Preparation of water for injection, preparation of injection of (a) procaine and adrenaline (b) procaine benzylpenicillin with benzylpenicillin; studies on the of formulation problems of vitamins with minerals; formulation of prolonged acting dosage forms
Ointments are semi-solid preparations intended for external application to the skin. They contain mostly oils and some water. Ointments are classified based on where they act - on the skin surface, penetrating the skin, or passing through the skin. The base used can be hydrocarbon, absorption, water-miscible, or water-soluble. The appropriate base depends on factors like the patient's skin condition and the drug's stability. Ointments are prepared by incorporation, fusion, or emulsification methods. They are evaluated based on penetration, drug release rate, absorption into blood, and irritancy. Ointments contain more oil and less water than creams, giving them a thicker consistency and longer moisture retention time.
This document discusses semisolid dosage forms in Ayurveda and modern medicine. [1] It defines semisolids as materials that retain shape when not confined but can deform or flow under pressure. [2] It describes various internal and external Ayurvedic semisolid forms like Rasakriya, Leha, and Lepa and their standard production procedures. [3] It also examines modern semisolid forms like ointments, pastes, and gels used externally and how rheology governs their consistency.
This document summarizes information about shampoos, including their introduction, requirements, classifications, types, mechanisms, compositions, formulations, evaluations, containers, specific examples, and references. Shampoos are preparations that use surfactants to remove dirt, grease, and debris from hair without harming the scalp. They are generally classified based on their base as soap-based or detergent-based shampoos. Common types include liquid, powder, lotion, cream, and aerosol shampoos. Shampoos are formulated with surfactants, conditioning agents, thickeners, preservatives, and other components to cleanse and condition hair while meeting various evaluation criteria.
This document provides an overview of pharmaceutical creams, including their definition, preparation methods, ingredients, and packaging. Creams are viscous emulsions for external use that can dissolve or suspend medicaments. They are classified as water-in-oil or oil-in-water depending on the emulsifying agent. Proper bases must be selected based on the intended use and stability of active ingredients. Creams are prepared through emulsification and incorporation processes and packaged in containers like jars or tubes with a typical discard date of 4 weeks.
This document provides an overview of pharmaceutical emulsions. It defines emulsions as dispersions of one liquid in another immiscible liquid, stabilized by an emulsifying agent. The key topics covered include the classification of emulsions as oil-in-water or water-in-oil, theories of emulsification, common emulsifying agents like surfactants and hydrocolloids, and factors affecting the stability of emulsions such as flocculation and creaming. Pharmaceutical applications of emulsions include lotions, creams, and ointments.
Semisolid dosage forms are neither solid nor liquid, however, they are a combination or mixture of both, and they used for both local and systemic effects. Pharmaceutical semisolid dosage forms such as creams, ointments, gels, suppositories, and paste are used for topical application. Semisolid dosage forms are intended used as drug carriers that are transported topically through the skin, buckle tissue, rectal tissue, outer ear lining nasal mucosa, urethral membrane, vagina, and cornea. The semisolid may adhere adequately before washing on the surface of the application; this helps to extend the supply of drugs on the application site.
This document discusses the formulation and evaluation of various cosmetic products. It begins by defining cosmetics and their classification. It then covers formulations for different types of creams, lotions, powders and color cosmetics like lipsticks and rouges. Specific formulations are provided for products like cleansing cream, cold cream, sunscreen lotion, face powder, lipstick etc. along with ideal properties and ingredients for each type of cosmetic.
The document discusses creams as a semisolid dosage form containing drug substances dispersed or dissolved in a suitable base. It defines oil-in-water and water-in-oil creams and provides examples of each. The key steps in cream preparation and various tests to characterize creams are described, including determining type of emulsion, viscosity, pH, globule size, stability, and spreadability. Creams offer advantages over other semisolid forms like being less greasy and more easily washed off.
Ointments are semi-solid preparations intended for external application to the skin. They contain mostly oils and some water. Ointments are classified based on where they act - on the skin surface, penetrating the skin, or passing through the skin. The base used can be hydrocarbon, absorption, water-miscible, or water-soluble. The appropriate base depends on factors like the patient's skin condition and the drug's stability. Ointments are prepared by incorporation, fusion, or emulsification methods. They are evaluated based on penetration, drug release rate, absorption into blood, and irritancy. Ointments contain more oil and less water than creams, giving them a thicker consistency and longer moisture retention time.
This document discusses semisolid dosage forms in Ayurveda and modern medicine. [1] It defines semisolids as materials that retain shape when not confined but can deform or flow under pressure. [2] It describes various internal and external Ayurvedic semisolid forms like Rasakriya, Leha, and Lepa and their standard production procedures. [3] It also examines modern semisolid forms like ointments, pastes, and gels used externally and how rheology governs their consistency.
This document summarizes information about shampoos, including their introduction, requirements, classifications, types, mechanisms, compositions, formulations, evaluations, containers, specific examples, and references. Shampoos are preparations that use surfactants to remove dirt, grease, and debris from hair without harming the scalp. They are generally classified based on their base as soap-based or detergent-based shampoos. Common types include liquid, powder, lotion, cream, and aerosol shampoos. Shampoos are formulated with surfactants, conditioning agents, thickeners, preservatives, and other components to cleanse and condition hair while meeting various evaluation criteria.
This document provides an overview of pharmaceutical creams, including their definition, preparation methods, ingredients, and packaging. Creams are viscous emulsions for external use that can dissolve or suspend medicaments. They are classified as water-in-oil or oil-in-water depending on the emulsifying agent. Proper bases must be selected based on the intended use and stability of active ingredients. Creams are prepared through emulsification and incorporation processes and packaged in containers like jars or tubes with a typical discard date of 4 weeks.
This document provides an overview of pharmaceutical emulsions. It defines emulsions as dispersions of one liquid in another immiscible liquid, stabilized by an emulsifying agent. The key topics covered include the classification of emulsions as oil-in-water or water-in-oil, theories of emulsification, common emulsifying agents like surfactants and hydrocolloids, and factors affecting the stability of emulsions such as flocculation and creaming. Pharmaceutical applications of emulsions include lotions, creams, and ointments.
