This document discusses compartment syndrome, which can occur in 75% of fractures and requires timely treatment to prevent serious complications. Compartment syndrome is a true orthopedic emergency where increased pressure in an anatomical space can reduce blood flow leading to tissue death. Measurement of compartment pressures is important and adequate analgesia, IV fluids, and urine output monitoring are needed. Fasciotomy surgery within 6 hours leads to almost complete recovery but delays over 12 hours significantly reduce limb function with risks of gangrene, contractures, and renal failure from rhabdomyolysis.