A 45-year-old man awoke with a painful and swollen right great toe after eating fried liver and drinking beer the night before. His uric acid level was elevated at 8.0 mg/dl, above the normal range. Both his father and grandfather, who were alcoholics, often had joint pain and swelling in their feet. The man likely has gouty arthritis, which is caused by elevated uric acid levels and is known to be associated with alcohol consumption and genetic predisposition.
these clearance test plays an very important role in determining the functioning capacity and working status of kidney.
and we estimate how amount of compund is excreted in the urine and absorption too.
and i also attached the mathematical caluculation to identify the metabolic valuve of urea, creatinine, inulin clearance by kidney.
these clearance test plays an very important role in determining the functioning capacity and working status of kidney.
and we estimate how amount of compund is excreted in the urine and absorption too.
and i also attached the mathematical caluculation to identify the metabolic valuve of urea, creatinine, inulin clearance by kidney.
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
This presentation includes Biochemistry of protein metabolism.
It deals with Digestion & absorption of protein, transamination, deamination, Nitrogen Metabolism & Meatbolism of Glycine, Aromatic Amino acids, Sulphur containing Amino acid, one carbon metabolism. it also includes cases and questions for self study.
The liver is the largest organ in the body
It is located below the diaphragm in the right upper quadrant of the abdominal cavity and extended approximately from the right 5th rib to the lower border of the rib cage.
Renal function tests are very useful for effective clinical evaluation of renal failure for effective management. So it is useful for medical and allied professional students and clinical practitioners.
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
This presentation includes Biochemistry of protein metabolism.
It deals with Digestion & absorption of protein, transamination, deamination, Nitrogen Metabolism & Meatbolism of Glycine, Aromatic Amino acids, Sulphur containing Amino acid, one carbon metabolism. it also includes cases and questions for self study.
The liver is the largest organ in the body
It is located below the diaphragm in the right upper quadrant of the abdominal cavity and extended approximately from the right 5th rib to the lower border of the rib cage.
Renal function tests are very useful for effective clinical evaluation of renal failure for effective management. So it is useful for medical and allied professional students and clinical practitioners.
http://curegoutpainnow.com - Gout is a painful condition, often affecting the toes, but it can affect many other joints as well. If left alone it can get worse, turn into a chronic problem and even cause permanent damage. Gout and uric acid levels in the body are inextricably intertwined as the uric acid leads to the gout problems
billirubin production billirubin transport and metabolism, different laboratory methods of billirubin estimation ,normal and abnormal levels of billirubin, different classification and types of jaundice and liver diseses, liver functioning, enterohepatic circulation, billirubin production and degradation, benefits and diseases of abnormal level of billirubin
http://curegoutpainnow.com
The best long term results are obtained by eating a properly planned uric acid diet. Any diet plan that is prescribed for gout patients must be able to reduce the level of uric acid in the blood.
http://curegoutpainnow.com
Uric acid crystals are the underlying problem causing gout pain and inflammation. When there is too much uric acid being produced in the body some of it will form hard microscopic crystals which build up in joint areas.
Grand Rounds which summarizes the data pointing to fructose and sugar intake as the chief cause of hypertension and the use of allopurinal to treat pediatric hypertension.
Inborn errors of metabolism
Definition:- Inborn errors of metabolism occur from a group of rare genetic disorders in which the body cannot metabolize food components normally.
These disorders are usually caused by defects in the enzymes involved in the biochemical pathways that break down food components.
Xanthinuria
Xanthinuria, also known as xanthine oxidase deficiency, is a rare genetic disorder causing the accumulation of xanthine. It is caused by a deficiency of the enzyme xanthine oxidase.
Orotic aciduria
Orotic aciduria is a disease caused by an enzyme deficiency resulting in a decreased ability to synthesize pyrimidines. It is the only known enzyme deficiency of the de novo pyrimidine synthesis pathway.
Gout
Gout is caused by a condition known as hyperuricemia, where there is too much uric acid in the body.
An inherited enzyme deficiency leading to the disruption of normal bodily metabolism.
Accumulation of a toxic substrate.
Impaired formation of a product normally produced by the deficient enzyme.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
1. Case Scenario!
•
A 45 year old man awoke from sleep with a painful and swollen right
great toe. On the previous night he had a meal of fried liver and
onions, after which he met with his poker group and drank a number
of beers.
