that ART was pioneered in the late 1970s with the first "test tube baby" born in 1978 using in vitro fertilization (IVF). Some main ART techniques discussed include IVF, zygote intrafallopian transfer (ZIFT), intra uterine transfer (IUT), gamete intrafallopian transfer (GIFT), and intracytoplasmic sperm injection (ICSI). Artificial insemination is also mentioned as a technique used for both human infertility treatment and livestock improvement.
Ethical issues associated with fertility treatmentChris Willmott
Dr. Chris Willmott gave a presentation on the ethical issues associated with fertility treatment. He discussed various fertility procedures like IVF, egg/embryo donation, and surrogacy. He also outlined some of the debates around who should have access to treatment, how many embryos should be transferred, the fate of leftover embryos, genetic screening of embryos, and resource allocation issues. The talk examined arguments both for and against different procedures from various ethical perspectives.
How to choose between drugs: efficacy / safety and cost effectiveness. In IVF, we have GnRHagonist and antagonists: how to choose based on best available evidence. This talk may help to answer this question
PRESENTED AT MASTER CLASS MUMBAI...........THNX TO MANY WHO HAVE CONTRIBUTED TO THIS PRESENTATION.....FEEL FREE TO USE THIS , BUT PLEASE ACKNOWLEDGE THE EFFORTS OF ALL ...........jaideep-narendra
This document discusses the principles of management of vesico-vaginal fistula (VVF). It begins with definitions and classifications of different types of fistulas. The main causes of VVF are discussed as obstructed labor and other obstetric complications. Clinical features include continuous urinary leakage. Surgical repair is the main treatment and involves excising scar tissue and closing the fistula in layers without tension. Factors like adequate drainage, preventing infection, and good surgical technique impact repair success.
Implementation of air quality control in the IVF laboratory and other critica...Sandro Esteves
This document summarizes Sandro C. Esteves' presentation on the implementation of air quality control in IVF laboratories and critical areas. It discusses the importance of air quality based on evidence from animal, human, and observational studies showing improved IVF outcomes with reduced particle and VOC levels. Regulatory agencies like the FDA, EU, and Brazil require particle and microbial filtration and some recommend VOC filtration. The presentation describes how ANDROFERT implemented air quality control through their facility design and ventilation system to meet ISO 5 cleanroom standards, including HEPA and activated carbon filtration. Monitoring equipment is used to ensure standards are maintained.
Legal , Ethical & Medical Issue of Commercial SURROGACY PROGRAMME in India, ...Lifecare Centre
Commercial surrogacy in India is legal and has grown into a large industry, but regulations are still lacking. The document discusses both positive and negative aspects of India's commercial surrogacy programs. It notes the financial benefits for surrogate mothers but also ways women may be exploited. It calls for standardized contracts, health protections, insurance requirements and citizenship guidelines for children to balance medical tourism growth with women's rights and welfare. Overall the need for improved laws and oversight is emphasized to manage the rapidly expanding industry.
This document discusses various assisted reproductive technologies (ART) such as in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and zygote intrafallopian transfer (ZIFT). It provides a brief history of ART and describes techniques like ovarian stimulation protocols, oocyte retrieval, fertilization, embryo culture, and preimplantation genetic diagnosis. Potential indications for ART include tubal factor infertility, endometriosis, and male factor infertility. Success rates are influenced by factors like maternal age and ovarian reserve.
THE ASSISTED REPRODUCTION TECHNOLOGY REGULATION RULES, 2010
Members of drafting committee11 members
1- Sr Advocate Supreme Court of India
2 – Public Interest Legal Support and Research
3 – Dept of Family Welfare, M of Fam Wel and Research
5 – experts from the field of Reproductive Medicine
This document discusses multiple pregnancies, specifically twins. It defines twins as the simultaneous development of more than one fetus in the uterus. The types of twins are discussed, including dizygotic/fraternal twins which develop from two separate eggs and monozygotic/identical twins which develop from one egg. The risks and complications associated with multiple pregnancies are summarized for both the mother and fetuses. The document concludes with describing the recommended management and care during antenatal, delivery, and postnatal periods for multiple pregnancies.
Dr Sujoy Dasgupta moderated a panel in “Milan”, the conference of all of the Obstetric and Gynaecological Societies of West Bengal, held in Kolkata in February, 2022
This document discusses various assisted reproductive techniques (ART) used to treat infertility. It begins by defining ART and infertility. It then describes techniques like artificial insemination (IUI, ICI), in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), and surrogacy. For each technique, it provides details on the procedure, indications for use, and success rates. It concludes by discussing some risks associated with IVF and ICSI, like prematurity, low birth weight, and possible genetic or epigenetic abnormalities in offspring.
