Experimental Epidemiology 1st Clinical trial Basic steps in RCT Randomization & its method Manipulation/ Intervention Types of RCT Phases in Clinical trial Hierarchy of epidemiological study

2. EPI DEMO LOGOS
Upon, on People, population, man the Study of
The study of anything that happens to
people
“That which befalls man”
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October 4, 1716 – July 13, 1794

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13

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Incidence of positive and negative results are compared in both
groups and differences if any are tested for statistical significance

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Firstly : Subject
Variation
on the part of
participants ,who
subjectively feel better
or report improvement
if they knew they were
receiving a new form
of treatment.
Secondly : Observer
Bias
Investigator measuring
outcome will be
influenced if he knows
before hand the
procedure or therapy
the patient has been
subjected to.
Thirdly : Bias In
Evaluation
Investigator
subconsciously
gives a favorable
report of the
outcome

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SINGLE
BLIND TRIAL
Participant is
not aware
whether he
belongs to study
or control group.
DOUBLE BLIND
TRIAL
Neither the doctor
nor participant is
aware of group
allocation and the
treatment received
TRIPLE BLIND
TRIAL
The participant,
the investigator
and the person
analyzing the
data are all
“blind”.

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24. Patients
Random Assignment Exposed to specific
Treatment
Unexposed to
specific treatment
Observation
Compare
Outcome
Compare
Outcome
Exposed and
Unexposed
to treatment
CONCURRENT PARALLEL STUDY DESIGN
CROSS-OVER TYPE OF STUDY DESIGN
Time
Patients
Random Assignment Exposed to
specific
Treatment
Unexposed to
specific treatment
Observation
Time 4/25/2020Dr. Animesh Gupta Epidemiology - RCT 24

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