This document summarizes drugs acting on the GI system. It discusses antiemetics which prevent nausea and vomiting like ondansetron, domperidone, and cyclizine. Emetics like ipecac and apomorphine induce vomiting. Laxatives like lactulose, bisacodyl, and docusate are used to treat constipation. Antacids like aluminum hydroxide and magnesium hydroxide neutralize stomach acid. Proton pump inhibitors like omeprazole and pantoprazole inhibit acid secretion. Antidiarrheals like loperamide and diphenoxylate decrease intestinal motility. Histamine receptor blockers like cimetidone and ranitidine inhibit
With more than 10% share of dispensed endocrine medications, levothyroxine sodium is the most prescribed drug by endocrinologists. The medication is used for hypothyroidism treatment, which is often a co-morbidity of diabetes. The second most common endocrine medication on the list, Synthroid, is a branded version of levothyroxine sodium.
With more than 10% share of dispensed endocrine medications, levothyroxine sodium is the most prescribed drug by endocrinologists. The medication is used for hypothyroidism treatment, which is often a co-morbidity of diabetes. The second most common endocrine medication on the list, Synthroid, is a branded version of levothyroxine sodium.
presented by: Miss Prajakta D. sawant, Lecturer at Genesis Institute of Pharmacy, radhanagari.
SECOND YEAR DIPLOMA IN PHARMACY. PHARMACOLOGY AND
TOXICOLOGY(0813).
short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
Diuretics | Definition | Mechanism of Action | Classes of DrugsChetan Prakash
This presentation provides knowledge about Diuretics,Role of sodium, types of urine output, General mechanism of action, Normal Physiolofy of urine formation, GFR Formation, Classes of Diuretics, diuretics abuse and recent discovery. An assignment for the subject, Advanced Pharmacology-I, 1st year M.Pharm, 1st semester.
Lecture slides for undergraduate MBBS class in Pharmacology on " Drugs for Diarrhoea" . It includes various treatment modalities which are used in the management of Diarrhoea. Basic source of information for preparing this slides is" Essentials of Pharmacology by KD tripathi, 7th Edition". Images are searched with the help of google images.
presented by: Miss Prajakta D. sawant, Lecturer at Genesis Institute of Pharmacy, radhanagari.
SECOND YEAR DIPLOMA IN PHARMACY. PHARMACOLOGY AND
TOXICOLOGY(0813).
short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
Diuretics | Definition | Mechanism of Action | Classes of DrugsChetan Prakash
This presentation provides knowledge about Diuretics,Role of sodium, types of urine output, General mechanism of action, Normal Physiolofy of urine formation, GFR Formation, Classes of Diuretics, diuretics abuse and recent discovery. An assignment for the subject, Advanced Pharmacology-I, 1st year M.Pharm, 1st semester.
Lecture slides for undergraduate MBBS class in Pharmacology on " Drugs for Diarrhoea" . It includes various treatment modalities which are used in the management of Diarrhoea. Basic source of information for preparing this slides is" Essentials of Pharmacology by KD tripathi, 7th Edition". Images are searched with the help of google images.
Drugs using for GI system(pharmacology)varsha surkar
INC Syllabus • Antiemetics • Emetics • Purgatives • Antacids • Cholinergic • Anticholinergics • Fluid and Electrolyte therapy • Antidiarrheals • Histamines Composition, Action, Dosage, Route, Indications, Contraindications, Drug Interactions, Side effects, Adverse effects, Toxicity & Role of nurse Proton pump inhibitors
3. Antiemetics •Antiemetics are the Drugs which prevent or control the Vomiting/Nausea.
4. Antiemetics • Antiemetic are the drugs which prevent or control the vomiting/nausea. Classification Ondansetron 5HT3 AntagonistsGranisetron Dolasetron Domperidone Prokinetics / Dopamine AntagonistsOlanzapine Metoclopramide Cyclizine Antihistamines Diphenhydramine Meclozine Promethazine Hydroxyzine Hyoscine & Dicyclomine Anticholinergics
5. Mechanism of action • 5HT3 Antagonists: They block serotonin receptors in CNS and Gastrointestinal tract So they can be used to treat post operative and cytotoxic (Chemotherapy) drugs nausea/ vomiting. • Prokinetics (Dopamine Antagonists): They block the dopamine neurotransmitter also they promote gastrointestinal motility & quicken gastric emptying. • Antihistamines: They block the histamine neurotransmitter and they act by an effect on vomiting center and by producing sedation. • Anticholinergics: An Anticholinergic agents block the neurotransmitter Acetyl choline in central and peripheral nervous system.
