1) Encephalitis is an acute inflammation of the brain that is usually caused by a viral infection. Children, the elderly, and those with weak immune systems are most at risk.
2) Diagnosis involves imaging tests like MRI and CT scans to view brain inflammation, as well as tests of cerebrospinal fluid and blood to identify potential viral causes.
3) Treatment depends on the severity and cause of the inflammation. Supportive care aims to help the body fight infection, while antiviral drugs may be given if a viral cause is identified.
Myelitis is a spinal disorder. Myelitis is the infection of the white matter of spinal cord. White matter of spinal cord is a part of the central nervous system that functions as a bridge between the brain and the rest of the body.
Myelitis can result in muscle weakness or paralyzing legs and then arms.
Encephalitis is a rare yet serious disease that can be life-threatening.
Encephalitis is an inflammation of the brain tissue.
The most common cause is viral infections.
In rare cases it can be caused by bacteria or even fungi.
Encephalitis is an inflammation of the brain tissue.
Primary encephalitis- It occurs when a virus directly infects the brain and spinal cord.
Secondary encephalitis- It occurs when an infection starts elsewhere in the body and then travels to your brain.
Older adults
Children under the age of 1 year
People with weak immune systems
Primary (infectious) encephalitis
Common viruses, including HSV (herpes simplex virus) and EBV (Epstein-Barr virus)
Childhood viruses, including measles and mumps
Arboviruses (spread by mosquitoes, ticks, and other insects), including Japanese encephalitis, West Nile encephalitis, and tick-borne encephalitis
Secondary encephalitis: could be caused by a complication of a viral infection.
Multiple sclerosis (MS) is a demyelinating disease of central nervous system which includes brain and spinal cord.
it affect the myelin and by damaging the the myelin producing cell -Oligodendrocytes, which leads to sensory, motor and cognitive problems.
Guillain-Barré syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes.
Although the classic description of GBS is that of a demyelinating neuropathy with ascending weakness, many clinical variants have been well documented in the medical literature.
Myelitis is a spinal disorder. Myelitis is the infection of the white matter of spinal cord. White matter of spinal cord is a part of the central nervous system that functions as a bridge between the brain and the rest of the body.
Myelitis can result in muscle weakness or paralyzing legs and then arms.
Encephalitis is a rare yet serious disease that can be life-threatening.
Encephalitis is an inflammation of the brain tissue.
The most common cause is viral infections.
In rare cases it can be caused by bacteria or even fungi.
Encephalitis is an inflammation of the brain tissue.
Primary encephalitis- It occurs when a virus directly infects the brain and spinal cord.
Secondary encephalitis- It occurs when an infection starts elsewhere in the body and then travels to your brain.
Older adults
Children under the age of 1 year
People with weak immune systems
Primary (infectious) encephalitis
Common viruses, including HSV (herpes simplex virus) and EBV (Epstein-Barr virus)
Childhood viruses, including measles and mumps
Arboviruses (spread by mosquitoes, ticks, and other insects), including Japanese encephalitis, West Nile encephalitis, and tick-borne encephalitis
Secondary encephalitis: could be caused by a complication of a viral infection.
Multiple sclerosis (MS) is a demyelinating disease of central nervous system which includes brain and spinal cord.
it affect the myelin and by damaging the the myelin producing cell -Oligodendrocytes, which leads to sensory, motor and cognitive problems.
Guillain-Barré syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes.
Although the classic description of GBS is that of a demyelinating neuropathy with ascending weakness, many clinical variants have been well documented in the medical literature.
How to Write Incredibly Awesome Press ReleasesCision
If you know you need to be issuing press releases, but aren’t sure exactly how to do it, this class will provide the pragmatic steps you’re looking for. From researching a topic, to choosing words to describe your news, to sentence structure and paragraph length, these slides will cover it all in a fun and non-intimidating way. No longer fear the blank white page and have confidence when distributing your press release.
Who Should Read This: Anyone who wants media coverage. Entrepreneurs, Small Business Owners, MidMarket Executives, Executive Assistants, Public Relations Professionals, Marketing Professionals, Social Media Professionals, and Interns.
About the Presenter: Rebecca Bredholt is a Manager of Vocus Marketing Consultants, the parent company to PRWeb. Rebecca helps her clients to grow their marketing, public relations and social media efforts by designing campaigns and creating deliverables. Rebecca focuses on assisting clients make a successful transition from traditional marketing to digital marketing. As her client’s consultant, she works one-on-one with companies and communication professionals to guide them through every step of their online marketing, from strategy to set-up to execution. Please note that PRWeb was acquired in 2006, as Vocus’ online news release service. PRWeb is the leader in online news distribution and publicity. http://service.prweb.com/about/
So as what the title implies, this powerpoint is all about a muscular disorder ( a pretty "interesting" first uploaded powerpoint, I must say). I hope you enjoy it :)
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
2. WHAT IS ENCEPHALITIS?
Acute inflammation of the brain.