Semisolid dosage forms are neither solid nor liquid, however, they are a combination or mixture of both, and they used for both local and systemic effects. Pharmaceutical semisolid dosage forms such as creams, ointments, gels, suppositories, and paste are used for topical application. Semisolid dosage forms are intended used as drug carriers that are transported topically through the skin, buckle tissue, rectal tissue, outer ear lining nasal mucosa, urethral membrane, vagina, and cornea. The semisolid may adhere adequately before washing on the surface of the application; this helps to extend the supply of drugs on the application site.
This document discusses the formulation and evaluation of various cosmetic products. It begins by defining cosmetics and their classification. It then covers formulations for different types of creams, lotions, powders and color cosmetics like lipsticks and rouges. Specific formulations are provided for products like cleansing cream, cold cream, sunscreen lotion, face powder, lipstick etc. along with ideal properties and ingredients for each type of cosmetic.
The document discusses creams as a semisolid dosage form containing drug substances dispersed or dissolved in a suitable base. It defines oil-in-water and water-in-oil creams and provides examples of each. The key steps in cream preparation and various tests to characterize creams are described, including determining type of emulsion, viscosity, pH, globule size, stability, and spreadability. Creams offer advantages over other semisolid forms like being less greasy and more easily washed off.
This document discusses pharmaceutical creams. It defines what a cream is and describes the anatomy of skin. It outlines different types of creams including cleansing, vanishing, foundation, night, massage, hand, body, and all-purpose creams. It discusses the components and manufacturing processes of creams and provides examples of formulations. Finally, it covers the uses of creams and some novel advances in cream technology.
Toothpaste is a paste or gel used to clean and maintain oral hygiene. It removes plaque and food from teeth, reduces bad breath, and delivers active ingredients to prevent cavities and gum disease. The document outlines the essential qualities of toothpaste including consistency, viscosity, pH, taste, and stability. It then lists the main ingredients - chalk powder as an abrasive to remove debris, soap as a foaming agent, and flavoring agents. A formula is provided using calcium carbonate, sodium lauryl sulphate, glycerin, acacia, saccharine, water, and flavoring. The procedure describes mixing the ingredients together with heat and agitation and then filling the paste into tubes.
This document provides information about semisolid dosage forms such as ointments, pastes, and jellies. It defines semisolids as topical dosage forms used for therapeutic, protective, or cosmetic purposes. The key ingredients in semisolids include a base, preservatives, humectants, antioxidants, emulsifiers, gelling agents, permeation enhancers, and buffers. The document discusses the ideal properties of bases and lists common bases such as petrolatum, lanolin, and polyethylene glycol. It also covers the advantages and disadvantages of semisolid dosage forms.
This document discusses classical dosage forms, which are conventional dosage forms prepared without advanced techniques. It describes lozenges as medicated candies dissolved in the mouth to soothe throat irritation. Pills are small, round solids containing medication. Cachets enclose medication within a wafer shell. Draughts are single-dose liquid preparations packaged in larger volumes. Suppositories and pessaries are solid medications inserted into orifices to exert local or systemic effects as they dissolve.
THIS PRESENTATION IS TO GIVE AN INFO ABOUT LIPSTICKS .... IT WAS CATEGORISED AS A COSMETIC PRODUCT FOR 3RD BPHARM STUDENTS IN THE 5TH SEMESTER. THIS PRESENTATION WILL HELP THEM AS A FASTRACK REFERENCE FOR EXAMS AND ALSO FOR COMPETITIVE EXAMINATIONS..
Cold Cream & Vanishing Cream Assignement (Industrial Pharmacy)RAHUL PAL
Cold creams are oil-in-water or water-in-oil emulsions used to provide smoothness to the skin and remove makeup. They should have low sensitization, be elegant, non-dehydrating, non-greasy, non-staining, and miscible with skin secretions. A typical cold cream contains beeswax, mineral oil, water, and borax. It is prepared by melting the beeswax and mixing it with the oils, then slowly adding the aqueous solution containing water and borax with stirring.
Vanishing creams, also known as day creams, provide emollient and protective effects. They are used to hold powder and improve adhesion. A vanishing cream
This document provides an overview of semi-solid dosage forms such as ointments, creams, pastes, and gels. It discusses their ideal properties and examples. It also describes the basic introduction, ingredients used in preparation including bases, preservatives, emulsifiers, and gelling agents. Methods of preparation like trituration, fusion, and emulsification are covered. The preparation of oil and aqueous phases and mixing of phases is explained. Finally, the document discusses the storage conditions and references for semi-solid dosage forms.
This document provides information on lipstick, including its definition, characteristics, composition, manufacturing process, potential defects, and evaluation methods. Lipstick is defined as a dispersion of coloring matter in a base of oils, fats, and waxes molded into a stick. It aims to impart attractive color and gloss to lips while preventing drying and cracking. The composition includes waxes, oils, coloring agents, preservatives, and fragrances. Potential defects include sweating, bleeding, and streaking. Lipstick is evaluated based on color consistency, melting point, softening point, microbial contamination, rancidity, breaking load, and rupture strength.
Pharmaceutical packaging serves several important functions: product identification, protection, promotion, and facilitating use. There are three main types of packaging - primary, secondary, and tertiary. Common materials used include glass, plastics, rubber, paper/cardboard, and metals. The choice of material depends on the level of protection needed, compatibility with dosage form, customer convenience, and cost. Glass, plastic, and metal are widely used with glass providing good protection but being fragile while plastic is flexible and resistant to breakage. Proper packaging helps ensure the safety, efficacy and quality of pharmaceutical products.
This document provides information about semisolid dosage forms such as ointments, pastes, creams, and gels. It defines these terms and discusses the anatomy of skin, factors affecting drug penetration through skin, and formulation and evaluation of semisolid dosage forms. The document covers the stratum corneum as the major barrier to drug penetration, routes of penetration, and biological and physicochemical factors influencing penetration. It also describes various ointment bases including oleaginous, absorption, emulsion, and water soluble bases and provides examples of each.
