This ppt gives you idea about pathophysiology of tuberculosis and the pharmacology of drugs used to treat this infection. And it also give deep introduction of molecular interaction of mycobacteria with body i.e.. immune response by human to this mycobacteria.
it also gives you idea about treatment regimens and strategy for TB. discussed the different types of TB and mechanism of development of resistance by mycobacteria for anti-TB drugs.
Definition of tuberculosis as scientific and practical problem.
Epidemiology of tuberculosis.
The etiology and pathogenesis of tuberculosis.
Immunity of tuberculosis.
Clinical classification of tuberculosis.
Objective :
Describe the morphology and structure of mycobacterial tuberculosis ?
What are the tests required for mycobacterial infection :
Mantoux skin test
Sputum examination using Ziehl-Neelsen staining
Sputum culture using lowenstein-jensen media
Discuss the clinical features and transmission of mycobacterial tuberculosis.
What are the pathological changes in mycobacterium tuberculosis?
How to control mycobacterial infection in the environment and vaccine available?
done by : asem shadid , college of medicine .
This presentation includes introduction, properties, transmission, epidemiology, pathogenesis, mechanism of infection, immunity and hypersensitivity, clinical manifestations, diagnosis, treatment, prevention and control of MYCOBACTERIUM TUBERCULOSIS.
Advertising media refers to the various channels or vehicles through which promotional content is communicated in various forms such as text, speech, images, videos etc.
antidotes and their MOA
An antidote is a substance which can counteract a form of poisoning. The term ultimately derives from the Greek αντιδιδοναι antididonai, "given against"
Natural compounds from the bark of the cinchona tree, most notably quinine was observed to exhibit antimalarial activity.
Until the development of synthetic derivatives (ie. 4-aminoquinoline antimalarials), quinine continued to be the first choice to treat malaria.
Quinine is associated with side effects such as diarrhœa.
4-aminoquinoline antimalarials such as amodiaquine and chloroquine largely replaced quinine because of reduced unpleasant side effects.
The life cycle of the parasite and the immunological defence mechanisms against the parasite are complex.
Part of the parasite’s life cycle involves invasion of red blood cells (erythrocytes).
The haemoglobin within the red blood cell is broken down by the parasite and is used as a source of amino acids.
The 4-aminoquinolines act at the erythrocytic stage of the parasite.
Doxycycline is a compound used in prophylaxis against plasmodial parasites.
Other compounds associated with treating malaria include halofantrine and lumefantrine, often used in combination with other drugs.
Pharmaceutical Quality Management of Dexamethasone tablets BP
Dexamethasone tablets USP
DEXAMETHSONE OPTHALMIC SUSPENSION BP
DEXAMETHSONE OPTHALMIC SUSPENSION USP
Dexamethasone is a synthetic (man-made) corticosteroid.
Corticosteroids are naturally-occurring chemicals produced by the adrenal glands located above the kidneys.
Epilepsy
Epilepsy is a group is neurological disorder. An epileptic seizure is a paroxysm(sudden) of uncontrolled discharges of neurons causing an event that is discernible(visible) by the person experiencing the seizures or by the observer. The tendency to have recurrent attacks is known as epilepsy.
phenytoin,phenobarbital,sodium valporate ,carbamazepine,clonazepam and diazepam, lamotrigine,pregabalin,felbamate,zonisamide, ETHOSUXIMIDE, LEVETIRACETAM, OXACARBAZEPINE, PRIMIDONE
RESEARCH IN HOSPITAL PHARMACY and PHARMACY EDUCATIONAsra Hameed
RESEARCH IN HOSPITAL PHARMACY:
Advancement of pharmacy practice and healthcare
Pharmacists play a vital role in the health care system through the medicine and information they provide. Pharmacy education is the broad term which mainly involves the
Pharmacist educational requirements and carrier
Patient education
1) BASED ON THE CHEMICAL NATURE OF NON SUGAR MOIETY
2) BASED ON TE NATURE OF SUGAR MOITY
3) BASED ON LINKAGE BETWEEN GLYCON AND AGLYCON PORTION
4) BASED ON THERAPEUTIC NATURE OF GLYCOSIDE
ALLAH Kareem nay Hazrat Muhammad S.A.W.W ko tmaam insaaniyat kay lye rehmat bna kr bheja, jnki sadaqat ki gawahi kaafir be daitay thay, tau aisay Nabi aur Khuda ka mazhab deshatgardi aur khoonraizi ki ijazat kaisay dy skta hai?
