This document discusses various drugs acting on the digestive system including antacids, drugs for peptic ulcer, emetics, antiemetics, cathartics, laxatives, and anti-diarrheal drugs. It defines these drug classes, discusses their mechanisms of action, examples, and uses. Key points covered include how antacids neutralize stomach acid, treatments for peptic ulcer like H2 blockers, how emetics and antiemetics work on the vomiting center, mechanisms of cathartics like senna and castor oil, and why opiates like paregoric are used to treat diarrhea.
Drugs affecting the GI system are used in the treatment of gastric acidity, peptic ulcers, and gastroesophageal reflux disease (GERD), bowel motility disorders (gastroparesis [delayed gastric emptying due to partial paralysis of the stomach muscles], constipation, and diarrhea), and for the treatment of nausea and vomiting.
Drugs affecting the GI system are used in the treatment of gastric acidity, peptic ulcers, and gastroesophageal reflux disease (GERD), bowel motility disorders (gastroparesis [delayed gastric emptying due to partial paralysis of the stomach muscles], constipation, and diarrhea), and for the treatment of nausea and vomiting.
short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
The urinary system, also known as the renal system or urinary tract, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressure, control levels of electrolytes and metabolites, and regulate blood pH.
This Presentation tries to make understand the System which plays a role in increasing Blood Pressure-Renin Angiotensin System & How the drugs and inhibiting Enzymes prevent this BP rise...
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short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
The urinary system, also known as the renal system or urinary tract, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressure, control levels of electrolytes and metabolites, and regulate blood pH.
This Presentation tries to make understand the System which plays a role in increasing Blood Pressure-Renin Angiotensin System & How the drugs and inhibiting Enzymes prevent this BP rise...
Diuretics | Definition | Mechanism of Action | Classes of DrugsChetan Prakash
This presentation provides knowledge about Diuretics,Role of sodium, types of urine output, General mechanism of action, Normal Physiolofy of urine formation, GFR Formation, Classes of Diuretics, diuretics abuse and recent discovery. An assignment for the subject, Advanced Pharmacology-I, 1st year M.Pharm, 1st semester.
Chronic and acute constipation
The herbal treatment of constipation by :
1- Increase stool bulk
ex. ulmus (slippery elm) and Plantago ovata (ispaghula).
2- Improve gastrointestinal lubrication.
ex. Linseeds are particularly suitable because of their oil and mucilage content
3- Use of Antiabsorptive and hydragogue
ex. rumex, taraxacum, senna and cascara.
4- Improve motor function with gastrointestinal spasmolytics such as matricaria (chamomile) or Viburnum opulus (cramp bark).
5- Improve liver function with choleretic and cholagogue herbs, e.g. taraxacum (dandelion root) and silybum.
The gastrointestinal tract is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces. The mouth, esophagus, stomach and intestines are part of the gastrointestinal tract
Drugs used in git system (GIT - Laxatives /purgatives , drugs used to treat p...Vinitkumar MJ
CLASS FOR OPHTHALMIC ASSISTANT STUDENTS ( O.A. STUDENTS 2nd year .
educational purpose
short description regarding GIT SYSTEM & drugs used to treat diarrhoea , peptic ulcer diseases , irritable bowel syndrome , IBS, antimotility drugs & laxatives /purgatives etc..
Prescription types, parts of prescription, handling and care required during dispensing prescription, sources of error in prescription & calculations involved in dispensing prescription-Imperial System & Metric System.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
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The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
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The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
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Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Chapter 3 - Islamic Banking Products and Services.pptx
8 Drugs acting on Digestive system.pptx
1. Prepared by
Ms. Nisha S. Mhaske
Lecturer
Email ID-nishamhaske@gmail.com
DRUGS ACTING ON
DIGESTIVE SYSTEM
2. Antacid- the drugs which are used to neutralize excessive acidity in
the stomach are called as antacids.
Classification
1. Systemic antacids (Water soluble)- when administered, get absorbed
into systemic circulation & may cause systemic alkalosis.
eg- Sodium bicarbonate
1. Non-systemic antacids (water insoluble)- when administered, form
insoluble complexes in the small intestine.
eg- Magnesium hydroxide, aluminum hydroxide gel, magnesium
trisilicate, calcium carbonate, magnesium oxide.
3. The antacids act as weak bases & reduce the quantity of free
hydrochloric acid in the stomach by the following
mechanisms.
1. Direct neutralization of pre-formed acid.
2. Buffering of pre-formed acids
4. It should have a capacity to neutralize excessive acidity.
It should have a quick & prolonged action
It should not interfere with digestion & absorption of food
It should be non-toxic, palatable, cheap & easily available.
It should not cause evolution of gas.
It should not cause constipation or diarrhea
It should not cause alkalosis.
5. Systemic antacids- Sodium bicarbonate
It is white, water soluble & completely absorbed antacid.
It reacts with gastric acid as follows.
It is effective & rapidly acting antacid.
1 gm drug neutralizes 120 ml of 0.1 N HCl.
During the neutralization process, carbon dioxide is liberated, which
gives the patient a sense of relief from abdominal discomfort.
It is not recommended for long term use as it produces systemic
alkalosis.
7. Is one of the common diseases of adult male.
It is caused as a result of digestive action of pepsin & dil.HCl
against which the normal stomach & duodenum are protected
by their mucus secretions.
In peptic ulcer, there is an excessive secretion of gastric acid.
Treatments
i. Controlling gastric acidity, hyper motility & spasms.
ii. Promoting ulcer healing.
iii. Use of antacids, milk or ion exchange resin.
iv. Withdrawal of stimulants of gastric acid like alcohol,
tobacco etc.
v. Surgical removal of acid producing gastric mucosa.
