This document summarizes the development and functions of T and B lymphocytes. It discusses how they develop from stem cells in the bone marrow or thymus, and how T cells undergo selection processes in the thymus. It describes the roles of cytotoxic T cells, helper T cells, and B cells, and how B cells differentiate and produce antibodies. The document also provides a brief overview of HIV/AIDS, including the virus structure and life cycle.
IT CONTAINS THE LATEST INFORMATION ABOUT MHC MOLECULE WHICH WILL BE HELPFUL FOR B.SC /M.SC/CSIR-NET/DBT-JRF/GATE STUDENTS. THIS IS IN VERY SIMPLE AND LUCID MANNER TO UNDERSTAND AND ONE CAN EASILY OPT FOR THIS TO PREPARE NOTES.
Hemo: Referring to blood cells
Poiesis: “The development or production of”
The word Hemopoiesis refers to the production & development of all the blood cells
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
dendritic cells are part of innate immune system, antigen presenting cells in skin, activation of t cells and inducing and maintaining immune tolerance, 4 types- langerhans cells, dermal dendritic cells, merkel cells, melanocytes
Constitutes 20 – 40 % of the body’s white blood cell and 99 % cells in the lymph.
Circulate continuously in the blood and lymph and migrates into the tissue spaces.
On the basis of function and cell membrane component, mainly 3 types :- B cells, T cells and NK (Natural killer cells)
IT CONTAINS THE LATEST INFORMATION ABOUT MHC MOLECULE WHICH WILL BE HELPFUL FOR B.SC /M.SC/CSIR-NET/DBT-JRF/GATE STUDENTS. THIS IS IN VERY SIMPLE AND LUCID MANNER TO UNDERSTAND AND ONE CAN EASILY OPT FOR THIS TO PREPARE NOTES.
Hemo: Referring to blood cells
Poiesis: “The development or production of”
The word Hemopoiesis refers to the production & development of all the blood cells
Humoral immunity is defined as the immunity mediated by antibodies, which are secreted by B lymphocytes.
B lymphocytes secrete the antibodies into the blood and lymph
dendritic cells are part of innate immune system, antigen presenting cells in skin, activation of t cells and inducing and maintaining immune tolerance, 4 types- langerhans cells, dermal dendritic cells, merkel cells, melanocytes
Constitutes 20 – 40 % of the body’s white blood cell and 99 % cells in the lymph.
Circulate continuously in the blood and lymph and migrates into the tissue spaces.
On the basis of function and cell membrane component, mainly 3 types :- B cells, T cells and NK (Natural killer cells)
Introduction to the topographical anatomy and operative sugerykavanvyas1
this short note contains all the necessary information about the basics of topographical anatomy and surgery , which is very helpful to beginners , especially medical aspirants.
Lymphocyte is a type of white blood cell in the immune system of jawed vertebrate. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). They are the main type of cell found in lymph, which prompted the name "lymphocyte". Th all myeloid and lymphoid cells develop from one type of stem cell called as Hematopoietic stem cell is a undifferentiated cell give rise to further diffetentiation of all the immune cell as well as blood cells include the T- cell and B-cell. The B-cell is synthesis and matured in the Bone Marrow and T- cell is synthesis in Bone marrow but matured in the thymus. In this topic will be discussed how the B-cell and T-cell are developed
T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response and are distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface.
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system.. B cells produce antibody molecules.
In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricus.
B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.
The immune system is a complex network of organs, cells and proteins that defends the body against infection, whilst protecting the body’s own cells.
The immune system keeps a record of every germ (microbe) it has ever defeated so it can recognise and destroy the microbe quickly if it enters the body again.
Abnormalities of the immune system can lead to allergic diseases, immunodeficiencies and autoimmune disorders.
On this page
Immune system
The immune system and microbial infection
Parts of the immune system
The body's other defences against microbes
Fever is an immune system response
Common disorders of the immune system
Immunisation
Where to get help
Immune system
The immune system is made up of a complex network of organs, cells and proteins that fight infection (microbes).
The immune system and microbial infection
The immune system keeps a record of every microbe it has ever defeated, in types of white blood cells (B-lymphocytes and T-lymphocytes) known as memory cells. This means it can recognise and destroy the microbe quickly if it enters the body again, before it can multiply and make you feel sick.
Some infections, like the flu and the common cold, have to be fought many times because so many different viruses or strains of the same type of virus can cause these illnesses. Catching a cold or flu from one virus does not give you immunity against the others.wThe immune system is a complex network of organs, cells and proteins that defends the body against infection, whilst protecting the body’s own cells.
The immune system keeps a record of every germ (microbe) it has ever defeated so it can recognise and destroy the microbe quickly if it enters the body again.
Abnormalities of the immune system can lead to allergic diseases, immunodeficiencies and autoimmune disorders.
On this page
Immune system
The immune system and microbial infection
Parts of the immune system
The body's other defences against microbes
Fever is an immune system response
Common disorders of the immune system
Immunisation
Where to get help
Immune system
The immune system is made up of a complex network of organs, cells and proteins that fight infection (microbes).
