This document discusses gastro-retentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs and target drug release in the upper gastrointestinal tract. It describes the physiology of the gastrointestinal tract and potential drug candidates for GRDDS. Various approaches for GRDDS are covered, including floating, high density, bioadhesive, swelling, and superporous hydrogel systems. Evaluation parameters, applications, marketed formulations, and conclusions about GRDDS are also summarized.
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
The device which is used in the intrauterine drug delivery system is known as an Intrauterine device (IUD) (2). IUDs or intrauterine devices are small artificial objects or devices inserted into the uterus to prevent the occurrence of pregnancy by disrupting the fertilization process as a result of sexual intercourse. They have gained popularity in recent times and are one of the most effective methods of birth control in terms of long-term contraception. It can be easily installed and is flexible. These devices are usually small in size and inserted through the cervix. IUDs reduce the need for abortion with unwanted pregnancies by preventing the effective movement of eggs and sperm. However, it cannot confirm the spread of STIs or STDs such as HIV, gonorrhoea, etc
Topics covered
Introduction
Advantages
Disadvantages
Development of intra uterine devices (IUDs)
Applications
References
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
The device which is used in the intrauterine drug delivery system is known as an Intrauterine device (IUD) (2). IUDs or intrauterine devices are small artificial objects or devices inserted into the uterus to prevent the occurrence of pregnancy by disrupting the fertilization process as a result of sexual intercourse. They have gained popularity in recent times and are one of the most effective methods of birth control in terms of long-term contraception. It can be easily installed and is flexible. These devices are usually small in size and inserted through the cervix. IUDs reduce the need for abortion with unwanted pregnancies by preventing the effective movement of eggs and sperm. However, it cannot confirm the spread of STIs or STDs such as HIV, gonorrhoea, etc
Topics covered
Introduction
Advantages
Disadvantages
Development of intra uterine devices (IUDs)
Applications
References
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
Video Lecture is available at https://www.youtube.com/watch?v=DXu_CLgB4q0
Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and
biological properties of drugs relevant to controlled release formulations.
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
Video Lecture is available at https://www.youtube.com/watch?v=DXu_CLgB4q0
Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and
biological properties of drugs relevant to controlled release formulations.
GRDDS is most widely used system for controlled delivery of drugs. various approaches for GRDDS is available including
floating ,gastroadhesive,high density ,unflatable system
Gastroretentive Drug Delivery System -> by Mohit kumarMohit Kumar
Contents
INTRODUCTION
WHAT IS GRDDS ?
NEED FOR GRDDS…?
POTENTIAL DRUG CANDIDATES
DRUGS THAT ARE UNSUITABLE FOR GASTRORETENTIVE DRUG DELIVERY SYSTEMS
FACTORS AFFECTING THE GASTRORETENTIVE SYSTEM.
ADVANTAGES OF GRDDS
DISADVANTAGES OF GRDDS
APPROACHES TO EXTEND GI TRANSIT
INTRODUCTION
Oral route has been the most convenient and accepted route of drug delivery.
Gastroretentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs.
WHAT IS GRDDS ?
Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects.
NEED FOR GRDDS…?
Oral drug delivery system, sustained drug delivery systems, these drug delivery systems suffer from mainly two adversities:
Short gastric retention time(GRT) and
Unpredictable short gastric emptying time (GET)
which can result in incomplete drug release from the dosage form in the absorption zone (stomach or upper part of small intestine) leading to diminished efficacy of administered dose.
To formulate a site-specific orally administered controlled release dosage form, it is desirable to achieve a prolong gastric residence time by the drug delivery.
Prolonged gastric retention time (GRT) in the stomach could be advantageous for local action e.g. treatment of peptic ulcer, etc.
POTENTIAL DRUG CANDIDATES FOR GASTRORETENTIVE DRUG DELIVERY SYSTEMS
Drugs that disturb normal colonic microbes e.g. antibiotics against Helicobacter pylori.
Drugs that degrade in the colon. e.g. Ranitidine, Metformin HCl.
Drugs which are absorbed rapidly from the GI tract. e.g. Metronidazole, tetracycline.
Drugs with a narrow window of absorption e.g. Cyclosporine, Methotrexate, Levodopa, etc.
Drugs that are poorly soluble at alkaline pH e.g. Furosemide, Diazepam, Verapamil, etc.
Drugs that are primarily absorbed in the stomach e.g. Amoxicillin.
Drugs acting locally in the stomach(active in stomach) e.g. Antacids and drugs for H. Pylori viz., Misoprostol
DRUGS THAT ARE UNSUITABLE FOR GASTRORETENTIVE DRUG DELIVERY SYSTEMS
Drugs that have very limited acid solubility phenytoin etc.
Drugs that suffer instability in the gastric environment e.g. erythromycin etc.
Drugs intended for selective release in the colon e.g. 5-amino salicylic acid and corticosteroids etc.
FACTORS AFFECTING THE GASTRORETENTIVE SYSTEM.
Density
Size
Shape of dosage form
Single or multiple unit formulation
Fed or unfed state.