Introduction:
Poverty Condition in Pakistan
Causes/Reasons of poverty in Pakistan
Effects of poverty in Pakistan
Solutions/Remedies to Overcome the Poverty in Pakistan
Conclusion
Dengue (pronounced DENG-gay) can affect anyone but tends to be more severe in people with compromised immune systems. Because it is caused by one of four serotypes of virus, it is possible to get dengue fever multiple times. However, an attack of dengue produces immunity for a lifetime to that particular serotype to which the patient was exposed.
Essential oils are volatile (quickly evaporating) aromatic fluids extracted from plants through steam distillation, or in the case of citrus fruits through expression (or cold pressing) of the rind to obtain an oil that retains a juicy, fresh fruit scent.
Various extraction methods are used in the manufacture and extraction of essential oils, and the method used is normally dependant on what type of botanical material is being used.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
Mycobacterium tuberculosis and Mycobacterium leprae
1.
2.
3.
4. TB has been known
as Pthisis, King’s
Evil, Pott’s
disease,
consumption, and
the White Plague.
Egyptian mummies
from 3500 BCE
have the presence
of Mycobacterium
tuberculosis
5. Started in Europe
in 1600’s
Reigned for around
200 years
Named for the loss
of skin color of
those infected
6. Infected the New
World before the
Europeans
10% deaths in the 19th
century were due to
TB
Isolated the infected
in sanitariums, which
served as waiting
rooms for death
7. Mycobacterium tuberculosis
Mycobacterium
tuberculosis is the
etiologic agent of
tuberculosis in
humans.
Humans are the only
reservoir for the
bacterium.
Humans can also be
infected by the
consumption of
unpasteurized milk.
This route of
transmission can lead
8. Cell Morphology
Weakly gram-positive,
strongly acid-fast, aerobic
bacilli (rod).
The rods are 2-4
micrometers in length and
0.2-0.5 um in width.
Lipid-rich cell wall,
making the organism
resistant to disinfectants,
detergents, common
antimicrobial drugs and
traditional stains.
Capable of intracellular
growth in inactivated
alveolar macrophages.
Disease primarily from
host response to infection.
9. SEM of M. tuberculosis
M. Tuberculosis
(stained in purple)
10. Humans are the only reservoir
Inhalation of droplet nuclei containing
M.tuberculosis
Replication in lungs
(granuloma formation)
Lymphohematogenous spread:
dissemination throughout body inside
macrophages
Cell-mediate immune response leads to
granuloma formation:
Latent infection
Reactivation
11. Granuloma formation:
activated lymphocytes,
macrophages, Langhans
giant cells, fibroblasts and
capillaries
Caseous necrosis: leads
to liquefaction of necrotic
tissue leads to cavitations
in lungs
MTB in granuloma latent
for years and then if
immunity wanes the AFB
can reactivate
12. The photomicrograph shows a caseous granulomatous lesion in a lymph
node and the causative agents are not decernible in the H&E stained
section. The inserted image(right hand corner) shows the section
following a Ziehl-Neelsen acid-fast special stain viewed under an oil
objective. The pink rod microbes,the causative agents engulfed in the
giant cells, are Mycobacteria tuberculosis.”
LYMPH NODE LUNGS TISSUE
13. M. Tuberculosis in sputum
(stained in red)
M. tuberculosis:
- Acid Fast Bacilli (AFB)
- Risk group 3 bacterium
- Humans are the only reservoir
Pathogenesis:
- Inhalation of infectious droplet nuclei
- unrestricted replication spreads throughout body
- Cell-mediated immune response
- Granuloma formation latent infection
- Reactivation if immunity wanes
Public Health Risk
- Pulmonary TB highest risk for spread
- HIV link
- MDR: multi-drug resistant strains
14. TB infection is detected by the administration of a tuberculin skin
test on the arm. A single needle is used to put some testing
material, called tuberculin, under the skin. In two or three days, a
nurse or a doctor will check to see if there is a reaction to the
test. The test is "positive" if a bump about the size of a pencil
eraser or bigger appears on the arm. This bump means a person
probably has TB infection. A chest X-ray is done to see if
someone with a positive skin tests (TB infection) also has TB
disease.