This document discusses stability factors and applications of pharmaceutical suspensions. It notes that small particle size, increasing viscosity, and maintaining optimal temperature contribute to suspension stability. Suspensions are used for insoluble drugs, to improve drug stability, and to mask unpleasant tastes. Key factors for stability include particle size, viscosity, temperature, surfactants, hydrophilic colloids, solvents, and proper mixing procedures.
This document provides information about pharmaceutical suspensions. It begins by defining a suspension as a disperse system where an insoluble solid internal phase is uniformly dispersed throughout an external liquid phase. Particle size is important for suspensions to be classified as coarse or colloidal. Suspensions differ from solutions in that particles remain dispersed rather than dissolving. Sedimentation occurs over time due to particle size and density. Suspending agents are added to prevent sedimentation by increasing viscosity. The document discusses formulation, applications, advantages, and disadvantages of suspensions.
Semisolid dosage form (paste, jellies, and poulties)Anil Deore
This document provides information about pastes as a semisolid dosage form for external application to the skin. It defines pastes and discusses their composition, preparation methods, storage, and differences from ointments. Pastes typically contain a large amount of solids and are thick and stiff formulations that form a protective coating when applied. They are prepared using methods like trituration and fusion that are also used to make ointments. The document also provides brief descriptions of jellies and poultices as other external semisolid dosage forms.
Suspension is made of two phase system, consisting of a finely divided solid particles (Dispersed phase) distributed in a particular manner throughout another medium (Continuous phase).
This document provides information about syrups and elixirs. It defines syrups as concentrated aqueous preparations containing sugar or sugar substitutes with or without flavoring agents and medicinal substances. Elixirs are sweetened, flavored, hydro-alcoholic solutions for oral use. The document discusses the types, components, preparation, and examples of both syrups and elixirs. It also provides a brief comparison of the key differences between syrups and elixirs.
This document defines creams and their types, describes their ideal properties and formulation methods. It discusses advantages and disadvantages of creams for drug delivery. Specifically, it outlines the two main types of creams - oil-in-water and water-in-oil. It also describes different cream formulations like cleansing creams, cold creams, vanishing/foundation creams, and all-purpose/sports creams. Evaluation methods for creams are provided at the end.
Cold creams are oil-in-water emulsions used to smooth skin and remove makeup. They produce a cooling effect due to the slow evaporation of water. Common ingredients include beeswax, mineral oils, and scents. Cold creams were traditionally made from animal fats but now use vegetable and mineral oils. When applied, the emulsion inverts from oil-in-water to water-in-oil. Cleansing creams are similar but contain detergents to clean the skin by removing dirt, oil, and dead cells in addition to makeup. Vanishing creams are oil-in-water emulsions that leave a thin, almost invisible layer of stearic acid on the skin.
The document discusses theories of emulsification including definitions, methods of preparation, factors affecting stability, and mechanisms of emulsification. Specifically, it describes three methods for preparing emulsions: the continental/dry gum method, English/wet gum method, and bottle/Forbes bottle method. It also outlines physical instability markers like flocculation, creaming, coalescence, and breaking as well as the concept of phase inversion in emulsions. Various emulsifying agents are discussed including their mechanisms of action through monomolecular adsorption and film formation, multimolecular adsorption, or solid particle adsorption.
B. Pharm. (Honours) Part-IV Practical, Pharmaceutical technology-III, MANIKImran Nur Manik
5. Pharmaceutical Technology-III: (Marks-35)
Preparation of water for injection, preparation of injection of (a) procaine and adrenaline (b) procaine benzylpenicillin with benzylpenicillin; studies on the of formulation problems of vitamins with minerals; formulation of prolonged acting dosage forms.
Introduction: OINTMENTS ARE SEMISOLID PREPARATION INTENDED FOR EXTERNAL APPLICATION TO SKIN AND MUCOUS MEMBRANE
Ideal Property: It should be non-irritating.
It should be non-dehydrating.
It should be non-greasy.
It should be inert and compatible with medicaments.
It should be stable.
It should be easily removable with water.
It should be able to absorb water and/or other liquids
It should be able to release medicament efficiently.
It should not interfere with skin functions.
It should be compatible with skin functions.
It should be non-hygroscopic
Classification of Ointment Bases: oleaginous, oily, or hydrophobic bases.
Absorption bases.
Emulsion bases.
Water-soluble bases.
Method of Preparation: Mechanical Incorporation Method.
Fusion Method.
Chemical reaction method.
Emulsification Method
This document discusses pharmaceutical creams. It defines what a cream is and describes the anatomy of skin. It outlines different types of creams including cleansing, vanishing, foundation, night, massage, hand, body, and all-purpose creams. It discusses the components and manufacturing processes of creams and provides examples of formulations. Finally, it covers the uses of creams and some novel advances in cream technology.
Toothpaste is a paste or gel used to clean and maintain oral hygiene. It removes plaque and food from teeth, reduces bad breath, and delivers active ingredients to prevent cavities and gum disease. The document outlines the essential qualities of toothpaste including consistency, viscosity, pH, taste, and stability. It then lists the main ingredients - chalk powder as an abrasive to remove debris, soap as a foaming agent, and flavoring agents. A formula is provided using calcium carbonate, sodium lauryl sulphate, glycerin, acacia, saccharine, water, and flavoring. The procedure describes mixing the ingredients together with heat and agitation and then filling the paste into tubes.
This document provides information about semisolid dosage forms such as ointments, pastes, and jellies. It defines semisolids as topical dosage forms used for therapeutic, protective, or cosmetic purposes. The key ingredients in semisolids include a base, preservatives, humectants, antioxidants, emulsifiers, gelling agents, permeation enhancers, and buffers. The document discusses the ideal properties of bases and lists common bases such as petrolatum, lanolin, and polyethylene glycol. It also covers the advantages and disadvantages of semisolid dosage forms.
This document discusses classical dosage forms, which are conventional dosage forms prepared without advanced techniques. It describes lozenges as medicated candies dissolved in the mouth to soothe throat irritation. Pills are small, round solids containing medication. Cachets enclose medication within a wafer shell. Draughts are single-dose liquid preparations packaged in larger volumes. Suppositories and pessaries are solid medications inserted into orifices to exert local or systemic effects as they dissolve.