Advantages of GRDDS
Increase in bioavailability and curative efficiency of drugs and economic usage of dosage.
Minimised factor of risk in resistance in antibiotics owing to stabilised therapeutic levels over prolonged periods removing fluctuations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
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The four main behavioral effects of AUD are impaired control over
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of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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1. GASTRO-RETENTIVE DRUG
DELIVERY SYSTEM
Submitted by:
Shweta Nehate
M. Pharm 1st sem
Guided by:
Dr. Hitesh Jain
Asso. Professor
Forwarded by:
Dr. D. B. Meshram
Principal
Pioneer Pharmacy Degree College, Vadodara
3. INTRODUCTION
Gastroretentive drug delivery is an approach to prolong
gastric residence time, there by targeting site-specific drugs
release in the upper gastrointestinal tract (GIT) for local or
systemic effects. It is obtained
by retaining dosage form into
stomach and by releasing the
in controlled manner.
3
5. POTENTIAL CANDIDATES FOR
GRDDS
Drugs acting locally in the stomach.
E.g. Antacids and drugs for H. Pylori viz., Misoprolol.
Drugs that are primarily absorbed in the stomach.
E.g. Amoxicillin
Drugs that is poorly soluble at alkaline pH.
E.g. Furosemide, Diazepam, Verampil, etc.
Drugs with a narrow absorption window.
E.g. Cyclosporine, Levodopa, Methotrexate etc.
5
6. Drugs which are absorbed rapidly from the GI tract.
E.g. Metronidazole, tetracycline.
Drugs that degrade in the colon.
E.g. Ranitidine, Metformin.
Drugs that disturb normal colonic microbes.
E.g. Antibiotics against H. Pylori.
Drugs with less half life.
6
7. DRUG CANDIDATES NOT
SUITABLE FOR GRDDS
7
Drugs that have very limited acid solubility.
E.g. Phenytoin, etc.
Drugs that suffer instability in the gastric environment.
E.g. Erythromycin, etc.
Drugs intended for selective release in the colon.
E.g. 5-Amino salicylic acid and corticosteroids, etc.
Drugs having extensive first pass metabolism.
8. FACTORS AFFECTING THE GRDDS
Density
Size and Shape of the dosage form
Single or Multi unit formulation
Age
Gender
Body posture
Frequency of intake
Diseased state of an individual
8
9. MERITS
Improved drug absorption.
Enhanced bioavailability.
Reduced dose frequency.
Controlled drug delivery of drugs.
Minimized mucosal irritation.
Local action.
Better patient compliance.
Site specific drug delivery.
9
10. DEMERITS
Drugs that cause gastric lesions. E.g. NSAIDs.
Drugs that undergo first pass metabolism. E.g. Nifedipine.
Drugs that have very limited acid solubility and stability.
E.g. Phenytoin.
Drugs that degrade in acidic environment.
Drugs which are well absorbed along the entire GIT.
Requires high levels of fluids in stomach.
Requires presence of food to delay gastric emptying.
10
12. APPROACHES TO GASTRIC
RETENSION
High density system
Low density system
Mucoadhesive system
Raft forming system
Swellable system
Superporous hydrogels
Self unfolding systems
12
14. A. FLOATING DRUG DELIVERY
SYSTEMS
Floating drug delivery systems have
a bulk density lower than gastric
fluids and thus remain buoyant in the
stomach for prolonged period of time,
without affecting the gastric emptying rate. While the system
is floating on the gastric contents, the drug is released slowly
at a desired rate from the system. This type is also called as
hydro dynamically balanced system (HBS).
14
15. MECHANISM OF FDDS
FDDS has a bulk density less than gastric fluids and soremain
buoyant in the stomach without affecting the gastric emptying
rate for a prolonged period of time.
F= buoyancy- gravity = (Df-Ds)gv
Where,F= total vertical force,
Df= fluid density,
Ds= object density,
v = volume,
g = acceleration due to
gravity.
15
17. 17
Effervescent system: This are low density FDDS is
based on the formation of CO2 within the device following
contact with the body.
18. Non effervescent system:
18
This system use a gel forming
(or) swellable cellulose type of
Hydrocolloids, polysaccharide,
matrix forming polymer like
polycarbonate, polystyrene and
polymethacrylate. One of the
formulation methods involves
the mixing of the drug with
gelforming hydrocolloids.
19. This hydrocolloids swell in contact with gastric fluid after
oral administration and maintains integrity of shape and a
bulk density barrier, the air trapped by swollen polymer
confer buoyancy to the dosage forms.
19
20. RAFT FORMING SYSTEM
This system is used for delivery of antacids and drug
delivery for treatment of gastrointestinal infections and
disorders.
The mechanism involved
in this system includes the
formation of a viscous
cohesive gel in contact
with gastric fluids, forming a continuous layer called raft.
20
21. MICROPOROUS COMPARTMENT
SYSTEM
This technology is based on the
encapsulation of a drug
reservoir inside a microporous
compartment with pores along
its top and bottom walls. The peripheral wall of the drug
reservoir compartment is completely sealed to prevent any
direct contact of gastric surface with the undissolved drug.
