why barbiturates has less therapeutic index than b hypnosis sedation barbiturates benzodiazipines sleep cycle sedative and hypnotic over view in brief drugs that produce sleep radiotherapy chemotherapy genetic defect in cancer mechanism of action of cisplatin cisplatin cancer toxicity study in animals oral toxicity study oral oecd organisation for economic co-orporation and develo oecd guidelines 425 423 421 401 420 toxicology study according to oecd guidelines blue card yellow card report of adverse drug reaction side effect reporting spontaneous repoting system adr reporting other approaches to treat cancer cancer pathology cancer treatment
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