Children, elderly and those with a weak immune
system are those who are more prone to
encephalitis.
The treatment given and the chances to
recovery depend completely on the virus
involved and how severe the inflammation is.
Acute – encephalitis : affects brain directly
Para - infectious : brain and spinal chord inflates
two weeks into contracting the virus or bacteria.
3. CAUSES
The exact cause of encephalitis is unknown.
Usually caused by a virus or sometimes even a bacterial
infestation as well as non infectious inflammatory
conditions may cause encephalitis .
Few viruses that may be instrumental in causing
encephalitis includes –
1)Herpes simplex
2) Polio viruses
3) Mosquito – borne viruses
4)Tick – borne
5) Rabies
6) childhood viruses
4. RATE OF INCIDENCE
There were no studies that specifically addressed the
incidence of AES. However, there were studies from
various countries that mentioned the incidence of
encephalitis in different settings. Those studies
suggested an IR of 1.77 to 6.34 for tropical countries
and an IR of 0.51-7.4 for Western industrialized
countries.
An IR of 145-185 was recorded during an epidemic in
Nepal in 1997. A hospital-based study from Andhra
Pradesh, India, suggested an IR of 1. A review article
suggested that the minimum IR must be fixed at 6.0
based on earlier studies
5. Biological Base
• Just as a thief with a copied key can open a lock that is not his,
a virus begins to enter a cell via a similar type of crime.
• Outermost layer of virus has special protiens that latch onto a
cell and “pick” the molecular locks on its surface.
• These locks, which cover the surface of a cell, are called
receptors.
6. • When there is no virus, receptors are used to
convey important signals from the outside
world to the inside of the cell.
• Unrelated viruses can attach (bind) at different
times to the same kind of receptor on a cell
surface.
• A virus’s preference for infecting a certain type
of cell (like a neuron) is called tropism, and is
caused by the specific interaction of the virus
with a receptor found on that kind of cell.
7. • In addition to binding to a cell surface receptor,
a virus often has to bind to a second cell
surface receptor, called co-receptor. In these
cases, its only after this second interaction that
a virus can enter into a cell.
10. Infectious Encephalitis
• Viruses are the most common agents that cause
Infectious Encephalitis. Within the British Isles
herpes simplex virus (the cold sore virus) is
the virus most frequently identified.
• Some of the known types of Infectious
Encephalitis are:
o Herpes Simplex Encephalitis
o West Nile Encephalitis
o Tick Borne Encephalitis
o Japanese Encephalitis
11. Autoimmune Encephalitis
• Autoimmune Encephalitis may be triggered by
infection in which case the term "Post-infectious
Encephalitis" is used. ADEM( Acute Disseminated
Encephalomyelitis ) is a Post-infectious Encephalitis.
The illness usually follows in the wake of a mild viral
infection (such as those that cause rashes in childhood)
or immunisations. Typically there is a delay of days to
two to three weeks between the triggering infection and
development of the Encephalitis.
• It has recently been recognised that there are other
types of Autoimmune Encephalitis resulting from an
attack of the brain by the body's immune system.
12. • Some of the known types of Autoimmune
Encephalitis are:
o Acute Disseminated Encephalomyelitis (ADEM)
o NMDA Receptor associated Encephalitis [N-methyl
D-aspartate (NMDA) ]
o Hashimoto’s Encephalopathy
o Rasmussen Encephalitis
13. Chronic Encephalitis
SSPE: A Chronic Encephalitis as a result of Measles
• SSPE stands for Subacute Sclerosing Panencephalitis and
refers specifically to a type of Encephalitis which can
follow natural (wild) measles virus infection. After the
initial measles infection, the virus lies passive in brain cells.
It does not cause SSPE for several years (average 6 years)
when eventually an inflammatory response is initiated
against the infected cells. It is more common in children
younger than 2 years who have had primary measles
infection, although the condition (SSPE) manifests itself
much later- older children and adults.
• Unfortunately SSPE is a progressive form of Encephalitis
without a cure. Despite multiple attempts, no satisfactory
treatment has been developed. In a few cases there has been
remission following use of a certain drug or drug
combination. However most of those affected die within
about 5 years of diagnosis.
