This document discusses anti-diuretic drugs, which reduce urine volume by affecting the reabsorption of water in the kidney tubules. It describes how anti-diuretic hormone (ADH) acts on collecting duct cells in the kidney to increase water permeability and diffusion of water into the interstitum. Example drugs that are anti-diuretic include ADH and desmopressin, which are used to treat conditions like diabetes insipidus and nocturia. Nurses should monitor patients taking these drugs for electrolyte imbalances, vital signs, and signs of adverse effects like nasal irritation or fluid retention.

1. ANTI DIURETIC DRUGS
PRESENTED BY
ABHILASHA VERMA
LECTURER

2. DEFINITION
• Drugs that reduce urine volume.
• Specially used in condition like diabetes insipidus
(DI).
• Dehydration ADH release
• Over hydration ADH inhibited.
• Reduce urine flow by affecting re-absorption of water by
kidney tubule.
MODE OF ACTION

3. PHARMACOLOGICAL ACTION
( KIDNEY)
ADH acts on
Collecting Duct
Cells
Increase water
permeability
Luman water diffuse
into interstitum

4. PHARMACOLOGICAL ACTION
( KIDNEY)
V1 receptor
action of ADH
Constrict vasa
recta
Diminished blood
flow to inner
medulla
Prevent urine
formation

5. S.No. DRUGS DOSES
1. Anti diuretic hormone
( Vesopressine)
5-10 unit
IM/ SC
2. Desmopressin 100- 400 mcg Oral
1-4 mcg IV
DRUG EXAMPLE & DOSES

6. • Diabetes insipidus ( DI)
• Bed wetting (Primary Nocturnal enuresis)
• Nocturia associated with multiple sclerosis.
• Renal concentration test
• Hypersensitivity
• Impaired renal function
• With ongoing diuretic treatment.
• Cautiously in CVS disease, HTN, cystic fibrosis, pregnancy lactation,
fluid and electrolyte imbalance.
INDICATION
CONTRA INDICATION

7. • Nasal irritation
• Congestion
• Rhinitis
• Ulceration
• Belching
• Abdominal cramps
• Urge to defecate
• Fluid retention
• Backache in female due to uterine contraction
ADVERSE EFFECTS

8. • Monitor electrolyte imbalance.
• Monitor vital sign regularly.
• Observe for sign of hypersensitivity reaction.
• Monitor laboratory values.
NURSING RESPONSIBILITY