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Subcutaneous mycoses
Subcutaneous mycoses are fungal infections that grow on soil or decaying vegetation. They must be introduced into subcutaneous tissue to cause disease. Lesions generally spread slowly from the area of implantation via lymphatics, except in cases of sporotrichosis where spread may be faster. Sporothrix schenckii is a dimorphic fungus that lives on plants or wood and causes sporotrichosis, a chronic granulomatous infection. Diagnosis involves culturing samples from lesions on Sabouraud's medium, where clusters of conidia indicate S. schenckii. Treatment includes oral antifungals like potassium iodide, amphotericin B, or ketocon
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Subcutaneous mycoses
- 1. SUBCUTANEOUS MYCOSES grow on soil or on decaying vegetation must be introduced into subcutaneous tissue in order to produce disease GENERALLY : lesions spread slowly from the area of implantation extension via lymphatics draining the lesion is slow (except in sporotrichosis) Thursday, January 19, 2012
- 2. SPOROTHRIX SCHENCKII dimorphic live on plants or wood causes sporotrichosis chronic granulomatous infection Thursday, January 19, 2012
- 3. SPOROTHRIX SCHENCKII DIAGNOSTICS: pus or biopsy from lesions as specimens culture on Saboraud’s with clusters of conidia = diagnostic converts to yeast form at 37C agglutination of yeast cell from sera = not diagnostic Thursday, January 19, 2012
- 4. SPOROTHRIX SCHENCKII TREATMENT: self-limited though chronic potassium iodide administered orally for weeks ampothericin B intravenously oral ketoconazole Thursday, January 19, 2012
- 5. CHROMOBLASTOMYCOSIS (Chomomycosis) slowly progressive granulomatous infection of skin caused by black molds Phialophora verrucosa, Fonsecaea pedrosoi, Rhinocladiella aquaspersa, Cladosporium carrionii Thursday, January 19, 2012
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- 10. CHROMOBLASTOMYCOSIS (Chomomycosis) DIAGNOSTICS: specimen: scrapings or biopsy from lesions microscopy: scrapings in 10% potassium hydroxide (dark, round fungus cells = sclerotic bodies diagnostic) culture in Saboraud’s and digests gelatin Thursday, January 19, 2012
- 11. CHROMOBLASTOMYCOSIS (Chomomycosis) TREATMENT: surgical excision with wide margins for small lesions chemotherapy with flucytosine or itraconazole for larger lesions locally applied heat may be beneficial relapse common Thursday, January 19, 2012