People who are infected with TB do not feel sick, do not have
any symptoms and have a normal chest X-ray cannot spread TB.
However, they may develop TB disease at some time in the
future. People with TB infection but are not yet sick can take
medicine so that they will never develop TB disease.
19. Extra-pulmonary TB: Symptoms depend on location of infection
General symptoms: fatigue, fever, loss of appetite, weight loss.
TB of lymph nodes: swelling of lymph nodes
TB meningitis: neurological symptoms including headache
Spinal TB: Mobility impairments, pain
20.
21.
22. •Mycobacterium tuberculosis is the
bacterial specie that causes most cases
of tuberculosis.
•Like all bacteria, Mycobacterium
tuberculosis is an extremely small
organism, having a rod-like body that is
only a few microns (1/10,000 of an inch)
in length.
•In many individuals, the body mounts
an immune response to this infection that
is successful in either clearing out the
bacteria or walling them off so they exist
in a dormant state.
•the invading organisms proceed to
destroy tissue and create lesions
(tubercles) in the lungs.
23. •Due to the notable slow growth rate of this
bacteria, death for the victim can take many
months or even years.
•Within the lungs, Mycobacterium
tuberculosis cells are ingested by specialized
cells of the body's immune system known as
macrophages.
• Due to their unique waxy surface coating, the
bacteria are not destroyed by this action as other
invaders would be, but instead begin to replicate
themselves within the macrophages.
•Other immune cells then swarm to the site of
infection to keep it from spreading further,
resulting in the formation of a dense spherical
mass termed a granuloma.
•n others, the bacteria persist and remain viable,
albeit in a dormant walled-off nodule. While the
latter outcome does lead to an asymptomatic
latent infection, this is nevertheless fully capable
of causing tuberculosis later in life if the body's
immune system becomes weakened or
compromised.
24. Proteins that are actively secreted during culture on synthetic
media represent a particular group of great current interest.
At least eight proteins secreted by Mycobacterium tuberculosis
have been isolated and characterized to various extents.
All of them contain typical signal sequences.
The proteins of the antigen 85 complex, which form the main
subject of this review, are often the most common proteins in
M. tuberculosis culture fluid.
The constituents denoted 85A, 85B, and 85C are encoded by
three genes located at different sites in the mycobacterial
genome and show extensive cross-reactivity as well as
homology at amino acid and gene levels.
Secreted mycobacterial antigens are expected to be of
particular significance in induction of various immune responses
that are responsible for development of protective immunity in
some individuals and for clinical symptoms and complications
of the ensuing disease in others.
25.
26. M. tuberculosis requires oxygen to grow. It does not
retain any bacteriological stain due to high lipid
content in its wall, and thus is neither Gram-positive
nor Gram-negative; hence Ziehl-Neelsen staining, or
acid-fast staining, is used. While mycobacteria do not
seem to fit the Gram-positive category from an
empirical standpoint (i.e., they do not retain the
crystal violet stain), they are classified as acid-fast
Gram-positive bacteria due to their lack of an outer
cell membrane.[1]
27. M. tuberculosis divides every 15–20 hours,
which is extremely slow compared to other
bacteria, which tend to have division times
measured in minutes (Escherichia coli can
divide roughly 20 minutes).
M. tuberculosis is characterized by
caseating granulomas containing
Langhans giant cells, which have a
"horseshoe" pattern of nuclei.
Organisms are identified by their red
color on acid-fast staining.
28.
29.
30.
31. The use of blood agar media for the recovery of M. tuberculosis was
reported early in the last century but has been removed from
contemporary microbiology manuals (4, 6). However, there have
been more recent reports, including one from 1998 in which Arvand
et al. isolated M. tuberculosis from a lymph node when investigating a
diagnosis of cat scratch disease (1). Even earlier, a comparative study
of different media conducted in 1977 suggested that penicillin blood
agar would be at least as good as, if not better than, Löwenstein-
Jensen medium for recovering M. tuberculosis (3).
The study of Drancourt et al. with clinical samples is very useful in once
again highlighting the ability of these media to grow M. tuberculosis,
in particular when this is not the organism being sought. Moreover, we
agree with Drancourt et al. in highlighting the importance of handling
in a secure manner culture media which are not specific for
mycobacteria but require prolonged incubation, as we have already
stated in our paper. Sealing the agar plates with adhesive tape
(Micropore surgical tape; 3M, St. Paul, Minn.) is a simple way to avoid
risks.
