This presentation discusses the causes, symptoms, classification and treatment of peptic ulcers. It begins with an introduction defining ulcers and their locations in the stomach and duodenum. The main causes of ulcers are identified as alcohol, NSAIDs, smoking, stress and Zollinger-Ellison syndrome. Common symptoms include epigastric pain relieved by food or antacids. The presentation then classifies treatments for ulcers including anti-secretory agents like H2 receptor antagonists and proton pump inhibitors, anticholinergic drugs, prostaglandin analogues, antacids, and anti-H. pylori treatments. Sucralfate is also discussed as an ulcer protective agent.
5-Hydroxytryptamine & it’s Antagonist is a Topic in Pharmacology which will defiantly Help You in pharmacy field All information is related to pharmacology drug acting and it's effect on body. it is collage project given by our department i would like to share with you.
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
5-Hydroxytryptamine & it’s Antagonist is a Topic in Pharmacology which will defiantly Help You in pharmacy field All information is related to pharmacology drug acting and it's effect on body. it is collage project given by our department i would like to share with you.
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
Histamine is an endogenous substance that is amine synthesized, stored and released by the various cells of the body: (a) Mast cells, which are abundant in the skin, GI, and the respiratory tract,
(b) Basophils in the blood, and (c) Some neurons in the CNS and peripheral NS.
It is an “Autocoid” that is secreted locally and regulate the activity of various near lying cells and neurons.
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
Biosynthesis of Histamine,Storage and release,Histamine H1-Receptor ,Histamine H1-Receptor Antagonists,Differences between first generation & second generation antihistamines,H2 receptor blockers
Peptic ulcers are open sores that develop on the inside lining of esophagus, stomach and/or the upper portion of small intestine. Peptic ulcer occur mainly due to imbalance between aggressive and defensive factors in the stomach.
Histamine is an endogenous substance that is amine synthesized, stored and released by the various cells of the body: (a) Mast cells, which are abundant in the skin, GI, and the respiratory tract,
(b) Basophils in the blood, and (c) Some neurons in the CNS and peripheral NS.
It is an “Autocoid” that is secreted locally and regulate the activity of various near lying cells and neurons.
Detailed information of all terms like Thyroid gland, Thyroxine, Triidothyronine, Calcitonine, growth and development , propylthiouracil, Calorigenesis, tadpole to frog, Oligomenorrhoea, snehal chakorkar, pharmacology, Cretinism, Myxoedema coma, Graves disease, Thiocynates, Perchlorate, Nitrates.
Radioactive iodine, I131
Biosynthesis of Histamine,Storage and release,Histamine H1-Receptor ,Histamine H1-Receptor Antagonists,Differences between first generation & second generation antihistamines,H2 receptor blockers
Peptic ulcers are open sores that develop on the inside lining of esophagus, stomach and/or the upper portion of small intestine. Peptic ulcer occur mainly due to imbalance between aggressive and defensive factors in the stomach.
Peptic Ulcer Disease Affects All Age Groups. Can occur in children, although rare. Duodenal ulcers tends to occur first at around the age 25 and continue until the age of 75. Gastric ulcers peak in people between the ages of 55 and 65. Men Have Twice The Risk as Women Do
pharmacothrapy of peptic ulcer
the topic contain antacid drugs, their uses, causes, symptoms, treatments etc.
the topic cover all the detail information on peptic ulcer
Gastrointestinal drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility, water flow, and improve digestion.
Presentation on Antacids and antiulcer drugs. Introduction to ulcers, classification of antiulcer drugs, their pharmacological actions, uses and adverse effects.
Pharmacology of Gastrointestinal Disorders dineshmeena53
This power point presentation will be helpful for Pharmacy, Medical and paramedical students. it consists of" what are the common GIT disorders and their pharmacological management "
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
1. Presentation By:
Mohd Taher Uddin
Dept. of Pharmacology.