EMERGENCY OBSTETRIC CARE - AN INTERVENTION OF MATERNAL MORTALITYImAn NoOr
This document discusses emergency obstetric care (EmOC) as an intervention for reducing maternal mortality. It notes that over 275,000 women die during childbirth each year globally. In Bangladesh, the maternal mortality ratio is 320 deaths per 100,000 births, with most deliveries occurring at home without skilled care. The document then outlines the direct and indirect causes of maternal mortality, as well as underlying social, economic, and medical factors. It describes the "three delays model" and introduces EmOC, which provides lifesaving obstetric functions. Key EmOC process indicators are presented, such as the number of EmOC facilities per population and the met need for EmOC services. The document recommends increasing EmOC availability,
ETHICAL ISSUES IN REPRODUCTIVE TECHNOLOGY AND ORGAN TRANSPLANTATIONaswathy krishna
This document discusses various ethical issues related to assisted reproductive technologies (ARTs) and organ transplantation. It provides an overview of ARTs including in vitro fertilization (IVF), surrogacy, and cloning. For IVF, it describes the basic process and notes both advantages like helping infertility as well as risks like multiple pregnancies. It discusses the first IVF babies and the growth of the IVF industry. For surrogacy, it defines traditional and gestational types and notes debates around commercial surrogacy and parental rights. For cloning, it explains the different types and highlights both potential medical benefits and risks/concerns about human cloning. The document also covers organ transplantation, including what can be donated, types of
In vitro fertilization and embryo transfer "IVF"; Overview on the Story FRO...Ahmed Mowafy
The document discusses the history and development of in vitro fertilization (IVF). It mentions:
- Aldous Huxley predicted IVF techniques in his 1931 novel "Brave New World".
- The first reported pregnancies from IVF occurred in the late 1950s and early 1960s involving animals.
- The first reported human pregnancy from IVF was in 1973, though it resulted in miscarriage.
- The first successful human birth from IVF, Louise Brown, occurred in 1978 in the UK from the work of Steptoe and Edwards.
This document summarizes surrogacy, including its history, types, and the Surrogacy Regulation Bill of 2020 in India. It defines surrogacy as when one woman bears a child for a couple with the intention of handing the child over after birth. The history of surrogacy began in the 1970s in the US and 1980s in India. There are two types - traditional surrogacy uses the surrogate's egg, while gestational uses IVF. The 2020 Bill legalizes only altruistic surrogacy and sets rules for intended parents, surrogate mothers, and clinics. It aims to prevent commercialization and ensure rights of the surrogate child.
The document discusses future developments in IVF labs in three main areas: 1) Embryo culture techniques aim to better mimic the reproductive tract using microfluidics and dynamic culture systems. 2) Automation seeks to robotically assist processes like ICSI. 3) Non-invasive embryo selection techniques study the chemical fingerprints embryos leave in culture media using spectroscopy and proteomics to predict viability without biopsy. The goal is improving IVF success rates through more physiological culture conditions, precision of techniques, and selecting the highest quality embryos.
This document summarizes key aspects of human oogenesis and oocyte quality assessment. It describes the process of oogenesis, including formation of follicles in the ovaries and maturation of oocytes. It also discusses morphological features used to assess oocyte quality, such as the cumulus-oocyte complex, nuclear maturity, size and shape, the zona pellucida, polar body morphology, and perivitelline space. While some studies found correlations between certain morphological features and development outcomes, others found no significant correlations. Overall assessment of oocyte quality relies on evaluating multiple morphological characteristics.
Ms. Doel Bose Pande discusses various semen preparation methods and principles. Common techniques include simple wash, swim-up, and density gradient centrifugation. The choice of method depends on factors like semen quality, intended use, and practical considerations. Density gradient is best for separating motile sperm from debris but is more time-consuming than direct swim-up. The goal is to recover high-quality sperm with minimal processing time and damage. Practical issues like sample volume and number of patients may also influence the choice of preparation technique.
