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TOCOPHEROL OR VITAMIN E
 It is also called anti-aging factor.
 The word tocopherol is derived from the word toco
meaning child birth and pheros meaning to bear.
 It is yellow oily liquid freely soluble in fat solvent.
 Tocopherol alpha, beta, gamma, lambda have been
obtained from the natural sources
VITAMIN E
ALPHATOCOPHEROL
ALPHATOCOTRIENOL
HO
O
HO
O
Tocopherols
HO
O
R1
R3
R2
CH3
CH3 CH3 CH3
CH3
R1 R2 R3 Relative activity
α – tocopherol CH3 CH3 CH3 1
β – tocopherol CH3 H CH3 0.4
γ – tocopherol H CH3 CH3 0.1 - 0.3
δ – tocopherol H H CH3 0.01
VITAMIN E (Tocopherols)
Alpha –tocopherol is the most active forms
SOURCES
 Cottonseed oil
 Corn oil
 Sunflower oil
 Wheat germ oil
 Margarine
 Green leafy
vegetables
RDA: 25-30 IU/day
Sources
 Vitamin E is synthesized only by plants.
 Plants foods (oils) provide primary
source
 α -tocopherol in leaves and other green
parts
 α -tocopherol in chloroplasts,
 β, γ, δ-tocopherols (nonchloroplasts) are
outside (soybeans)
 More vitamin E in green plants
 Different forms (α, β, γ, δ) , the most
active form is (α )
 Vit E is antioxidant for body fats (unsat
lipids), preserve RBC from hemolysis ,
control metabolism of (PUFA) such as
linoleic (18:2) and linolenic (18:3) .
 Daily req. 5 IU (infants) & 30 IU (adults)
.
11
ABSORPTION
 small intestine
 it enters the blood stream
via the lymph.
STORAGE  liver &
fatty tissue
EXCRETION  urine
1. Antioxidant role: Vitamin-E is the most potent
natural antioxidant.
2. Removal of Free radicals: Vitamin-E removes
free radicals, prevents their peroxidative
effects on unsaturated lipids of membrane and
thus maintains integrity of membranes.
3. Protective role: i. Vitamin-E prevents massive
hepatic necrosis produced on diet deficient in
sulphur containing aminoacids.
4. Role in reproduction: It is required for normal
reproduction, muscle integrity and for
resistance of erythrocytes to hemolysis.
5. Role in Heme Synthesis: Vitamin-E
also takes part in the synthesis of
heme. Vitamin-E induces enzymes
ALA-synthase and ALA-dehydratase.
6. A derivative of vitamin-E is said to be
necessary for the synthesis of CoQ which is
the component of mitochondrial electron
transport chain.
Functions of vitamin E
VITAMIN E
 Functions & mechanisms of action
 Antioxidant role
 Free radical termination
 Singlet molecular oxygen destruction
 Other roles
 Vitamin E & heart disease
 Vitamin E & eye health
 Other conditions
FUNCTIONS
 REPRODUCTIVE FUNCTION –
it has got protective effect on reproduction and
prevention of sterility.
 BLLOD FLOW AND CLOTTING MECHANISM –
it dilates the capillaries & enables the blood to
flow freely.
 ELECTRON TRANSPORT SYSTEM -
it functions as co factor in electron transport
system
Functions of vitamin E
22
 Men 8 – 10 mg
 Women 5 – 8 mg
 Children 8.3 mg
 Infants 4 – 5 mg
DEFICIENCY
 Muscular dystrophies
Nocturnal muscular cramps
Intermittent claudication
Fibrocystic Breast Disease
Atherosclerosis
 Hemolytic anemia- susceptibility of
RBCs to hemolysis
 Dietary hepatic necrosis
 Neurological disorders
Deficiency causes:
 Slow tissue healing
 Dry hair or loss of
hair
 Gastrointestinal
diseases
 Leg cramps
 Muscular weakness
DEFICIENCY
 REPRODUCTIVE – abortion of fetus in
females & atrophy of spermatogenic structure in
males leading to permanent sterility.
 HEART - there is necrosis & fibrosis of heart
muscle.
 BLOOD CAPILLARIES – may lead to
degenerative changes in the blood capillaries
ORAL MANIFESTATION –
 loss of pigmentation ,
 atrophic degenerative changes in enamel Of
vitamin E deficient rat
 MANAGEMENT –
vitamin E is given in the doses of 100 to
400mg.
Misuse
 No known toxicity up to 3200 IU, though it
should not be taken by those who are allergic
to vitamin E.
 It can elevate blood pressure when first taken,
so those with high blood pressure or heart
disease should not take more than 200 IU
 vitamin E may cause blood clots if
taken in doses above 800 lU/day.
 Symptoms are dizziness, and headaches. It may
also cause abdominal pain, diarrhea, fever,
chapped lips, muscle aches, nausea, upset
stomach, fatigue, weakness, and blurred vision,
though these are rare.
 Allergies can also occur when vitamin E is used
in skin preparations, but these are extremely rare.

