The document discusses peptic ulcers, including their causes, risk factors, symptoms, diagnosis, and treatment. Peptic ulcers are open sores in the lining of the stomach or small intestine caused by an imbalance of protective and damaging factors. Common treatments include H2 blockers, proton pump inhibitors, antacids, and antibiotics to treat Helicobacter pylori infections. These drugs help reduce acid production and promote healing of ulcers.
Peptic ulcers are sores that develop in the lining of the stomach, lower esophagus, or small intestine. They're usually formed as a result of inflammation caused by the bacteria H. pylori, as well as from erosion from stomach acids. Peptic ulcers are a fairly common health problem.
This ppt is suitable for b.pharma students. This ppt is prepared according to b.pharma IInd semester syallbus. In this ppt we provide all topics related to pathophysiology of peptic ulcer. In this ppt we covered introduction, types, sign & symptoms, pathophysiology, diagnosis, complications and treatments.
Peptic ulcers are sores that develop in the lining of the stomach, lower esophagus, or small intestine. They're usually formed as a result of inflammation caused by the bacteria H. pylori, as well as from erosion from stomach acids. Peptic ulcers are a fairly common health problem.
This ppt is suitable for b.pharma students. This ppt is prepared according to b.pharma IInd semester syallbus. In this ppt we provide all topics related to pathophysiology of peptic ulcer. In this ppt we covered introduction, types, sign & symptoms, pathophysiology, diagnosis, complications and treatments.
Peptic ulcers are open sores that develop on the inside lining of esophagus, stomach and/or the upper portion of small intestine. Peptic ulcer occur mainly due to imbalance between aggressive and defensive factors in the stomach.
Peptic ulcers are open sores that develop on the inside lining of esophagus, stomach and/or the upper portion of small intestine. Peptic ulcer occur mainly due to imbalance between aggressive and defensive factors in the stomach.
Pharmacology of Gastrointestinal Disorders dineshmeena53
This power point presentation will be helpful for Pharmacy, Medical and paramedical students. it consists of" what are the common GIT disorders and their pharmacological management "
This presentation is to help readers to be equipped with knowledge on predisposing factor to peptic ulcer disease and how it can be managed in the clinical/hospital setup.
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
1. Peptic ulcer ( Duodenal ulcer + Gastric Ulcer)
• Peptic ulcer are the open sores that occurs in the lining of
the stomach or small intestine. It is the erosion of mucosal
layer and break in the lining of the stomach.
• Peptic ulcer results from imbalance of protective factors
(bicarbonate & mucus) and damaging factors (acid &
pepsin).
• Incidence of duodenal ulcer is more common than gastric
ulcer.
Risk Factors:
• Smoking
• Alcohol intake
• Spicy Food
• Prolong use of NSAIDS (e.g: Paracetamol, Ibuprofen, etc)
• H. Pylori
• Stress like major injuries, illness, tumor, etc
2. Symptoms
• Epigastric pain
• Nausea
• Vomiting
• Dyspepsia
• Bloating
• Belching
• Pain after food
intake
Diagnosis
• Endoscopy
• Barium swallow
• Lab test for H. pylori infection
3. DRUGS FOR PEPTIC ULCER
A. Reduction of gastric acid secretion
1. H2 antihistamines: Cimetidine, Ranitidine, Famotidine
2. Proton Pump Inhibitors (PPI): Pantoprazole, omeprazole,
rabeprazole, lansoprazole, esomeprazole
3. Anticholinergics: Pirenzepine, propantheline, oxyphenonium
4. Prostaglandin analogues: Misoprostol, enprostil, rioprostil
B. Antacids
1. Systemic: sodium bicarbonate, sodium citrate
2. Non-systemic: magnesium hydroxide, magnesium trisilicate,
aluminium hydroxide, magaldrate, calcium carbonate
C. Ulcer proctectives: sucralfate, colloidal bismuth subcitrate
D. Anti H. Pylori Drugs: Amoxicillin, Metronidazole,
Tetracycline, Clarithromycin
5. H2 ANTIHISTAMINES
• MOA: Drugs act on H2 receptors as antagonist &
blocks histamine mediated gastric release.
• Cimetidine
H2 receptor antagonist
Blocks histamine induced gastric secretion
Well absorbed orally, bioavailability 60-80%
• Ranitidine: 5 times more potent than cimetidine
• Famotidine: 5-8 times more potent than ranitidine
& longer duration of action
• Roxatidine: twice potent & longer acting than
ranitidine
• Nizatidine: high bioavailability
6. Indications
1. Duodenal ulcer
2. Gastric ulcer
3. Stress ulcer & Gastritis
4. Zollinger Ellision Syndrome (ZES): It is a gastric
hypersecretory state due to tumor secreting
gastrin.
5. Gastroesophageal reflux disease (GERD): It is a
recurrent reflex of gastric contents into the
esophagus that produces symptoms of heartburn
or causes esophageal injury.
6. Prophylaxis of aspiration pneumonia:
preanaesthetic medicine before surgery
7. Adverse effects
• reduced gastric acid production.
• headache, dizziness, diarrhoea, and muscular pain.
• confusion and hallucinations occur primarily in elderly
patients and after intravenous administration.
• gynecomastia and galactorrhea (continuous
release/discharge of milk).