This document discusses Assisted Reproductive Technologies (ART) such as in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT). It outlines the steps of an IVF cycle including down regulation, ovarian stimulation, oocyte retrieval, fertilization, embryo transfer, and luteal phase support. Key indications for IVF include tubal disease, endometriosis, male factor infertility, and others. Ideal patient selection criteria include age under 35, normal ovarian reserve, and screened partners. GIFT is a more invasive procedure that involves transferring eggs and sperm directly into the fallopian tubes for fertilization to occur in vivo.
This document provides an overview of Assisted Reproductive Technology (ART) including a brief history and description of some key ART techniques. It notes that ART was pioneered in the late 1970s with the first "test tube baby" born in 1978 using in vitro fertilization (IVF). Some main ART techniques discussed include IVF, zygote intrafallopian transfer (ZIFT), intra uterine transfer (IUT), gamete intrafallopian transfer (GIFT), and intracytoplasmic sperm injection (ICSI). Artificial insemination is also mentioned as a technique used for both human infertility treatment and livestock improvement.
Ethical issues associated with fertility treatmentChris Willmott
Dr. Chris Willmott gave a presentation on the ethical issues associated with fertility treatment. He discussed various fertility procedures like IVF, egg/embryo donation, and surrogacy. He also outlined some of the debates around who should have access to treatment, how many embryos should be transferred, the fate of leftover embryos, genetic screening of embryos, and resource allocation issues. The talk examined arguments both for and against different procedures from various ethical perspectives.
How to choose between drugs: efficacy / safety and cost effectiveness. In IVF, we have GnRHagonist and antagonists: how to choose based on best available evidence. This talk may help to answer this question
This study aimed to compare the endometrial secretory cytokine profiles between women with recurrent implantation failure (RIF) and fertile controls. Endometrial fluid was collected from 16 RIF patients and 20 controls using an embryo transfer catheter. Levels of 23 cytokines were measured using luminex technology. Only beta-nerve growth factor (bNGF) showed a significant difference between RIF and controls by univariate analysis. Multivariate analysis using partial least squares modeling showed clear separation of the two groups, with 8 cytokines including leukemia inhibitory factor (LIF) being lower in RIF patients. This suggests alterations in endometrial secretions may influence implantation success.
Chromosomal abnormalities, inadequate culture conditions, and suboptimal embryo development are major factors contributing to recurrent implantation failure (RIF) after in vitro fertilization (IVF). While preimplantation genetic screening (PGS) aimed to improve outcomes by selecting chromosomally normal embryos, evidence suggests it does not increase live birth or implantation rates in RIF patients. New techniques like time-lapse imaging, metabolomics, and comprehensive chromosome screening may provide better embryo assessment but require further evaluation. Optimal culture conditions, blastocyst transfer, and assisted hatching in selected cases may help overcome challenges, but the safety and efficacy of emerging treatments should be established through randomized trials before routine use.
N-acetyl cysteine (NAC) may be an effective adjuvant to clomiphene citrate (CC) therapy for inducing ovulation in women with polycystic ovary syndrome (PCOS) resistant to CC alone. A randomized controlled trial assigned 150 such women to receive either NAC plus CC or placebo plus CC for 5 days. The results showed significantly higher ovulation and pregnancy rates in the NAC group compared to the placebo group, demonstrating NAC's potential as a novel adjuvant to CC therapy for PCOS patients. NAC appears to be a safe and inexpensive addition that could help more women with PCOS achieve ovulation and pregnancy when standard CC treatment is ineffective.
Recurrent pregnancy loss is defined as the loss of three or more consecutive pregnancies. It can be caused by anatomical, genetic, infectious, immune, or other factors. Common anatomical causes include uterine abnormalities like septate uterus and fibroids. Genetic factors may include chromosomal abnormalities in the products of conception or balanced translocations in one or both parents. Infectious causes like bacterial vaginosis can also contribute. The immune condition antiphospholipid antibody syndrome, characterized by antibodies that cause blood clots, increases the risk of recurrent loss. Treatment depends on the underlying cause but may include surgery to correct uterine anomalies, antibiotics for infections, low-dose aspirin with or without heparin for antiphospholip
interest in stem cells is raising in different field of medicine. The question is : is it successful in Gynecology or it is still too early to say that. The present talk may help to explore this .
1. Fertility Europe (FE) is an umbrella organization of European associations involved with infertility issues that aims to improve rights of those affected by difficulties conceiving, build a strong cross-border network, promote social change regarding infertility perception, and promote reproductive health education.
2. Infertility is classified as a disease by major health organizations and affects approximately 15% of Europeans. It prevents people from fulfilling the important life goal of parenthood and can impact relationships, identity, and purpose. Medical treatments have been developed to help but infertility remains a socially taboo subject.
