The document discusses drugs that affect the kidney, focusing on different classes of diuretics. It describes five major classes of diuretics: thiazides and thiazide-like drugs, loop diuretics, potassium-sparing diuretics, carbonic anhydrase inhibitors, and osmotic diuretics. Each class is explained in terms of prototypes, pharmacodynamics, side effects, and special uses. The nursing process for safely administering diuretics is also outlined.

1. Renal Pharmacology Drugs affecting the Kidney pinoynursing.webkotoh.com

2. Drug classification The nursing process applied to pharmacology Pharmacokinetics Pharmacodynamics

13. Diuretics Comparison Hypokalemia Ototoxicity Loop of Henle 3. Loop diuretics Hypovolemia & hypotension Glomerulus 5. Osmotic diuretic Hyperkalemia Distal tubule 4. Potassium sparing Hyperuricemia Hypokalemia Proximal tubule 2. Thiazide and thiazide like Acidosis Proximal tubule 1. Carbonic anhydrase inhibitor Special Side effect (s) Major site of action Diuretic class

14. Diuretics Comparison Hypercalcemia 3. Loop diuretics Increased ICP LITHIUM TOXICITY 5. Osmotic diuretic CHF taking digoxin 4. Potassium sparing Nephrolithiasis due to calcium stones Hypocalcemia 2. Thiazide and thiazide like Mountain sickness Meniere’s disease 1. Carbonic anhydrase inhibitor Special Uses Diuretic class

21. Loop Diuretics

25. Potassium sparing diuretics