14. Limbic Encephalitis
• The term ‘Limbic Encephalitis’ (LE) is used
when the limbic areas of the brain are inflamed
(swollen) and consequently not functioning
properly.
15. HIV Encephalitis
Human Immunodeficiency Virus (HIV) can affect the
brain in different ways.
• HIV-meningoencephalitis is infection of the brain and
the lining of the brain by the HIV virus. It occurs
shortly after the person is first infected with HIV
and may cause headache, neck stiffness, drowsiness,
confusion and/or seizures.
• HIV-encephalopathy (HIV-associated dementia) is the
result of damage to the brain by longstanding HIV
infection. It is a form of dementia and occurs in
advanced HIV infection.
• Mild Neurocognitive Disorder is problems with
thinking and memory in HIV, however is not as severe
as HIV-encephalopathy. Unlike HIV-encephalopathy it
can occur early in HIV infection and is not a feature of
Aquired Immune Deficiency Syndrome - AIDS.
16. Encephalitis Lethargica
• Encephalitis Lethargica (EL) is a serious sporadic
form of Encephalitis.
• a form of encephalitis caused by a virus and
characterized by headache and drowsiness leading to
coma.
• The term "sleeping sickness", where people seem to
fall asleep or freeze whilst eating or working was
first used to describe two cases in Vienna.
21. Encephalitis with focus or diffused
neurological symptoms
• Behavioral and personality changes.
• Decreased level of consciousness.
• Stiff neck, photophobia and lethargy.
• Generalized or localized seizure.
• Acute confusion or amnestic states.
• Flaccid paralysis(10%)
25. Viral encephalitis – clinical symptoms
• Typical presentation
– Acute flu-like prodrome
– High fever, severe headache
– Altered consciousness (lethargy, drowsiness, confusion, coma)
– Seizures
– Focal neurological signs
• More subtle presentations
– Low grade fever
– Speech disturbances (dysphasia, aphasia)
– Behavioural changes
– Subacute and chronic presentations can be caused by CMV,
VZV, HSV (immuno-compromised)
26. Possible Complications
• Permanent brain damage may occur in severe
cases of encephalitis. It can affect:
Hearing
Memory
Muscle control
Sensation
Speech
Vision
28. DIAGNOSIS
• Because the various types of encephalitis produce
similar symptoms, doctors cannot rely on clinical
features to differentiate among the many causes of
brain inflammation. The primary objective in
diagnosing viral encephalitis is to determine if it is
caused by:
• Herpes simplex or other conditions that
can be treated with specific medications
• Arboviruses or other viruses that can be
managed only by targeting symptoms
29. IMAGING TECHNIQUES
• For suspected encephalitis scanning technique is often
the first diagnostic step.
• Computerized tomography (CT) or magnetic resonance
imaging (MRI) scans can show the extent of the
inflammation in the brain and help differentiate
encephalitis from other conditions. MRIs are
recommended over CT scans because they can detect
injuries in parts of the brain that suggest infection with
herpes virus at the onset of the disease, while CT scans
cannot.
• Electroencephalogram (EEG), which records brain
waves, may reveal abnormalities in the temporal lobe
that are indicative of herpes simplex encephalitis.
30. CEREBROSPINAL FLUID TESTS
• When encephalitis is suspected, a sample of
cerebrospinal fluid is taken using a lumbar puncture.
• The sample is taken to count white blood cells and
identify specific blood cell types, to measure proteins
and blood sugar levels, and to determine spinal fluid
pressure.
• Doctors use CSF to test for herpes simplex virus, Epstein-
Barr virus, varicella-zoster virus, enteroviruses, and to
look for the presence of antibodies to the West Nile virus.
• While cerebrospinal fluid tests may help diagnose
encephalitis, they cannot provide information on how
severe the disease will be.
31. BLOOD TESTS
• Blood tests may be used to test for West Nile virus
and other arbovirus infections.
• Blood and urine tests are used to isolate and
identify viruses.
• Enzyme-linked immunosorbent assays (ELISA),
including IgM-capture ELISA (MAC-ELISA) and IgG
ELISA, can identify viruses that cause encephalitis
soon after infection.
• Polymerase chain reaction (PCR) can identify small
amounts of viral DNA.
32. BRAIN BIOPSY
• Tiny samples of brain tissue are surgically removed
for examination and testing for the presence of the
virus.
• Tissue is prepared using staining techniques and
then viewed under an electron microscope.
• In a few cases, the viruses in brain cells are able to
be cultured; that is, the viruses can actually be
made to replicate in samples.