THIS PRESENTATION IS TO GIVE AN INFO ABOUT LIPSTICKS .... IT WAS CATEGORISED AS A COSMETIC PRODUCT FOR 3RD BPHARM STUDENTS IN THE 5TH SEMESTER. THIS PRESENTATION WILL HELP THEM AS A FASTRACK REFERENCE FOR EXAMS AND ALSO FOR COMPETITIVE EXAMINATIONS..
Cold Cream & Vanishing Cream Assignement (Industrial Pharmacy)RAHUL PAL
Cold creams are oil-in-water or water-in-oil emulsions used to provide smoothness to the skin and remove makeup. They should have low sensitization, be elegant, non-dehydrating, non-greasy, non-staining, and miscible with skin secretions. A typical cold cream contains beeswax, mineral oil, water, and borax. It is prepared by melting the beeswax and mixing it with the oils, then slowly adding the aqueous solution containing water and borax with stirring.
Vanishing creams, also known as day creams, provide emollient and protective effects. They are used to hold powder and improve adhesion. A vanishing cream
This document provides an overview of semi-solid dosage forms such as ointments, creams, pastes, and gels. It discusses their ideal properties and examples. It also describes the basic introduction, ingredients used in preparation including bases, preservatives, emulsifiers, and gelling agents. Methods of preparation like trituration, fusion, and emulsification are covered. The preparation of oil and aqueous phases and mixing of phases is explained. Finally, the document discusses the storage conditions and references for semi-solid dosage forms.
This document provides information on lipstick, including its definition, characteristics, composition, manufacturing process, potential defects, and evaluation methods. Lipstick is defined as a dispersion of coloring matter in a base of oils, fats, and waxes molded into a stick. It aims to impart attractive color and gloss to lips while preventing drying and cracking. The composition includes waxes, oils, coloring agents, preservatives, and fragrances. Potential defects include sweating, bleeding, and streaking. Lipstick is evaluated based on color consistency, melting point, softening point, microbial contamination, rancidity, breaking load, and rupture strength.
Pharmaceutical packaging serves several important functions: product identification, protection, promotion, and facilitating use. There are three main types of packaging - primary, secondary, and tertiary. Common materials used include glass, plastics, rubber, paper/cardboard, and metals. The choice of material depends on the level of protection needed, compatibility with dosage form, customer convenience, and cost. Glass, plastic, and metal are widely used with glass providing good protection but being fragile while plastic is flexible and resistant to breakage. Proper packaging helps ensure the safety, efficacy and quality of pharmaceutical products.
This document provides information about semisolid dosage forms such as ointments, pastes, creams, and gels. It defines these terms and discusses the anatomy of skin, factors affecting drug penetration through skin, and formulation and evaluation of semisolid dosage forms. The document covers the stratum corneum as the major barrier to drug penetration, routes of penetration, and biological and physicochemical factors influencing penetration. It also describes various ointment bases including oleaginous, absorption, emulsion, and water soluble bases and provides examples of each.
This document discusses stability factors and applications of pharmaceutical suspensions. It notes that small particle size, increasing viscosity, and maintaining optimal temperature contribute to suspension stability. Suspensions are used for insoluble drugs, to improve drug stability, and to mask unpleasant tastes. Key factors for stability include particle size, viscosity, temperature, surfactants, hydrophilic colloids, solvents, and proper mixing procedures.
This document provides information about pharmaceutical suspensions. It begins by defining a suspension as a disperse system where an insoluble solid internal phase is uniformly dispersed throughout an external liquid phase. Particle size is important for suspensions to be classified as coarse or colloidal. Suspensions differ from solutions in that particles remain dispersed rather than dissolving. Sedimentation occurs over time due to particle size and density. Suspending agents are added to prevent sedimentation by increasing viscosity. The document discusses formulation, applications, advantages, and disadvantages of suspensions.
Semisolid dosage form (paste, jellies, and poulties)Anil Deore
This document provides information about pastes as a semisolid dosage form for external application to the skin. It defines pastes and discusses their composition, preparation methods, storage, and differences from ointments. Pastes typically contain a large amount of solids and are thick and stiff formulations that form a protective coating when applied. They are prepared using methods like trituration and fusion that are also used to make ointments. The document also provides brief descriptions of jellies and poultices as other external semisolid dosage forms.
Suspension is made of two phase system, consisting of a finely divided solid particles (Dispersed phase) distributed in a particular manner throughout another medium (Continuous phase).
This document provides information about syrups and elixirs. It defines syrups as concentrated aqueous preparations containing sugar or sugar substitutes with or without flavoring agents and medicinal substances. Elixirs are sweetened, flavored, hydro-alcoholic solutions for oral use. The document discusses the types, components, preparation, and examples of both syrups and elixirs. It also provides a brief comparison of the key differences between syrups and elixirs.
This document defines creams and their types, describes their ideal properties and formulation methods. It discusses advantages and disadvantages of creams for drug delivery. Specifically, it outlines the two main types of creams - oil-in-water and water-in-oil. It also describes different cream formulations like cleansing creams, cold creams, vanishing/foundation creams, and all-purpose/sports creams. Evaluation methods for creams are provided at the end.
Cold creams are oil-in-water emulsions used to smooth skin and remove makeup. They produce a cooling effect due to the slow evaporation of water. Common ingredients include beeswax, mineral oils, and scents. Cold creams were traditionally made from animal fats but now use vegetable and mineral oils. When applied, the emulsion inverts from oil-in-water to water-in-oil. Cleansing creams are similar but contain detergents to clean the skin by removing dirt, oil, and dead cells in addition to makeup. Vanishing creams are oil-in-water emulsions that leave a thin, almost invisible layer of stearic acid on the skin.
The document discusses theories of emulsification including definitions, methods of preparation, factors affecting stability, and mechanisms of emulsification. Specifically, it describes three methods for preparing emulsions: the continental/dry gum method, English/wet gum method, and bottle/Forbes bottle method. It also outlines physical instability markers like flocculation, creaming, coalescence, and breaking as well as the concept of phase inversion in emulsions. Various emulsifying agents are discussed including their mechanisms of action through monomolecular adsorption and film formation, multimolecular adsorption, or solid particle adsorption.
