This document discusses novel drug delivery systems (NDDS) as an advancement over conventional drug delivery systems (CDDS). NDDS aim to improve drug potency, provide sustained release, increase safety, and target delivery to specific tissues. Some key points: - NDDS can deliver drugs that cannot be administered through non-invasive or invasive CDDS routes due to factors like size, charge, and susceptibility to degradation. - NDDS provide controlled, modulated, or targeted release through various formulations and medical devices to maintain therapeutic drug levels over long periods with fewer side effects. - Examples of NDDS include liposomes, nanoparticles, microspheres, and modulated delivery devices like nebulizers and metered dose in

1. NDDS
(NOVEL DRUG DELIVERY SYSTEMS)

2. DRUG DELIVERY
• Routes of drug administration 0r Drug delivery
is a method to administer the compound to
achieve therapeutic effects in humans &
animals.
• Conventional drug delivery system (CDDS) &
Novel drug delivery system (NDDS)
• CDDS from many decades
• NDDS at present

3. CDDS
Common methods of administration are :
Non-Invasive methods
&
Invasive methods

4. Non-Invasive methods
• Oral route
• Topical route (Skin)
• Transmucosal route (Nasal, ophthalmic etc.)

5. Invasive methods
• Parenteral (Injecting drugs into the systemic
circulation by using syringe and needle)
• SC/IM/IV are the examples

6. • Some medications like proteins, peptides,
antibodies, vaccines, gene based drugs may
not be administered using the common non-
invasive routes because they might be
susceptible to enzymatic degradation or
cannot be absorbed into the systemic
circulation efficiently because of their
molecular size and charge so as to be
therapeutically effective.
• Example – protein or peptide based drugs are
administered using parenteral route

7. Here the use/importance of NDDS begins
Some drugs are there which cant be
administered CDDS (neither by non-invasive
nor by invasive methods), in that conditions
NDDS is used.

8. NDDS
• It is a combination of advanced technique and
new dosage forms, which are therapeutically
better than conventional dosage forms and
involves medical devices.
• It improves drug potency, control drug release
to give a sustained therapeutic effect
• NDDS provides greater safety and target a
drug to a effected tissue.

9. Advantages of NDDS over CDDS
The drawback in conventional dosage forms are :
• Immediate drug release
• Causes change in drug level in blood
depending upon dosage form.
NDDS maintains constant drug concentration in
blood within therapeutically effective range

10. MODES OF NDDS
• Targeted drug delivery system
• Controlled drug delivery system
• Modulated drug delivery system

11. TARGETED DRUG DELIVERY SYSTEM
• The drug is administered/delivered in
such a way that the drug is only
active in the target area of the body
e.g. cancerous tissues in which drug
is released over a period of time in a
controlled manner

12. CONTROLLED RUG DELIVERY SYSTEM
• Drug releases for a long period.
• The rate/speed at which the drug is released is
controlled by modification in formulation e.g.
Nifedipine
• Nifedipine is a medicine used to treat high
blood pressure, helps to prevent future heart
disease, heart attacks and strokes

14. MODULATED DRUG DELIVERY SYSTEM
• In modulated drug delivery system, the rate of
drug release is controlled and modulated by
devices such as nebulizer, metered dose
inhaler etc.
• What is Nebulizer?
• What is MDI (Metered dose inhaler)?

15. NEBULIZER
• Nebulizer is a drug delivery device used to
administer medication in the form of
aaerosol/droplets inhaled into the lungs.
• Nebulizers are commonly used for the
treatment of asthma and respiratory diseases
or disorders.

17. METERED DOSE INHALER (MDI)
• A metered dose inhaler is a device that
delivers a specific amount of medication to
the lungs in the form of aerosolized medicine
• By inhalation, patients can administer
medicine theselves.
• It is the most commonly used delivery system
for treating asthma and other respiratory
diseases.

19. CARRIER DRUGS IN NDDS
• Nanosomes
• Liposomes
• Niosomes
• Nanoparticles
• Nanosphere
• Microsphere
• Microparticle
• Microemulsion
• Nanosuspension
• Micelles

20. ADVANTAGES OF NDDS
• Frequency of dose can be reduced
• Increase in drug concentration in blood can be
reduced
• Sustained and consistent drug level in blood can
be maintained within therapeutic window
• Bioavailability can be enhanced
• A targeted drug delivery can be achieved
• Side effects can be reduced
• Improved patient compliance

21. TAPAN KUMAR MAHATO
tapan.mahato@gmail.com