3. Patient associations contribute to reducing anxiety by informing people about reproductive biology, pathology, and treatment options. They also offer support groups with information about
There is a recent and strong trend in western countries to advocate single embryo transfer (eSET). The rational behind this trend is to avoid complications of multiple pregnancy after IVF. However, we would urgue that twin pregnancy is totally different from high order multiple pregnancy and the long term economic analysis of twin pregnancy has never been explored before. We tried to calculate the risks and benefits of twin pregnancy from a society perspectives. Based on our model, it seems that double embryo transfer (DET) is still a valid option.
This document discusses reasons why IVF cycles may fail and provides guidance on learning from failed cycles. It defines recurrent IVF failure and recurrent implantation failure. Common causes of failure discussed include embryo quality, endometrial factors, and uterine issues like polyps or hydrosalpinx. Investigations like hysteroscopy and salpingectomy are recommended to address correctable causes. Other potential factors explored are endometrial thickness, scratching, and refractory endometrium. The goal is to identify avoidable causes and improve outcomes in subsequent cycles.
This document discusses preimplantation genetic screening and diagnosis (PGS/PGD) which involves biopsy of embryos during in vitro fertilization to test for genetic disorders and chromosomal abnormalities. It notes that PGS can provide useful information on embryo quality in addition to morphology. Several biopsy techniques are mentioned including blastomere biopsy, trophectoderm biopsy, and PB biopsy. The benefits of PGS are debated but PGD is seen as a solid diagnostic tool. Ethical issues surrounding PGS/PGD are also noted. The document also discusses factors important for blastocyst implantation like LIF and the role of p53 in regulating LIF expression.
This document discusses how evidence-based medicine is changing attitudes in gynecologic practice. It provides an example of a randomized controlled trial comparing two ovarian induction protocols for intrauterine insemination. The trial found that using clomiphene citrate along with human menopausal gonadotropin reduced the rate of premature luteinizing hormone surges compared to human menopausal gonadotropin alone, with no significant differences in clinical pregnancy rates. The document outlines how evidence from randomized trials, prognostic models, economic analyses and other studies can inform clinical decision-making and change practices in gynecology.
This document discusses recurrent implantation failure (RIF) after in vitro fertilization. It defines RIF and reviews its potential causes and treatments. The etiology of RIF may involve endometrial factors, gamete/embryo issues, or multifactorial causes. Investigations aim to identify specific causes, and treatments target the endometrium, embryos, or multiple contributing issues. While some interventions like hysteroscopy, endometrial injury, and blastocyst transfer have shown benefits, individualized, multidisciplinary care is needed given the complex, multifactorial nature of RIF.
recurrent miscarriage is a real clinical problem with different aetioogies. However, recent observations pointed to vascular dysfunction as a main underlying factor: how ? this talk may help in illustrating this
- Recurrent pregnancy loss is defined as 3 or more consecutive miscarriages before 20 weeks.
- Genetic causes like chromosomal abnormalities are a major cause and account for around 70% of early miscarriages. Karyotyping of pregnancy tissue can identify chromosomal abnormalities.
- Advanced parental age increases the risk of genetic defects leading to miscarriage due to declining egg/sperm quality. Parental karyotyping may identify balanced translocations in 3-5% of couples.
- A thorough evaluation including genetic, endocrine, anatomical, immunological, and infectious factors can identify a cause in 60% of recurrent pregnancy loss cases.
A Guide to SlideShare Analytics - Excerpts from Hubspot's Step by Step Guide ...SlideShare
This document provides a summary of the analytics available through SlideShare for monitoring the performance of presentations. It outlines the key metrics that can be viewed such as total views, actions, and traffic sources over different time periods. The analytics help users identify topics and presentation styles that resonate best with audiences based on view and engagement numbers. They also allow users to calculate important metrics like view-to-contact conversion rates. Regular review of the analytics insights helps users improve future presentations and marketing strategies.
- Infertility is considered a disease by the WHO and most countries, so infertility treatment is allowed. Donor gametes and surrogacy are generally not permitted in Islam.
- Assisted reproduction technologies like IVF and PGD are allowed to help couples conceive, but third parties are not acceptable. Embryo research is only permitted using spare IVF embryos.
- While stem cells are being studied for conditions like premature ovarian failure, there is no evidence they can differentiate into eggs. The risks of stem cell therapy for fertility are still unclear. Cryopreservation and some new techniques also have uncertain religious rulings.
