Implantable Drug Delivery System | 7th Semester | Tanisha Das & Swastik Roy | BASICS | Subject : NOVEL DRUG DELIVERY SYSTEM

1. IMPLANTABLE DRUG
DELIVERY SYSTEM
Presented By
Tanisha Das -18601917021
Swastik Roy -18601917022
B.Pharm, Sec-A, Sem-
6th

2. CONTENT
Introduction
Ideal properties
Application
Advantages
Disadvantages
Mechanism
Devices
Conclusion &
Reference
[Fig. No. – 01]

3. INTRODUCTION
Implantable Drug Delivery System -
 Implants are the small sterile solid devices
containing highly purified substances mad
by the mechanism of compression or
moulding .
 In case of drug delivery implants are
designed to transmit drugs and fluids into
the bloodstream of our body without
repeated insertion of needles.
SUBDERMAL IMPLANT
[Fig. No. – 02]

4. IDEAL PROPERTIES
Environmentally stable.
Bio-compatible.
Easy to sterilize.
Rate controlled release of drug.
Easy to manufacture.
Reducing the frequency of the
drug administration.
Inexpensive.
Good mechanical strength.
[Fig. No. – 03]
FIRST DRUG DELIVERY MICROCHI

5. APPLICATIONS
Chronic Disease –
Cardiovascular disease – Zoladex,
Diabetes – Insulin
Women Health - Contraception.
Infectious Disease – Tuberculosis. [Fig. No. – 04]
Examples of
some Implants

6. ADVANTAGES
Controlled drug delivery for a longer period.
Decrease frequency of dose.
Avoid first path metabolism.
Minimize drug side effects.
Improve drug stability and bioavailability.

7. DISADVANTAGES
Surgery needed for large implantation.
Therapy cannot be discontinued easily.
Biocompatibility issue. Reaction between host
and implant.
Implants infection, Inflammatory reactions.
Device failure & implant dislocation
Commercial disadvantage – Costly.

8. MECHANISM
Classificatio
n
Rate
Programmed
Drug Delivery
System
- Membrane Permeation.
- Matrix Diffusion.
- Membrane Matrix Hybrid Type.
- Micro reservior Partition
controlled.
Activation Modulated
drug Delivery System
Physical Activation
- Osmotic Pressure
- Vapour pressure
- Phonophoresis
- Hydration
- Magnetically Activated
- Chemically Activation
- Hydrolysis
Feedback
Regulated
Process
Bio-erosion
Bio-resonsive

9. DEVICES
Birth Control Occlusion devices
Breast Implants
Dental Implants
Biosensors
Heart valve repairs, etc.

10. CONCLUSION & REFERENCE
Conclusion
Drug delivery systems, capable of offering the flexibility of maintaining
pharmacologically effective therapeutic drug levels for extended periods
of time while also allowing “dosing-on demand,” would be considered
extremely valuable tools in modern medicine. Implantable drug delivery
systems (IDDSs) offer physicians the choice of precision delivery, either
locally or into systemic circulation, while guaranteeing optimal dosing
over the course of treatment.
Reference
 Y W. Chien Novel Drug Delivery Systems, 2nd edition, Revised and Expanded, Marcel
Dekker, Inc., New York, 1992.
 Sarah A. Stewart, Juan Domínguez-Robles, [...], and Eneko Larrañeta, Implantable
Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical
Applications, 2018.
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401754/