pptm slides on cream as topical drug delivery system.

1. REVIEW ON CREAM AS TOPICAL
DRUG DELIVERY SYSTEM
By : Siddhant Sanjay Hagavane
Final Year ( B.pharm )

2. CONTENT
1.Introduction
2.Advantages and Disadvantages
3. Type of skin cream
4.General ingredients used in skin creams
5.Methods of preparation of creams
6.Evaluation parameters of creams
7.Applications
8.Conclusion
9.References
10.Summary

3. INTRODUCTION
● The word ‘Cosmetic’ derived from a Greek word – ‘kosmesticos’ that means to adorn.
From that time any actually stems from its use in Ancient Rome.
● Cosmetics products have been generally defined as “articles intended to be applied to the
human body by being rubbed, proud, sprinkled, or sprayed for cleansing, promoting,
attractiveness, beautifying, or altering the appearance”.

4. ADVANTAGES &
DISADVANTAGES
●
1.It is the easiest way to deliver a drug.
2.It does not show the side effect on the other body organ.
3.Convenient and easy to apply.
4.It does not show the side effect on the other body organ.
5.It can slow down the sign of aging.
6.Less greasy compared to ointment.

5. ●
1.Skin irritation.
2.Possibility of allergic reactions.
3.Stability is not as good as ointment.
4.Some drugs show low penetrable through the skin.
5.They are less hydrophobic than other semisolid preparation,
so risk contamination is high than others.

6. Type of skin
creams :
●
●

7. CLASSIFICATION OF CREAMS
● A. All the skin creams can be classified on different basis :
1. According to function, e.g. cleansing, foundation, massage, etc.
2. According to characteristics properties, e.g. cold creams, vanishing creams.
3. According to the nature or type of emulsion.

8. B. Types of creams according to function, characteristic properties and type of emulsion :
1.Make-up cream : ( o/w emulsion )
a. Vanishing creams :
b. Foundation creams :
2. Cleansing creams : ( w/o emulsion )
3. Winter creams :
4. All purpose creams and general creams.
5. Night cream or massage creams.
6. Skin protective creams.
7. Hand and body creams.

9. GENERAL INGREDIENTS USED
IN SKIN CREAMS
● Water.
● Oil, fats and waxes.
● Mineral oil.
● Glyceride oil.
● Vegetable oil.
● Waxes.
● Fats.

10. ● Lanolin.
● Colours.
● Emollients.
● Humectants.
● Perfumes.
● Vitamins.
● Preservatives.

11. METHOD OF PREPARATION
1. Preparation of o/w emulsion cream :
The oil soluble components and the emulsifier are taken in one beaker and melted
Bath at 75 C. and in other beaker water , preservatives and water-soluble
components are taken and melted at 75C. After heating, the oil phase was taken in
mortar and pestle and slowly the water phase was added and triturated till clicking
sound was heard. Finally, when the temp cools down, perfuming agents or
preservatives are added. In this preparation, water content will be more than the
oil.

12. 2. Preparation of w/o emulsion creams :
The oil soluble components and emulsifier are taken in one beaker and melted at
75C. And in another beaker water and water-soluble components are taken and
melted at 75C. After melting, water phase are taken mortar and pestle and slowly
oil phase was added and triturated till clicking sound was heard. And when the
temp of the cream will get cooled, then the perfuming agent are added. In this
preparation, water phase will be less and oil phase will be more.

13. EVALUATION PARAMETERS OF
CREAMS
1. Determination of pH.
2. Physical appearance.
3. Saponification.
4. Spreadability.
5. Acid value.
6. Viscosity.
7. Homogeneity.
8. Removal.
9. Dye test.
10. After feel.
11. Type of smear.
12. Irritancy study.
13. Accelrated stability study.

14. APPLICATIONS
1. Skin softening.
2. Smoothing.
3. Cooling.
4. Moisturizing.
5. Antiseptic.
6. Cleaning.
7. Astringent.
8. Antifungal

15. CONCLUSION
Creams are semisolid formulations widely acceptable by the society. The skin is the
most accessible part of the body and such is also highly vulnerable to injuries. In
case of cuts, burns, and wounds, topical formulations such as creams are the most
preferred for treatment. Research and development for the formulations for the
formulation of pharmaceutical creams for wound healing healing purpose has
grown in recent decades owing to its obvious benifits. With the progress in the
pharmaceutical field and industry. It is assured that pharmaceutical creams will still
be an interesting and appealing area of research for years to come.