B. Pharm. (Honours) Part-IV Practical, Pharmaceutical technology-III, MANIKImran Nur Manik
5. Pharmaceutical Technology-III: (Marks-35)
Preparation of water for injection, preparation of injection of (a) procaine and adrenaline (b) procaine benzylpenicillin with benzylpenicillin; studies on the of formulation problems of vitamins with minerals; formulation of prolonged acting dosage forms.
Introduction: OINTMENTS ARE SEMISOLID PREPARATION INTENDED FOR EXTERNAL APPLICATION TO SKIN AND MUCOUS MEMBRANE
Ideal Property: It should be non-irritating.
It should be non-dehydrating.
It should be non-greasy.
It should be inert and compatible with medicaments.
It should be stable.
It should be easily removable with water.
It should be able to absorb water and/or other liquids
It should be able to release medicament efficiently.
It should not interfere with skin functions.
It should be compatible with skin functions.
It should be non-hygroscopic
Classification of Ointment Bases: oleaginous, oily, or hydrophobic bases.
Absorption bases.
Emulsion bases.
Water-soluble bases.
Method of Preparation: Mechanical Incorporation Method.
Fusion Method.
Chemical reaction method.
Emulsification Method
This document provides information on principles of formulation and building blocks of skin care products. It discusses different types of creams like vanishing cream, cold cream, moisturizing cream and their functions, chemical composition, common advantages and examples. It also covers cleansers, face washes, antiperspirants, deodorants and their formulations, mechanisms of action, and applications. The key components of most skin care products are discussed in detail including creams, oils, emulsifiers, preservatives and more.
Review on cream as topical drug delivery system.pptm SiddhantHagavane
The document reviews cream as a topical drug delivery system. Creams have advantages like being easy to apply and not showing side effects on other organs, but also disadvantages like possible skin irritation and allergic reactions. Creams are classified by function, properties, and emulsion type, and are commonly used as makeup, cleansing, moisturizing products. General ingredients include oils, waxes, preservatives, and vitamins. Creams are prepared using methods like heating oil and water phases separately before combining. They are evaluated based on attributes such as pH, spreadability, and viscosity. Applications include skin softening, cooling, and acting as antiseptics or antifungals.
This document discusses ointments, including their functions, bases, and methods of preparation. It provides definitions and characteristics of an ideal ointment base. The main types of ointment bases are hydrocarbon, absorption, water-removable, and water-soluble bases. Ointments are prepared using methods like fusion, trituration, chemical reaction, and emulsification. Key factors in selecting an ointment base include dermatological and pharmaceutical considerations. The document outlines the various ointment base types and provides examples of common ointment formulations.
Cold cream b pharm sem 6 industrial pharmacy.pptxNidhi Joshi
This document provides information about cold creams, including their ideal characteristics, common ingredients, preparation methods, and evaluation tests. Cold creams are water-in-oil emulsions that produce a cooling sensation and act as a moisturizer. They should have a smooth texture and not be sticky, dirty, or cause irritation. Common ingredients include emollients like oils, emulsifiers like borax, and humectants like glycerin. Preparation involves melting and combining the oil and wax phases with the water phase. Evaluation tests assess organoleptic properties, spreadability, viscosity, and potential for irritation or microbial growth.
This document provides information about cold creams, including their ideal characteristics, common ingredients, preparation methods, and evaluation tests. Cold creams are water-in-oil emulsions that produce a cooling sensation and act as a moisturizer. They should have a smooth texture and not be sticky, dirty, or cause skin irritation. Common ingredients include emollients like oils, emulsifiers like borax, and humectants like glycerin. Preparation involves melting and combining the oil and wax phases with the water phase. Evaluation tests assess organoleptic properties, spreadability, viscosity, and potential for irritation.
This document provides information about emulsions, including:
- An emulsion is a biphasic liquid with two immiscible liquids made miscible through an emulsifying agent.
- Common types are oil-in-water and water-in-oil emulsions. Emulsifying agents lower the interfacial tension between the phases.
- Factors that affect emulsion stability include phase volume, electrolyte concentration, and temperature during storage. Stability can be compromised through processes like creaming, cracking, or phase inversion.
This document discusses skin creams and their classification. It provides a brief history of skin care preparations dating back to antiquity. Modern creams are typically emulsion-based and can range in consistency from liquid to solid. Creams are classified by function, with some of the main types being cleansing/cold creams, foundation/vanishing creams, and hand/body creams. The document also provides several formulations for beeswax-borax cold creams and liquefying cleansing creams.
Cosmetics are substances used to enhance one's appearance. This document discusses formulations for several common cosmetic products including lipsticks, shampoos, cold cream, vanishing cream, toothpastes, and hair dyes. It provides details on the ingredients, preparation methods, and evaluation of these products. The key components of lipsticks are oils, waxes, pigments and solvents which are mixed together and molded. Shampoos contain detergents, conditioning agents, and thickeners. Creams are oil-in-water or water-in-oil emulsions containing emollients, preservatives, and other additives. Toothpastes and hair dyes aim to clean
This document discusses ointments and their characteristics. It describes the different types of ointment bases including oleaginous, absorption, water-removable emulsion, and water soluble bases. It explains how ointments are classified based on their therapeutic properties and penetration of the skin. The document also outlines methods for preparing ointments and some common ointment bases such as petrolatum, lanolin, and polyethylene glycol polymers.
This document discusses the manufacturing of sterile ointments, specifically for ophthalmic use. It provides details on ointment formulation considerations including the need for sterility, appropriate preservatives and bases. The document describes various ointment bases like hydrocarbon, absorption, water miscible and water soluble bases. It outlines the specific steps for manufacturing an ophthalmic ointment under aseptic conditions including melting and filtering ingredients and filling into sterile containers. Key evaluation tests for the sterile ointment are also summarized such as sterility testing, identification of active ingredients and assay to check drug content.