170122887001
Under Guidance of:
Dr. R Padhmavati
Associate professor
Dept. of Pharmacology.
G. PULLA REDDY COLLEGE
OF PHARMACY, HYDERABAD
2. INTRODUCTION
• Ulcer: Formation of an erosion on the inner lining of
stomach (Peptic Ulcers)
• It is often characterized by a break in skin or
mucous membrane with loss of surface tissue,
disintegration and necrosis of epithelial tissue, and
often pus.
• Ulcers in stomach – Gastric Ulcers
• Ulcers in duodenum – Duodenal ulcers
Department of Pharmacology, GPRCP.
3. What can be the
causes of ulcer?
• Disruption of mucosal lining by the action of gastric acid and
pepsin is the main reason for formation of an peptic ulcer.
• Some of the common causes are:
• Drinking too much alcohol
• Regular use of aspirin, ibuprofen, naproxen, or other nonsteroidal
anti-inflammatory drugs (NSAIDs)
• Smoking cigarettes or chewing tobacco
• Radiation treatments
• Stress
• A rare condition, called Zollinger-Ellison syndrome, causes
stomach and duodenal ulcers.
• Ref// pennmedicine.org
Department of Pharmacology, GPRCP.
4. Expected symptoms
• Symptoms of peptic ulcer disease include epigastric
discomfort (specifically, pain relieved by food intake or
antacids and pain that causes awakening at night or that
occurs between meals), loss of appetite, and weight loss.
• Older patients and patients with alarm symptoms
indicating a complication or malignancy should have
prompt endoscopy.
• Intestinal bleeding: indication of surgery
• Ref// Peptic Ulcer Disease KALYANAKRISHNAN RAMAKRISHNAN, MD, FRCSE, and ROBERT C. SALINAS, MD University
of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Department of Pharmacology, GPRCP.
6. Anti Secretory agents
These are the agents which act upon receptors ad suppresses or reduces
the gastric acid secretion
Gastric acid regulation->
Department of Pharmacology, GPRCP.
7. H2 – Receptor antagonists
• Examples: Ranitidine, Cimetidine, Famotidine, etc.
• These agents blocks the action of histamine at the H2
receptors by competing with histamine for H2 receptors.
• H2 receptors are located on the basolateral membrane
of the parietal cells of GIT, and are responsible for
increased gastric acid secretion
• H2 receptor antagonists bind to H2 receptors and reduce
gastric acid secretion thereby used in prophylaxis of
peptic ulcers.
Department of Pharmacology, GPRCP.
8. CIMETIDINE (prototype)
• Pharmacological actions:
1) H2 blockade – Blocks histamine induced gastric acid
secretion, cardiac stimulation and uterine relaxation.
2) Gastric secretion - Marked inhibition of gastric secretion,
the volume, pepsin content and intrinsic factor secretion
are reduced
• Pharmacokinetics:
• Well absorbed orally, absorption is not interfered by
present of food in stomach.
• About 2/3 of dose is excreted unchanged in urine and bile
• Elimination T ½ is 2-3 hours
Department of Pharmacology, GPRCP.
9. • Adverse effects:
1. Anti-androgenic action
2. Inhibits degradation of estradiol by liver
3. High doses – Gynecomastia
4. Loss of Libido, Impotence
5. Temporary decrease in sperm count
• Therapeutic uses:
1. Duodenal and gastric ulcers
2. Stress induced ulcers and gastritis
3. Zollinger- Ellison syndrome
4. GERD
Department of Pharmacology, GPRCP.
10. Proton pump inhibitors
(PPIs)
• Examples: Omeprazole, Pantoprazole, Rabeprazole, etc.
• These agents inhibits the gastric acid secretion by blocking the proton pump(H+K+
ATPase Pump)
• General MOA:
Department of Pharmacology, GPRCP.