This document discusses various ethical issues related to reproductive health, including abortion, surrogacy, cloning, in vitro fertilization (IVF), adoption, and more. It presents two case studies, one involving the denial of an abortion to a rape victim and another involving delaying cancer treatment to retrieve eggs. It notes ethical dilemmas around issues like commercial surrogacy, informed consent for research, and paying IVF doctors based on results. Specific techniques discussed include IVF, preimplantation genetic diagnosis, amniocentesis, and contraception. Stances on being "pro-choice" or "pro-life" in the abortion debate are presented.
The document discusses secular and non-secular views on various types of assisted reproductive technologies (ART). It describes several ART procedures including artificial insemination by husband or donor, in vitro fertilization, surrogacy, intracytoplasmic sperm injection, gamete intrafallopian transfer, and zygote intrafallopian transfer. It notes that some religious views accept ART within marriage but reject those using genetic material from third parties, while secular views generally support women's autonomy in choosing reproductive options.
1. Infertility is defined as the inability to conceive after one year of unprotected intercourse. Around 10-15% of the population experiences infertility.
2. There are several requirements for natural conception, including the production of healthy eggs and sperm, unblocked fallopian tubes, fertilization, and implantation. When these requirements are not met, Assisted Reproductive Technologies (ART) may help.
3. ART includes procedures like in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), frozen embryo transfer, and pre-implantation genetic screening. The goal is to help sperm fertilize eggs or implant embryos when natural conception is not possible. Selecting an experienced ART
Assisted Reproductive Technology in Nigeria: Practices and ControversiesArowojolu Samuel
Assisted Reproductive Technology presentation by Arowojolu Boluwaji S. practices of assisted reproductive technology, controversies of assisted reproductive technology. ART Techniques of ART, role of nurses in ART. regulations of ART. test tube baby. concept of assisted reproductive technology. ovulation induction, invitro fertilization.
There are many ethical aspects which derive from the application of reproduction control in women's health. Women's health can be enhanced if women are given the opportunity to make their own reproduction choices about sex, contraception, abortion and application of reproductive technologies.
The Assisted Reproductive Techniques - ART (IVF, IUI, ZIFT, GIFT, ICSI etc.)Muhammad Anas Shamsi
Assisted reproductive technology (ART) is used to treat infertility. It includes fertility treatments that handle both a woman's egg and a man's sperm. It works by removing eggs from a woman's body. The eggs are then mixed with sperm to make embryos. The embryos are then put back in the woman's body. In vitro fertilization (IVF) is the most common and effective type of ART.
The term in vitro, from the Latin meaning in glass, is used, because early biological experiments involving cultivation of tissues outside the living organism from which they came, were carried out in glass containers such as beakers, test tubes, or petri dishes.
The document discusses reproductive biotechnology and assisted reproductive technology (ART). It defines infertility and describes various causes of infertility for both males and females. It then explains several ART techniques used to treat infertility including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), egg donation, and surrogacy. For each technique, it provides details on the procedures involved and success rates. It also discusses risks of ART and some ethical issues surrounding its use.
This document summarizes a consultation with a 23-year-old unmarried Muslim woman requesting contraception as she is sexually active with her boyfriend. Her medical history and examination are unremarkable. The document discusses various contraceptive methods including their permissibility according to Islamic law and medical guidelines. Key factors discussed are the use of condoms to prevent sexually transmitted infections, as well as intrauterine devices and emergency contraception pills as temporary contraceptive options.
The document discusses various aspects of reproductive health in India including family planning programs, awareness initiatives, contraception methods, population explosion, medical termination of pregnancy, sexually transmitted diseases, and infertility treatment. It describes how the government has created awareness through various media and education programs. It also outlines different contraception methods, issues related to population growth, and assisted reproductive technologies to treat infertility.
Challenges related to Islamic Medical Ethics.pptxRukhsarSalim1
This presentation discusses several medical ethics issues from an Islamic perspective, including abortion, assisted reproductive technology, end-of-life issues, and organ transplantation. Regarding abortion, it is only permitted if the mother's life is at risk or the fetus has abnormalities, and it must be done within the first 40 days if resulting from rape. Assisted reproduction is allowed if it only uses a married couple's genetic material. End-of-life decisions aim to save life but withdrawing life support is permitted if three doctors agree further treatment is ineffective. Organ donation is acceptable unless it harms the donor, but trading organs is prohibited.