• A brain biopsy is the gold standard for diagnosing
rabies.
33. TREATMENT
• The goals of treatment are to provide supportive care (rest,
nutrition, fluids) to help the body fight the infection, and to relieve
symptoms. Reorientation and emotional support for confused or
delirious people may be helpful.
Medications may include:
• Antiviral medications, such as acyclovir (Zovirax) and
foscarnet (Foscavir) -- to treat herpes encephalitis or other severe
viral infections (however, no specific antiviral drugs are available
to fight encephalitis)
• Antibiotics -- if the infection is caused by certain bacteria
• Anti-seizure medications (such as phenytoin) -- to prevent
seizures.
• Steroids (such as dexamethasone) -- to reduce brain swelling
(in rare cases)
• Sedatives -- to treat irritability or restlessness
• Acetaminophen -- for fever and headache.
34. TREATING PROBABLE CAUSES OF
ENCEPHALITIS
• Since it is difficult to determine the cause of encephalitis, and
rapid treatment is essential, clinical guidelines recommend
immediately administering intravenously the antiviral drug
acyclovir without waiting to determine the cause of the illness.
• Once the doctor receives results from diagnostic tests, drug
treatment depends on the cause of the encephalitis. Antiviral
drug treatments for specific causes of encephalitis include:
• Herpes Simplex Virus . Acyclovir is recommended.
• Varicella-Zoster Virus . Acyclovir is recommended.
Ganciclovir or adjunctive corticosteroids may also be
considered.
• Epstein-Barr Virus . Corticosteroids may be used,
although risks may outweigh benefits. (Acyclovir is not
recommended.)
• For bacterial meningitis, antibiotics (not antiviral drugs) are
used.
35. ADDITIONAL TREATMENTS
• Other encephalitis treatments are aimed at
reducing symptoms.
• Seizures may be prevented by using oral
anticonvulsant drugs or intravenous lorazepam
(Ativan).
• Sedatives may be prescribed for irritability or
restlessness.
• Simple pain relievers may be used for fever and
headache.
36. Prognosis
• Acute phase of illness different from person to
person
• Some recover with slight disability, others
profound disability and a few need residential
care for a life time
• Degree and type of damage
cause of inflammation
severity of the infection
area affected
delay in seeking treatment
37. Post encephalitis
presentation
• Personality changes
• Physical difficulties
• Memory problems
• Emotional problems
• Problems with pain and
other sensations
• Problems with daily living
skills
• Fatigue
• Hormone problems
• Cognitive Problems
• Problems with new
learning
• Inability to understand
and communicate
• Epilepsy
• Inappropriate behavior
and poor social skills
38. Psychosocial Rehabilitation
After acute phase,
safe environment +gentle stimulation
spontaneous recovery
Later phase,
new skills, habits and strategies to cope
Family and Patient requirement of time to cope varies
39. Barbara Wilson – Cutting Edge developments in Neurological
Rehabilitation and possible Future directions (2011)
• Comparison focused therapy (CFT) – refocus emotional
responses from self-critical to self acceptance
• Music intonation therapy- music engages brain and
behavior functions. Improve attention, memory, executive
functions, unilateral neglect, anxiety, depression
• Virtual reality assessments – make more able for patients
to become more able to participate in community life.
• Restitution of working memory deficits by computerized
working memory training
• Errorless learning for people with language deficits
• Problem solving therapy for people with executive
function deficits
• Assistance in early stages of deterioration.
40. Recent trends
Extensive frontal gray matter volume reduction related to a
possible sequalae of encephalitis (Evernsel & etal, 2015)
39 year old man
Normal growth till 2 years
At 2, a febrile illness with convulsions- unconscious for a week.
No treatment given
Could walk only at 5, no speech, lacking self-care,
disorganized behavior and mental retardation
Untreated encephalitis at 2 years damaged frontal region
41. • Encephalitis sequalae causes
mental retardation
• Frontal Necrosis leads to
disinhibition
• Low dose of antipsychotic and
antiepileptic drugs for
symptomatic treatment
Fig 1. MRI of the brain showing extensive
frontal and mild right parietal gliosis and
encephalomalacia.
42. Encephalitis – a service orphan: The need for more
research and access to neuropsychology (Easton,
Alkin & Dowell 2006)
• Aimed to spread awareness of neuropsychology in
management of encephalitis
• More psychological disorders in people with Acquired
Brain Injury
• After acute phase of encephalitis, marked changes in
behavior
Memory problems, personality change, personality and
spatial disorders etc
• Family and caregiver outcomes
• Social Outcomes
• Rehabilitation