• Prodrugs
• Gets activated (after absorption)
• Ionization (results in formation of sulphenic acid and
sulphenamide)
• Suphenamide reacts with sulfhydryl group present in proton pump
• Inactivation of proton pump
• Suppression of gastric acid secretion
12. Department of Pharmacology, GPRCP.
All PPIs are
administered
enteric coated
Oral
bioavailability is
50% due to acid
instability
Food interferes
with absorption
Should be taken
1 hour prior to
meal
Plasma t1/2 is1
hour
Metabolites are
excreted in urine
Nausea, loose
stools, headache,
abdominal pain,
muscle and joint
pains and rashes
Leucopenia
Hepatic dysfunction
Gynecomastia and
erectile dysfunction
(lately observed)
Pharmacokinetics: Adverse effects:
14. Anti Cholinergic agents
• Examples: Pirenzepine, Telenzepine.
• These agents blocks the action of Acetylcholine on
autonomic effectors exerted through muscarinic
receptors.
• Pirenzepine is a selective M1 blocker and inhibits
gastric action
• These receptors are present in Autonomic ganglia
and gastric glands
• Pirenzepine and telenzepine works through G
Protein coupled receptors
Department of Pharmacology, GPRCP.
15. Ph’Col actions Pharmaco
kinetics
Adverse effects Uses
Similar to
Atropine
Rapidly
absorbed
from GIT
General:
Dry mouth, difficulty in
swallowing,
micturition
Duodenal ulcers
Decreases
secretion of:
50%
metabolize
d in liver
and rest is
excreted in
urine
CNS:
Excitement, psychotic
behavior and
hallucinations
Stomach ulcers
Gastric acid T1/2 = 3-4
hours
Eyes:
Dilated pupil,
photophobia, blurred
near vision and
palpitation
Used along with
antacids for
treatment of
peptic ulcers
Pepsin CVS:
Hypotension, weak
and rapid pulse
Also used to
prevent nausea,
vomiting, and
motion sickness.
Department of Pharmacology, GPRCP.
16. Prostaglandin
analogues
• These are the agents that enhance mucosal
defense
• Prostaglandins are produced in the gastric mucosa
and appear to serve a protective role by inhibiting
acid secretion and promoting mucus and
bicarbonate secretion.
• In addition, PGs inhibits gastrin production, increase
mucosal blood flow and probably have an ill defined
cytoprotective action.
• DRUGS: Misoprostol, Rioprostil
Department of Pharmacology, GPRCP.
17. • MECHANISM:
• Misoprostol acts upon gastric parietal cells, inhibiting the
secretion of gastric acid via G-protein coupled receptor-
mediated inhibition of adenylate cyclase, which leads to
decreased intracellular cyclic AMP levels and decreased
pump activity at the apical surface of the parietal cell
• Adverse effects:
• Diarrhea
• Other common side effects include: abdominal pain,
nausea,
• flatulence, headache, dyspepsia, vomiting, and
constipation.
Department of Pharmacology, GPRCP.
19. Antacids
• These are basic substances which neutralize gastric
acid and raise pH of gastric contents.
• Antacids does not decrease acid production rather,
these are the agents that raise anthral pH to more
than 4.
• Peptic activity is indirectly reduced if the pH rises
above 4
• The potency of an antacid is generally expressed in
terms of its acid neutralizing capacity (ANC)
Department of Pharmacology, GPRCP.
20. • Systemic Antacids
• Sodium bicarbonate and Sodium citrate
• It is water soluble, acts instantaneously, but the duration of
action is short.
• It is a potent neutralizer (1 g → 12 mEq HCI), pH may rise
above 7. However, it has several demerits:
• (a) Absorbed systemically.
• (b) Produces CO2 in stomach.
• (c) Acid rebound.
Department of Pharmacology, GPRCP.