This document provides information on creams as a semisolid dosage form. It begins by defining creams and describing the two main types: oil-in-water (O/W) and water-in-oil (W/O) emulsions. The uses and manufacturing process of creams are then outlined. The document also includes details on specific types of creams, formulations, quality control testing using vertical diffusion cell methods, and concludes with a case study example of a betamethasone cream.
The document discusses various types of cosmetic products like face powders, lipsticks, nail polishes, hair dyes, and shampoos. It provides details on the formulation, ingredients, and functions of these cosmetics. The document also covers topics like hair removal methods, treatment of dandruff, and the causes and control of dandruff.
This document discusses different types of creams and their formulation and preparation methods. It begins with introducing creams as semisolid emulsions for topical application containing one or more drug substances. The main types are oily/oil-in-water creams and aqueous/water-in-oil creams. It then covers the purposes of creams, common ingredients in formulations, quality control testing methods like vertical diffusion cell testing, and provides an example formulation for betamethasone cream. The document aims to provide information on creams for pharmaceutical applications.
Formulation and preparation of cold cream and vanishing creamSoumiliPaul1
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Cold cream , vanishing cream , IDEAL PROPERTIES OF VANISHING CREAMS , MAJOR INGREDIENTS USED FOR THE PRODUCTION OF VANISHING CREAMS , FORMULATION OF VANISHING CREAM , IDEAL CHARACTERISTICS OF COLD CREAM , INGREDIENTS USED FOR PREPARATION OF COLD CREAM , FORMULATION OF COLD CREAM
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Pharmaceutical technology III (Practical) MANIK
1. 1
INDEX
Sl. No. Date Name of the experiment Page No.
01 15.02.12 Preparation of cold cream. 2 – 5
02 15.02.12 Preparation of vanishing cream. 6 – 8
03 15.02.12 Preparation of shaving cream. 9 – 12
2. 2
Experiment No. 01 Date: 15.02.12
Name of the experiment: Preparation of cold cream.
Introduction:
Cold cream is a perfect semisolid water in oil w/o type emulsion. In cold cream, the
main ingredient is oil. It is also referred to as beeswax-borax emulsion.
In cold cream, 1-4% water is dispersed at 96-99% of oil. When it is applied to skin, cream
is readily absorb and produces a feeling of coolness.
In winter season, water evaporates from the skin. So, skin becomes dry and rough. Cold
cream gives an oily protective covering over the skin and consequently water cannot
evaporate out.
Formula of cold cream:
Ingredients Theoretical content Weighed content
1. Beeswax 24.5 gm
2. Liquid paraffin 56 ml
3. Borax 0.5 gm
4. Glycerin 4.28 ml
5. Distilled water 14 ml
6. Methyl paraben 0.2 gm
7. Propyl paraben 0.02 gm
8. Perfume 0.5 ml
9. Tween-80 0.5 ml
Ideal characteristics of cold cream:
1. The pH of the cold cream must be optimum for maintaining the normal pH of the
skin. It should be 4.6–6.
2. Its consistency should be optimum, so that it can be put out easily from the container
and apply easily.
3. There should have no oily appearance of cream and should give cooling effect on skin
after application.
4. It must provide a waxy protective layer on skin to protect the water evaporation.
5. It should give faster emollient effect, so that very dry skin can swell up and become
soft within short time.
6. It should be easily spread on skin.
7. It should be free from gritty particles.
8. It should be nonirritant and nontoxic.
9. It should be attractive in appearance.
10. It should be physically and chemically stable throughout its shelf-life.
11. The additives should be compatible with each other.
3. 3
Function of ingredients:
1. Beeswax: Beeswax is an important factor in determining quality of the cream. It is the
basic raw material of natural origin. It consists of:
a. Approximately 71% esters of wax acid
b. Approximately 10.5–13.5% hydrocarbon
c. Approximately 13.5–14.5% free wax acid
d. 1–1.25% free higher alcohol
e. Cholesterol esters of fatty acid
Purpose of beeswax:
i. It does not develop rancidity.
ii. It has no irritant or sensitizing activity.
iii. It produces good odour in final product.
iv. It generally forms a soft emulsion.
2. Liquid paraffin: It is a hydrocarbon. It is oily in nature and constitutes the oil phase
of cold cream.
3. Borax Na2B4O7 . 10H2O: It is a salt that act as an emulsifying agent. It gives an
opaque or white appearance to the preparation and also used for its antiseptic property.
4. Glycerin: It is a hygroscopic substance. It acts as humectants and maintains water
content of the preparation. It provides a protective layer on the skin and also helps in
smoothing the skin.
5. Perfume: It is essential for cold cream. It should be mildly perfumed so that, it
imparts light perfume to the final product. Generally flower fragrances like rose, jasmine,
labendar are mainly used.
6. Water: It constitutes the water phase of cold cream. It must be distilled, free from
large amount of electrolytes such as Na+
, K+
, Ca2+
etc.
7. Other additives: These are used to increase the stability, quality and other properties
of cold cream. These are given below:
a. Antioxidant: It should be used because of the presence of oil phase. Oil phase is
very susceptible to oxidation by atmospheric oxygen, become rancid and produce
bad odour to the preparation. Some examples of antioxidant are BHT, BHA,
ascorbic acid, tocopherol etc. The usual range is 0.01–0.03%.
b. Preservative: It is used to prevent the bacterial contamination to the water phase
as well as the oily phase. It must be dissolved in both water and oil phase. Some
examples of preservative are methyl paraben, propyl paraben etc.
c. Colour: Generally no colour is used, because borax provides a very nice white
colour. The white colour is sufficient to make the preparation very attractive. If
any required, FDA colour should be used.
4. 4
Apparatus:
1. Beaker 5. Thermometer
2. Balance 6. Measuring cylinder
3. Water bath 7. Container
4. Glass rod 8. Heater
Procedure:
The following steps are involved in the preparation of cold cream:
1. Preparation of oil phase
2. Preparation of water phase
3. Addition of water phase to oil phase
4. Milling of cream
5. Filling, labeling and packaging of cream
1. Preparation of oil phase: At first all the required ingredients were dispensed for the
preparation. Beeswax and liquid paraffin were melted in a beaker at 70C and the oil phase
was prepared. Proper care was taken so that, temperature did not exceed 70C.
