This ppt is suitable for b.pharma students. This ppt is prepared according to b.pharma IInd semester syallbus. In this ppt we provide all topics related to pathophysiology of peptic ulcer. In this ppt we covered introduction, types, sign & symptoms, pathophysiology, diagnosis, complications and treatments.
This PPT covers the Pathophysiology of Peptic ulcer. It includes factors causing peptic ulcer, factors causing peptic ulcer, diagnosis and complications of peptic ulcer.
Peptic ulcers are sores that develop in the lining of the stomach, lower esophagus, or small intestine. They're usually formed as a result of inflammation caused by the bacteria H. pylori, as well as from erosion from stomach acids. Peptic ulcers are a fairly common health problem.
Gastro esophageal Reflux Disease (GERD) and its managementDr. Ankit Gaur
In this presentation I have tried to explain in brief about gastro esophageal Reflux Disease (GERD), its etiology, risk factors, diagnosis, and its management via pharmacotherapy.
This PPT covers the Pathophysiology of Peptic ulcer. It includes factors causing peptic ulcer, factors causing peptic ulcer, diagnosis and complications of peptic ulcer.
Peptic ulcers are sores that develop in the lining of the stomach, lower esophagus, or small intestine. They're usually formed as a result of inflammation caused by the bacteria H. pylori, as well as from erosion from stomach acids. Peptic ulcers are a fairly common health problem.
Gastro esophageal Reflux Disease (GERD) and its managementDr. Ankit Gaur
In this presentation I have tried to explain in brief about gastro esophageal Reflux Disease (GERD), its etiology, risk factors, diagnosis, and its management via pharmacotherapy.
This is a presentation about gastrointestinal tract disorders concerning a medical informations about an important disorders that affect GIT of human being.
This is a presentation about gastrointestinal tract disorders concerning a medical informations about an important disorders that affect GIT of human being.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. INTRODUCTION
Peptic ulcer also known as peptic ulcer disease.
A condition in which there is a discontinuity in the
entire thickness of the gastric or duodenal mucosa that
persists as a result of acid and pepsin in the gastric
juice.
The term peptic ulcer applies to mucosal ulceration
near the acid bearing regions of GIT.
3. A condition in which wounds appear in the lining
of stomach or duodenum, along with a burning
stomach pain is termed peptic ulcer.
In this case, a low pH peptic juice (acid) secreted
by the walls of stomach or duodenum starts
eroding the mucosa.
Peptic ulcer disease (PUD) = Mucosal defect in the
GIT (gastric or duodenal) exposed to acid and pepsin
secretion.
6. Types: Peptic ulcer are mainly of following
of two types-
Gastric ulcers: This ulcer type affect the stomach
lining and may be acute or chronic. It is
characterized by pain while the food is still in the
stomach.
Duodenum ulcers: This ulcer type affect the
upper part of small intestine and may acute or
chronic. It is characterized by pain when
stomach is empty, or may result after several
hours of food consumption.
7. Epigastric pain occurring 30
minutes to 1 hour after
meals
Aggravated by eating
(because acid secretion
increase at meal time) leads
to weight loss.
Relieved by vomiting
(because acid is expelled
out).
No pain at hours of sleep
(HCL production decrease at
hours of sleep).
More common in person
older than age 50.
Epigastric pain occurring 2-3
hours after meals.
Relieved by food (because
the pyloric sphincter, at the
junction of stomach and
duodenum, closes upon
eating to concentrate food in
the stomach) causes weight
gain.
Not relived.
Pain at hours of sleep
(because gastric emptying
continuous at hours of
sleep).
More common between age
25 and 50.
Gastric ulcer Duodenum ulcer
8. ETIOLOGY/CAUSES OF PEPTIC ULCER
Helicobacter pylori, Gram –ve microaerophillic
bacterium found in gastric antrum of human
stomach. 95% duodenum ulcer & 80% gastric
ulcer associated with H.Pylori.