21. • Non systemic antacids
• Insoluble and poorly absorbed basic substance react in
stomach to form corresponding chloride salts
• The chloride salts reacts with intestinal bicarbonate so that
HCO3 in spread for absorption- no acid basic disturbances
occurs
• Magnesium hydroxide (milk of magnesia) with 30mEq HCI
• Magnesium trisilicate: mg salts are having laxative action
generation osmotically active MgCl2 induced cholecystokinin
hormone
Department of Pharmacology, GPRCP.
22. • Aluminum hydroxide:
• It ANC depends upon storage, it activity decline as
storage time increases
• Aluminum hydroxide binds phosphate in the intestine and
prevents its absorption-hypophosphatemia occurs on
regular use. This may: (a) cause osteomalacia (b)used
therapeutically in hyperphosphatemia and phosphate
stones.
• Small amount of Al3+ that is absorbed is excreted by
kidney. This is impaired in renal failure-aluminium
toxicity(encephalopathy, osteoporosis) can occur.
Department of Pharmacology, GPRCP.
23. Anti - H. pylori drugs
• Helicobacter pylori is a gram negative bacteria which breaks
down mucosal defense.
• It is known as an important contributor in causing gastritis,
dyspepsia, peptic ulcer, gastric carcinoma, etc.
• Up to 90% patients of duodenal and gastric ulcer have tested
positive for H. pylori.
• Antimicrobials that have been found clinically effective against
H. pylori are:
• Amoxicillin, clarithromycin, tetracycline, and
metronidazole/tinidazole.
Department of Pharmacology, GPRCP.
25. Ulcer protectives
• Ulcer protectives or mucosal protective agents
are medications that protect the mucosal lining of
the stomach from gastric acid, and are used to treat
conditions like peptic ulcers, NSAID-induced ulcers,
and gastroesophageal reflux disorder or GERD.
• Example: Sucralfate
Department of Pharmacology, GPRCP.
26. Sucralfate is a locally acting substance that in an acidic environment (pH <
4),reacts with hydrochloric acid in the stomach to form a cross-linking,
viscous, paste-like material capable of acting as an acid buffer for as long as
6 to 8 hours after a single dose.
It also attaches to proteins on the surface of ulcers, such as albumin and
fibrinogen, to form stable insoluble complexes.
These complexes serve as protective barriers at the ulcer surface,
preventing further damage from acid, pepsin, and bile.
Department of Pharmacology, GPRCP.
MECHANISM
27. • ADR:
• It is not absorbed → virtually devoid of systemic ADR
• Inducing hypophosphatemia by binding phosphate ions in
the intestine
• Constipation (2%) due to aluminum salt
• Long term uses → may cause aluminum toxicity
• Contraindication :Avoid kidney patients prolonged use
Department of Pharmacology, GPRCP.
28. • Interaction:
• May bind to Tetracycline, Digoxin, Cimetidine & Phenytoin
impairing their absorption
• It should not be given with antacids → neutralize gastric acid &
raises pH → At pH > 4, Sucralfate cannot polymerize & thus
not able to protect ulcer
• Uses:
• Ulcer protective in peptic ulcer
• Stress ulcer → prophylaxis
• Bleeding in critically ill patient
• Gastritis
• Bile reflux
Department of Pharmacology, GPRCP.
29. References
•
• Pennmedicine.org
• Review article: Peptic ulcer disease Kalyanakrishnan Ramakrishnan,
MD, FRCSE, and Robert C. Salinas, MD university of Oklahoma
health sciences center, Oklahoma
• Essentials of Medical Pharmacology, 7th Edt., K D Tripathi
• Lippincott Illustrated Reviews Pharmacology, 6th Edit., Richard A.
Harvey
• Exam Preparatory Manual for Undergraduates Pharmacology, 1st
Edt., Gobind Rai Garg & Sparsh Gupta
• Pharmacology for MBBS, 1st Edt., S.K. Srivastava
• Medical Pharmacology, 5th Edt., Padmaja Udaykumar.
Department of Pharmacology, GPRCP.