• He saw his doctor that morning and some tests were ordered. His
serum uric acid level was elevated at 8.0 mg/dl. (What is normal
value?)
• The man recalled that his father and his grandfather, both of whom
were alcoholics, often complained of joint pain and swelling in their
feet.
•
What can be his probable diagnosis?
Gouty Arthritis
8. Degradation of Pyrimidines
1. CMP and UMP degraded to bases similarly to purines.
A. Dephosphorylation
B. Deamination
C. Glycosidic bond cleavage
2. Uracil reduced in liver, forming β-Alanine
3. Converted to malonyl-CoA
energy metabolism
fatty acid synthesis for
9. Important points about Uric Acid
1. Final breakdown product of purine degradation in humans.
2. Urates, the ionized forms of uric acid, predominate in
plasma extracellular fluid and synovial fluid, with ~98%
existing as monosodium urate at pH 7.4.
3. Urate is produced only in tissues that contain xanthine
oxidase, primarily the liver and small intestine.
4. Two-thirds to three-fourths of urate is excreted by the
kidneys, and most of the remainder is eliminated through
the intestines.
10. Important points about Uric Acid (Contd..)
1.Daily synthesis 400mg
2.Dietary sources 300mg
3.Normal uric acid pool: 1200mg in males and 600mg in
females.
4.75% excreted in urine, remainder in GIT where it’s degraded
to Allantoin by bacterial enzymes.
11. Hyperuricemia
Defined as a plasma urate concentration > 7.0 mg/dl
Increased production of uric acid
Primary
• Adenine phosphoribosyl
transferase (APRT)
• Hypoxanthine-Guanine
phosphoribosyl
transferase [Lesch-Nyhan
Syndrome]
• Increased phosphoribosyl
pyrophosphatase activity.
Secondary
• Myeloproliferative
disease
• Lymphoproliferative
disease
• Hemolitic anemia
• Drugs:
Low-doses
salicylate,
diuretis,
pyrazinamide,
ethambutol,
nicotinamide,
ethanol,
cytotoxic
drugs.
Decreased excretion of uric acid
• Alterated uric acid excretion could result
from decreased glomerular filtration,
decreased tubular secretion or enhanced
tubular reabsorption.
• Diabetic ketoacidosis, starvation,
lactic
acidosis, and salicylate intoxication are
accompanied by accumulations of organic
acids
(B-hydroxybutyrate, acetoacetate,
lactate or salicylates) that compete with
urate for tubular secretion.
12. Lesch-Nyhan Syndrome
A defect in production or activity of HGPRT
Causes increased level of hypoxanthine and Guanine (↑ in
degradation to uric acid)
Also,PRPP accumulates.
Stimulates production of purine nucleotides (and thereby increases
their degradation)
Causes gout-like symptoms, but also neurological symptoms
spasticity, aggressiveness, self-mutilation, head banging.
First neuropsychiatric abnormality that was attributed to a single
enzyme.
Up to 20 times the uric acid in the urine than in normal individuals.
Uric acid crystals form in the urine.
Life expectancy is early- to mid-20s.
13. ADENOSINE DEAMINASE DEFICIENCY
In purine degradation, adenosine
ADA deficiency results
immunodeficiency”
in
inosine enzyme is ADA.
SCID
“severe
combined
Selectively kills lymphocytes - both b- and t-cells.
Mediate much of immune response.
One of first diseases to be treated with gene therapy.
ADA gene inserted into lymphocytes; then lymphocytes returned
to patient.
14. Glucose-6-phosphatase (G6Pase) deficiency
1. Also known as von Gierke's disease.
2. Unable to dephosphorylate G6P.
3. Glucose-6-P goes into Pentose Phosphate shut.
4. Excess production of ribose-5-phosphate.
5. Cause hypoglcemia as liver fails to form glucose from
glycogen. [Glycogen storage disease type I (GSD I)]
15. Colorimetric determination of uric acid in serum
SPECIMEN
• Serum is the best, heparinized plasma can be used.
•
Lipemic and increased bilirubin sample should be avoided.
•
Drugs such as thiazide and salicyclate cause elevation in uric acid. Why?
•
Uric acid levels are effected by diet esp. red meat. Why? So will you ask
your patient to fast overnight?
•
Serum should be separated quickly from whole blood. Why?
16. Method Used
1. Chemical method --- phosphotungstic acid method
2. Enzymatic ---- uricase methods.