This randomized controlled trial compared an early goal directed nutrition (EGDN) strategy to standard care nutrition in critically ill patients requiring mechanical ventilation. The EGDN strategy aimed to meet 100% of calculated energy and protein needs within 24 hours and throughout the ICU stay based on indirect calorimetry and nitrogen balance measurements. While the EGDN group received higher energy and protein delivery in the ICU, there were no differences in physical quality of life scores at 6 months or other clinical outcomes like mortality, infections, or length of stay between the two groups. The study found that targeting early and full nutritional needs did not provide additional benefits over standard care in critically ill patients.
Peter McCanny is part of the LearnECMO team. In this podcast he explains some of the background and history of ECMO CPR, what evidence there is to support its use and where we're heading in the future.
Objectives:
1.To understand the current evidence on ICU nutrition.
2.To translate this evidence into practice for energy.
3.To translate this evidence into practice for macronutrients.
Watch the webinar http://bit.ly/1FBMckB
Peter McCanny is part of the LearnECMO team. In this podcast he explains some of the background and history of ECMO CPR, what evidence there is to support its use and where we're heading in the future.
Objectives:
1.To understand the current evidence on ICU nutrition.
2.To translate this evidence into practice for energy.
3.To translate this evidence into practice for macronutrients.
Watch the webinar http://bit.ly/1FBMckB
Emma Ridley, ANZIC-RC, Monash University and Alfred Health
Emma leads the ICU Nutrition Research Program at the Australian and New Zealand Intensive Care Research Centre, Melbourne, Australia and has 13 years of clinical dietetic experience, including as a senior dietitian in the ICU at The Alfred Hospital, Melbourne. Emma’s research interests include the clinical application of indirect calorimetry, as well as the effect of optimal nutrition delivery on short and long-term outcomes in ICU patients. Emma was awarded a prestigious Churchill Fellowship in 2011 to investigate the role of indirect calorimetry internationally and regularly delivers invited national and international presentations. Emma is on the management committee for the TARGET trial (the largest blinded enteral nutrition trial conducted in critical care) and has been a named investigator on $6.2 million dollars of research funding, including a project based on findings from her PhD of $2.3 million dollars (NCT03292237).
Feasting or fasting in ICU? by Professor Marianne ChapmanSMACC Conference
Despite the publication of a number of studies over recent years looking at energy delivery and outcomes in the critically ill population we remain uncertain how best to determine optimal calorie delivery for our patients. The concept that energy delivery should match energy consumption is plausible and intellectually attractive bu Broadly speaking clinicians can be divided into 3 categories according to their approach on energy delivery to the critically ill. Some believe that optimal clinical outcomes are achieved by closely approximating energy consumption i.e. providing full calorie requirement, usually around 2000kcal/d for the standard sized adult. This position is supported by a number of observational studies, however, patients usually only receive about 60% of what they are prescribed. Some believe that attempting to provide full feeding exposes the patient to the risk of overfeeding and that ‘permissive’ underfeeding is safe and better tolerated in critically ill patients where gastrointestinal function is frequently deranged. Interestingly, recent data suggest that the patient group potentially most at risk of overfeeding are those who are malnourished at presentation. Finally, some believe that the amount of energy delivered during ICU stay has little impact on recovery. Only when the ICU stay becomes unusually prolonged may the amount of energy delivered become important. There is evidence to suggest that some nutrition should be given enterally from early in the ICU stay to provide gastrointestinal mucosal protection and improve subsequent gut function. In recent years there have been several randomised controlled trials addressing energy delivery but they have unfortunately given conflicting results. Furthermore, these studies have had a number of limitations including: being underpowered to show an effect on survival; open to bias because of being open-labelled; most have not delivered full energy requirements so the effect of this on outcomes remains uncertain. It is hoped that many of these issues will be addressed in the currently recruiting TARGET trial which will be completed next year.t, while energy delivery can be measured with indirect calorimetry, this is not a technique that lends itself to routine clinical care. Accurate measurement or calculation of day to day energy expenditure is not currently routinely possible. Delivery of nutrition is an important supportive activity in the ICU. Patients generally receive less than prescribed nutritional needs and there is no robust evidence as yet to suggest that this is deleterious to outcomes.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...
EAT ICU Trial
1. EAT-ICU TRIAL
D e p a r t m e n t o f I n t e n s i v e c a r e ,
C o p e n h a g e n U n i v e r s i t y H o s p i t a l ,
R i g s h o s p i t a l e t , C o p e n h a g e n , D e n m a r k
Journal Club
Sabahat Zaidi
Senior Clinical Fellow
NUH
2. Background. The need.
Critical illness leaves patients with nutritional deficit, muscle weakness,
anorexia, global muscle loss.
ICU Acquired Weakness (ICU-AW). Critical care myopathy. Critical Care
polyneuropathy.
Nutrition in critically ill is good.
How much to feed?
How to calculate the requirements? Individualistic vs. generalist
When to start EN vs. PN? Early vs. late? ESPEN (early parenteral) vs. ASPEN
(late parenteral)
3. The Question!
In critically ill patients, does Early Goal Directed Nutrition (EGDN) during
ICU stay compared to standard care nutrition delivery result in improved
physical quality of life at 6 months?
4. Design of the trial
Single center study,
Randomized control trial, (1:1) two computer-generated randomization lists
with random block size.
Blinded Outcome Assessment.
Allocation were concealed in envelopes in accordance with SNOSE principle.
Intervention commenced within 24 hours.
200 pts. were required to demonstrate a 15% relative reduction in physical
component summary (PCS) score at 6 months with a significance level 0.05
and 80% power.