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The document discusses various aspects of surrogacy including definitions, methods, assisted reproductive techniques used, legal issues around commercial surrogacy in different countries, proposed legislation in India, health issues related to surrogacy, and legal issues around surrogacy contracts. It analyzes topics such as parenthood determination, enforceability of surrogacy contracts, and their constitutionality. The conclusion states that the legal position on surrogacy in India remains ambiguous and more research is needed on its health implications before decisions are made.
The document discusses various topics related to human reproduction including contraception, sterilization, abortion, assisted reproduction, and surrogacy. It outlines the goals of presenting on these topics and provides definitions. For each topic, it discusses relevant moral and ethical considerations including individuals' reproductive rights and health issues. The document also describes different techniques within assisted reproduction such as artificial insemination, in vitro fertilization, and related ethical debates.
Human fetal sex determination – implications in India.pdfsoniaangeline
The document discusses human fetal sex determination and its implications in India. It provides background on India's preference for male children and the history of female infanticide. It summarizes the Prenatal Diagnostic Techniques Act passed in 1994 that banned determining the gender of fetuses to address the issue. The act was later upgraded in 2003 as the PC-PNDT Act to further ban related advertisements and technologies. However, sex-selective abortions still illegally occur and the act has been criticized by some. The document also describes medical techniques like amniocentesis and CVS that can determine fetal sex but also carry risks.
This document discusses medical ethics related to reproduction and infertility treatment. It begins by defining infertility and outlining the evolution of assisted reproductive technologies, including artificial insemination, in vitro fertilization, and surrogacy. Potential ethical and legal issues are then examined for each technique, such as concerns about commercialization, parental rights, and the separation of biological and social roles of parenting. The document also covers criminal abortion and debates around its legalization.
Third party reproduction ppt by Dr.GayathiriMorris Jawahar
This document discusses third party reproduction and oocyte donation. It provides information on the requirements and screening process for oocyte and sperm donors according to ICMR guidelines. Key points include that the donor's age is the primary factor impacting IVF success rates, with higher pregnancy rates seen in donor egg programs compared to routine IVF. Embryo donation success depends on embryo viability. The rights of children born through ART technologies and relevant legal issues are also outlined.
Fertility treatments like IUI, IVF, and ICSI help couples conceive when natural conception is not possible by assisting the fertilization process in the body or in a lab. These treatments involve stimulating a woman's ovaries to produce multiple eggs, collecting and preparing sperm, fertilizing the eggs, culturing any resulting embryos, and transferring embryos into the uterus. While they do not guarantee pregnancy, they can increase the chances of pregnancy by helping the biological process of reproduction.
we need to update our knowledge regarding management of endometriosis.
Which is better: medications or surgery? let's see what can this talk tell us about
what is the efficacy of Dienogest for management of endometriosis? let's see what research can tell us
Is it better that other modalities of management?
This document outlines a 4G ovarian stimulation protocol. It discusses mono follicular versus multifollicular development in ovarian stimulation for IUI and IVF/ICSI. It also discusses luteal phase support strategies, including route of progesterone administration. Recombinant FSH, HMG, and gonadotropin dose are discussed. The document concludes by discussing a business model for an IVF center located within a hospital.
This document discusses ways to reduce miscarriage rates. It begins by outlining the agenda and introducing progesterone and NIPGT (non-invasive preimplantation genetic testing) as potential approaches. It then discusses how progesterone has immunomodulatory properties and supports the luteal phase in ART cycles. Several studies are summarized that show progesterone supplementation can reduce miscarriage rates. NIPGT is introduced as a less invasive way to assess chromosomal defects in embryos compared to traditional PGT. The document concludes that while progesterone is effective for reducing miscarriage, more evidence is still needed to determine if NIPGT could help in cases of recurrent miscarriage, especially in older patients.
This document discusses the pros and cons of transferring embryos on day 5 (blastocyst stage) versus day 3. It raises questions about whether day 5 transfer should be routine practice and whether there are any adverse effects. Specifically, it notes that day 5 transfer is not suitable for all women, especially those with a limited number of embryos, and that an increased incidence of autism has been reported. It also discusses whether day 5 transfer is practical given the infrastructure needed, and whether it is really of any value if more than one embryo is being transferred. The conclusion is that day 5 transfer should only be offered for highly selected cases.
- There is consensus that submucosal fibroids interfere with fertility and should be removed in infertile patients, regardless of size or symptoms. Subserosal fibroids do not impact fertility.
