The document discusses various drug delivery systems and technologies that facilitate the administration of therapeutic substances to patients. It covers different drug delivery devices, methods, and companies, detailing innovations like liposomes and micelles for targeted and efficient drug delivery. Future prospects in drug delivery include advancements for treating cancers and improving patient compliance.

1. DRUG DELIVERY
SYSTEM
Health Biotechnology
Superior University
Group 8
Ayesha Hashmi
Ayesha Yasin
Usama Mukhtar

2. • Drug Delivery System
• What are drug delivery devices?
• What Are the Four Drug Delivery Methods?
• Drug delivery technology
• Drug delivery technology companies
• Possible Systems for drug delivery
• Targeted drug delivery system
• Future Perspectives
Content

3. Drugs
Drugs have played a pivotal role in alleviating illnesses, enhancing well being, and extending
both human and animal lifespans.
Drug delivery system
Drug delivery systems describe technologies that carry drugs into or throughout the body.
What are drug delivery devices?
Drug delivery devices are specialized equipment designed to facilitate therapeutic substances to
patients.
INTRODUCTION

4. • Syringes and Needles
These are widely used for injections. Syringes allow for precise measurement
and controlled delivery of liquid medications.
• Auto injectors
These devices are designed to deliver a pre-measured dose of medication through a needle
with the push of a button. They are often used for severe allergic reactions.
• Insulin Pens
These are specialized devices used by people with diabetes to inject insulin. They offer a
convenient and discreet way to self-administer insulin.

5. • Nebulizers
Nebulizers convert liquid medication into a fine mist that can be inhaled into the
lungs. They are commonly used for respiratory conditions, such as asthma.
Fig: Insulin Pen Fig: Nebulizers

6. • Immediate Release
The dosage form that is designed to give a rapid and complete release of the drug.
• Non-Immediate Release
The dosage form encompassing drugs that do not fully release upon administration.
What Are the Four Drug Delivery Methods?

7. • Site-Specific Release
The dosage form that offers targeted delivery of a drug directly to the
location where it is administered.
• Sustained Release
The dosage form that releases a drug continuously at a slow or controlled
rate over a prolonged period of time.
What Are the Four Drug Delivery Methods?

8. DRUG DELIVERY TECHNOLOGY

9. • Drug delivery technology means finding smart ways to give medicines
to the body in a precise and controlled manner.
• It can take various forms, including drug-loaded nanoparticles,
liposomes, micelles, implantable devices, and transdermal patches.
DRUG DELIVERY TECHNOLOGY

10. Pharmaceutical Technology has listed companies providing products and services related to
drug delivery, including:
• Oral drug delivery technologies
• Transdermal drug delivery systems
• Self-injection devices
• Automated test solutions for pharmaceutical drug delivery systems.
DRUG DELIVERY TECHNOLOGY COMPANIES

11. •Insulet: This company is headquartered in Billerica, Massachusetts. It touts the
OmniPod Delivery System, which is a tubeless system to deliver insulin.
•Becton Dickinson: As one of the largest medical device companies in the world,
Becton Dickinson is involved in innovative drug delivery development.
•Ipsen SA and Insmed Inc: These companies are key patent filers in
nanoparticles for drug delivery.
DRUG DELIVERY TECHNOLOGY COMPANIES

12. POSSIBLE SYSTEMS FOR DRUG DELIVERY

13. • Colloidal drug strategies involve utilizing drug carriers that contain
microscopically dispersed drug particles suspended in a colloidal suspension.
• They are tiny and invisible delivery vehicles for medicines, such as micelles
and liposomes.
• The purpose is to obtain systems with optimized drug loading and release
properties, long shelf-life and low toxicity.
COLLOIDAL DRUG CARRIERS

14. COLLOIDAL DRUG CARRIERS

15. • Liposomes are spherical vesicles made up of
biodegradable natural or synthetic
phospholipids.
• They are amphipathic characterized by
lipophilic tail and hydrophilic head on the
same molecule.
LIPOSOMES

16. • Water-soluble drugs are trapped inside the hydrophobic core, while fat-soluble
drugs are incorporated into the phospholipid layer of liposomes.
• Liposomes attach to cellular membranes and appear to fuse with them,
releasing their or drugs into the cell.
• In the case of phagocytic cells, the liposomes are taken up, the phospholipid
walls are acted upon by organelles called lysosomes, and the medication is
released.
LIPOSOMES

17. Liposome
Doxorubicin Sulphate
Lipid bilayer
Incorporation in
blood stream
Liposome accumulation in
tumor tissue
EXAMPLE
Fig: Mechanism of Liposome drug delivery system for
tumor cells
Endocytosis and
Doxorubicin Sulphate
releases
Induce the
Controlled death
of tumor cells

18. • Increased stability and decreased toxicity of encapsulated drug.
• Both hydrophilic and hydrophobic drugs can be carried.
• Non – toxic and non – pyrogenic.
Advantages of Liposomes

19. • Micelles are molecular aggregates formed by
substances dispersed in a liquid phase from
which they colloid.
• Micelles formed by self-assembly of amphiphilic
block copolymers (5-50 nm) in aqueous
solutions.
MICELLES

20. • Micelles have a protective shell that keeps the drug safe from breaking down in body or
being destroyed by enzymes.
• The drugs can be physically entrapped in the core of block copolymer micelles, which can
help them dissolve better in water.
Fig: Micelles forming Assemblies
MICELLES

21. • Helps medicines to dissolve in water easily.
• Protects the medicines from breaking down in the body or being
destroyed by enzymes.
Advantages of Micelles

22. Drug delivery systems can provide advanced
efficacy and decrease toxicity for anticancer
agents.
 Anticancer drugs:-
Anticancer drugs provide current information
on the clinical and experimental effects of
toxic and non-toxic cancer agents in cancer
treatment.
Fig: Protein and peptide delivery to lungs by using
advanced targeted drug delivery system
Targeted drug delivery system

23.  Lung-specific drug delivery
Pulmonary drug delivery offers several advantages in the treatment of respiratory
diseases (such as pulmonary, arterial hypertension) over other routes of
administration.
 Targeting to brain
The great interest in mucosal vaccine delivery arises from the fact that mucosal
surfaces represent the major site of entry for many pathogens.

24.  Strategies for drug delivery to the brain:
Several drugs do not have physiochemical characteristics such as high lipid solubility, low
molecular size and positive charge which are essential to succeed in traversing BBB (blood
brain barrier).
• Disruption of the BBB
Approach was to break down the
barrier by injecting mannitol
solution into arteries in the neck.

25. • Nanoparticulate systems for brain delivery of drugs
One of the possibilities to deliver drugs to the brain is the employment of
nanoparticles.
Other controlled drug delivery system
• Oral
There is a great need in oral delivery of protein and peptide drugs, suitable devices for
delivering the therapeutic agent.
• Parenteral
Medications placed into the tissues and the circulatory system by injection.

26. • The colon specific drug delivery System
(CDDS)is beneficial not only for the oral
delivery of proteins and peptide.
• It is also for the delivery of low molecular
weight compounds used to treat diseases
associated with the colon or large intestine.
THE COLON SPECIFIC DRUG DELIVERY SYSTEM

27. Advances in surface technology of nanoparticles have allowed nanocarriers to engage
applicants for future work involving targeted drug delivery and they are currently
used to diagnose or treat several types of cancer. Additionally, there are different
formulations, which are now in different stages of clinical trials to
• Enhance therapeutic efficacy
• Reducing toxicity
• Increasing patient compliance
• Enabling entirely new medical treatments.
FUTURE PROSPECTIVES

28. THANK YOU