6. Drug example and doses S. No. Drugs Doses 1 Hyoscine 200-600mg (SC) 2 Diclomine 40mg 6hourly 3 Cyclizine 50mg 4-6 hour 4 Meclizine 25mg/day. 5 Metoclopramide 10mg 6 Domperidone 10-20 mg 4-6hours 7 Ondansetron 8-16mg
7. Indications / Uses •5HT3 antagonists are used in management of nausea vomiting associated with chemotherapy. •Antihistamine such as diphen hydramine is used for motion sickness and morning sickness. •Metoclopramide is used for gastric emptying in patient’s receiving tube feeding. •Anticholinergic such as hyoscine, Dicyclomine are useful in travel sickness.
8. Contraindication / Precautions •Diphenhydramine is contraindicated in hypertensive patients. •Metoclopramide is contraindicated in suspected gastrointestinal problem. •Use cautiously and reduced dose in renal impairment conditions.
9. Adverse effects •Hypotension. •Constipation. •Dryness of mouth. •Blurred vision. •Pain in IM injection site. •Drowsiness. •Rectal irritation. •Photo sensitivity reaction.
10. Drug interactions •Use antihistamine, other CNS depressants including opioids and sedative – hypnotic drugs causes additive CNS depression. •Metoclopramide affects GI motility and alter GI absorption of other drugs such as salicylates, levodopa, diazepam, lithium, tetracycline.
11. Nursing Responsibilities •Assess the patient for nausea/vomiting and fluid and electrolyte imbalances. •Decrease metoclopramide dose 50% of usual recommended dose if creatinine clearance is less than 40ml/min. •Instruct the patient not to consume alcohol when taking an antiemetic drugs. •Advise the patient to take oral antiemetics 1hour.
laxatives and purgatives. Pharma pptx by Mr. Praveen JaiswalPraveenJaiswal44
This presentation contains information about the commonly used laxative and purgative drugs. This presentation can be used to teach nursing and allied health students.
A neurological examination is the assessment of sensory neuron and motor responses, especially reflexes, to determine whether the nervous system is impaired. This typically includes a physical examination and a review of the patient's medical history, but not deeper investigation such as neuroimaging.
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June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
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The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
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The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
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5. Antiemetics
event or control the• Antiemetic are the drugs which pr
vomiting/nausea.
Classification
Ondansetron
5HT3AntagonistsGranisetron
Dolasetron
Domperidone
Prokinetics / DopamineAntagonistsOlanzapine
Metoclopramide
Cyclizine
Antihistamines
Diphenhydramine
Meclozine
Promethazine
Hydroxyzine
Hyoscine & Dicyclomine Anticholinergics
6. MECHANISM OF ACTION
• 5HT3 Antagonists: They block serotonin receptors in CNS and
Gastrointestinal tract So they can be used to treat post operative and
cytotoxic (Chemotherapy) drugs nausea/ vomiting.
• Prokinetics (Dopamine Antagonists): They block the dopamine
neurotransmitter also they promote gastrointestinal motility &
quicken gastric emptying.
• Antihistamines: They block the histamine neurotransmitter and
they act by an effect on vomiting center and by producing sedation.
• Anticholinergics: An Anticholinergic agents block the
neurotransmitter Acetylcholine in central and peripheral nervous
system.
7. Dr g example and dos sS.NO. Drugs Doses
1 Hyoscine 200-600mg (SC)
2 Diclomine 40mg 6hourly
3 Cyclizine 50mg 4-6 hour
4 Meclizine 25mg/day.
5 Metoclopramide 10mg
6 Domperidone 10-20 mg 4-6hours
7 Ondansetron 8-16mg
8. INDICATIONS / USES
•5HT3 antagonists are used in management of
nausea vomiting associated with chemotherapy.