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Adenomyosis is a difficult disease to diagnose due to overlapping symptoms with other conditions like fibroids. While historically considered a disease of parous women, it is increasingly being identified in nulliparous women as well. MRI is the gold standard for diagnosis but ultrasound, especially 3D ultrasound of the junctional zone, can also provide clues. Treatment depends on patient goals and includes long acting progestins, long protocol IVF to suppress symptoms during fertility treatment, and in some cases focused ultrasound or uterine sparing surgery. More research is still needed on newer minimally invasive treatments.
How to prevent occurrence of severe ovarian hyperstimulation in IVF. Is there a way ? this talk will present a pilot randomised study that may shed the light on this
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This document discusses new concepts in oral contraceptive intake, specifically the 24/4 regimen. It begins by providing background on different generations of combined oral contraceptives. It then introduces the 24/4 regimen, which contains ethinylestradiol and drospirenone over 24 days followed by 4 hormone-free days. Studies show this regimen more effectively inhibits follicular development compared to the traditional 21/7 regimen. The 24/4 regimen provides 3 extra days of anti-mineralocorticoid and antiandrogenic effects, and may reduce hormone-withdrawal symptoms. A large observational study found the 24/4 regimen with drospirenone, specifically Yaz, had the lowest contraceptive failure rates including in
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
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In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
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Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
1. 1
In the Name of Allah the
Most Gracious
The Most Merciful
2. 2
Ethical aspects of ART in
the Arabic-speaking world
Professor Hesham Al-Inany, M.D, Ph.D.
Professor of Obstetrics & Gynecology
Faculty of Medicine , Cairo University
3. 3
Please note:
• The population diversity of more than
300 millions from 22 Arab countries is
not easy to demonstrate.
• At certain points one or more countries
are selected as representatives or used
as examples.
4. 4
Introduction
• The ability to reproduce is a basic
element of reproductive health.
• Infertility, in itself, may not threaten
physical health, but it can certainly
have a serious impact on mental and
social health.
5. 5
ART
• IUI, IVF, ICSI, and recently PGS,
PGD have offered solutions to
subfertile couple to achieve their
parenthood dreams.
• More than 3 million babies have
been delivered by ART till now
allover the world
6. 6
Arab World
• The ethical aspects of ART are very
important in determining the degree
of acceptability of such programs in
Arab world
• the conservative culture of Arab
world is governed by strong religious
sentiments
7. 7
Arab World
• More than 90% of arab are muslims
• The basic concept of Islam is to
avoid mixing genes,
• As Islam enjoys the purity of genes
and heredity, It deems that each child
should relate to a known father and
mother.
8. 8
Not only patients
• The physician is also concerned
about the legal basis of acts
undertaken on the basis of ethical
precepts
9. 9
LAW
• In all arab countries, there is no official
legislation to control assisted
reproduction, with the exception of
Tunisia
• Although most Western countries have
adopted legislation to govern ARTs,
Canada to date has not.
11. 11
Religious
• Since marriage is a contract between
the wife and husband during the span
of their marriage, no third party can
intrude into the marital functions of sex
and procreation.
• A third party is not acceptable whether
he or she is providing a sperm, an egg,
an embryo or a uterus (Serour and
Omran, 1992).
12. 12
Fatwa
• So long as these procedures are
carried out by expert scientists
• and are clearly indicated for the
couple, and so long as the sperm
cell is from the husband and the egg
is from the wife with no mixing with
other cells from other couples or
other species,
13. 13
Fatwa (cont.)
• and that the conceptus is implanted in
the uterus of the same wife from
whom the ova were taken, then IVF is
an acceptable line of treatment (al-
Azhar Fatwa, 1980).
14. 14
Christianpointofview
• About seven million Egyptians are
Christians (Copts). Christian minorities
are also present in almost all Arab
countries. They follow the Alexandria
Orthodox Church, the Catholic Church
and a smaller number follow the
Protestant church.
15. 15
• The pope of Alexandria, who is the
spiritual leader of the Orthodox
Church, clearly stated that Christian
beliefs are identical to Muslim beliefs
concerning assisted reproduction.
(Aboulghar et al, 2007)
16. 16
• These religious regulations for both
Muslims and Christians are followed
strictly by all IVF centres in the Arab
world with the exception of Lebanon.