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Vitamin E MUHAMMAD MUSTANSAR

  • 1. 1
  • 2. 2
  • 3. TOCOPHEROL OR VITAMIN E  It is also called anti-aging factor.  The word tocopherol is derived from the word toco meaning child birth and pheros meaning to bear.  It is yellow oily liquid freely soluble in fat solvent.  Tocopherol alpha, beta, gamma, lambda have been obtained from the natural sources
  • 4.
  • 6.
  • 7. Tocopherols HO O R1 R3 R2 CH3 CH3 CH3 CH3 CH3 R1 R2 R3 Relative activity α – tocopherol CH3 CH3 CH3 1 β – tocopherol CH3 H CH3 0.4 γ – tocopherol H CH3 CH3 0.1 - 0.3 δ – tocopherol H H CH3 0.01
  • 8. VITAMIN E (Tocopherols) Alpha –tocopherol is the most active forms SOURCES  Cottonseed oil  Corn oil  Sunflower oil  Wheat germ oil  Margarine  Green leafy vegetables RDA: 25-30 IU/day
  • 9. Sources  Vitamin E is synthesized only by plants.  Plants foods (oils) provide primary source  α -tocopherol in leaves and other green parts  α -tocopherol in chloroplasts,  β, γ, δ-tocopherols (nonchloroplasts) are outside (soybeans)  More vitamin E in green plants
  • 10.  Different forms (α, β, γ, δ) , the most active form is (α )  Vit E is antioxidant for body fats (unsat lipids), preserve RBC from hemolysis , control metabolism of (PUFA) such as linoleic (18:2) and linolenic (18:3) .  Daily req. 5 IU (infants) & 30 IU (adults) .
  • 11. 11 ABSORPTION  small intestine  it enters the blood stream via the lymph. STORAGE  liver & fatty tissue EXCRETION  urine
  • 12.
  • 13. 1. Antioxidant role: Vitamin-E is the most potent natural antioxidant. 2. Removal of Free radicals: Vitamin-E removes free radicals, prevents their peroxidative effects on unsaturated lipids of membrane and thus maintains integrity of membranes.
  • 14. 3. Protective role: i. Vitamin-E prevents massive hepatic necrosis produced on diet deficient in sulphur containing aminoacids. 4. Role in reproduction: It is required for normal reproduction, muscle integrity and for resistance of erythrocytes to hemolysis.
  • 15. 5. Role in Heme Synthesis: Vitamin-E also takes part in the synthesis of heme. Vitamin-E induces enzymes ALA-synthase and ALA-dehydratase.
  • 16. 6. A derivative of vitamin-E is said to be necessary for the synthesis of CoQ which is the component of mitochondrial electron transport chain.
  • 18. VITAMIN E  Functions & mechanisms of action  Antioxidant role  Free radical termination  Singlet molecular oxygen destruction  Other roles  Vitamin E & heart disease  Vitamin E & eye health  Other conditions
  • 19. FUNCTIONS  REPRODUCTIVE FUNCTION – it has got protective effect on reproduction and prevention of sterility.  BLLOD FLOW AND CLOTTING MECHANISM – it dilates the capillaries & enables the blood to flow freely.
  • 20.  ELECTRON TRANSPORT SYSTEM - it functions as co factor in electron transport system
  • 22. 22  Men 8 – 10 mg  Women 5 – 8 mg  Children 8.3 mg  Infants 4 – 5 mg
  • 23. DEFICIENCY  Muscular dystrophies Nocturnal muscular cramps Intermittent claudication Fibrocystic Breast Disease Atherosclerosis  Hemolytic anemia- susceptibility of RBCs to hemolysis  Dietary hepatic necrosis  Neurological disorders
  • 24. Deficiency causes:  Slow tissue healing  Dry hair or loss of hair  Gastrointestinal diseases  Leg cramps  Muscular weakness
  • 25. DEFICIENCY  REPRODUCTIVE – abortion of fetus in females & atrophy of spermatogenic structure in males leading to permanent sterility.  HEART - there is necrosis & fibrosis of heart muscle.  BLOOD CAPILLARIES – may lead to degenerative changes in the blood capillaries
  • 26. ORAL MANIFESTATION –  loss of pigmentation ,  atrophic degenerative changes in enamel Of vitamin E deficient rat  MANAGEMENT – vitamin E is given in the doses of 100 to 400mg.
  • 27. Misuse  No known toxicity up to 3200 IU, though it should not be taken by those who are allergic to vitamin E.  It can elevate blood pressure when first taken, so those with high blood pressure or heart disease should not take more than 200 IU  vitamin E may cause blood clots if taken in doses above 800 lU/day.
  • 28.  Symptoms are dizziness, and headaches. It may also cause abdominal pain, diarrhea, fever, chapped lips, muscle aches, nausea, upset stomach, fatigue, weakness, and blurred vision, though these are rare.  Allergies can also occur when vitamin E is used in skin preparations, but these are extremely rare.