Novel Drug Delivery System (NDDS)

Novel Drug Delivery System (NDDS)

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  Presented By Mr. Mukesh,Md.Shahajad Md.Faizan D.Pharm.1st Year Under The Supervision Mr. Prateek Mishra Asst. Prof. KIP
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  CONTENT • Drug DeliverySystem. • Conventional Drug Delivery System. • Novel Drug Delivery System. • Classification Of NDDS. • Route Of Administration. • Advantage. • Disadvantage. • Challenges Of NDDS.
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  ➢What is drugdelivery? Drug delivery is as a method or a process of administering or delivering a pharmaceutical compound in systemic circulation to achieve its therapeutic effect in humans or in animals. ➢Types of Drug Delivery System • Conventional/Traditional Drug Delivery System • Novel Drug Delivery System ➢ Conventional/Traditional Drug Delivery System Conventional drug delivery systems (tablets, capsules, syrups, ointments, etc.) suffer from poor bioavailability and fluctuations in plasma drug level and are unable to achieve sustained release.
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  ➢ Why dowe need NDDS? • Patients compliance. • The conventional dosage forms provide drug release immediately and it causes fluctuation of drug level in blood depending upon dosage form. • Therefore to maintain the drug concentration within therapeutically effective range need novel drug delivery system. ➢ What is NDDS ? A Novel Drug Delivery System (NDDS) can be defined as a new approach that combines innovative development, formulations, new technologies, novel methodologies for delivering pharmaceutical compounds in the body as needed to safely achieve its desired pharmacological effects.
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  ➢ NDDS isa system for delivery of drug other than conventional drug delivery system. NDDS is a combination of advance technique and new dosage forms which are far better than conventional dosage forms. ➢ The AIM • NDDS is to provide a therapeutic amount of drug to the appropriate site in the body to accomplish promptly and then maintain the desired drug concentration. • For drug to reach the targeted site with little or no side effects. • To minimize drug degradation and loss. • To increase bioavailability of the drug.
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  Classification of NDDS ➢By Mode Of NDDS • Targeted drug delivery system. • Sustained release drug delivery system. • Controlled release drug delivery system. ➢ By Route Of Administration • Oral drug delivery system. • Nasopulmonary drug delivery system. • Mucoadhesive Drug Delivery System • Implatable drug delivery system. • Others.
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  ➢ Targeted DrugDelivery System Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others, By route of implant.
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  ➢ Sustained ReleaseDrug Delivery System Drug Delivery system that are designed to achieve prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose.” The basic goal of therapy is to achieve steady state blood level that is therapeutically effective and non toxic for an extended period of time.
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  ➢ Controlled ReleaseDrug Delivery System Controlled release are drug delivery system which maintain constant level of drug in blood and tissue for extended period of time. It implies A predictability and reproducibility in drug release kinetics. Polymer Matrix
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  ➢ Graphical RepresentationOf NDDS
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  ➢ Oral DrugDelivery System The oral drug delivery method is a favorable route for the administration of the drug, leading to increased treatment efficacy and patient compliance and reducing drug administration frequency.
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  Pulmonary drug deliveryis a route of administration in which patients use an inhaler to inhale their medications and drugs are absorbed into the bloodstream via the lung mucous membrane. ➢Nasopulmonary drug delivery system
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  Implantable drug deliverysystems are bioengineering devices surgically placed inside the patient's tissues to avoid first-pass metabolism and reduce the systemic toxicity of the drug by eluting the therapeutic payload in the vicinity of the target tissues. ➢ Implantable drug delivery systems
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  ➢ Mucoadhesive DrugDelivery System Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Mucoadhesive drug delivery systems prolong the residence time of the dosage form at the site of application or absorption.
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  ➢ Advantage • Improvepatient compliance • Accurate dosing. • Enhanced efficacy and safety • Decreased toxicity/side effects • Controlled delivery by maintaining desired drug concentration and contralled rate. • Beneficial to patients with improved comfort and standard of living. • Reduction in drug accumulation with chronic therapy ➢ Disadvantages • Less patients compliance. • Repeated dosage is necessary. • Large amount of drug deliver.
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  ➢ Challenge ofnovel drug delivery systems (NDDS) • Problems involved and overcoming challenges in the delivery of poorly soluble drugs. • Novel approaches in the delivery of poorly soluble drugs. • Overcoming bioavailability hurdles for poorly soluble clinical candidates. • Rationale formulation design for poorly soluble compounds. • Overcoming challenges in protein drug delivery. • Challenges in pediatric and geriatric drug delivery. • Overcoming addictive nature of drug