17. 17
Guidelines
• The Ministry of Health, the doctors’
syndicate, the Egyptian Fertility
Society and the Middle East Fertility
Society all issued guidelines which
conform with the religious regulations.
• In addition there are detailed
specifications for an IVF centre and
description of inspection and quality
control procedures
18. 18
However
• IVF centres in general do not conform
to recommendations concerning the
number of embryos transferred
19. 19
Guidelines
• A November 2000 workshop
organized by the International Islamic
Center for Population Studies and
Research, Al-Azhar University, Cairo,
considered use of assisted
reproduction technologies (ART) in
the Islamic world.
20. 20
Tunisian law
• Tunisia is the only Arabic-speaking
country which has a law to regulate IVF.
• The law states that ARTshould be
performed with gametes of a married
couple, and frozen gametes or embryos
are only to be used if the couple is alive
and the marriage contract is valid and
with valid consent.
21. 21
• The law provides specifications for IVF
centres and regulations to maintain
standards and it ensures regular
inspections and confidentiality for all
patients.
• All centres should keep a complete and
detailed register of all procedures.
There are different levels of penalties
for centres violating the law.
22. 22
Lebanon: anexception
• The presence of so many ethnic
groups in Lebanon and several
religions allow more freedom in family
and heredity laws. Each sect can use
the regulations of his or her ethnic or
religious background.
23. 23
For example
• According to the Druze religion (a
minority group), donation of oocytes
between sisters may be permitted.
25. 25
Cryopreservation
• According to Islamic Sharia or law
there has been no definite clear
opinion regarding cryopreservation.
In Egypt cryopreservation is done
under strict conditions after couples
have signed a consent for the wife
who is still legally married to the
same husband
26. 26
• Transfer of frozen-thawed embryos, or
using frozen-thawed sperm after
termination of the marriage contract
by divorce or death of the husband is
also forbidden.
27. 27
In Tunisia
• Cryopreservation is allowed for five
years, but it can be extended with a
written consent signed by the couple for
another period of five years.
28. 28
PGD
• It is accepted to use preimplantation
genetic diagnosis to prevent
hereditary diseases
• sex selection has been permitted for
family balancing.
• Certain precautions and restriction
were suggested to be applied to
avoid its abuse
29. 29
Cloning
• human reproductive cloning is
condemned, but cloning human
embryos for stem cell research is
considered acceptable Serour &
Dickens , 2001
• The majority of Muslim jurists
distinguish between reproductive
and therapeutic cloning (Larijani ,
Zahedi F.,2004)
30. 30
Surrogate Mother
• surrogate motherhood is not allowed
because of the legal position of the
mother in Islamic shari'a and
consequent inheritance rights on the
one hand and sociological
significance of motherhood on the
other. (Arbach , 2002)
31. 31
Multifetal pregnancy reduction
• According to Islamic view, MFPR is
only allowed if the prospect of
carrying the pregnancy to viability is
very small.
• It is also allowed if the life or health of
the mother is in jeopardy.
• Every attempt should be made to
prevent the incidence of multiple
pregnancy, especially high-order
multiple pregnancy.
32. 32
• When MFPR is performed, it is not
performed with the objective of inducing
abortion. MFPR is performed with the
objective of increasing the chances of
continuation of the pregnancy and the
chances of survival of the remaining
fetus or fetuses (al-Shazil, 1995).
34. ART allow postmenopausal women to
become pregnant. The physiological
process occuring with pregnancy no
doubt task and exhaust the health
reserves of the woman.
Pregnancy in the postmenopause,
involves egg donation, accordingly,
using donated eggs is ethically
unacceptable in the Muslim World
35. Pregnancy in the postmenopausal using
couple’s frozen embryos is associated
with increased maternal risks and need
further evaluation.
36. 36
Embryo research
• According to religious
recommendations, research would
occur only on spare embryos
created as by-products of IVF
treatment for infertility.
• However, the wide use of
cryopreservation of extra embryos
has limited the number of embryos
donated for research
37. 37
• Cryopreserved pre-embryos may be
used for research purposes with the
free and informed consent of the
couple.
• These pre-embryos are not to be
transferred to the uterus of the wife
or that of any other woman
38. 38
Summary
In the Arabic-speaking countries, assisted
reproduction treatment is strictly controlled
by religious rules that basically do not allow
involvement of a third party in the procedure.
39. 39
• Egg donation, sperm donation and
surrogacy are not allowed.
• Assisted reproduction treatment should
only be performed in the presence of a
valid marriage contract