•Antihistamine such as diphen hydramine is used
for motion sickness and morning sickness.
•Metoclopramide is used for gastric emptying in
patient’s receiving tube feeding.
•Anticholinergic such as hyoscine, Dicyclomine
are useful in travel sickness.
9. CONTRAINDICATION / PRECAUTIONS
•Diphenhydramine is contraindicated in
hypertensive patients.
•Metoclopramide is contraindicated in
suspected gastrointestinal problem.
•Use cautiously and reduced dose in renal
impairment conditions.
11. DRUG INTERACTIONS
•Use antihistamine, other CNS depressants
including opioids and sedative – hypnotic
drugs causes additive CNS depression.
•Metoclopramide affects GI motility and
alter GI absorption of other drugs such as
salicylates, levodopa, diazepam, lithium,
tetracycline.
12. NURSING RESPONSIBILITIES
•Assess the patient for nausea/vomiting and fluid and
electrolyte imbalances.
•Decrease metoclopramide dose 50% of usual
recommended dose if creatinine clearance is less than
40ml/min.
•Instruct the patient not to consume alcohol when taking an
antiemetic drugs.
•Advise the patient to take oral antiemetics 1hour before
exposures to conditions causing motion sickness or before
travelling.
14. MECHANISM OF ACTION
•They stimulate the chemoreceptor
trigger zone and gastric mucosa to
induce vomiting.
15. DRUG EXAMPLE AND DOSES
S.
No.
Drugs Doses
1 Apomorphine 5mg IM
2 Copper sulfate Given in water every 5 min. until emesis occur.
3 Sodium chloride
(NaCl)
2 table spoon of NaCl in glass of warm water
4 Ipecac syrup 15-30ml (followed by 200ml of water.
16. INDICATIONS / USES
•To induce vomiting.
•To treat poisoning.
•Treatment of overdose of drug.
20. NURSING RESPONSIBILITIES
•Assess the consciousness level of patient before
administering drug.
•Follow administration of Ipecac syrup with one or two
passes of tepid water or other clear liquid.
•Obtain a history, to find out caustic substances to
determine possible antidotes.
•We should know that lavage is necessary if second dose
not produce vomiting Ipecac may be cardiotoxic if
absorbed.
21. LAXATIVES/PURGATIVES
•These drugs are combinedly knows as
purgatives, which includes laxatives and
cathartics these drugs are used to
overcome the constipation and proper
evacuation of bowels.
22. MECHANISM OF ACTION
•Osmotic laxatives (Magnesium hydroxide) draw water into
the intestine to increase the mass of stool, stretching
musculature which results in peristalsis.
•Stimulant laxatives result in stimulation of intestinal
peristalsis.
•Lubricant laxatives increase water retention in the stool,
prevent water absorption from the stool, and lubricate as
well as soften intestinal contents.
•Stool softener allow more fluid are fat to penetrate the
faeces, producing a softer fecal mass.
23. DRUG EXAMPLE AND DOSES
S.
No.
Drugs Doses
1 Bilk forming laxatives (Methyl
Cellulose)
2 tablets 1000mg orally with 8oz of
liquid up to 6times a day.
2 Lubricant laxatives include mineral oil
(Kondremal, Fleet mineral oil enema.
-
3 Hyperosmotic laxatives include
lactulose.
10mg BD
4 Stimulant laxatives (Bisacodyl, Castor
oil)
5-10 mg sodium Pico sulfate 15-20 ml
5 Stool softener (Docusate Calcium,
Docusate potassium)
240mg 50-400mg orallyb1to 4 equally
divided dose each day.
24. INDICATIONS / USES
•To treat or prevent constipation.
•To prepare the bowel for radiologic or endoscopic
procedures.
•Short term treatment of constipation caused high dose of
opioid use.
•Osmotic laxatives are used to rapid evacuation of the bowel
after ingestion of poison or following anti-helminthic
therapy to rid of the body from dead parasites.
•Methyl cellulose and psyllium are used to many chronic
diarrhea.
26. ADVERSE EFFECTS
• GI irritation.
• Rectal burning sensation.
• Osmotic laxatives may causes dehydration.
