This document discusses proton pump inhibitors (PPIs) which are a group of drugs that reduce gastric acid production. PPIs are used to treat common gastrointestinal issues like gastritis, dyspepsia, peptic ulcers, and gastroesophageal reflux disease (GERD). The causes, symptoms, and treatment approaches for each condition are described. Specifically, the document focuses on esomeprazole as a clinically used PPI and discusses its unique selling propositions and market share.

1. Proton Pump Inhibitor (PPI)
Md. Saiful Islam
Executive
PMD
REPHCO Pharmaceuticals Ltd.

2. What is PPI???
• Proton Pump
Inhibitors (PPI) are
a group of drugs
whose main action
is a pronounced
and long-lasting
reduction of gastric
acid production.

3. USE OF PPI
Main GIT problem
↓
1. Gastritis
2. Dyspepsia
3. Peptic ulcer diseases (PUD)
4. Gastroesophageal reflux disease (GERD)

4. Causes & Symptoms

5. Causes & Symptoms
Gastritis Dyspepsia
Gastritis is
an inflammation,
irritation or
erosion of the
lining of
the stomach. It
can occur
suddenly (acute)
or gradually
(chronic).
Dyspepsia is an
uncomfortable
feeling in the
upper middle
part of the
stomach.

6. Causes & Symptoms
Peptic Ulcer GERD
Peptic ulcer
disease refers to
painful sores or
ulcers in the
lining of
the stomach or
first part of the
small intestine,
called the
duodenum.
Gastroesophageal
reflux disease,
or GERD, is a
digestive disorder
that affects the
lower esophageal
sphincter (LES),
the ring of muscle
between
the esophagus and
stomach.

7. Gastritis Dyspepsia Peptic ulcer GERD
• Bloating
•Unexpected
weight loss
• Yellow, green
or bloody
vomiting.
•Belly pain or
discomfort.
•Bloating
• Feeling
uncomfortably full
after eating
•Nausea
•Loss of appetite
•Heartburn
•Burping up food
or liquid
(regurgitation)
•Burping.
• A feeling of
fullness
• Difficulty
drinking as
much liquid as
usual
• Hunger and
an empty
feeling in the
stomach soon
after eating
• Mild nausea
• Stomach pain
that wakes up
at night.
• Heartburn
• Asthma false
symptoms
• Chest pain
• Bad breath
• Nausea
• Increased
salivation
• Feeling as if
there is a
lump in the
throat.

8. How deal with that???
Life Style Neutralizing
Acids
Blocking acid
production
1. Smoking
2. Weight loss
3. Eating habits
4. Alcohol
5. Posture after meal
1. Antacid
(Very temporary
treatment)
1. H2 blockers
2. PPI

9. Proton Pump Inhibitor
Clinically Used PPIs
Omeprazole
Lansoprazole
Esomeprazole
Pantoprazole
Rabeprazole

10. Esomeprazole
(Esolin-20,40)

17. Unique Selling Propositions (USP)

18. Market share of Esomeprazole

19. Thanking you
Have a good
day………………. 19