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this presentation gives the knowledge about the decongestants are a type of medication that can provide short relief for a blocked nose ................
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Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
2.
Antitussives are drugs that suppress coughing,
possibly by reducing the activity of the cough
center in the brain.
Antitussive agents are used to relieve dry cough.
3.
Cough is protective reflex, its purpose being
expulsion of respiratory secretions or foreign
particles from the lungs and upper airway
passages.
7.
Codeine is an opioid (methylmorphine) with a
relatively limited analgesic effect; it does not
cause significant respiratory depressions but has
good antitussive properties.
Codeine raises the stimulus threshold of the
cough center and thus has a cough suppressing
effect.
8.
In most humans 10% of a codeine dose is
transformed to morphine through demethylation in
the liver. This explains the analgesic effect that is
absent in individuals with the respective genetic
traits.
9.
10.
Codeine sulfate is an opioid analgesic, related to
morphine, but with less potent analgesic properties.
Codeine is selective for the mu receptor, but with a much
weaker affinity than morphine. The analgesic properties
of codeine have been speculated to come from its
conversion to morphine, although the exact mechanism
of analgesic action remains unknown.
12.
Codeine is the cough medicine to which all other
antitussive drugs are compared.
Compared to placebos it has been demonstrated to
reduce coughing by 40% with a dose of 15 mg and by
60% with a dose of 60 mg.
Other opioids such as hydrocodon are likely to be even
stronger but they are also accompanied by much greater
risks (respiratory depression, dependence).
13.
Codeine is suitable for the treatment of mild and
moderate pain.
The analgesic action of 30 mg of codeine corresponds
approximately to 325-600 mg of paracetamol or aspirin.
Codeine can be combined advantageously with nonopioid analgesics. Aspirin (500 mg), paracetamol (500
mg), or other more recent non-steroidal antiinflammatory agents can be suitably combined with
codeine (30 mg). Such combinations can be used after
dental surgery or for tumor pains.
15.
The effect of codeine is increased by other drugs with
centrally suppressing effects (e.g. alcohol) and by the
enzyme inhibitor cimetidine.
Neuroleptic and antidepressive agents can competitively
inhibit the enzyme responsible for the analgesic effect of
codeine
16.
Expectorants are agents given orally to liquefy
respiratory secretions and allow for their easier removal.
Guaifenesin is the most commonly used expectorant. It
is available alone and as an ingredient in many
combination cough and cold remedies, although
research studies do not support its effectiveness and
many authorities do not recommend its use.
17. Other expectorants (hot beverages, potassium
iodide, and ipecac) stimulate production of watery
mucus.
18.
Guaifenesin is an expectorant, the action of which
promotes or facilitates the removal of secretions
from the respiratory tract.
19.
By increasing sputum volume and making sputum
less viscous, guaifenesin facilitates expectoration
of retained secretions.
22.
Temporarily relieves cough due to minor throat and
bronchial irritation as may occur with the common cold
or inhaled irritants.
Calms the cough control center and relieves coughing.
Helps loosen phlegm (mucus) and thin bronchial
secretions to rid the bronchial passageways of
bothersome mucus, drain bronchial tubes, and make
coughs more productive.
23.
Dizziness,
Headache and rash (including urticaria).
Rare drowsiness or mild gastrointestinal
disturbances are the only side effects associated
with extromethorphan in clinical use.
24.
Mucolytics are administered by inhalation to liquefy
mucus in the respiratory tract. Solutions of mucolytic
drugs may be nebulized into a face mask or mouthpiece
or instilled directly into the respiratory tract through a
tracheostomy.
Sodium chloride solution and acetylcysteine
(Mucomyst) are the only agents recommended for use
as mucolytics.
25.
Acetylcysteine is effective
within 1 minute after
inhalation, and maximal effects
occur within 5 to 10 minutes. It
is effective immediately after
direct instillation.
Oral acetylcysteine is widely
used in the treatment of
acetaminophen overdosage