• Long term use and abuse of laxatives may cause permanent
loss of colonic motility. Laxative dependence and electrolyte
imbalances.
• Nutritional deficiencies (with lubricant laxatives).
• Belching (with osmotic laxatives)
• Electrolyte imbalance. (with saline laxatives)
28. NURSING RESPONSIBILITIES
•Assess for abdominal pain, distention,
nausea/vomiting, bowel sounds.
•Monitor the patient for fluid electrolyte
imbalances.
•Evaluate stools for frequency and
consistency.
•Mix bulk forming laxatives in full glass of
water or juice.
30. MECHANISM OF ACTION
•They achieve their effects by
neutralizing gastric acid, inhibiting
gastric acid secretion or protect
gastric mucosa.
31. DRUG EXAMPLE AND DOSES
S.
No.
Drugs Doses
1 Sodium bi carbonate 1-5 gram orally
2 Magnesium hydroxide 0.5-1gm
3 Aluminum Hydroxide Up to 1gm daily
4 Magnesium carbonate 250-500 mg orally
5 Calcium carbonate Up to 1.5gm daily
36. NURSING RESPONSIBILITIES
• Give antacids at least one hour after meal and at least one hour a
part from enteric coated tablets.
• Always give combination of aluminum and magnesium hydroxide
because they make a balance (constipation effects of aluminum
with laxative effects of magnesium).
• Give pre-cautiously to kidney and heart patient.
• Check antacids labels for sodium content and to use only low
sodium preparation.
• Teach the patient to avoid gastric irritants such as smoking,
alcohols, caffeine, NSAID’s because they counteract the effect of
drug.
37. Cholinergic - Information for GI system
•Parasympathomimetic or cholinomimetics
•Stimulate parasympathetic nervous system in same manner
as does acetylcholine
•May stimulate cholinergic receptors directly or slow
acetylcholine metabolism at synapses (affect the enzyme
acetylcholinesterase)
•Useful in treating Alzheimer’s Disease, Myasthenia gravis
and to treatment atony of the smooth muscle of the GI
system or urinary system
38. GI EFFECTS
•Acetylcholine stimulates cholinergic receptors in
the gut to promote normal secretory and motor
activity
•Cholinergic activity in the gut will increase
peristalsis and facilitates movement of flatus and
feces
•The secretory functions of the salivary and gastric
glands also stimulated.
•Increased tone and contractility in GI smooth
muscle, relaxation of sphincters, increased salivary
gland and GI secretions.
39. Anticholinergics – Information for GI system
• Also called cholinergic blocking agents or parasympatholytics
• Again, focus is on the parasympathetic nervous system
• Parasympathetic system acts as a resting and reparative function
• Functions include digestion, excretion, cardiac decelertion,
anabolism and near vision.
• Most anticholinergic drugs interact with the muscarinic
receptors in the brain, secretory glands, heart, and smooth
muscle
• A few can also affect the nicotinic receptors. Glycopyrrolate
(Robinul) is an example
40. MECHANISM OF ACTION:
Act by occupying receptor sites at parasympathetic
nerve endings, thereby leaving fewer receptor sites
free to respond to acetylcholine.
•Distribution of receptors is broad so effects of
anticholinergics will be diffuse.
•Helpful in treating irritable colon or colitis.
•Useful in gastritis, pylorospasm and ulcerative
colitis as they slow motility.
41. Fluid and Electrolyte therapy
• Assignment: Refer to paper notes and Brief/summarize it and
submit..
42. PROTON PUMP INHIBITORS
•These agents are used in patient
with peptic ulcers (who have
failed to respond H2 blockers)
43. MECHANISM OFACTION
It acts by inhibiting proton pump which is
final common step in gastric acid
secretion. It also have antisecretory
action.
44. DRUG EXAMPLE AND DOSES
S.
No.
Drugs Doses
1 Omeprazole 20mg daily
2 Lansoprazole 30 mg OD.
3 Pantoprazole 40mg
4 Rabeprazole 20mg
45. INDICATIONS / USES
•Peptic ulcer.
•Reflux esophagitis.
•Zollinger – elision syndrome.
•Prevent and treat NSAID’s related to
gastric ulcer.