2. Preparation of water phase: Borax and glycerin were dissolved in water in another
beaker and the temperature was brought to 70C. The prepared solution was water phase.
3. Addition of water phase to oil phase: The water phase was then added to the oil
phase with continuous one direction stirring.
4. Milling of cream: All other ingredients were added at 70C except perfume and
stirring was continued. When the temperature reduced to 45C then perfume was added. The
methyl paraben should be dissolved in small amount of water before adding it.
5. Filling, labeling and packaging: Finally it was checked analytically. When the
temperature of the cold cream reduced to 40C, then it was filled in a suitable jar. The jar was
properly labeled and packaged in a suitable container or paper package.
Mechanism of emulsion formulation:
Borax is added as an emulsifying agent. The basic reaction involves in the manufacturing
of beeswax-borax cleansing cream is the hydrolysis of borax and subsequently reaction with
free acids present in beeswax to form the corresponding salt or soap. This soap emulsified the
liquid paraffin in water. Other components of beeswax are myricyl alcohol, myricyl palmitate
etc.
5. 5
Uses of cold cream:
i. Cold cream is used for skin care. Skin gradually losses water and oil content. As a
result it becomes rough and fails to retain normal features. To avoid these conditions, cold
cream is applied to the skin.
ii. Cold cream gives an oily protective layer in the skin.
iii. The oil content of cream gives polishing effect on the skin.
iv. It removes oil soluble impurities.
Labeling:
Homa
Cold cream Moisture control 100 gm
MRP:
Batch No.:
Mfg date:
Exp date:
Manufactured by: Pharmaceutical Lab. of RU.
Ingredients: Beeswax, Borax, Liquid
paraffin, Glycerin, Water, Methyl and
Propyl paraben, Perfume and Tween-80.
Precaution: Store in cool and dry place.
For external use only.
Direction to use: Use twice daily on
cleaned face for best results.
Market preparation:
1. Lakme 4. Pond’s
2. Garnier 5. Johnson Johnson’s baby cream
3. Meril 6. Cute
6. 6
Experiment No. 02 Date: 15.02.12
Name of the experiment: Preparation of vanishing cream.
Introduction:
Vanishing cream is a perfect semisolid oil water o/w emulsion. It must be vanished after
use. Appearance is fairly light. It is well polished preparation with pearl like appearance. It is
softer than cold cream.
Ideal characteristics of vanishing cream:
1. It should be easily spread on the skin.
2. It should be vanished after application.
3. It should be physically and chemically stable.
4. Ingredients used must be compatible with each other.
5. It should not too alkaline and pH about 6 should be maintained properly.
6. It should not be too much greasy or oily.
7. It should not be too viscous.
8. It should be nontoxic and nonirritant.
9. It should not be too much dry before application.
10. It should be easy to wash out after application.
Formula of a vanishing cream:
Ingredients Theoretical content Weighed content
1. Stearic acid 25 gm
2. NaOH 0.5 gm
3. Glycerin 3 ml
4. Methyl paraben 0.25 gm
5. Propyl paraben 0.002 gm
6. Perfume 0.5 ml
7. Distilled water 70 ml
Function of ingredients:
1. Stearic acid: It is used to constitute the oil phase of vanishing cream. It is very
popular, because it provides sparkling appearance to the cream.
2. NaOH: NaOH forms the salt Na-stearate with stearic acid which acts as both
emulsifier and opacifier. It partially dissolved in water, which makes the product more stable.
All NaOH must be neutralized by reacting with stearic acid, otherwise excess NaOH will
cause skin irritation. Instead of NaOH, KOH can be used.
7. 7
3. Glycerin: It acts as humectants i.e. it hold water in the skin and also in the
preparation. In the formulation, it also helps to dissolve NaOH in solution.
4. Preservatives: As the vanishing cream is an o/w type emulsion, it is very much
susceptible to the microbial contamination. To prevent this, preservatives are used. Some
examples are methyl paraben, propyl paraben etc.
5. Water: It constitutes the water phase of the vanishing cream. It must be distilled, free
from large amount of electrolytes such as Na+
, K+
, Ca2+
etc.
6. Other additives: These are used to increase the stability, quality, attractiveness and
other properties of vanishing cream. These are given below:
a. Antioxidant: Though vanishing cream contains small amount of oil, but there is a
chance of oxidation of oil which may cause degradation of the formulation. To
prevent this oxidation, antioxidants are used. Some examples of antioxidant are
BHT, BHA, ascorbic acid, tocopherol etc. The usual range is 0.01–0.03%.
b. Colour: Generally no colour is used in the preparation of vanishing cream. If any
required, FDA colour should be used.
c. Perfume: It is must for vanishing cream. Generally aromatic water and perfumery
oil are used to get strong fragrance.
Apparatus:
1. Beaker 5. Thermometer
2. Balance 6. Measuring cylinder
3. Water bath 7. Container
4. Glass rod 8. Heater
Procedure:
The steps which were followed during the preparation of vanishing cream are given below:
1. At first, all the ingredients required for the preparation were dispensed properly.
2. Stearic acid was melted at 60–70C in a beaker, which constituted the oil phase of the
cream.
3. NaOH was dissolved in glycerin and water in another vessel and the temperature of
that solution was brought to 65C. This solution constituted the water phase.
4. Then oil phase was dispersed in water phase by continuous one-direction stirring and
maintained the same temperature.
5. At the same time, all other excipients except perfume were added with continuous
stirring. Finally perfume was added to the formulation at 40-42C.
6. When the temperature of the preparation reached to 30C, then it was filled in a
suitable jar and labeled.
8. 8
Mechanism of emulsion formulation:
The basic reaction involves in the manufacturing of vanishing cream is the reaction of the
stearic acid with NaOH to form the corresponding salt or soaps Na-stearate. These soaps
emulsify the water in stearic acid. Na-stearate acts both as an oil phase and emulsifier.