8. Drug treatments for peptic ulcer
i. Aluminium hydroxide gel
ii. Magnesium hydroxide
iii. Aluminium trisilicate
iv. Magnesium oxide
v. H2 receptor antagonists
a) Ranitidine- tablet 150 mg oral
b) Cimetidine- 200 mg –Tagamet
9. The drugs which induce vomiting are called emetics.
Emesis- it is the process of vomiting.
It can be caused due to:
1. Stimulation of CTZ
2. Local irritation in GIT
3. Vestibular stimulation
4. Psychological
Drugs- Apomorphine, ipecac, mustard, sodium chloride solution
Uses of emetics
1. In poisoning cases for gastric lavage
2. As expectorants.
10.
11. The drugs which prevent or relieve nausea and vomiting are
called antiemetic.
Classification
1. Anticholinergics- scopolamine
2. Antihistaminics- Diphenhydramine, cyclizine
3. Antidopaminergics- Chlorpromazine
4. Miscellaneous- Haloperidol, Tri-metho-benzamide, Benz-
quinamide.
Mechanism of action
1. By acting directly on vomiting centre
2. By acting on CTZ (Chemo Receptor Trigger Zone)
3. By acting peripherally.
12. Preparations
1. Scopolamine hydrobromide- 0.6 mg to 1 mg s.c
2. Chlorpromazine- 10-25 mg
Uses of antiemetic
1. To control vomiting during cancer therapy.
2. Preanaesthetic medication
3. To treat vomiting during pregnancy
4. To treat vomiting due to motion sickness.
5. To treat vomiting during GIT disturbances
6. To treat vomiting due to psychological reasons.
13. Cathartics- it is a pharmacological agent, which when
administered, increase tone, motility, peristalsis & relieves
constipation.
Purgatives- the drugs which promote defecation are called
purgatives.
These are drastic cathartics, which when administered, relieve
constipation, by causing gripping pain in abdomen & loss of
water.
Laxatives- these are mild cathartics, which when
administered, relieve constipation without gripping pain in
abdomen & loss of water.
16. Senna
1. Senna is a stimulant purgative.
2. Senna contains anthraquinone
glycosides which act by stimulation
of large bowel & also probably by
inhibiting NaCl & water reabsorption
in the colon.
3. Hence increase evacuation of faecal
matter from the colon & produce
purgation.
Preparations- senna (Glaxena)- 0.6-
2 gm at bed time.
17. Castor oil
1. When castor oil is ingested orally, it is hydrolyzed by
pancreatic lipase to glycerol & ricinoleic acid.
2. This ricinoleic acid, by its irritant action, stimulated the
peristaltic movements of intestine & produces
purgation.
3. Full dose of castor oil produces purgation within 2-6
hrs.
18. Saline purgatives
1. These drugs act by maintaining a volume of fluid in the bowel by
osmosis.
2. These drugs increase the osmotic pressure by secreting additional
fluid in the intestinal tract resulting in increase in bulk &
stimulate the peristalsis of GIT, hence they are used in
constipation.
Examples
1. Magnesium sulphate- 5-15 gm before breakfast
2. Magnesium carbonate- 2-4 gm as required
3. Magnesium hydroxide- 2-4 gm as required.
19. Clinical application of cathartics
1. To treat constipation.
2. In food or drug poisoning saline purgatives are used.
3. In hemorrhoids.
4. Used before radiological examination of GIT.
5. In gynecological practice.
6. In case with anal fissures.
20.
21. Diarrhea is defined as rapid passage of fecal matter
through gastro-intestinal tract & a frequent passage of
semisolid or liquid feces.
Anti-diarrhoeal drugs are pharmacological agents,
which when administered, alter the tone & motility of
bowels, or act as adsorbents, which adsorb the irritants.
23. 1. The opiates
Opiates are used for symptomatic relief of diarrhea.
When administered, these agents reduce the propulsive movements
of the colonic muscle & thereby allow the feces to remain for a
longer time in the lumen so that water is re-absorbed.
Disadvantage is that, these agents may cause addiction & tolerance,
if taken frequently.
Preparations
I. Paregoric- camphorated preparation of opium-4 ml
II. Codeine phosphate- 16-30 mg
24. Hydrophilic agents- when administered, absorb water in the
lumen & form gelatinous mass. This reduce free water content
of stool.
Methyl cellulose- Celevac- 1-3 gm
Isapgula husk- Isogel- 3-5 gm
Demulcent- when administered, provide soothing effect to the
irritated intestinal mucosa.
Bismuth carbonate- 2 gm orally
Magnesium oxide- 1 gm orally.
25. Why morphine does produce constipation?
Morphine reduces peristaltic movements of the gut.
Due to this there is a delay in passage of food in intestine &
thus large amount of water is reabsorbed from the intestinal
contents.
Hence intestinal contents become hard & do not evacuate
easily. Hence morphine produce constipation.
26. Why is tincture of opium used in diarrhoea?
Because morphine is a main alkaloid of opium.
Morphine reduces peristalsis & motility of the gut.
Morphine increases reabsorption of water from the intestine &
prevents the evacuation of watery stools.
Hence due to constipating effect, morphine is used in
diarrhoea.
27. 1. Define antacid. Classify it with example.
2. Give ideal properties of antacid.
3. What is peptic ulcer? Give causes & treatment of peptic ulcer.
4. Define emetics. Enlist causes of emesis. Give drugs with their uses.
5. Define antiemetic with examples? Enlist uses of antiemetic.
6. What are purgative? Classify it with example.
7. How does senna acts as purgatives?
8. How does castor oil acts as purgatives?
9. Why morphine does produce constipation?
10. Write a note on saline/osmotic purgatives.
11. What is the difference between laxatives & purgatives?
12. Why is tincture of opium used in diarrhea?