• Reduce absorption of drugs such as ketoconazole
Contraindications
• Concurrent use with drugs like metronidazole,
phenytion will inhibit their metabolism
• Coadminstration with drugs like antacids will decrease
their absorption
8. PROTON PUMP INHIBITORS (PPI)
• MOA: Drug inactivates H+K+ATPase enzyme in parietal
cells & suppress the secretion of gastric acid. It is very
effective inhibition of gastric acid secretion.
• Omeprazole: Potent & prolong action PPI that irreversibly
inhibit H+K+ATPase enzyme & inhibit gastric acid secretion.
(Dose: 20-40 mg OD)
• Pantoprazole: high bioavailability & available as i.v.
(Dose: 40 mg OD)
• Rabeprazole: high Pka, fast suppression of gastric acid
secretion (Dose: 20-40 mg OD)
• Lansoprazole: more potent, higher bioavailability, faster
action (Dose: 30 mg OD)
• Esomeprazole : s-enantiomer of omeprazole, have higher
bioavailabilty (Dose: 20-40 mg OD)
9. Indications
1. Peptic ulcer
2. Bleeding peptic ulcer
3. Stress ulcer
4. Zollinger Ellision Syndrome (ZES): It is a gastric
hypersecretory state due to tumor secreting
gastrin.
5. Gastroesophageal reflux disease (GERD): It is a
recurrent reflex of gastric contents into the
esophagus that produces symptoms of heartburn
or causes esophageal injury.
6. Aspiration pneumonia: preanaesthetic medicine
before surgery to avoid aspiration of gastric
contents
10. Adverse effects
• nausea, loose stools, headache, abdominal pain,
muscle and joint pain, dizziness are complained by 3–
5%.
• rashes (1.5% incidence), leucopenia & hepatic
dysfunction
• atrophic gastritis, hypergastrinemia on prolonged use.
• gynaecomastia & erectile dysfunction in some patients
• accelerated osteoporosis among elderly patients
Contraindications
• PPI inhibits metabolism of diazepam, phenytoin and
warfarin.
• Reduced gastric acidity decreases absorption of
ketoconazole and iron salts.
11. ANTICHOLINERGICS
Drugs block the muscarinic receptor in parietal
cell that cause decreased intracellular ca++ level &
decreases gastric acid secretion.
• Pirenzepine: selective M1 anticholinergic with
fewer side effects (Dose 100-150 mg OD)
PROSTAGLANDIN ANALOGUES
Drugs stimulate secretion of mucus &
bicarbonate ion for protection of stomach lining
& inhibit secretion of gastric acid.
• Misoprostol: longer acting & inhibit acid output
dose dependently (Dose 200 µg QID)
• Contrainication: Pregnancy (may cause abortion)
12.
13. ANTACIDS
• Drugs that neutralize gastric acid & raise pH of gastric
contents.
• e.g:-magnesium hydroxide, magnesium trisilicate,
aluminium hydroxide, magaldrate, calcium carbonate,
sodium bicarbonate, sodium citrate
• Acid Neutralizing Capacity: Number of mEq of 1N HCl that
are brought to pH 3.5 in 15 min by unit dose of antacid
(1g).
Functions of antacids:
• Neutralization of gastric acidity
• Inactivate pepsin due to increase pH (>4.0)
• Reduce peptic activity
• Reduction of helicobacter pylori
• Stimulation of PG synthesis
15. Adverse effects
• Systemic alkalosis
• Distension, discomfort and belching
• Sodium overload (edema)
• Constipation & diarrhoea
Contraindications
• Antacids decrease the absorption of many drugs,
especially tetracyclines, iron salts, fluoroquinolones,
ketoconazole, H2 blockers, diazepam,
phenothiazines, indomethacin, phenytoin, isoniazid,
ethambutol and nitrofurantoin.
16. ULCER PROTECTIVES
• Drugs enhance mucosal protection and prevent mucosal
injury, reducing inflammation, and healing existing ulcers.
• Sucralfate: It binds to proteins of mucosa and forms
complex which creates a physical barrier between acid and
stomach. It also stimulates prostaglandin release as well as
mucus and bicarbonate output, and it inhibits peptic
digestion.
• Since it requires an acidic pH for activation, sucralfate
should not be administered with PPIs, H2 antagonists, or
antacids.
• Colloidal Bismuth subsitrate: CBS have anti H. Pylori
actions, inhibit the activity of pepsin, increase secretion of
mucus, and interact with glycoproteins in mucosal to coat
and protect the ulcer.
17. • H. pylori is a Gram negative bacteria associated with gastritis, gastric
& duodenal ulcers, gastric adenocarcinoma.
ANTI H. PYLORI DRUGS
• Triple therapy (3 drug regimen) for 1 or 2 weeks
• PPI, Amoxicillin, Clarithromycin, Metronidazole/Tinidazole
• Quadruple therapy (4 drug regimen)
• CBS 120 mg QID + Tetracycline 500 mg QID +
metronidazole 400 mg TDS + omeprazole 20 mg BD
18. • Miscellaneous Drugs
• Simethicone: antifoaming agent that reduces
surface tension, breaks bubble formation and
prevents reflux
• Alginates: Forms a layer of foam on top of
gastric contents & reduce reflux
• Oxethazaine: Surface anaesthetic