NSAID’S like aspirin, ibuprofen, etc. used
frequently.
Alcoholism
Smoking
Radiotherapy
Cancer of stomach
9. PATHOPHYSIOLOGY
Pepsinogen is activated to pepsin in
presence of HCl and a pH of 2 to 3.
Secretion of HCl by parietal cells has a pH of
0.8.
pH reaches 2 to 3 after mixing with
stomach contents.
Surface mucosa of stomach is renewed about
every 3 days.
Mucosa can continually repair itself except
in extreme instances.
10. Mucosal barrier prevents back diffusion of acid
from gastric lumen through mucosal layers to
underlying tissue.
Mucosal barrier can be impaired and back
diffusion can occur.
HCL freely enters mucosa when barrier is
broken
Result:
Injury to tissue occurs
cellular destruction and inflammation
12. H.PYLORI INDUCED ULCER
Gram negative bacteria produced heat shock proteins
Cytokines, histamine, lipopolysaccharides, certain enzymes
Phospholipase
Urease, protease, etc.
•Urease convert in acidic media urea into
ammonia and carbon dioxide. Ammonia itself
cause destruction of mucosal lining.
13. Ammonia cause infection of mucosal lining and
ultimately inflammatory mediators release.
Cytokines, leukocytes adhesion and
inflammatory reactions starts
Damage mucosa of GIT
Ulcer occurs
14. DRUG INDUCED ULCER
Approximately 15% of patients on long-term
NSAID develop PUD.
NSAIDs - ↓prostaglandin (PG) by inhibiting the
cyclooxygenase (COX) enzymes.
Three iso-enzymes COX-1, COX-2, COX-3
COX-1 → PG production in gastric mucosa.
16. STRESS INDUCED ULCER
In stress energy consumption increase so
increase glycolysis which is usually done by
cortisol hormone
This hormone inhibit phospholipase A2
No arachidonic acid formation no
prostaglandin increase gastric juice
secretions
Cause ulcer
17. STEROIDS INDUCED ULCER
Steroids acts
on cell
membrane
(Phospholipid)
Inhibit
phospholipase
Inhibits
arachidonic
acid no
prostaglandins
and damaging
of mucosal
lining cause
ulcer
18. SIGNS & SYMPTOMS
Abdominal pain
Nausea
Vomiting
Weight loss
Fatigue
Heartburn
Indigestion
Chest pain
Blood in vomiting
Bloody or dark tarry stools
Loss of appetite
19. COMPLICATIONS
1. Hemorrhage
Blood vessels damaged as ulcer erodes into the
muscles of stomach or duodenal wall
Coffee ground vomits or occult blood in tarry stools
2. Perforation
An ulcer can erode through the entire wall.
Bacteria and partially digested food spill into
peritoneum, resulting in acute peritonitis.
3. Narrowing & Obstruction
Swelling and scarring can cause obstruction of food
leaving stomach, resulting repeated vomiting.
20. DIAGNOSIS
1. Endoscopy
2. X-ray studies- performed after drinking a thick
barium solutions.
3. Other test-
Blood test for haemoglobin- for detecting
presence of anaemia.
Stool occult blood test- for detecting blood in
stool.
Bacterial culturing for H.Pylori
21. TREATMENT
Ulcer can be treated by following ways-
Lifestyle changes
Medications
Surgery
23. MEDICATIONS
Proton pump inhibitors (PPIs)
Reduce acid level and allow ulcer to heal
These include-
Esomeprazole
Lansoprazole
Omeprazole
Pantoprazole
Rabeprazole
24. MEDICATION (CONT.)
Antibiotics
Used for H.Pylori induced ulcer
Multiple combinations of antibiotics
Taken for 2-3 weeks along with PPIs
25. MEDICATIONS (CONT.)
Antacids- Neutralise the gastric acidity and
reduce pepsin activity
Cytoprotective agents- protect the tissues
lining the stomach and small intestine