Uses of vanishing cream:
i. It supplies water to the skin, so it remains smooth and soft.
ii. The oil content of the cream gives a polishing effect to the skin.
iii. It removes some extent water soluble impurities.
iv. It is used for skin care.
v. It gives an emollient action on the skin.
Labeling:
Homa
Vanishing cream Oil control system 100 gm
MRP:
Batch No.:
Mfg date:
Exp date:
Manufactured by: Pharmaceutical Lab. of RU.
Ingredients: Stearic acid, NaOH,
Glycerin, Methyl and Propyl paraben,
Perfume and water.
Precaution: Store in cool and dry place.
For external use only.
Direction to use: Use twice daily on
cleaned face for best results.
Market preparation:
1. Lakme 4. Pond’s
2. Garnier 5. Fair Lovely
3. Meril 6. Cute
9. 9
Experiment No. 03 Date: 15.02.12
Name of the experiment: Preparation of lather shaving cream.
Introduction:
Lather shaving cream is a cream which is used for smooth, easy and comfortable shave
and to keep the skin rich and refresh afterwards. Shaving with a razor without assistance of
cosmetic preparation is possible but certainly less convenient. In less favourable
circumstance, shaving cream can lead to discomfort irritation and actual physical damage of
the skin. These hazards can be minimized by the intelligence choice of shaving cream and
shaving instruments.
Ideal characteristics of lather shaving cream:
1. A small quantity must give sufficient lather.
2. It must produce stable foam on shaving.
3. It causes hair swelling and softening.
4. It must be free from skin irritation.
5. Must have no smarting or astringent effect on the skin.
6. Must remain soft in the tube and not go lumpy if overheated.
7. Its stability should be adequate at various temperatures with geographically different
areas.
8. It should be noncorrosive to razor blade and not cause dulling of razor blade.
9. Must be sufficiently tacky to adhere to both brush and face yet be easily washed of the
razor.
Formula of lather shaving cream:
Ingredients Theoretical content Weighed content
1. Stearic acid 35 gm
2. Coconut oil 10 ml
3. Glycerin 10 ml
4. Borax 0.6 gm
5. NaOH 2 gm
6. Perfume 0.5 ml
7. Water 36 ml
8. KOH 6.1 gm
9. Methyl paraben 0.18 gm
10. Propyl paraben 0.02 gm
10. 10
Function of each ingredients:
1. Stearic acid: In shaving cream, stearic acid acts as super fatting agent. It is used for
the following purposes:
a. To make the lather soften.
b. To increase the stability of foam.
c. As a lubricating agent on skin.
d. To neutralize any free alkali that might be present in the preparation.
e. To act as oil phase.
2. Coconut oil: In shaving cream, coconut oil serves as super fatting agent. It helps:
a. To make the cream softer.
b. To increase the stability of the foam.
c. It has lubricating effect on the skin.
3. Glycerin: It acts as humectants which often help to retain water in the formulation
and thus help to keep normal form i.e. the cream soft. Other functions are:
a. Improves wetting property of cream
b. Prevent too rapid drying of lather
c. Make the skin more elastic
d. Soften the beard
e. Facilitate the transit of the razor over the face
4. Borax Na2B4O7 . 10H2O: In lather shaving cream, minor quantity 0.1–1% has
been used as viscosity imparting agent.
5. NaOH: NaOH forms the salt Na-stearate with stearic acid. Na-stearate acts both as oil
phase and emulsifier.
6. Water: It is used as water phase.
7. Preservatives: Shaving cream is slightly alkaline. This alkalinity favours the growth
of microorganism. Due to stability consideration and economical view points, shaving creams
are not sterilized. So, preservatives are included to inhibit the microbial growth.
8. Perfumes: These are used to mask the unpleasant odour of the surfectants and super
fatting agent and to offer a pleasant sensation.
9. Viscosity imparting agent: It is essential for shaving cream to keep them correctly
consistent which must remain stable over a wide range of temperature.
10. Colour: It is not essential in shaving cream.
11. Antiseptic: Minor cuts may occur during shaving. To set remedy from every hazard,
antiseptic is added to the formulation.
12. Astringent: During shaving, bleeding may occur due to any cuts. So, astringents e.g.
alum are used which constricts the exposed capillary and help to stop bleeding.
11. 11
Apparatus:
1. Beaker
2. Balance
3. Water bath
4. Glass rod
5. Thermometer
6. Measuring cylinder
7. Container
8. Heater
Procedure:
The following steps are involved in the preparation of vanishing cream:
1. At first, all the ingredients required for the preparation were dispensed properly.
2. Stearic acid and coconut oil were heated together at 75–80C. This mixture is called
as oil phase.
3. Water, glycerin, NaOH and Borax as well as KOH were heated together to the same
temperature. It is called as water phase.
4. The water phase was added to the oil phase with slow agitation and continuous one-
way gentle stirring. The stirring was continued to 45-47C and perfume was added. After
that, the product was allowed to cool without further stirring.
5. When the temperature of the shaving cream reached to room temperature, then it was
filled in a suitable jar and labeled.
Mechanism of emulsion formulation:
The basic reaction involves in the manufacture of the shaving cream is the reaction of
stearic acid with NaOH to form the corresponding soaps i.e. Na-stearate. These soaps
emulsify the water in the preparation of the lather shaving cream.
12. 12
Uses of lather shaving cream:
i. It removes the stiffness, roughness of the hair.
ii. It causes swelling and softening the hair.
iii. It removes oily layer from the hair secreted by sebaceous glands, thus shaving
becomes easy and smooth.
iv. It helps to hold the hair erect.
v. The foam produced provides a lubricating effect.
Labeling:
Homa
Lather shaving cream 100 gm.
MRP:
Batch No.:
Mfg date:
Exp date:
Manufactured by: Pharmaceutical Lab. of RU.
Ingredients: Stearic acid, Coconut oil,
Glycerin, NaOH, KOH, Borax, Water,
Methyl and Propyl paraben and Perfume.
Precaution: Store in cool and dry place.
For external use only.
Direction to use: Use on wet and cleaned
face for best results.
Market preparation:
1. Gillete 3. Tibet
2. BiC 4. Kool