48. DRUG INTERACTIONS
•Proton pump inhibitor interfere with
the absorption of drugs
(Ketoconazole, iron and ampicillin)
that depends on gastric PH
absorption.
49. NURSING RESPONSIBILITIES
•Monitor the patient for diarrhea and
abdominal pain.
•Teach the patient to swallow capsule whole
and not to chew or crush them.
•Teach the patient to avoid gastric irritants,
such as smoking alcohol, aspirin containing
products, caffeine, NSAIDs and food that
causes irritation.
51. MECHANISM OF ACTION
•Antidiarrheals active opioids
receptor in G.I. tract to decrease
intestinal motility and to increase
the absorption of fluid and sodium
in the intestine.
52. DRUG EXAMPLE AND DOSES
S.
No.
Drugs Doses
1 Loperamide 2-4mg
2 Diphenoxylate 5-10mg
3 Octreotide 100-250 mcg TID
4 Polycarbophil ----
5 Bismuth subsalicylate 60 ml 6hourly suspension
53. INDICATIONS / USES
•To treat underlying cause of diarrhea.
•To control the relive symptoms of acute
and chronic diarrhea.
54. CONTRAINDICATION / PRECAUTIONS
•Contraindicated in abdominal pain of
unknown pathology.
•There is an increase risk of megacolon in
clients with inflammatory bowel
disorders. This could lead to a serious
complication such as perforation of
bowel.
57. NURSING RESPONSIBILITIES
• Assess for the abdominal pain and distension, nausea, vomiting,
and bowel sounds.
• Assess the patients skin turgor and monitor fluid and electrolyte
balance for evidence of dehydration resulting from diarrhea.
• Advise patient to avoid drinking plain water because it does not
content necessary electrolytes that have been loss in the stool.
• Advise clients to avoid caffeine. Caffeine exacerbate diarrhea by
increasing GI motility.
• Client with severe case of diarrhea may be hospitalized for
management of diarrhea.
• Know that high dose, long term use of defenoxin or
diphenoxylate may cause dependence.
58. Histamines (Histamine Receptors
Antagonist/H2 blockers)
•They are also called as H2 antagonists.
These agents block the action of
histamine, thus it reduce the amount of
acid released into the stomach. They also
promote ulcer healing.
59. MECHANISM OF ACTION
•They inhibit gastric acid secretion
by inhibiting the action of histamine
and histamine 2 receptors in gastric
parietal cells.
60. DRUG EXAMPLE AND DOSES
S.
No.
Drugs Doses
1 Cimetidine 400mg B.D.
2 Ranitidine 150mg twice daily.
3 Famotidine 20-40 mg.
4 Nizatidine 150 mg twice daily.
64. DRUG INTERACTIONS
•Antacids may inhibit absorption of H2
receptors antagonists.
•Cigarette smoking increases gastric acid
secretions and may decreases the
effectiveness of H2 receptors antagonists.
65. NURSING RESPONSIBILITIES
•Don’t give an antacid within 1 hour of
administration of H2 receptors antagonists it may
decrease the absorption.
•Teach the patients to avoid gastric irritants, such as
smoking alcohol aspirin containing products,
caffeine, NSAID’s and food that cause G.I. irritation.
•Teach the patient that smoking worsens ulcer
disorders and counteracts the effect of H2 blockers.
66. References
1. Dr. P.K. Panwar, Essentials of pharmacology for nurses,AITBS pub. 2017,
India, Pg no. 38 – 48.
2. Dr. Suresh k sharma, Textbook of pharmacology, pathology & genetics for
nurses, Jaypee pub. 2016 India Pg no 132 – 160.
3. Tara v. Shanbhag, Smita shenoy, Pharmacology preparation manual for
undergraduate, Elsevier pub. 2014. Pg no. 259 – 280.
4. Marilyn Herbert – Ashton, Nancy Clarkson, Pharmacology, Jones & Barllet
pub 2010 India, Pg no 527 – 550.
5. Govind s. mittal, Pharmacology at a glance, Paras medical book pub. 2009
India 35 – 40.
6. Madhuri Inamdar, Pharmacology in nursing, Vora medical pub. 2006 India
1st edition, Pg no 99 – 110.