The immune system and microbial infection
The immune system keeps a record of every microbe it has ever defeated, in types of white blood cells (B-lymphocytes and T-lymphocytes) known as memory cells. This means it can recognise and destroy the microbe quickly if it enters the body again, before it can multiply and make you feel sick.
Some infections, like the flu and the common cold, have to be fought many times because so many different viruses or strains of the same type of virus can cause these illnesses. Catching a cold or flu from one virus does not give you immunity against the others.The immune system is a complex network of organs, cells and proteins that defends the body against infection, whilst protecting the body’s own cells.
The immune system keeps a record of every germ (microbe) it has
Adaptive/Acquired Immunity
Antigens – Anything that cases a biological immune response by this system of cells
Specificity – Some antibodies are quite specific to an antigen others are general to a “type” or “form”
Memory – b-memory cells are formed and remain to combat future exposures quickly (Active vs Passive immunity
Antibodies – the proteins formed by b-cells that combat antigens whether chemical or biological
Lymphocytes – cells involved in this response
introduction of adaptive immunity. classification of adaptive immunity, factor affecting it and mechanism of adaptive immunity comparison between adaptive immunity and innate immunity. characteristic of adaptive immunity . cell mediated immune responses immunoglobulins
types of immunoglobulins. functions of immunoglobulins, hypersensitivity reactions
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. Content of the lecture
1. Birth of T & B Lymphocytes.
2. How they grow up?
3. What purpose they are serving in your body?
4. Little bit about MHC.
5. AIDS
6. Kaun Banega Crorepati !!
3. Birth of T & B Lymphocytes
a. In fetus, blood cell
precursor is found in liver
and yolk sac.
b. In adult, blood cell
precursor is found bone
marrow.
Stem Cell
Erythroid
Myeloid
B lymphocytes
Lymphoid
T lymphocytes
4. T lymphocytes selection in thymus
Pre
thymocytes
Thymus
Thymic
epithelial
cells
TCR
Death
Death
Death
5. T lymphocytes selection in thymus
CD 4+
CD 8+
TCR
CD 4+
CD 8TCR
Differentiation of double positive
cells into a single positive cell (either
CD 4+ or CD8+) upon contact with
either class II or class I MHC
protein.
CD 4CD 8+
TCR
6. What is the function of T lymphocyte?
Cytotoxic T cell
• Extracellular pathogen
Antibodies
• What if the pathogen is predominantly intracellular?
• T cells continuously scan all the cell surfaces and kill
those that exhibit foreign antigen.
• “Cut & display” method used by all the cells of the body.
The peptide of the intracellular intruder is displayed in
association with MHC I protein.
• Scanning cytotoxic cells (CD8+) then destroy the
infected cell.
7. What is the function of T lymphocyte?
Helper T cell
• Helper T cell (CD4+) recognizes peptides bound to MHC class II and
not class I.
• They scan APCs like macrophages, dendritic cells and B cells.
• The peptide attach to MHC II comes from proteins that are
internalized by endocytosis.
• Helper T cells then signals the B cells to proliferate and produce Ig.
• Presentation of peptide attached to MHC I is a call for destruction.
• Presentation of peptide attached to MHC II is a call for help.
12. Functions of Immunoglobulin
3.
Toxin receptors
Bacterial toxins
Host
cell
Neutralization by antibody
Forming phagosome Fc
receptor
Phagocytosis of
antibody-antigen
complex by
macrophage
15. Class Switching
An antibody-producing cell first synthesizes IgM and then makes either IgG, IgA,
IgD, or IgE of the same specificity. In this switch, the light chain is unchanged.
Furthermore, the variable region of the heavy chain stays the same. Only the constant
region of the heavy chain changes. This step in the differentiation of an antibodyproducing cell is called class switching.
16. HIV & AIDS
1. Virus Coat
2. Viral Core
3. Enzymes
4. Nuclear Material
5. Genes
17. HIV Life Cycle
1. Entry
2. Reverse Transcription and Integration
3. Transcription and Translation
4. Assembly, Budding and Maturation
18.
19. Question Round (True/False)
1. Macrophages have receptors for Fab fragment of Immunoglobulin molecule on their
surfaces.
2. Antibody specificity is determined by the amino acid sequence of the variable regions of
both light and heavy chain.
3. IgA acts as a first line of defense against bacterial and viral antigen.
4. A child stung by a bee experiences respiratory distress within minutes and lapses into
unconsciousness. This reaction is probably mediated by IgM.
5. AIDS is caused by a human retrovirus that kills CD8+ cells.
6. After binding to its specific antigen, a B lymphocyte may switch its constant region of the
immunoglobulin light chain.
21. Maximum concentration of this immunoglobulin is
present in which of the following?
Secretory Piece
A. Urine
B. Heart
C. Clostrum
D. All of the above
J Chain/
T Piece
22. This is an example of ………………?
A. Isotypic Difference
B. Allotypic difference
C. Idiotypic difference