5. Population
Inclusion Criteria: 18 years of age or older within 24 h of any ICU admission
for inclusion if they were
acutely admitted to the ICU;
had an expected length of stay in the ICU of more than 3 days;
were mechanically ventilated via a cuffed endotracheal or tracheotomy tube;
had a central venous catheter and
were expected to read and understand Danish.
8. Intervention
Early Goal Directed Nutrition Arm
Calculated nutrition requirements:
Energy delivery directed by indirect calorimetry (IC) at randomization and every other day 24-h
urinary urea excretion (nitrogen use) was assessed daily and converted to metabolic protein
consumption using Bistrian’s equation.
Nutrition provision was titrated to IC and nitrogen balance with the aim to meet 100% of energy and
protein needs on the first full trial day and for the duration of ICU stay (to a maximum of 90 days).
Protein was provided as at least 1.5 g/kg/day at all times during admission, regardless of urea
excretion.
Enteral nutrition was initiated within 24 h of randomization and supplemented with PN if necessary
to reach goal requirements.
In case of sustained hyperglycemia (defined as insulin requirement of at least 5 IU/h for > 12
consecutive hours), glucose was reduced and at a plasma urea above 20 mmol/l, protein was reduced
by 0.2 g/kg/day
Supplemental PN was used if energy and protein needs could not be met by EN alone.
9. Control
Standard Care
Energy requirements calculated by 25 kcal/kg/day
EN commenced within 24 hours of randomization and gradually increase as tolerated.
If on day 7 energy needs were not met, supplemental PN was provided.
10. Outcome
Primary outcome:
Physical quality of life after 6 months based on PCS score (Mean PCS score 22.9 vs. standard care: 23.0; p
= 0.99) did not differ between the two groups.
Secondary outcomes:
Mortality at day 28, day 90 and at 6 months: no statistical difference between groups
Day 28: 20% dead in EGDT vs. 21% in control group
Day 90: 30% dead in EGDT vs. 32% in control group
6 months: 37% dead in EGDT vs. 34% in control group
Cumulative energy and protein balances at day 1, 3 and 7 and over the course of the ICU stay was higher
in the EGDN group.
Insulin requirement: the EGDN group received a greater median (IQR) dose of insulin and had a
greater proportion of BGL ≥ 15 mmol/L,
Episodes of hyperglycemia: More patients in the EGDN group experienced at least one episode of
hyperglycemia
No difference in: length of stay among survivors in ICU or hospital, new organ failure, time to any
infection or type of nosocomial infection, rates of hypoglycemia.
11. Authors Conclusion
The EGDN strategy resulted in greater energy and protein delivery in the ICU
compared to standard care, but no differences were observed in PSC score at 6
months or any other clinically important outcomes.
12. Strengths
A highly relevant clinical question especially when previous evidences are
unequivocal.
Randomized, blinded outcome assessment.
The primary outcome was physically focused outcome as compared to muscle
functionality.
Study design attempts to titrated nutrition based on metabolic changes
that occur during critical illness. Measured energy expenditure.
Provides further evidence about the utility of IC in critical illness.
Strictly followed the ESPEN guidelines.
13. Limitations
Single center study, and so the results may not be generalizable to all
populations.
The primary outcome was a long term outcome, but the intervention was early
and very short duration. It may not be biologically plausible that the
intervention would effect the outcome.
Missing data was imputed. It seemed to be well understood and conducted by
the authors but there is always a risk of inappropriate imputation.
The patients may not have been likely to benefit from intervention as they were
not long stay patients (7 days).
Early nutrition intervention when metabolic processes are aimed to mobilize
endogenous energy stores may place the patient under further metabolic stress
14. My take!
Doesn’t change practice. Probably will delay PN feeding in critically ill patient
as no outcome benefit. High glucose production initially, may lead to
overfeeding.
Septic patients 47% hasn’t shown any benefit per say. Need more info on non-
septic patients.
Calories were administered as per actually energy expenditure. IC.
Significantly low HRQOL score. Low skeletal muscle functional scores, mass scores.
Less gut translocation, Meets the catabolic demands of the body, supports the immune response to illness.
A cookie or Grand Big Macburger. Overfeeding risks hyperlipidemia, hyperglycemia, azotemia, fluid overload, CO2 production, liver damage.
21 RCT has supported early EN. However, anorexia is an evolutionary response to illness hence don’t feed early. Early PN in EPaNIC trial has not shown benefits!
Sequentially Numbered, Opaque Sealed Envelopes (SNOSE).
Estimates were based on previous study in ICU population.
Physical and mental comment summary is part of Short Form-12.
physical health problems (4 items), bodily pain (2 items), general health (5 items), vitality (4 items), social functioning (2 items)
Values are medians (interquartile ranges) or numbers (%). Additional baseline characteristics are presented in Table S1, ESM
BMI body mass index, ICU intensive care unit, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment
a BMI was calculated as estimated weight (kg) divided by height (cm) squared
b Patients were included within 24 h of admission to any ICU
c Stratification variable
d SAPS II was calculated from 17 variables. Scores range from 0 to 163 with higher scores indicating more severe disease
e SOFA score includes subscores ranging from 0 to 4 for each of 5 components (circulation, lungs, liver, kidneys and coagulation), aggregated scores ranging from 0 to
20 with higher scores indicating more severe organ failure. The scores were modified as cerebral failure was not assessed
Management common to both groups
The same EN and PN solutions
The same blood glucose level (BGL) aims (6-10 mmol/l)
Supplemental trace elements and vitamins based on measurements
The same gastric residual volume (GRV) cut off and protocol for management (based on usual practice in the ICU)
The same mobilization protocol (based on usual practice in the ICU)
Primary outcomes is highly variable in nutrition based trials in ICU.
Imputation is a process of replacing the data with substituted values.
On an average 7 days.