The document provides an overview of MR Guided Focused Ultrasound (MRgFUS) and its present and future clinical research studies for various applications. It discusses how MRgFUS works using focused ultrasound to ablate tissue only at the focal point with MR guidance and thermometry for precise targeting and treatment monitoring. Current research studies described include pain palliation of bone metastases, breast cancer, and prostate cancer treatments. Preliminary results for bone metastases and breast cancer indicate reduced pain and high tumor necrosis. Future areas of research discussed include brain treatments and expanding applications to other organs.