32. Tuberculosis (TB) is the most common major infectious disease today. It is
estimated that two billion people--or one-third of the world's population--are
chronically infected without active symptoms. Nine million new cases of
active disease are diagnosed annually, resulting in two million deaths. TB is
predominantly a lung disease. It is caused by a microbe called
Mycobacterium tuberculosis which infects lung cells, but it is still not clear how
exactly this happens. Ludovic Tailleux, Olivier Neyrolles, and colleagues (from
the Pasteur Institute, in collaboration with the Necker and Saint-Louis Hospitals,
in Paris) have found that a molecule called DC-SIGN plays a crucial part.
33. The researchers wanted to examine whether lung cells from patients with TB
were different from those of healthy people or those with different lung diseases,
and what that tells us about the way the infection spreads in the lung. In
particular, they looked at the surface of the lung cells, because this is the part
directly involved in the first contact with the Mycobacterium. As they report
now in the international open-access medical journal PLoS Medicine, they
studied 74 individuals, 40 of whom had TB, 25 had other inflammatory lung
diseases, and 9 had neither active TB nor lung inflammation and served as
healthy "controls." The patients underwent a procedure called broncho-
alveolar lavage that washes out some of the secretions and cells from the lower
respiratory tract. The researchers then analyzed the cells in different ways. They
concentrated on a type of cell called a macrophage (the natural target of
Mycobacterium) and found that macrophages from patients with TB had much
more the DC-SIGN protein on their surface than macrophages from patients
with other diseases or from the control individuals.
They then took macrophages from a control individual (which had very low
levels of DC-SIGN) and infected them with Mycobaterium under laboratory
conditions. They found that shortly after infection not only the infected cells but
also some of their neighbours started to display DC-SIGN on their surface. They
also found that having DC-SIGN on the surface made uninfected cells much
more susceptible to infection.
34.
35. highly fatal form if not adequately treated. In
fact, once the bacilli enter the bloodstream,
they can travel to almost any organ of the
body, including the lymph nodes, bones...
When still active, pulmonary tuberculosis is a
constant threat to the patient, because
blood-borne spread may occur at any time.
Diffuse spread of tuberculosis in the lung
(known as miliary tuberculosis)
36. An Infection Of The Meninges That
Cover The Brain Causes Tuberculous
Meningitis; Before The Advent Of
Specific Drugs, This Disease Was
Always Fatal, Though Most Affected
People Now Recover.
In Many Developing Countries,
Tuberculous Meningitis Is Common.
37. The global tuberculosis epidemic
An estimated 14 million people worldwide are infected with active
tuberculosis (TB), which is a disease of poverty affecting mainly young
adults in their most productive years. In 2009 there were 9.4 million
new cases of TB and 1.7 million deaths, including 380,000 deaths from
TB among people with HIV. The vast majority of deaths from TB are
in the developing world.
The latest data released by the World Health Organization (WHO) in
November 2010 show that the number of new cases continues to fall
globally and in five of the six WHO regions. The exception is
Southeast Asia, where incidence remains stable. In many countries TB
prevalence is declining. Worldwide, deaths from TB fell by 35 percent
between 1990 and 2009.
If current trends continue the world can meet the Millennium
Development Goal target for incidence – that new cases should be
falling by 2015 – and the Stop TB Partnership target to halve TB
mortality by 2015 in comparison with 1990.
38. Progress in tackling the global TB burden is associated with DOTS, the basic
package that underpins the Stop TB Strategy, which was adopted by the WHO
in 1993. The expansion of DOTS across the world since the mid-1990s is
tracked through the proportion of estimated new TB cases that are detected –
or “notified” – and successfully treated under DOTS.
In 2009 5.8 million cases of all kinds of TB were notified globally, equivalent
to a 63 percent case detection rate compared with 61 percent in 2008.*
Treatment success rates continue to be measured in terms of smear-positive
pulmonary TB only. Of the 2.6 million cases notified in 2008, 86 per cent were
successfully treated against the new 90 percent target included in the 2011-
2015 update of the Global Plan to Stop TB.
A total of 41 million TB patients were successfully treated in DOTS programs
between 1995 and 2009.