21
22. ALGINATE BEADS
It is prepared by dropping sodium alginate solution into
solution of calcium chloride, causing the precipitates of
calcium alginate.
Freeze dry in liquid nitrogen at -40ºc for 24 hrs.
Formation of porous system which can maintain a floating
force over 12 hrs.
22
23. MICROSPHERES
Microballons/ hollow microspheres loaded with drugs
prepared by solvent evaporation or solvent diffusion/
evaportaion methods.
Buoyancy and drugs release depends on quality of
polymers, plasticizer polymer and solvents used.
23
24. MAGNETIC SYSTEM
This approach to enhance the GRT is based on the simple
principle that the dosage form contains a small internal
magnet, and a magnet placed on the abdomen over the
position of the stomach.
Although magnetic system
seems to work, the external
magent must be positioned
with a degree of precision
that might compromise patient compliance.
24
25. B. HIGH DENSITY SYSTEM
Gastric contents have a density close to water.
A density close to 2.5g/cm3 is necessary for
significant prolongation of gastric
residence time.
The commonly used excipients in high density system includes
barium sulphate, zinc oxide, iron powder, and titanium dioxide.
The major drawback with such systems is that it is technically
difficult to manufacture them with a large amount of drug (>50%)
and to achieve the required density.
25
26. C. BIOADHESIVE OR
MUCOADHESIVE SYSTEM
Bio/ muco-adhesive are those which bind to the gastric
epithelial cell surface or mucin and serve as a potential
means of extending the GRT of drug delivery system (DDS)
in the stomach,by interesting the intimacy and duration of
contact of drug with the biological membrance.
The basis of adhesion in that a dosage form can stick to the
mucosal surface by different mechanism. These mechanism
are:
26
27. 1. The wetting theory.
2. The diffusion theory.
3. The absorption theory.
4. The electron theory.
27
POLYMER
MUCUS
MEMBRANE
28. D. SWELLABLE SYSTEMS
These are dosage forms which after swallowing, swell to an
extent that prevents their exit from the pylorus. As a result,
the dosage form is retained in stomach for a long period of
time. These systems may be named as “plug type system”,
since they exhibit tendency to remain logged at the pyloric
sphincter.
28
29. E. SUPERPOROUS HYDROGELS
29
a) Superporous hydrogel in dry state.
b) Superporous hydrogel in water swollen state.
c) On the right, schematic illustration of the transit or superporous
hydrogels
30. Swellable agents with pore size ranging between 10nm and
10µm, absorption of water by conventional hydrogel is very
slow process and several hours may be needed to reach as
equilibrium state during which premature evacuation of the
dosage form may occur.
Superporous hydrogels swell to equilibrium size with in a
minute, due to rapid water uptake by capillary wetting
through numerous interconnected open pores.
30
31. F. SELF UNFOLDING SYSTEM
These systems are made of biodegradable polymers and are
capable of being mechanically increased in size relative to
the initial dimensions.
After being swallowed, these dosage forms swell to a size
that prevents their passage
though rough the pylorus
and therefore, the dosage
form is prone to be retained
in the stomach for a long
period of time.
31
33. EVALUATION PARAMETERS
Pre- compression test:
• Size and shape
• Particle size
• Density
• Specific gravity
• Flow properties
Post compression test:
• Thickness and diameter
• Hardness and friability
• Weight variation test
• floating time
• Content uniformity
• Dissolution test
• Mucoadhesive test
33
34. IN VITRO TEST:
Floating lag time
Floating time
Dissolution study
Swelling index
Mucoadhesive test
Density
IN VIVO TEST:
• Radiology
• Scintigraphy
• Gastroscopy
• Magnetic marker
monitoring
• Ultrasonography
34
35. APPLICATIONS
Enhanced bioavailability
Sustained drug delivery
Site specific drug delivery system
Absorption enhancement
Minimized adverse activity at the colon
Reduced fluctuation of drug concentration
35
37. CONCLUSION:
FDDS promise to be potential approach for gastric retention.
The goal of any drug delivery system is to provide a
therapeutic amount of drug to the proper site in the body and
also to achieve and maintain the desired plasma concentration
of the drug for a particular period of time.
However, incomplete release of the drug, shorter residence
times of dosage forms in the upper GIT leads to lower oral
bio-availability.
Such limitations of the conventional dosage forms have paved
way to an era of controlled and novel drug delivery system.
37
38. REFERNCE:
Doshi S.M., Tank H.M., “Gastro Retention, An Innovation
over Conventional poorly Soluble Drugs: A Review”,
International Journal of Pharmaceutical and Chemical
Science, 2012;1(2):859-866.
S.P. Vyas, Roop K. Khar, CONTROLLED DRUG
DELIVERY – Concepts & Advances, Vallabh Prakashan,
pp- 196-217.
N.K. Jain, Progress in controlled & Novel Drug Delivery
System, 1st edition 2004 CBS Publishers, pp- 76-97.
38
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