The Global Fund has helped to accelerate case detection and successful
treatment in recent years, with 1.7 million additional cases of TB detected and
treated by Global Fund-supported programs in 2010, compared with 1.4
million in 2009 and 1.3 million in 2008. Since the Global Fund’s inception in
2002, programs it has financed had supported DOTS for a total of 7.7 million
people by December 2010.
39. A child receiving a tuberculosis vaccine at school in Bulacan province,
Philippines, c. 1952.
40.
41.
42.
43. The micro bacterial leprae
generation time is 12 to14
days!
it is an Acid Fast Bacteria i.e
the decolorizer used in its
gram staining is a very strong
acid and they are very
resistant to even acid!
It presence is indicated by
the appearance of red color
in slide
Optimum temperature
required for max growth is 30
degree.
It shows preference of
growth in outer cooler
places.
leprosy have never been
grown in artificial media!
50. Leprosy is a chronic infectious
disease caused by
mycobacterium leprae, an acid-
fast, rod-shaped bacillus.
The disease mainly affects the
skin, the peripheral nerves,
mucosa of the upper respiratory
tract and also the eyes, apart
from some other structures.
Leprosy has afflicted humanity
since time immemorial. It once
affected every continent and it
has left behind a terrifying image
in history and human memory -
of mutilation, rejection and
exclusion from society
51. The bacterium that causes Leprosy is rod-
shaped and called Mycobacterium leprae.
When Mycobacterium leprae enters the
body, one of these things can happen:
1)Tuberculoid leprosy (TT) :
The body's immune cells attempt to seal off
the infection from the rest of the body by
surrounding the offending pathogen.
2)Lepromatous leprosy (LL) :
• This is the more dangerous type, in which
the body's immune system is unable to
mount a strong response to the invading
organism. Hence, the organism multiplies
freely in the skin. This type of leprosy is also
called the multibacillary (MB) leprosy,
because of the presence of large numbers
of bacteria. Occasionally, the mucous
membranes of the eyes, nose, and throat
may be involved.
52. Leprosy has struck fear into human beings for thousands of years, and
was well recognized in the oldest civilizations of China, Egypt and
India.
Since ancient times, leprosy has been regarded by the community as
a contagious, mutilating and incurable disease.
There are many countries in Asia, Africa and Latin America with a
significant number of leprosy cases. It is estimated that there are
between one and two million people visibly and irreversibly disabled
due to past and present leprosy who require to be cared for by the
community in which they live.
When M.leprae was discovered by G.A. Hansen in 1873, it was the
first bacterium to be identified as causing disease in man. However,
treatment for leprosy only appeared in the late 1940s with the
introduction of dapsone, and its derivatives.
53. The most widely held belief
was that the disease was
transmitted by contact
between cases of leprosy
and healthy persons.
More recently the
possibility of transmission
by the respiratory route is
gaining ground.
There are also other
possibilities such as
transmission through
insects which cannot be
completely ruled out
TRANSMISSION BY CONTACT:
The term 'contact' in leprosy is generally not
clearly defined. All that we know at present is that
individuals who are in close association or
proximity with leprosy patients have a greater
chance of acquiring the disease.
In general, closeness of contact is related to the
dose of infection which in turn is related to the
occurrence of disease. Of the various situations that
promote close contact, contact within the
household is the only one that is easily identified.
TRANSMISSION THROUGH INSECTS:
With the available evidence on intracutaneous
inoculation as a successful method of transmission
of M.leprae in the mouse footpad model and a
similar situation possibly existing in human beings,
54. "scaly skin."
Kingdom: Bacteria
Phylum: Actinobacteria
Order: Actinomycetales
Suborder: Corynebacterineae
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: M. leprae
It's easy to look at a listing of the scientific classification, but why does it
belong to each of those groups? Here is a brief explanation...
Kingdom: Bacteria
This organism belong to the kingdom bacteria because it fits the typical
characteristics of prokaryotic bacteria,
55.
56.
57. Signs and Symptoms of Leprosy
Signs and symptoms of leprosy usually appear
three to five years after becoming infected with
Mycobacterium leprae -- the bacteria responsible
for the disease. Leprosy usually affects the skin
and peripheral nerves. However, once signs and
symptoms of leprosy begin, there can be a wide
variety of symptoms and severity. The type of
leprosy a person has is also a factor.